Population Pharmacokinetics
... Rapid maturation of organ functions important for drug absorption, distribution and elimination is a specific feature of very young paediatric patients, therefore changes in dose may be necessary for a patient over time, based on individual maturation. Pharmacokinetic studies in the paediatric p ...
... Rapid maturation of organ functions important for drug absorption, distribution and elimination is a specific feature of very young paediatric patients, therefore changes in dose may be necessary for a patient over time, based on individual maturation. Pharmacokinetic studies in the paediatric p ...
FLAVONOIDS
... Flavonoids are now referred to as “venoactive” or “vascular protective and venous tonic agents”. ...
... Flavonoids are now referred to as “venoactive” or “vascular protective and venous tonic agents”. ...
horse and topical anesthetic
... cell layers and anterior stroma are richly innervated, with unsheathed nerve endings present in the epithelium.1 The density and distribution of corneal nerves have been extensively studied in humans, dogs, cats, and rabbits but have not been determined to date in horses, to our knowledge.2–4 Cornea ...
... cell layers and anterior stroma are richly innervated, with unsheathed nerve endings present in the epithelium.1 The density and distribution of corneal nerves have been extensively studied in humans, dogs, cats, and rabbits but have not been determined to date in horses, to our knowledge.2–4 Cornea ...
Speed or Safety
... diseases, like diabetes or liver problems, the risk of danger would be high. The main problem with buying the pill at drugstores without a prescription is some people don’t pay attention to drug labels or specific instructions. If a prescription is required to buy the pill in Korea, people must go t ...
... diseases, like diabetes or liver problems, the risk of danger would be high. The main problem with buying the pill at drugstores without a prescription is some people don’t pay attention to drug labels or specific instructions. If a prescription is required to buy the pill in Korea, people must go t ...
PRODUCT MONOGRAPH DESIPRAMINE
... exaggerated. This drug should be discontinued as soon as possible prior to elective surgery because of possible cardiovascular effects. Hypertensive episodes have been observed during surgery in patients taking desipramine hydrochloride. The contraindication regarding its concomitant use with MAO in ...
... exaggerated. This drug should be discontinued as soon as possible prior to elective surgery because of possible cardiovascular effects. Hypertensive episodes have been observed during surgery in patients taking desipramine hydrochloride. The contraindication regarding its concomitant use with MAO in ...
National report 2014: Poland - European Monitoring Centre for
... 2014 NATIONAL DRUG REPORT (2013 data) TO THE EMCDDA by the Polish REITOX Focal Point ...
... 2014 NATIONAL DRUG REPORT (2013 data) TO THE EMCDDA by the Polish REITOX Focal Point ...
Cocaine - Youville
... they do, it can be one of the hardest drug habits to break. People who become addicted to cocaine lose control over their use of the drug. They feel a strong need for cocaine, even when they know it causes them medical, psychological and social problems. Getting and taking cocaine can become the mos ...
... they do, it can be one of the hardest drug habits to break. People who become addicted to cocaine lose control over their use of the drug. They feel a strong need for cocaine, even when they know it causes them medical, psychological and social problems. Getting and taking cocaine can become the mos ...
patrick_tb_ch22
... basic than the nitrogen. b. The side chain has an inductive electron donating effect on the ring making the nitrogen less basic than the nitrogen. c. The side chain has an inductive electron withdrawing effect on the ring making the nitrogen less basic than the nitrogen. d. The side chain ...
... basic than the nitrogen. b. The side chain has an inductive electron donating effect on the ring making the nitrogen less basic than the nitrogen. c. The side chain has an inductive electron withdrawing effect on the ring making the nitrogen less basic than the nitrogen. d. The side chain ...
Novel psychoactive substances: types, mechanisms of action, and
... phencyclidine, though the evidence emerging from NPS case studies literature fits with these.46 47 Deaths are primarily accidental, through impulsive and careless behaviours,10 although there are reports of fatalities directly linked to methoxetamine toxicity.49 50 Consistent with ketamine and phenc ...
... phencyclidine, though the evidence emerging from NPS case studies literature fits with these.46 47 Deaths are primarily accidental, through impulsive and careless behaviours,10 although there are reports of fatalities directly linked to methoxetamine toxicity.49 50 Consistent with ketamine and phenc ...
Heparin, low-molecular–weight heparins, and heparin - hem
... Knowing the pathogenic trigger is helpful in the optimization of therapeutic or prophylactic use of these drugs. It is well appreciated that antithrombotic drugs represent a wide spectrum of naturally, synthetically, semisynthetically, and biotechnologically produced agents with marked differences i ...
... Knowing the pathogenic trigger is helpful in the optimization of therapeutic or prophylactic use of these drugs. It is well appreciated that antithrombotic drugs represent a wide spectrum of naturally, synthetically, semisynthetically, and biotechnologically produced agents with marked differences i ...
dose - Recherche Clinique Paris Centre
... • Widely used as a reference inhibitor to test in vivo the potential effect of CYP3A inhibition on drugs being a substrate for this enzyme ● The aim of this study is to assess the effect of a repeated ketoconazole administration on the pharmacokinetic profile of a single oral dose of the IP, in heal ...
... • Widely used as a reference inhibitor to test in vivo the potential effect of CYP3A inhibition on drugs being a substrate for this enzyme ● The aim of this study is to assess the effect of a repeated ketoconazole administration on the pharmacokinetic profile of a single oral dose of the IP, in heal ...
Clinical relevance of the small intestine as an organ of
... metabolism by the gut and liver, respectively. This simple equation demonstrates the impact of a second presystemic site of metabolism on Fora,. For example, if a drug is absorbed into enterocytes intact (Fabs = 100%), and has an FG of 60% and an FL of 40%, then an Fora, of 24% is predicted, which ...
... metabolism by the gut and liver, respectively. This simple equation demonstrates the impact of a second presystemic site of metabolism on Fora,. For example, if a drug is absorbed into enterocytes intact (Fabs = 100%), and has an FG of 60% and an FL of 40%, then an Fora, of 24% is predicted, which ...
A Brief History of Great Discoveries in Pharmacology: In Celebration
... aspect that sets present-day science apart from the past is how rapidly it progresses. The number of publications continues to grow to such an extent that many investigators now consider it an inefficient utilization of time to devote their attention to the older literature in their respective field ...
... aspect that sets present-day science apart from the past is how rapidly it progresses. The number of publications continues to grow to such an extent that many investigators now consider it an inefficient utilization of time to devote their attention to the older literature in their respective field ...
Product Data Sheet - Douglas Laboratories
... A clinical trial demonstrated PectaSol’s ability to bind and remove toxic heavy metals from the body, without affecting essential minerals. Heavy metal removal with Pecta-Sol has been shown in multiple case studies to play a role in ongoing health maintenance. A hospital case study in 2008 reported ...
... A clinical trial demonstrated PectaSol’s ability to bind and remove toxic heavy metals from the body, without affecting essential minerals. Heavy metal removal with Pecta-Sol has been shown in multiple case studies to play a role in ongoing health maintenance. A hospital case study in 2008 reported ...
Serum albumin, the most abundant protein in the
... Serum albumin, the most abundant protein in the circulatory system, has been one of the most extensively studied of all proteins 1. Serum albumins are prone to bind effectively many small organic molecules. Bovine serum albumin (BSA), a large globular protein (65,000 Daltons), consists of a single c ...
... Serum albumin, the most abundant protein in the circulatory system, has been one of the most extensively studied of all proteins 1. Serum albumins are prone to bind effectively many small organic molecules. Bovine serum albumin (BSA), a large globular protein (65,000 Daltons), consists of a single c ...
Synthesis, Molecular Docking, and Biological Evaluation of Some
... COX-2 enzymes were determined in vitro, and they were also tested for their ulcerogenic effect. Molecular docking was performed on the active site of COX-2 to predict their mode of binding to the amino acids. Most of the synthesized compounds showed good antiinflammatory activity especially compound ...
... COX-2 enzymes were determined in vitro, and they were also tested for their ulcerogenic effect. Molecular docking was performed on the active site of COX-2 to predict their mode of binding to the amino acids. Most of the synthesized compounds showed good antiinflammatory activity especially compound ...
Cytochrome P450 and Chemical Toxicology
... individuals who used drugs that inhibit P450 3A4 (e.g., ketoconazole and erythromycin), terfenadine accumulated in the plasma and cardiac tissue. Dietary constituents (e.g., grapefruit) can also inhibit P450s, although not to the extent to present serious danger with terfenadine (61). Terfenadine it ...
... individuals who used drugs that inhibit P450 3A4 (e.g., ketoconazole and erythromycin), terfenadine accumulated in the plasma and cardiac tissue. Dietary constituents (e.g., grapefruit) can also inhibit P450s, although not to the extent to present serious danger with terfenadine (61). Terfenadine it ...
Cocaine - South Carolina Department of Alcohol and Other Drug
... blood tests? The time period during which cocaine use can be detected varies according to the type of test (or “screen”) being used and the limits assigned to each individual test. Generally, cocaine use can be detected for as long as 10 days to five weeks after use by high-dose abusers, and from tw ...
... blood tests? The time period during which cocaine use can be detected varies according to the type of test (or “screen”) being used and the limits assigned to each individual test. Generally, cocaine use can be detected for as long as 10 days to five weeks after use by high-dose abusers, and from tw ...
CYP2B6, CYP2D6, and CYP3A4 Catalyze the Primary Oxidative
... High-Performance Liquid Chromatography Assay of the 4-Monohydroxy Metabolites of (ⴙ)- and (ⴚ)-PHX. The formation of cis-, trans1-, and trans2-OH-(⫹)-PHX from (⫹)-PHX and cis-, trans1-, and trans2-OH-(⫺)PHX from (⫺)-PHX in microsomal incubations was determined using a recently developed method (Davie ...
... High-Performance Liquid Chromatography Assay of the 4-Monohydroxy Metabolites of (ⴙ)- and (ⴚ)-PHX. The formation of cis-, trans1-, and trans2-OH-(⫹)-PHX from (⫹)-PHX and cis-, trans1-, and trans2-OH-(⫺)PHX from (⫺)-PHX in microsomal incubations was determined using a recently developed method (Davie ...
Formulation of Effervescent Ibuprofen
... is a medication in the nonsteroidal anti-inflammatory drug (NSAID) fig(1) class that is used for treating pain, fever, and inflammation.5 This includes painful menstrual periods, migraines, and rheumatoid arthritis.5 About 60% of people improve with any given NSAID, and it is recommended that if one ...
... is a medication in the nonsteroidal anti-inflammatory drug (NSAID) fig(1) class that is used for treating pain, fever, and inflammation.5 This includes painful menstrual periods, migraines, and rheumatoid arthritis.5 About 60% of people improve with any given NSAID, and it is recommended that if one ...
anticholinergic drugs and dementia
... People may feel drowsy and less attentive after they have taken an anticholinergic medicine, but these are short-term, reversible changes. Older people may be more susceptible to anticholinergic effects such as confusion or delirium, which in turn may increase their risk of falls or hospitalisation. ...
... People may feel drowsy and less attentive after they have taken an anticholinergic medicine, but these are short-term, reversible changes. Older people may be more susceptible to anticholinergic effects such as confusion or delirium, which in turn may increase their risk of falls or hospitalisation. ...
Could Science-Based Regulation Make Tobacco Products Less
... cigarettes and smokeless tobacco was largely driven by addiction to nicotine. Nicotine is a powerful and potent drug (about five to ten times more potent than cocaine in the alteration of mood and behavior) that naturally occurs in the tobacco plant.8 It has been used as a pharmacological tool to ex ...
... cigarettes and smokeless tobacco was largely driven by addiction to nicotine. Nicotine is a powerful and potent drug (about five to ten times more potent than cocaine in the alteration of mood and behavior) that naturally occurs in the tobacco plant.8 It has been used as a pharmacological tool to ex ...
Neurobiological substrates for the dark side of compulsivity in
... individuals can evolve into an opioid-like situation in which they must have alcohol available at all times to avoid the negative consequences of abstinence. Tobacco addiction contrasts with the above patternsdthe binge/intoxication stage forms a minor component of nicotine dependence. The pattern o ...
... individuals can evolve into an opioid-like situation in which they must have alcohol available at all times to avoid the negative consequences of abstinence. Tobacco addiction contrasts with the above patternsdthe binge/intoxication stage forms a minor component of nicotine dependence. The pattern o ...
What are the differences between different brands of mesalazine
... Octasa MR 400mg was previously branded as Mesren MR. Octasa MR has not been compared to other mesalazine MR preparations in patient studies because to obtain a licence as a generic medicine, the product only needs to demonstrate bioequivalence to the brand leader (17, 21). Choice of preparation The ...
... Octasa MR 400mg was previously branded as Mesren MR. Octasa MR has not been compared to other mesalazine MR preparations in patient studies because to obtain a licence as a generic medicine, the product only needs to demonstrate bioequivalence to the brand leader (17, 21). Choice of preparation The ...
Full Text - AIMS Press
... tetracycline structure. The modifications were still able to bind HA but did not retain the biological activity.[42] Despite these efforts, its complicated chemical structure and its poor stability during chemical modifications, pledged its use.[36] Unlike tetracycline, bisphosphonates have attracte ...
... tetracycline structure. The modifications were still able to bind HA but did not retain the biological activity.[42] Despite these efforts, its complicated chemical structure and its poor stability during chemical modifications, pledged its use.[36] Unlike tetracycline, bisphosphonates have attracte ...
Drug design
Drug design, sometimes referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is often referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.The phrase ""drug design"" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and efficacious drug. These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.