CHEMICAL STABILITY STUDIES OF BIOADHESIVE TOPICAL GEL Research Article LALIT KUMAR
... significant by studying one way ANOVA at p<0.05 level. In last it was concluded that, BNTG3 will be more effective and stable if it is stored at or below 25±2°C. So, BNTG3 was successfully developed and standardized for improved topical therapeutics. Keywords: Gel, Bioadhesion, Stability Study, ...
... significant by studying one way ANOVA at p<0.05 level. In last it was concluded that, BNTG3 will be more effective and stable if it is stored at or below 25±2°C. So, BNTG3 was successfully developed and standardized for improved topical therapeutics. Keywords: Gel, Bioadhesion, Stability Study, ...
Reflection Paper co-development of PG biomarkers and Assays in
... The co-development of the PGBM/assay and a drug should be seen as a continuous process that goes through analytical validity of the PGBM assay at early stage of the drug development, clinical validity / studies of PGBM (to ensure that the PGBM assay is able to select/stratify patients) and ultimatel ...
... The co-development of the PGBM/assay and a drug should be seen as a continuous process that goes through analytical validity of the PGBM assay at early stage of the drug development, clinical validity / studies of PGBM (to ensure that the PGBM assay is able to select/stratify patients) and ultimatel ...
Heroin: A Hundred-Year HabitHeroin: A Hundred
... academic honours by the author of ‘Faust’, Goethe himself. The possibility of obtaining morphine and other pure drugs from plants brought commercial reward for entrepreneurs such as Georg Merck (1825-73), who turned his family’s seventeenth-century pharmacy in Darmstadt into a major supplier of thes ...
... academic honours by the author of ‘Faust’, Goethe himself. The possibility of obtaining morphine and other pure drugs from plants brought commercial reward for entrepreneurs such as Georg Merck (1825-73), who turned his family’s seventeenth-century pharmacy in Darmstadt into a major supplier of thes ...
Structure-function of the ADP/ATP carrier
... visualized that a translocation channel exists within each subunit formed by the three repeat domains along the pseudo threefold symmetry axis. Another model depends on the dirneric structure of these carriers. T h e carrier homodirners have been shown to have only one binding site for specific inhi ...
... visualized that a translocation channel exists within each subunit formed by the three repeat domains along the pseudo threefold symmetry axis. Another model depends on the dirneric structure of these carriers. T h e carrier homodirners have been shown to have only one binding site for specific inhi ...
isotonics_2012_part2
... Eye drops commonly use boric acid to adjust the tonicity. You are asked to prepare an isotonic formulation of 6.25% streptomycin sulfate (SCE = 0.06) and 0.5% chlorbutol (SCE = 0.24). What amount of boric acid (SCE ...
... Eye drops commonly use boric acid to adjust the tonicity. You are asked to prepare an isotonic formulation of 6.25% streptomycin sulfate (SCE = 0.06) and 0.5% chlorbutol (SCE = 0.24). What amount of boric acid (SCE ...
ANTI-INFLAMMATORY ACTIVITY OF PLANTAGO EROSA WALL EXTRACTS IN RATS
... Northeast India including the state of Manipur is the abode of several native medicinal plants and has a long tradition of using these plants as therapeutic agent. Scientific study and relevant verifications of these plants for their various medicinal properties are the need of the hour. as These tr ...
... Northeast India including the state of Manipur is the abode of several native medicinal plants and has a long tradition of using these plants as therapeutic agent. Scientific study and relevant verifications of these plants for their various medicinal properties are the need of the hour. as These tr ...
Patient Education/Discharge Planning
... Demonstrate understanding of drug therapy Demonstrate evidence of resolution of diagnosed infection after drug therapy is completed Maintain adequate fluid and electrolyte balance Implementation Interventions and (Rationales) Patient Education/Discharge Planning Safety for use by children un ...
... Demonstrate understanding of drug therapy Demonstrate evidence of resolution of diagnosed infection after drug therapy is completed Maintain adequate fluid and electrolyte balance Implementation Interventions and (Rationales) Patient Education/Discharge Planning Safety for use by children un ...
What you need to know…NOW
... maintain any sort of permanent tool or device to ingest the drug. However, if the user is injecting the drug then there will be needles, syringes and any items that can be used as a tourniquet. Potential for abuse: There is huge potential for abuse with this type of drug in that it tends to cause us ...
... maintain any sort of permanent tool or device to ingest the drug. However, if the user is injecting the drug then there will be needles, syringes and any items that can be used as a tourniquet. Potential for abuse: There is huge potential for abuse with this type of drug in that it tends to cause us ...
Dementia and Pharmacy Intervention
... • Occur when the effectiveness or toxicity of a drug is altered by the concomitant administration of another drug • 3 classifications of drug interactions ...
... • Occur when the effectiveness or toxicity of a drug is altered by the concomitant administration of another drug • 3 classifications of drug interactions ...
Buffered Isotonic Solutions
... for Liso, namely 3.4. As a result of this similarity between compounds of a given ionic type, It will be observed that for dilute solutions of nonelectrolytes, Liso is approximately equal to Kf. . A plot of iKf against molar concentration of various types of .electrolytes, from which the values of L ...
... for Liso, namely 3.4. As a result of this similarity between compounds of a given ionic type, It will be observed that for dilute solutions of nonelectrolytes, Liso is approximately equal to Kf. . A plot of iKf against molar concentration of various types of .electrolytes, from which the values of L ...
AntiretroviralAgents..
... polyproteins - Virions are produced but they are incomplete and noninfectious ...
... polyproteins - Virions are produced but they are incomplete and noninfectious ...
No Slide Title
... Toxicological Profile of Newly Submitted Therapeutics Integrated knowledge base(OTR Programs); Proposed to support entry of women of child bearing potential into phase I clinical trials (FDA/Office of Women’s Health) ...
... Toxicological Profile of Newly Submitted Therapeutics Integrated knowledge base(OTR Programs); Proposed to support entry of women of child bearing potential into phase I clinical trials (FDA/Office of Women’s Health) ...
Sheet_18
... As a definitive therapy, doxycycline can be used for treatment of atypical pneumonia. (after the culture results are back telling you that the cause of atypical pneumonia in your patient is mycoplasma for example). Mycoplasma pneumoniae is a common cause of peumonia in young adults and in people w ...
... As a definitive therapy, doxycycline can be used for treatment of atypical pneumonia. (after the culture results are back telling you that the cause of atypical pneumonia in your patient is mycoplasma for example). Mycoplasma pneumoniae is a common cause of peumonia in young adults and in people w ...
![7. Calculation of Doses- General considerations.ppt [相容模式]](http://s1.studyres.com/store/data/006006284_1-d1ebc8ccd289cccf8e1ae3da44a9ffb1-300x300.png)
7. Calculation of Doses- General considerations.ppt [相容模式]
... mg/day for 5 days by intravenous infusion. The usual daily dose of prednisone is 5 to 60 mg/day, depending on the condition being treated. Calculate the doses that the patient received, as a multiple of the highest usual daily dose. q ...
... mg/day for 5 days by intravenous infusion. The usual daily dose of prednisone is 5 to 60 mg/day, depending on the condition being treated. Calculate the doses that the patient received, as a multiple of the highest usual daily dose. q ...
Naprox®
... Naprox® and other non-steroidal anti-inflammatory drugs can reduce the anti-hypertensive effect of propranolol and other beta-blockers. The natriuretic effects of frusemide have been reported to be inhibited by some drugs of this class. Probenecid given concurrently increases naproxen plasma levels ...
... Naprox® and other non-steroidal anti-inflammatory drugs can reduce the anti-hypertensive effect of propranolol and other beta-blockers. The natriuretic effects of frusemide have been reported to be inhibited by some drugs of this class. Probenecid given concurrently increases naproxen plasma levels ...
OLANZAPINE (ZYPREXA®)
... High blood sugar or diabetes, high cholesterol, and weight gain have happened with drugs like this one. These changes may raise the chance of heart and brain blood vessel disease. Talk with the doctor. Have your child’s blood sugar and blood work checked as you have been told by your child’s doc ...
... High blood sugar or diabetes, high cholesterol, and weight gain have happened with drugs like this one. These changes may raise the chance of heart and brain blood vessel disease. Talk with the doctor. Have your child’s blood sugar and blood work checked as you have been told by your child’s doc ...
Drug discovery from medicinal plants
... exploring the creation of natural product and natural-productlike libraries that combine the structural features of natural products with the compound-generating potential of combinatorial chemistry (Hall et al., 2001a; Eldridge et al., 2002; Burke et al., 2004; Ganesan, 2004; Tan, 2004). Drugs deri ...
... exploring the creation of natural product and natural-productlike libraries that combine the structural features of natural products with the compound-generating potential of combinatorial chemistry (Hall et al., 2001a; Eldridge et al., 2002; Burke et al., 2004; Ganesan, 2004; Tan, 2004). Drugs deri ...
Importance of in -vitro in -vivo studies in pharmaceutical
... drug is an identical, or bioequivalent to a brand name drug in dosage form, safety, strength, route of administration, quality, performance characteristics and intended use. Once innovator patents and exclusivity periods of the innovator expires, generic company can market their product by proving e ...
... drug is an identical, or bioequivalent to a brand name drug in dosage form, safety, strength, route of administration, quality, performance characteristics and intended use. Once innovator patents and exclusivity periods of the innovator expires, generic company can market their product by proving e ...
Gastroretentive Drug Delivery Systems As A Potential Tool For
... dissolution medium. The best formula selected on the basis of in-vitro evaluation was subjected to in-vivo radiographic studies by incorporating barium sulfate. These studies revealed that the tablets remained in the stomach for 180 ± 30 min in fasting human volunteers indicating prolongation of gas ...
... dissolution medium. The best formula selected on the basis of in-vitro evaluation was subjected to in-vivo radiographic studies by incorporating barium sulfate. These studies revealed that the tablets remained in the stomach for 180 ± 30 min in fasting human volunteers indicating prolongation of gas ...
Pharmacy Benefit Management 101
... Rebate is a refund received from drug manufacturers for the inclusion of their products on a formulary or a payment from a manufacturer to offset the cost of a brand-name drug ...
... Rebate is a refund received from drug manufacturers for the inclusion of their products on a formulary or a payment from a manufacturer to offset the cost of a brand-name drug ...
comments - Association of National Advertisers
... July 2, 2010 whether a major statement is presented in a ‘neutral’ manner.”11 As a consequence, FDA says it “ . . . will provide an opportunity for public comment on the results of the analyses either during the existing comment period or through reopening the comment period if necessary.” Put diffe ...
... July 2, 2010 whether a major statement is presented in a ‘neutral’ manner.”11 As a consequence, FDA says it “ . . . will provide an opportunity for public comment on the results of the analyses either during the existing comment period or through reopening the comment period if necessary.” Put diffe ...
Enhanced water solubility for enhanced oral drug delivery via the
... Enhancing Permeability and Absorption The transport of a drug to its site of action usually requires passage through several lipid membranes; therefore, membrane permeability has a considerable influence on drug efficacy. In oral drug delivery in particular, which is the preferred route for the m ...
... Enhancing Permeability and Absorption The transport of a drug to its site of action usually requires passage through several lipid membranes; therefore, membrane permeability has a considerable influence on drug efficacy. In oral drug delivery in particular, which is the preferred route for the m ...
Scope And Significance Of Floating Drug Delivery System
... the hydrophobic pockets of protein receptors. Delivery of drugs at a specific region in gastrointestinal tract, the so called absorption window needs the development of gastro retentive dosage forms. The attempts to develop gastro retentive drug delivery systems may be largely divided into two class ...
... the hydrophobic pockets of protein receptors. Delivery of drugs at a specific region in gastrointestinal tract, the so called absorption window needs the development of gastro retentive dosage forms. The attempts to develop gastro retentive drug delivery systems may be largely divided into two class ...
Drug design
Drug design, sometimes referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is often referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.The phrase ""drug design"" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and efficacious drug. These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.