Hallucinogenic Drugs
... LSD. He later wrote of his experience, ‘There surged upon me an uninterrupted stream of fantastic images of extraordinary plasticity and vividness and accompanied by an intense, kaleidoscope-like play of colors.’ LSD was not the first hallucinogen to be produced synthetically (the first was mescaline ...
... LSD. He later wrote of his experience, ‘There surged upon me an uninterrupted stream of fantastic images of extraordinary plasticity and vividness and accompanied by an intense, kaleidoscope-like play of colors.’ LSD was not the first hallucinogen to be produced synthetically (the first was mescaline ...
Acetylfentanyl - World Health Organization
... Drugs. Desmethyl fentanyl is a synonym for acetylfentanyl, likely due to the removal of a methyl group from the structure of fentanyl. Acetylfentanyl is convertible into fentanyl and is identified as an impurity during the production of fentanyl. It has no known approved medical or industrial applic ...
... Drugs. Desmethyl fentanyl is a synonym for acetylfentanyl, likely due to the removal of a methyl group from the structure of fentanyl. Acetylfentanyl is convertible into fentanyl and is identified as an impurity during the production of fentanyl. It has no known approved medical or industrial applic ...
fast dissolving films - Asian Journal of Pharmaceutical Science and
... technology evolved over the past few years from the confection and oral care markets in the form of breath strips and became a novel and widely accepted form by consumers, so OFDFs are gaining the interest of large number of pharmaceutical industries. The main advantage of this technology is the adm ...
... technology evolved over the past few years from the confection and oral care markets in the form of breath strips and became a novel and widely accepted form by consumers, so OFDFs are gaining the interest of large number of pharmaceutical industries. The main advantage of this technology is the adm ...
Pharmaceutical Price Policies and Practices in China
... Note: in column 3, figures are first given in billion Yuan and then in billion US$ equivalent. ...
... Note: in column 3, figures are first given in billion Yuan and then in billion US$ equivalent. ...
Analytical method development for pharmaceutical
... separations. These HPLC conditions will be used for all subsequent method development experiments. 3. To develop a suitable sample preparation scheme for the drug product. 4. To determine an appropriate standardization method and the use of relative response factors in calculations. 5. To identify t ...
... separations. These HPLC conditions will be used for all subsequent method development experiments. 3. To develop a suitable sample preparation scheme for the drug product. 4. To determine an appropriate standardization method and the use of relative response factors in calculations. 5. To identify t ...
The DEA`s War on Doctors - Association of American Physicians and
... There is an historical parallel with the DEA’s current prosecution of medical doctors in its war on drugs. Before World War I, narcotics were legal and widely used to relieve pain and treat illness. The public was unaware of the addictive potential of these drugs. For example, morphine was commonly ...
... There is an historical parallel with the DEA’s current prosecution of medical doctors in its war on drugs. Before World War I, narcotics were legal and widely used to relieve pain and treat illness. The public was unaware of the addictive potential of these drugs. For example, morphine was commonly ...
Isoniazid, rifampicin and pyrazinamide plasma concentrations 2 and
... drugs, were also identified in 34% of our patients. Although the prevalence of low drug plasma concentrations may show wide variations for a particular drug in TB patients,7,10 other studies have reported that low drug concentrations were associated with factors such as patient age, sex, drug dosage ...
... drugs, were also identified in 34% of our patients. Although the prevalence of low drug plasma concentrations may show wide variations for a particular drug in TB patients,7,10 other studies have reported that low drug concentrations were associated with factors such as patient age, sex, drug dosage ...
HIV-1 Antiretroviral Drug Resistance and Resistance Testing
... appropriate mutations are established by clinical data ...
... appropriate mutations are established by clinical data ...
application of nanotechnology in diagnosis, drug discovery and drug
... tumors, nanoparticles may penetrate the lesion. ...
... tumors, nanoparticles may penetrate the lesion. ...
Novel Detoxification from Opiates
... Now, if you apply for an exemption to prescribe, rational detoxification is possible Some will tolerate rapid detoxification (one to two weeks) Some will require stabilization prior to detoxification Buprenorphine is a great detoxification medication ...
... Now, if you apply for an exemption to prescribe, rational detoxification is possible Some will tolerate rapid detoxification (one to two weeks) Some will require stabilization prior to detoxification Buprenorphine is a great detoxification medication ...
Unit 13: Biochemistry and Biochemical Techniques
... Some knowledge of the chemical structure of the functional groups of the monomers is required: this gives a better understanding of the overall polymeric structure and the biological properties which these groups confer on the polymers. For example, with carbohydrates the aim is to provide sufficien ...
... Some knowledge of the chemical structure of the functional groups of the monomers is required: this gives a better understanding of the overall polymeric structure and the biological properties which these groups confer on the polymers. For example, with carbohydrates the aim is to provide sufficien ...
SPECTROPHOTOMETRIC DETERMINATION OF PRASUGREL IN BULK, DOSAGE AND BIOLOGICAL FLUIDS Research Article
... colour intensity. Finally the concentration of the analyte was also studied. The correlation coefficient was found to be 0.999. The recovery was done by standard addition technique and results were found to be accurate (Table 1). ...
... colour intensity. Finally the concentration of the analyte was also studied. The correlation coefficient was found to be 0.999. The recovery was done by standard addition technique and results were found to be accurate (Table 1). ...
IDENTIFICATION OF DUAL AGONISTIC NOVEL LIGANDS FOR INSULIN RECEPTOR AND... THROUGH MOLECULAR DOCKING
... involved ligand receptor hydrogen bonds are presented in Table-3. DISCUSSION ...
... involved ligand receptor hydrogen bonds are presented in Table-3. DISCUSSION ...
Drug Delivery to the Back of the Eye Following
... towards the development of effective drugs that penetrate into the posterior tissues following topical administration. There has been a limited number of studies published in the literature supporting the penetration of drugs into the vitreous and retina after topical instillation in rabbits [18]. H ...
... towards the development of effective drugs that penetrate into the posterior tissues following topical administration. There has been a limited number of studies published in the literature supporting the penetration of drugs into the vitreous and retina after topical instillation in rabbits [18]. H ...
Organogels: Properties and Applications in drug delivery
... solubility limit of the organogelators. This results in the precipitation of the organogelators as fiber-like structures which undergoes physical interaction so as to form a gelled structure. These solid fiber-like structures align themselves into bundles. On the other hand, fluid-fiber matrix is fo ...
... solubility limit of the organogelators. This results in the precipitation of the organogelators as fiber-like structures which undergoes physical interaction so as to form a gelled structure. These solid fiber-like structures align themselves into bundles. On the other hand, fluid-fiber matrix is fo ...
Lewis 2013
... The rise and spread of antibiotic resistance presents a unique challenge to both science and medicine. Today, the crisis is epitomized by the spread of multidrug-resistant ‘ESKAPE’ organisms (Enterococcus spp., Staphylococcus aureus, Klebsiella spp., Acinetobacter baumannii, Pseudomonas aeruginosa a ...
... The rise and spread of antibiotic resistance presents a unique challenge to both science and medicine. Today, the crisis is epitomized by the spread of multidrug-resistant ‘ESKAPE’ organisms (Enterococcus spp., Staphylococcus aureus, Klebsiella spp., Acinetobacter baumannii, Pseudomonas aeruginosa a ...
Heart Rhythm Disturbances Associated With Rupatadine
... reactions. In particular, the centers request reports of severe events and of events associated with the use of recently marketed drugs. Ad hoc committees evaluate reports using an algorithm to determine whether a causal relationship exists. Reports are included in the databases regardless of causal ...
... reactions. In particular, the centers request reports of severe events and of events associated with the use of recently marketed drugs. Ad hoc committees evaluate reports using an algorithm to determine whether a causal relationship exists. Reports are included in the databases regardless of causal ...
QuickTox Drug Screen Dipcard Quick Reference Guide
... urine-based drugs-of-abuse screening tests. The QuickTox® family of urine drug screen tests is based on the principle of the highly specific immunochemical reactions between antigens and antibodies. The QuickTox® Drug Screen Dipcard Test is based on a competitive immunoassay procedure in which immob ...
... urine-based drugs-of-abuse screening tests. The QuickTox® family of urine drug screen tests is based on the principle of the highly specific immunochemical reactions between antigens and antibodies. The QuickTox® Drug Screen Dipcard Test is based on a competitive immunoassay procedure in which immob ...
DRUG ELIMINATION THE KIDNEY Anatomic Considerations
... energy input, because the drug is transported against a concentration gradient. The carrier system is capacity limited and may be saturated. Drugs w ith similar structures may compete for the same carrier system. Tw o active renal secretion systems have been identified, systems for (1) w eak acids a ...
... energy input, because the drug is transported against a concentration gradient. The carrier system is capacity limited and may be saturated. Drugs w ith similar structures may compete for the same carrier system. Tw o active renal secretion systems have been identified, systems for (1) w eak acids a ...
Codeine Intoxication in the Neonate
... seldom recommended for infants ,6 months of age, because the major metabolic pathway for the metabolism of codeine is not fully developed.16 In addition, the rate of morphine elimination is much slower in the neonate than in older children or adults because of lower clearance rates. This suggests th ...
... seldom recommended for infants ,6 months of age, because the major metabolic pathway for the metabolism of codeine is not fully developed.16 In addition, the rate of morphine elimination is much slower in the neonate than in older children or adults because of lower clearance rates. This suggests th ...
PHAR 7633 Chapter 7 Routes of Drug Administration
... By-pass liver - Some (but not all) of the veins draining the rectum lead directly to the general circulation thus bypassing the liver. Therefore there may be a reduced first-pass effect. Useful - This route may be most useful for patients unable to take drugs orally or with younger children. Disadva ...
... By-pass liver - Some (but not all) of the veins draining the rectum lead directly to the general circulation thus bypassing the liver. Therefore there may be a reduced first-pass effect. Useful - This route may be most useful for patients unable to take drugs orally or with younger children. Disadva ...
- American Heart Journal
... assessment of QT prolongation. Preclinical safety pharmacologic studies are commonly performed before firstin-human testing to provide an indication of a study drug's likely clinical QT risk. Pharmacologic characterization of the study agent in animals may further reveal circumstances in which incre ...
... assessment of QT prolongation. Preclinical safety pharmacologic studies are commonly performed before firstin-human testing to provide an indication of a study drug's likely clinical QT risk. Pharmacologic characterization of the study agent in animals may further reveal circumstances in which incre ...
Drug design
Drug design, sometimes referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is often referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.The phrase ""drug design"" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and efficacious drug. These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.