A stability indicating RP-HPLC method for the determination of
... respectively. It is available in different brand names such as Amitrol, Elavil, Endep, Levate, Tryptizol, Vanatrip. Amitriptyline Hydrochloride contains not less than 99.0percent and not more than 100.5percent of C20H23N·HCl, calculated on the dried basis. The chemical structure of the drug is given ...
... respectively. It is available in different brand names such as Amitrol, Elavil, Endep, Levate, Tryptizol, Vanatrip. Amitriptyline Hydrochloride contains not less than 99.0percent and not more than 100.5percent of C20H23N·HCl, calculated on the dried basis. The chemical structure of the drug is given ...
geriatric pharmacology
... hypotension) often follows a large meal, presumably as a result of shift in blood flow from the periphery to the mesenteric bed and can be an important cause of falls a6a ...
... hypotension) often follows a large meal, presumably as a result of shift in blood flow from the periphery to the mesenteric bed and can be an important cause of falls a6a ...
epilepsy - ichapps.com
... dizziness, and gastrointestinal upset. There is some indication in postmarketing surveillance that seizures have occurred in patients who did not have epilepsy when the drug was used. Tiagabine has not been approved for use for any other indication. Topiramate: Topiramate possesses several actions t ...
... dizziness, and gastrointestinal upset. There is some indication in postmarketing surveillance that seizures have occurred in patients who did not have epilepsy when the drug was used. Tiagabine has not been approved for use for any other indication. Topiramate: Topiramate possesses several actions t ...
Terminology and information on drugs
... of abuse. Rather, it is an attempt on the part of the Laboratory and Scientific Section to provide to the interested reader some basic, generally accepted information on selected drugs of abuse, their abuse patterns, pharmacological effects and medical use, if any. As the dynamic global drug abuse s ...
... of abuse. Rather, it is an attempt on the part of the Laboratory and Scientific Section to provide to the interested reader some basic, generally accepted information on selected drugs of abuse, their abuse patterns, pharmacological effects and medical use, if any. As the dynamic global drug abuse s ...
Effects of UN and Russian Influence on Drug Policy in Central Asia
... serve primarily as fora for regular rhetorical reinforcement of the “war on drugs.” However, Russian law has clearly been exported as a model and has had some impact. We consider the national approach to drugs in the four Central Asian countries that are members of the CIS, and trace similarities be ...
... serve primarily as fora for regular rhetorical reinforcement of the “war on drugs.” However, Russian law has clearly been exported as a model and has had some impact. We consider the national approach to drugs in the four Central Asian countries that are members of the CIS, and trace similarities be ...
Acetazolamide: Considerations for Systemic Administration
... is a carbonic anhydrase inhibitor that is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure (IOP). This article highlights important considerations, contraindications, and dosing adjustments for this drug to help streamline de ...
... is a carbonic anhydrase inhibitor that is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure (IOP). This article highlights important considerations, contraindications, and dosing adjustments for this drug to help streamline de ...
2015 Annual Drug Report - Alaska Department of Public Safety
... contributing cause of death. The number of Medicaid health care services payment requests for heroin poisoning increased almost ten-fold from 2004 to 2013. During the years 2009–2013, heroin-related admissions to publicly- funded substance use treatment centers nearly doubled, and the majority of pa ...
... contributing cause of death. The number of Medicaid health care services payment requests for heroin poisoning increased almost ten-fold from 2004 to 2013. During the years 2009–2013, heroin-related admissions to publicly- funded substance use treatment centers nearly doubled, and the majority of pa ...
Amphetamines: An Update on Forensic Issues
... favored. The first is a reduction of/-ephedrine or d-pseudoephedrine over red phosphorus with hydroiodic acid. The enantiospecific product with either precursor is d-methamphetamine, with yields of 54-82%. The red phosphorus is obtained from matchbook striker plates or road flares, and although the ...
... favored. The first is a reduction of/-ephedrine or d-pseudoephedrine over red phosphorus with hydroiodic acid. The enantiospecific product with either precursor is d-methamphetamine, with yields of 54-82%. The red phosphorus is obtained from matchbook striker plates or road flares, and although the ...
as a PDF here
... many more variant alleles for CYP2D6 have been described (up to CYP2D6*63 at this moment (www.cypalleles.ki.se)). These variant alleles can be divided in functional alleles (like *1, *2, *35, encoding normal activity), null alleles (like *3, *4, *5, encoding no activity at all) and decreased activit ...
... many more variant alleles for CYP2D6 have been described (up to CYP2D6*63 at this moment (www.cypalleles.ki.se)). These variant alleles can be divided in functional alleles (like *1, *2, *35, encoding normal activity), null alleles (like *3, *4, *5, encoding no activity at all) and decreased activit ...
DEVELOPED AND VALIDATED REVERSE PHASE HPLC METHOD FOR THE DETERMINATION
... the formationand deposition of monosodium urate (MSUr) crystals. The condition is associated with recurrent episodes of acute joint pain due to the deposition of MSUr crystals in the synovial fluid. In addition to the effects observed in the joints, skin/subcutaneous tissue and kidneys may also be a ...
... the formationand deposition of monosodium urate (MSUr) crystals. The condition is associated with recurrent episodes of acute joint pain due to the deposition of MSUr crystals in the synovial fluid. In addition to the effects observed in the joints, skin/subcutaneous tissue and kidneys may also be a ...
phentermine HCl - Citius Pharmaceuticals
... tablet from the bottle. Immediately place the Suprenza tablet on top of the tongue where it will dissolve, then swallow with or without water. 3 DOSAGE FORMS AND STRENGTHS ...
... tablet from the bottle. Immediately place the Suprenza tablet on top of the tongue where it will dissolve, then swallow with or without water. 3 DOSAGE FORMS AND STRENGTHS ...
MORINGA OLEIFERA IN SILICO Research Article
... Receptor 2) and ERK (Extracellular Regulated Kinase) which usually require cPAP for their dephosphorylation and inactivation, were chosen as the drug targets. M. oleifera flower compounds were analyzed for their interactions with the drug targets using in silico methods and calculated for their suit ...
... Receptor 2) and ERK (Extracellular Regulated Kinase) which usually require cPAP for their dephosphorylation and inactivation, were chosen as the drug targets. M. oleifera flower compounds were analyzed for their interactions with the drug targets using in silico methods and calculated for their suit ...
Nasal Drug Delivery in EMS
... assist you in predicting times when nasal drug delivery may not be effective. ...
... assist you in predicting times when nasal drug delivery may not be effective. ...
Companion Animal Pain Management
... dogs that affect pain medication absorption, metabolism, and excretion Recognize the indications, side effects, and counseling points of pain management treatment options in cats and dogs Recall veterinary-label medications used for cat and dog pain management ...
... dogs that affect pain medication absorption, metabolism, and excretion Recognize the indications, side effects, and counseling points of pain management treatment options in cats and dogs Recall veterinary-label medications used for cat and dog pain management ...
O - Angelfire
... century. These natural products constituted the main source of organic chemicals and afforded the main problem of organic chemistry. Only with growth of synthesis was the field freed from a dependence on compounds available from natural sources. However, the variety of structures found in natural pr ...
... century. These natural products constituted the main source of organic chemicals and afforded the main problem of organic chemistry. Only with growth of synthesis was the field freed from a dependence on compounds available from natural sources. However, the variety of structures found in natural pr ...
Medication errors related to transdermal opioid reporting system
... system rather than solely the act of the individual [16], information that was not available in this dataset on a case by case basis. Wrong dose constituted 23% of the reported MEs, a diverse error type that was further divided into several subtypes. Analyzing wrong dose – high as well as wrong dose ...
... system rather than solely the act of the individual [16], information that was not available in this dataset on a case by case basis. Wrong dose constituted 23% of the reported MEs, a diverse error type that was further divided into several subtypes. Analyzing wrong dose – high as well as wrong dose ...
Directed Evolution of ATP Binding Proteins from a Zinc Finger
... display has been the most popular method for selecting functional molecules from new scaffolds; the following are examples of successful experiments. The lipocalin fold was re-engineered into a scaffolded library by randomizing specific residues that line its ligand binding cavity; proteins that spe ...
... display has been the most popular method for selecting functional molecules from new scaffolds; the following are examples of successful experiments. The lipocalin fold was re-engineered into a scaffolded library by randomizing specific residues that line its ligand binding cavity; proteins that spe ...
Gram positive cocci Family Micrococcaeceae
... Oxacillin and other penicillinase- resistant penicillin such as methicillin , naficillin cloxacillin , constitutes the drug class of choice for treating staphylococcal infection . Staphylococcal resistance to the penicillinase- resistant penicillin is due to the presence of a unique penicillin bindi ...
... Oxacillin and other penicillinase- resistant penicillin such as methicillin , naficillin cloxacillin , constitutes the drug class of choice for treating staphylococcal infection . Staphylococcal resistance to the penicillinase- resistant penicillin is due to the presence of a unique penicillin bindi ...
Author`s personal copy
... systems are planned to be used with different drugs. However, there are several strategies to modulate drug solubility, e.g. the use of solubilizers described in detail elsewhere [2]. Two compartment osmotic pumps (Fig. 1C) store drug formulation and osmotic agent in two separate compartments. Durin ...
... systems are planned to be used with different drugs. However, there are several strategies to modulate drug solubility, e.g. the use of solubilizers described in detail elsewhere [2]. Two compartment osmotic pumps (Fig. 1C) store drug formulation and osmotic agent in two separate compartments. Durin ...
Stable drug encapsulation in micelles and microemulsions
... surfactants. Additionally, for pharmaceutical applications, ionic surfactants are not preferred due to toxicological concerns. Microemulsions often include a cosurfactant. A cosurfactant is an amphiphilic molecule that substantially accumulates with the surfactant at the interfacial layer. Usually a ...
... surfactants. Additionally, for pharmaceutical applications, ionic surfactants are not preferred due to toxicological concerns. Microemulsions often include a cosurfactant. A cosurfactant is an amphiphilic molecule that substantially accumulates with the surfactant at the interfacial layer. Usually a ...
Rx FACTS October 2003
... The World Health Organization reported approximately 50% of people are non-compliant in taking their prescription medications. Doctors believe this may explain why some drugs do well in clinical trials but are not as effective once they are approved. The percentage of non-compliance appears to be th ...
... The World Health Organization reported approximately 50% of people are non-compliant in taking their prescription medications. Doctors believe this may explain why some drugs do well in clinical trials but are not as effective once they are approved. The percentage of non-compliance appears to be th ...
Hallucinogenic Drugs
... LSD. He later wrote of his experience, ‘There surged upon me an uninterrupted stream of fantastic images of extraordinary plasticity and vividness and accompanied by an intense, kaleidoscope-like play of colors.’ LSD was not the first hallucinogen to be produced synthetically (the first was mescaline ...
... LSD. He later wrote of his experience, ‘There surged upon me an uninterrupted stream of fantastic images of extraordinary plasticity and vividness and accompanied by an intense, kaleidoscope-like play of colors.’ LSD was not the first hallucinogen to be produced synthetically (the first was mescaline ...
(HMG-CoA) Reductase Inhibitors
... 80 mg daily, as single evening dose or two divided doses 10-17 years of age: 40 mg once daily with evening meal 8 years to 13 years of age: 20 mg once daily 14 years to 18 years of age: 40 mg once daily 10-17 years of age: 20 mg once daily 10-17 years of age: 40 mg once daily in evening ...
... 80 mg daily, as single evening dose or two divided doses 10-17 years of age: 40 mg once daily with evening meal 8 years to 13 years of age: 20 mg once daily 14 years to 18 years of age: 40 mg once daily 10-17 years of age: 20 mg once daily 10-17 years of age: 40 mg once daily in evening ...
Formulation, Development and Evaluation of delayed release
... Preparation of enteric coating suspension: Acetone and water were taken in 8:2 ratio in a stainless steel vessel. HPMCP (HP-55), HPMCP (HP50), were slowly added to this solvent, under stirring and the contents were mixed for 15 minutes under continuous stirring. TEC, Talc were added to the above sol ...
... Preparation of enteric coating suspension: Acetone and water were taken in 8:2 ratio in a stainless steel vessel. HPMCP (HP-55), HPMCP (HP50), were slowly added to this solvent, under stirring and the contents were mixed for 15 minutes under continuous stirring. TEC, Talc were added to the above sol ...
Drug design
Drug design, sometimes referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is often referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.The phrase ""drug design"" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and efficacious drug. These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.