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Lecture 08
Lecture 08

... Image source: http://www.ncbi.nlm.nih.gov/books/NBK10855/ ...
Memory from the dynamics of intrinsic membrane currents
Memory from the dynamics of intrinsic membrane currents

... been proposed to underlie some short-term memory tasks (see other papers in this colloquium). For many years, the assumption was made that such sustained activity resulted from reverberating activity through excitatory feedback loops. However, many neurons display plateau properties (whose expressio ...
Nonneurolnal cells engineered to express neuroligins
Nonneurolnal cells engineered to express neuroligins

... scaffolding and signaling molecules, possibly via the PDZ-binding motif at the C-terminus. This scaffold may then signal the assembly of the exocytotic machinery and recruit additional neurexins and thereby neuroligins to form an expanding contact zone. Postsynaptic neuroligin-1 oligomers may contri ...
Anatomy of a Neuron
Anatomy of a Neuron

... In many ways, a neuron is like an electric wire. Although electric wires and neurons carry signals in different ways, their basic jobs are the same; to carry electricity. An electric wire in a radio, for example, may carry signals from a transistor to a speaker, where the signals are changed into so ...
File - LC Biology 2012-2013
File - LC Biology 2012-2013

...  Organisms must be aware of what is happening around them, as this affects their survival chances.  Co-ordination of an organism’s activities is carried out by the nervous system and the endocrine system.  A nervous system allows an organism to detect and respond to stimuli in its internal or ext ...
GBA deficiency promotes SNCA/α-synuclein accumulation through
GBA deficiency promotes SNCA/α-synuclein accumulation through

... Figure S4. C2-ceramide treatment conditions for maximal PPP2A activity. Optimal C2 concentration and application time (5 μM for 8 h) were determined according to the peak increase in PPP2A activity. *P<0.05 vs. control group, #P<0.05 vs. other C2 treatment groups; n=6. ...
LIFE OF A LAB FISH - Vanderbilt University
LIFE OF A LAB FISH - Vanderbilt University

... some aspects of its operation, such as the way the crankshaft turns linear motion into rotation. But in some other areas, like carburetion and combustion, such an anatomical approach is far less likely to be helpful. But there is another strategy that can: Removing parts (or replacing them with part ...
Neurons and Neurotransmitters
Neurons and Neurotransmitters

Ca 2+
Ca 2+

... Quantal content was increased to 154%!! After a single injection of alphaBTX mEPPs were reduced in size by 60% but no increase in quantal content was observed! At timepoints between acute treatment and 6 weeks with alphaBTX quantal content increased, reaching a plateau Between 20 and 30 days. A mech ...
Modeling stability in neuron and network function: the role of activity
Modeling stability in neuron and network function: the role of activity

... the values that are measured from slice and culture experiments in which the natural patterns of activity of a network are altered prior to measurement will differ from those that contribute to network dynamics during behavior. Building models from measured means of a population of neurons with vari ...
Biosc_48_Chapter_7_part_2_lecture
Biosc_48_Chapter_7_part_2_lecture

... In the PNS, nitric oxide is secreted by autonomic neurons onto cells in the digestive tract, respiratory passages, and penis, causing muscle relaxation.  Responsible for an erection  The drug Viagra works by increasing NO ...
Neurons and Circuits - UT Computer Science
Neurons and Circuits - UT Computer Science

... cell gives us 1015 connections total. While the nerve cells working together form a very complex system, the connections are a major, if not the major component that describes how the brain will process information. So much so, that scientists working on large scale models of neural networks are cha ...
Chapter 10 – Sensory Physiology
Chapter 10 – Sensory Physiology

... 7. Give main parts of visual pathway. (Cornea  aqueous humor  pupil  aqueous humor  lens  vitreous humor  cone or rod cells  bipolar neurons  ganglion cells  optic nerve  optic chiasm  optic tract  optic radiation  primary visual cortex) 8. Outline transduction of sound by ear. (Auricle ...
Neuromodulation of in Layer II Medial Entorhinal Cortex I
Neuromodulation of in Layer II Medial Entorhinal Cortex I

... HEPES, 0.2 EGTA, 20 KCL, 2 MgCl, 7 diTrisPhCr, 4Na2ATP, and 0.3 TrisGTP (pH adjusted to 7.3 with KOH). Recordings were made using a Multiclamp 700B amplifier (Molecular Devices). The data were low-pass filtered at 10 kHz and digitized using Digidata 1320 at a sampling frequency of 20 kHz. Recorded s ...
regional difference in stainability with calcium
regional difference in stainability with calcium

... fMCI is the signal source identification, that is, fMCI can precisely determine the locations of individual cells that fire spikes and even do not fire spikes. This identification cannot be achieved by electrophysiological single-unit and multiple-unit recording techniques. Moreover, fMCI is, curren ...
Sensory and Motor Mechanisms
Sensory and Motor Mechanisms

... Hair cell bundle from a bullfrog; the longest cilia shown are ...
dendritic integration
dendritic integration

... (as their name implies); they are also particularly sensitive to rotational flow fields (Fig. 1; see also Supplementary Fig. 1 of the paper by Haag and Borst1). A rotating visual stimulus is what is seen when one looks at the center of a propeller; a rotational flow field is the visual stimulus gene ...
[j26] Chapter 10#
[j26] Chapter 10#

... ___ 30. Chemoreceptors can be characterized as interoceptors or exteroceptors based on the source of the chemical stimuli. ___ 31. Both salt and sour tastes are mediated by receptors that are coupled to G-proteins that, in turn, activate second-messenger systems within the cytoplasm of the receptor ...
action potential
action potential

... Concept 37.3: Action potentials are the signals conducted by axons  Researchers can record the changes in membrane potential when a neuron responds to a stimulus  Changes in membrane potential occur because neurons contain gated ion channels that open or close in response to stimuli ...
Chapter 12 - Nervous Tissue
Chapter 12 - Nervous Tissue

... B. _________ - nerve cells that conduct nerve impulses at up to 280 mph; lengths range from 1 mm to longest cells in body (from brain to toes). Neurons are long lived, have a high metabolic rate, and do not divide. Neuron ________: ...
Chapter 9 - Nervous System
Chapter 9 - Nervous System

... Motor neurons are multipolar neurons that conduct impulses from the CNS to effectors. 9.5 The Synapse (Fig. 9.8) A. Nerve impulses travel from neuron to neuron along complex nerve pathways. B. The junction between two communicating neurons is called a synapse; there exists a synaptic cleft between t ...
Synapse
Synapse

... • By stimulation of a single presynaptic neuron repetitively (successively) within very short duration (less than 15 m.sec). ...
No Slide Title
No Slide Title

... • specific areas of the cerebral cortex receive somatic sensory input from various parts of the body • precise localization of these somatic sensations occurs when they arrive at the primary somatosensory area • some regions provide input to large regions of this area (e.g. cheeks, lips, face and to ...
Optogenetic Functional Magnetic Resonance Imaging (ofMRI
Optogenetic Functional Magnetic Resonance Imaging (ofMRI

... (CMRO2) following neuronal activity [2]. Candidate circuit elements for triggering BOLD signal include excitatory neurons, mixed neuronal populations, astroglia, and axonal tracts or fibers of passage [3]. Importantly, it is not clear which kinds of activity are capable of triggering BOLD responses, ...
Session 2 Neurons - Creature and Creator
Session 2 Neurons - Creature and Creator

... let sodium ions pour into the cell. The membrane potential goes away – depolarization. It even briefly becomes positive on the inside. Inactivation occurs and the neuron is no longer permeable to sodium ions. The pumps remove all the excess sodium that entered the cell and then some – causing the me ...
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Electrophysiology



Electrophysiology (from Greek ἥλεκτρον, ēlektron, ""amber"" [see the etymology of ""electron""]; φύσις, physis, ""nature, origin""; and -λογία, -logia) is the study of the electrical properties of biological cells and tissues. It involves measurements of voltage change or electric current on a wide variety of scales from single ion channel proteins to whole organs like the heart. In neuroscience, it includes measurements of the electrical activity of neurons, and particularly action potential activity. Recordings of large-scale electric signals from the nervous system such as electroencephalography, may also be referred to as electrophysiological recordings.
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