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Dr. Coyle`s NIH Biosketch
Dr. Coyle`s NIH Biosketch

... I have a forty-year record of translational research on the neurobiology of neuropsychiatric disorders with a particular emphasis on the role of glutamatergic neurotransmission. An overarching goal has been to develop animal models of neuropsychiatric disorder to understand the neurobiology of the d ...
Assessing similarity to primary tissue and cortical layer identity in
Assessing similarity to primary tissue and cortical layer identity in

... layer-specific effects (7,8). The development of single-cell gene expression platforms, such as microfluidic chips, as well as evolving chip-free single-cell RNA-seq technologies, make such studies a viable method to investigate iPSC-derived cortical neuron cultures at single-cell resolution (9,10). T ...
Spatial Representation and Navigation in a Bio
Spatial Representation and Navigation in a Bio

... orientations were updated using integrated odometer signals, but the place cell activity depended only on the visual input. Burgess et al. [21, 22] described a robotic implementation of an earlier neurophysiological model of the rat hippocampus [23]. Some place cells were shown to fire at a relativel ...
The Projection from the Superficial to the Deep Layers
The Projection from the Superficial to the Deep Layers

... 1987). They will be recapitulated only briefly in this section. Animalpreparation.The injected cells in this study were selected (see below) from a series of 25 1 male and female hamsters (age 3-9 months) in which we have carried out intracellular recording and injection experiments over the last 4 ...
Anatomy Written Exam #2 Cranial Nerves Introduction Embryological
Anatomy Written Exam #2 Cranial Nerves Introduction Embryological

... i. Afferents from thalamus and cerebral cortex ii. GABA efferents back to thalamus c. Functional Organization of Thalamic Nuclei  All thalamic nuclei, except or the reticular nucleus, project to IPSILATERAL cerebral cortex 1. Specific Nuclei- have point to point projections between individual thala ...
An Introduction to the ANS and Higher
An Introduction to the ANS and Higher

... Two divisions have opposing effects on heart function 1. Parasympathetic division • Acetylcholine released by postganglionic fibers slows heart rate 2. Sympathetic division • NE released by varicosities accelerates heart rate • Balance between two divisions • Autonomic tone is present • Releases sma ...
Evidence of a Specific Spinal Pathway for the
Evidence of a Specific Spinal Pathway for the

... Iannetti, G.D., A. Truini, A. Romaniello, F. Galeotti, C. Rizzo, M. Manfredi, and G. Cruccu. Evidence of a specific spinal pathway for the sense of warmth in humans. J Neurophysiol 89: 562–570, 2003; 10.1152/jn.00393.2002. While research on human sensory processing shows that warm input is conveyed ...
Interplay of environmental signals and progenitor diversity on fate
Interplay of environmental signals and progenitor diversity on fate

... the ionotropic serotonin receptor 5HTR-3A. These cells comprise ∼20–30% of GABAergic neurons in the somatosensory cortex and represent the largest group of superficial neocortical interneurons (Morales and Bloom, 1997; Xu et al., 2010b). Despite the heterogeneity of co-labeling with CCK, NPY, and nNO ...
Evidence of a Specific Spinal Pathway for the Sense of Warmth in
Evidence of a Specific Spinal Pathway for the Sense of Warmth in

... Iannetti, G.D., A. Truini, A. Romaniello, F. Galeotti, C. Rizzo, M. Manfredi, and G. Cruccu. Evidence of a specific spinal pathway for the sense of warmth in humans. J Neurophysiol 89: 562–570, 2003; 10.1152/jn.00393.2002. While research on human sensory processing shows that warm input is conveyed ...
SC1l Terminology TRACK CHANGES
SC1l Terminology TRACK CHANGES

... A target material used to motivate and assess a canine’s performance during extended operations A conditioning technique in which the subject learns to escape or terminate an unpleasant stimulus by performing a desired response. A response identified by the handler indicating that something is true ...
Understanding Glial Differentiation in Vertebrate Nervous - J
Understanding Glial Differentiation in Vertebrate Nervous - J

... asymmetrically, and is segregate unevenly. Thus, asymmetrical segregation of Numb appears to modulate Notch signaling so that daughter cells assume different fates (Wakamatsu et al. 1999, 2000; Fig. 2). Is Notch signaling directly involved in satellite glia differentiation? We have previously report ...
File
File

...  The neuroglia are non-conductive cells.  They covers some axons forming a layer called myelin sheath.  Myelin is composed largely of lipid tissue SO it give white colour to the myelinated axons.  Myelin sheath support and protect the neurons and provide insulations.  Clinically, these cells ar ...
PPT Lecture Slides: January 22, 2002
PPT Lecture Slides: January 22, 2002

... PSCY202-005, Term 2, Copyright Jason Harrison, 2002 ...
Structure and functions of the Human Nervous system
Structure and functions of the Human Nervous system

... Mostly we use both halves of the brain at the same time ...
Biopsychology – Paper 2
Biopsychology – Paper 2

... Sensory neurons are also known as afferent neurons, meaning moving towards a central organ or point, that is they move impulses towards the CNS . This type of neuron receives information or stimuli from sensory receptors found in various locations in the body, for example the eyes, ears, tongue, sk ...
PAPER Glucosensing neurons do more than just sense glucose
PAPER Glucosensing neurons do more than just sense glucose

... brain areas such as the hypothalamus, glucosensing neurons also contain receptors for insulin, leptin, monoamines and other transmitters and peptides involved in energy homeostasis.8 – 12 Thus, many or all glucosensing neurons respond to both short- and long-term signals relating to both the physica ...
Neurons and Synapses
Neurons and Synapses

...  OPTIONAL “This is Your Brain” Curriculum worksheets by NSTA Purchase it here  OPTIONAL “This is Your Brain” Curriculum PPT Transparencies H & I Download it here WASS: (Middle School): 6-8 LS1-C Multicellular organisms have specialized cells that perform different functions. These cells join toget ...
Chapter 12: Neural Tissue
Chapter 12: Neural Tissue

... **Tend to be Antagonistic to Each Other** ...
Data Visualization Optimization Computational Modeling of Perception
Data Visualization Optimization Computational Modeling of Perception

... neurons along a branch called an axon. Neurons make on the order of 10,000 connections, called synapses, to other neurons. Depending on the neurotransmitter used by the neuron, its signals may have either excitatory or inhibitory effects on the recipient neuron. Signals from an excitatory neuron mak ...
Anatomy of the Spinal Cord
Anatomy of the Spinal Cord

...  Tracts are often named according to their points of origin and destination, e.g. ...
of sleep
of sleep

... • Each neuron receives signals from hundreds of other neurons • Some signals are excitatory, accelerating the receiving neuron’s activity. Others are inhibitory. • If (excitatory signal) – (inhibitory signal) > threshold, the neuron fires ...
A Model of Surround Suppression Through Cortical Feedback
A Model of Surround Suppression Through Cortical Feedback

... populations have different offset, gain, and maximum firing rate values obtained from the literature, as discussed below. All five V1 regions send feedforward projections to the V2 region. The feedforward projections originate from the V1 neurons and terminate on both excitatory and inhibitory neuro ...
Eye presentation
Eye presentation

... points to eventually meet at one point. ● Diverging means to separate or to split apart from the main direction and to go to a different direction ...
Brain
Brain

... Problems with breathing, which can also affect speech. ► Difficulty swallowing food and water (dysphagia). ► Difficulty with organization/perception of the environment. May not be able to reach out and grasp objects. ► Problems with balance and movement. May be unable to walk or make rapid movements ...
action potential
action potential

... refractory period - after you flush the toilet, it won’t flush again for a certain period of time, even if you push the handle repeatedly threshold - you can push the handle a little bit, but it won’t flush until you push the handle past a certain critical point - this corresponds to the level of ex ...
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Feature detection (nervous system)

Feature detection is a process by which the nervous system sorts or filters complex natural stimuli in order to extract behaviorally relevant cues that have a high probability of being associated with important objects or organisms in their environment, as opposed to irrelevant background or noise. Feature detectors are individual neurons – or groups of neurons – in the brain which code for perceptually significant stimuli. Early in the sensory pathway feature detectors tend to have simple properties; later they become more and more complex as the features to which they respond become more and more specific. For example, simple cells in the visual cortex of the domestic cat (Felis catus), respond to edges – a feature which is more likely to occur in objects and organisms in the environment. By contrast, the background of a natural visual environment tends to be noisy – emphasizing high spatial frequencies but lacking in extended edges. Responding selectively to an extended edge – either a bright line on a dark background, or the reverse – highlights objects that are near or very large. Edge detectors are useful to a cat, because edges do not occur often in the background “noise” of the visual environment, which is of little consequence to the animal.
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