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Differentiated Parkinson patient-derived induced
Differentiated Parkinson patient-derived induced

... transplanted differentiated S1 PDiPS cells into the dorsolateral striatum of 6-hydroxydopamine (6-OHDA)–lesioned rats (n = 12), which serve as an animal model of PD, and grafts were analyzed histologically 16 wk after transplantation (Fig. 3). As in the previously described bioassays, the grafts wer ...
Title: 공학도를 위한 생물학 (2)
Title: 공학도를 위한 생물학 (2)

... And I think taking that respective, it's critical understanding the earth. And a quite easy way to make this point is to ask… Having you think about difference in how do you view world as a scientist, and as a person. So this is very obviously in our lives as people, about scientists, we are very of ...
Cell Communication - Science Take-Out
Cell Communication - Science Take-Out

... diabetes have Type 1 diabetes.  Type 1 diabetes is called  an autoimmune disease because the immune system  Type 1 diabetes occurs attacks the person’s own pancreas cells.  The cells in the  when the immune system attacks the insulin-producing pancreas that produce and release insulin are destroyed. ...
Motor system - Brain Facts
Motor system - Brain Facts

... The Premotor Cortex (PM), largest part of area 6. Sends fewer fibers to the spinal cord than SMA but has strong connections with the RF, red nucleus, basal ganglia. It has important projection to M1. The PM is important for the control of visually guided movements, such as the proper orientation of ...
Chapter 2 - landman
Chapter 2 - landman

... The structures listed below are often considered to constitute the limbic system. This system is involved in olfaction, emotions, learning, and memory. The limbic system was introduced as a concept by Paul MacLean in 1952 and was long considered the seat of the emotions. Though some of the structure ...
Restraining influence of A2 neurons in chronic control of arterial
Restraining influence of A2 neurons in chronic control of arterial

... cardiovascular responses observed. Rats were supplied with normal rat chow and drinking water ad libitum, and kept on a 12 h light–12 h dark cycle in a sound proofed, temperature and humidity controlled room. Water drunk and urine produced were measured daily. A radio-telemetry system (Data Sciences ...
Nerves and nervous impulses File
Nerves and nervous impulses File

... neurons synapse with neurons in the brain. What is the significance of this? • two relay neurons synapsing with two motor neurons- one stimulating the triceps and one stimulating the biceps- remember that they are antagonistic • Synapse to the brain so that you become aware of the stimulus (e.g. pai ...
Under Pressure: Preventing Cell Death
Under Pressure: Preventing Cell Death

... loss until the disease is already quite advanced, as one’s field of vision shrinks at the periphery first. Once vision is lost, it cannot be regained. While glaucoma can be treated with medication and/or surgery to slow vision loss, it remains a chronic and currently incurable neurodegenerative cond ...
Mitochondrial dysfunction in neurodegenerative disorders
Mitochondrial dysfunction in neurodegenerative disorders

... in skeletal-muscle biopsies [37,38] and in cybrids made from thrombocytes of ALS patients fused to rho-zero cells [39]. In addition to certain rare mtDNA mutations being suggested to play a role in the pathogenesis of the disease [40], an important mechanism explaining at least the mitochondrial dys ...
PRINCIPLES OF SENSORY TRANSDUCTION
PRINCIPLES OF SENSORY TRANSDUCTION

... cell, whereas in the visual system, an interneuron receives synapses from the photoreceptor and in turn synapses on the retinal ganglion cell. Adapted from Bodian (1967). ...
Novel approaches to explore mechanisms of
Novel approaches to explore mechanisms of

... treatment strategies are highly needed, as well as increased understanding of the hippocampal components and signaling properties involved in the mechanisms of epileptogenesis and induction of seizures, to guide a rational search for such future treatments. In the present thesis, we have applied opt ...
How Microscopy Produces a Sharper Image
How Microscopy Produces a Sharper Image

... noninvasive collection of very thin, highresolution optical sections. These sections ...
How Microscopy Produces a Sharper Image
How Microscopy Produces a Sharper Image

... noninvasive collection of very thin, highresolution optical sections. These sections ...
epigenetic control of cellular differentiation
epigenetic control of cellular differentiation

... Embryonic stem cells (ESCs) are derived from the ICM of day 5–8 blastocyst-stage or morula-stage embryos (see Figure 12.1). ESCs are pluripotent and are capable of karyotypically stable, prolonged self-renewal. They are characterized by their potential to differentiate into cells of the three germ l ...
Symbolic Reasoning in Spiking Neurons:
Symbolic Reasoning in Spiking Neurons:

... without any random variation to changes in their inputs. We thus adapt their model, replacing individual idealized neurons with groups of realistic leaky-integrate-and-fire (LIF) spiking neurons. For our neurons, the membrane time constant (τRC; controlling the amount of current leaking out of the n ...
ppt - UK College of Arts & Sciences
ppt - UK College of Arts & Sciences

... events. The synaptic potentials can be obtained using the loose patch technique by lightly placing a 10-20 m firepolished glass electrode directly over various regions on a muscle fiber. The evoked field excitatory postsynaptic potentials (fEPSPs) and field miniature excitatory postsynaptic potenti ...
PDF
PDF

... liberty to explore and discuss a mathematical approach to the following three questions: (1) What is the architectural abstraction principle for evolution to build the brain?; (2) How do neural networks give rise to intelligence that is capable of dealing with uncertainties and infinite possibilitie ...
Article Review - Make up assignment
Article Review - Make up assignment

... 12. In the case of acids what specific chemical causes depolarization? Which type of taste is this phenomenon associated with? ...
FIGURE LEGNEDS FIGURE 24.1 A dorsal root ganglion cell is a
FIGURE LEGNEDS FIGURE 24.1 A dorsal root ganglion cell is a

... endings of nociceptors and thermo-receptors, the rapidly adapting afferents associated with Meissner’s corpuscle and the type I slowly adapting afferents that end as Merkel’s disks. Deep receptors include a rapidly adapting receptor enclosed by a Pacinian corpuscle and a type II slowly adapting affe ...
Synchronization and coordination of sequences in two neural
Synchronization and coordination of sequences in two neural

... 共Received 12 August 2004; published 21 June 2005兲 There are many types of neural networks involved in the sequential motor behavior of animals. For high species, the control and coordination of the network dynamics is a function of the higher levels of the central nervous system, in particular the c ...
evolution of the first nervous systems ii
evolution of the first nervous systems ii

Full version (PDF file)
Full version (PDF file)

Substrate Stiffness and Adhesivity Influence Neuron Axonal Growth
Substrate Stiffness and Adhesivity Influence Neuron Axonal Growth

... allows the body to function as a whole and interact with the external environment. It is clear then that the nervous system is integral to the function and survival of those organisms in which it has developed; and yet much is lacking in our understanding of the system’s key constituents: neuronal c ...
Association of type I neurons positive for NADPH
Association of type I neurons positive for NADPH

... subset has been identified within the parenchyma of the corpus callosum, where a role in circuitry might seem less likely. Since these neurons are more abundant in development, they have been considered as likely to figure in processes of axon guidance (Riederer et al., 2004; Niquille et al., 2009). I ...
Model Description Sheet
Model Description Sheet

... to the trans form, and opsin is activated; nerves then signal the brain. The opsin complex, sensitive to specific wavelengths of light, is identified by the wavelength that activates it; long (L), middle (M), or short (S). Mutations in opsin may lead to visual problems, including the inability to di ...
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Channelrhodopsin



Channelrhodopsins are a subfamily of retinylidene proteins (rhodopsins) that function as light-gated ion channels. They serve as sensory photoreceptors in unicellular green algae, controlling phototaxis: movement in response to light. Expressed in cells of other organisms, they enable light to control electrical excitability, intracellular acidity, calcium influx, and other cellular processes. Channelrhodopsin-1 (ChR1) and Channelrhodopsin-2 (ChR2) from the model organism Chlamydomonas reinhardtii are the first discovered channelrhodopsins. Variants have been cloned from other algal species, and more are expected.
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