Antiinfective Agents
... Many different antiinfective drugs are available to treat infections. All antiinfective drugs share several different adverse reactions and drug interactions. Review each antiinfective to determine whether it has an adverse reaction or drug interaction that is not shared by all. ...
... Many different antiinfective drugs are available to treat infections. All antiinfective drugs share several different adverse reactions and drug interactions. Review each antiinfective to determine whether it has an adverse reaction or drug interaction that is not shared by all. ...
NSAIDs Guidelines
... only factor to consider when trying to predict the safety of an NSAID. There are several other issues to consider. Firstly, the risks of adverse events can be affected by tissue concentrations of the drug – where the extracellular fluid is of a lower pH than the intracellular fluid, ‘ion trapping’ o ...
... only factor to consider when trying to predict the safety of an NSAID. There are several other issues to consider. Firstly, the risks of adverse events can be affected by tissue concentrations of the drug – where the extracellular fluid is of a lower pH than the intracellular fluid, ‘ion trapping’ o ...
rational use of diuretics and pathophysiology of edema
... to completely nullify the gain from the prior natriuresis. This rebound antinatriuretic effect (braking phenomenon) attenuates the normal dose-response relationship and can last several hours, thus limiting the efficacy of therapy. It can be overcome by administering multiple daily doses of the diur ...
... to completely nullify the gain from the prior natriuresis. This rebound antinatriuretic effect (braking phenomenon) attenuates the normal dose-response relationship and can last several hours, thus limiting the efficacy of therapy. It can be overcome by administering multiple daily doses of the diur ...
An overview of interactions between grapefruit juice and drugs ReView Abstract
... reduce the formation of artherosclerotic plaques.3,4 It may also inhibit cancer cell proliferation.5,6 As many as 15 years ago, investigators found that grapefruit juice can markedly augment oral drug bioavailability. This was an unexpected observation from an interaction study between the dihydropy ...
... reduce the formation of artherosclerotic plaques.3,4 It may also inhibit cancer cell proliferation.5,6 As many as 15 years ago, investigators found that grapefruit juice can markedly augment oral drug bioavailability. This was an unexpected observation from an interaction study between the dihydropy ...
The pharmacokinetics and metabolism of ivermectin in domestic
... Ivermectin is mainly eliminated in the faeces in all species regardless of the route of administration, and faecal excretion accounts for 90% of the dose administered with <2% of the dose excreted in urine. Bile is the main route of excretion. As P-glycoprotein is also present in biliary canalicules ...
... Ivermectin is mainly eliminated in the faeces in all species regardless of the route of administration, and faecal excretion accounts for 90% of the dose administered with <2% of the dose excreted in urine. Bile is the main route of excretion. As P-glycoprotein is also present in biliary canalicules ...
1.1. An overview of reports on agomelatine Introduction
... yet to be determined [2]. Since Valdoxan has obtained a market authorization from EMA, there has been some discussion regarding the risk-benefit balance of this drug. According to a recently published article, several international experts are not convinced agomelatine has additional value in the tr ...
... yet to be determined [2]. Since Valdoxan has obtained a market authorization from EMA, there has been some discussion regarding the risk-benefit balance of this drug. According to a recently published article, several international experts are not convinced agomelatine has additional value in the tr ...
The Effect of Corticosteroids on Aqueous Humor Formation
... The effect of corticosteroids on aqueous humor (AH) formation rate and outflow facility was measured in the cat eye. AH formation rate was determined by continuous posteroanterior chamber perfusion with an AH-like buffer containing inulin-C1*. It was found that the total quantity of inulin-CJi recov ...
... The effect of corticosteroids on aqueous humor (AH) formation rate and outflow facility was measured in the cat eye. AH formation rate was determined by continuous posteroanterior chamber perfusion with an AH-like buffer containing inulin-C1*. It was found that the total quantity of inulin-CJi recov ...
Dronabinol and Marijuana in HIV
... day, thereby maintaining double-blind dosing. Four days of placebo washout separated each active cannabinoid condition. Results: As compared with placebo, marijuana and dronabinol dose dependently increased daily caloric intake and body weight in HIVpositive marijuana smokers. All cannabinoid condit ...
... day, thereby maintaining double-blind dosing. Four days of placebo washout separated each active cannabinoid condition. Results: As compared with placebo, marijuana and dronabinol dose dependently increased daily caloric intake and body weight in HIVpositive marijuana smokers. All cannabinoid condit ...
The Dopamine Transporter and Cocaine Medication Development
... clear and clinically relevant characterization of medication effectiveness in subjects with a documented history of drug use under well controlled laboratory conditions. The problems of polydrug use and lifestyle characteristics that are major concerns in human studies are eliminated. Research effor ...
... clear and clinically relevant characterization of medication effectiveness in subjects with a documented history of drug use under well controlled laboratory conditions. The problems of polydrug use and lifestyle characteristics that are major concerns in human studies are eliminated. Research effor ...
maxzide
... The exact mechanism of hydrochlorothiazide’s antihypertensive action is not known although it may relate to the excretion and redistribution of body sodium. Hydrochlorothiazide does not affect normal blood pressure. Following oral administration, peak hydrochlorothiazide plasma levels are attained i ...
... The exact mechanism of hydrochlorothiazide’s antihypertensive action is not known although it may relate to the excretion and redistribution of body sodium. Hydrochlorothiazide does not affect normal blood pressure. Following oral administration, peak hydrochlorothiazide plasma levels are attained i ...
Chemical - Cleveland Clinic
... arthritis and Crohn’s disease (a type of inflammatory bowel disease), has shown promise in treating patients with psoriasis. In a clinical study, Remicade improved symptoms in 88 percent of patients receiving the highest dose of the drug. Remicade is an antibody used to block the protein that causes ...
... arthritis and Crohn’s disease (a type of inflammatory bowel disease), has shown promise in treating patients with psoriasis. In a clinical study, Remicade improved symptoms in 88 percent of patients receiving the highest dose of the drug. Remicade is an antibody used to block the protein that causes ...
Drugs and Thyroid - Journal of the Association of Physicians of India
... atoms, which constitute approximately 37% of its mass. Hence, a patient taking a 200-mg daily dose of amiodarone ingests 75 mg of organic iodine each day. 10% of the molecule is deiodinated daily. So a maintenance daily dose of 200 to 600 mg results in approximately 721 mg iodide each day. The opti ...
... atoms, which constitute approximately 37% of its mass. Hence, a patient taking a 200-mg daily dose of amiodarone ingests 75 mg of organic iodine each day. 10% of the molecule is deiodinated daily. So a maintenance daily dose of 200 to 600 mg results in approximately 721 mg iodide each day. The opti ...
Guidelines on Similar Biologic: Regulatory Requirements for
... The Similar Biologics are regulated as per the Drugs and Cosmetics Act, 1940, the Drugs and Cosmetics Rules, 1945 (as amended from time to time) and Rules for the manufacture, use, import, export and storage of hazardous microorganisms/ genetically engineered organisms or cells, 1989 (Rules, 1989) n ...
... The Similar Biologics are regulated as per the Drugs and Cosmetics Act, 1940, the Drugs and Cosmetics Rules, 1945 (as amended from time to time) and Rules for the manufacture, use, import, export and storage of hazardous microorganisms/ genetically engineered organisms or cells, 1989 (Rules, 1989) n ...
Comparison of the effects of cimetidine and hyoscine-n
... negligible absorption occurring in the stomach [24, 25, 26]. The relative bioavailability ranges from 85% to 98% [27]. Peak levels of 10-20 mg/l are achieved within one to 2 hours after the administration of a 1000-mg dose orally. Serum concentrations between 10 and 20 µg mL-1 are generally consider ...
... negligible absorption occurring in the stomach [24, 25, 26]. The relative bioavailability ranges from 85% to 98% [27]. Peak levels of 10-20 mg/l are achieved within one to 2 hours after the administration of a 1000-mg dose orally. Serum concentrations between 10 and 20 µg mL-1 are generally consider ...
labetalol hydrochloride injection usp
... heart rate, again without significantly influencing cardiac output. Following oral administration to hypertensive patients, labetalol decreases plasma renin activity and aldosterone levels, both at rest and during exercise, particularly when these were elevated prior to treatment. Labetalol is signi ...
... heart rate, again without significantly influencing cardiac output. Following oral administration to hypertensive patients, labetalol decreases plasma renin activity and aldosterone levels, both at rest and during exercise, particularly when these were elevated prior to treatment. Labetalol is signi ...
Management of Familial Hypercholesterolemia: A Review of the
... the use of statins or adjunctive therapies in patients with FH. Although statins are generally inexpensive, adjunctive therapies such as other LDL-C–lowering drugs and apheresis can be expensive and come with high patient out-of-pocket contribution requirements.26 This review includes management opt ...
... the use of statins or adjunctive therapies in patients with FH. Although statins are generally inexpensive, adjunctive therapies such as other LDL-C–lowering drugs and apheresis can be expensive and come with high patient out-of-pocket contribution requirements.26 This review includes management opt ...
Combined use of ECT and psychotropic drugs
... proven, high clinical efficacy. In the management algorithms it is still considered as a method of choice in treatment of drug-resistant patients. No wider use of ECT may in part result from fears of potential interactions with pharmacotherapy, or need to interrupt the current treatment. The issue o ...
... proven, high clinical efficacy. In the management algorithms it is still considered as a method of choice in treatment of drug-resistant patients. No wider use of ECT may in part result from fears of potential interactions with pharmacotherapy, or need to interrupt the current treatment. The issue o ...
Republic of Palau - World Health Organization
... 2.2 pounds (lbs.) = 1 kg Example 1: A patient weighs 140lbs. How many kilograms? 2.2 lbs. = 1 kg 140 lbs. patient = 140 X 1 kg ...
... 2.2 pounds (lbs.) = 1 kg Example 1: A patient weighs 140lbs. How many kilograms? 2.2 lbs. = 1 kg 140 lbs. patient = 140 X 1 kg ...
Volume 4, Supplement 1
... chemistry and biological advances in the fundamental and clinical study of antiviral diseases and their treatment. Areas covered include HIV, hepatitis B, hepatitis C and emerging viruses, co-infections, vaccines, animal models, pharmacology, microbicides, alternative therapies, viral dynamics and r ...
... chemistry and biological advances in the fundamental and clinical study of antiviral diseases and their treatment. Areas covered include HIV, hepatitis B, hepatitis C and emerging viruses, co-infections, vaccines, animal models, pharmacology, microbicides, alternative therapies, viral dynamics and r ...
Novartis Pharmaceuticals to Pay $390 Million
... In their court filings, the government plaintiffs alleged that Novartis paid kickbacks to the pharmacies to corrupt the pharmacies' interactions with patients by inducing the pharmacies to exaggerate the dangers of not taking Exjade, emphasize Exjade's benefits, and downplay the severity of Exjade' ...
... In their court filings, the government plaintiffs alleged that Novartis paid kickbacks to the pharmacies to corrupt the pharmacies' interactions with patients by inducing the pharmacies to exaggerate the dangers of not taking Exjade, emphasize Exjade's benefits, and downplay the severity of Exjade' ...
Studies on PJP prophylaxis efficacy
... There were no cases of PJP but the numbers in the study are too small and the prophylaxis regimes too varied to determine either the background risk of PJP or the efficacy of prophylaxis. Unknown number of cases within the NHL group with PCP diagnosed by throat swab only, and no clinical symptoms. T ...
... There were no cases of PJP but the numbers in the study are too small and the prophylaxis regimes too varied to determine either the background risk of PJP or the efficacy of prophylaxis. Unknown number of cases within the NHL group with PCP diagnosed by throat swab only, and no clinical symptoms. T ...
Asthma: Latest in Diagnostic and Treatment Modalities
... –Asthma is increasing –Asthma is more severe –Poor management of the disease –Poor patient compliance –Inadequate patient and provider response to signs of worsening trouble ...
... –Asthma is increasing –Asthma is more severe –Poor management of the disease –Poor patient compliance –Inadequate patient and provider response to signs of worsening trouble ...
GHB
... Begin in 10 to 20 minutes Last up to 4 hours Higher doses may result in sleep, coma, or death. Clears quickly from body, making it virtually undetectable ...
... Begin in 10 to 20 minutes Last up to 4 hours Higher doses may result in sleep, coma, or death. Clears quickly from body, making it virtually undetectable ...
Sample Size Calculations in Clinical Trials
... The purpose of this Bachelor’s thesis is to give an overview of calculating sample size in clinical trials. Clinical trials are studies carried out to test new experimental treatments before they can be made available for the market. These studies may have different purposes. The objectives of clini ...
... The purpose of this Bachelor’s thesis is to give an overview of calculating sample size in clinical trials. Clinical trials are studies carried out to test new experimental treatments before they can be made available for the market. These studies may have different purposes. The objectives of clini ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.