... Abnormal hepatic function has been reported rarely and has been caused by both the oral and parenteral administration of tetracyclines, including doxycycline. Use in patients with renal impairment: Excretion of doxycycline by the kidney is about 40%/72 hours in individuals with normal renal function ...
2015 AAHA/AAFP Pain Management Guidelines for Dogs and Cats*
... maladaptive forms. Degenerative joint disease is one of the most significant and under-diagnosed diseases of cats and dogs. Degenerative joint disease is ubiquitous, found in pets of all ages, and inevitably progresses over time; evidencebased strategies for management are established in dogs, and e ...
... maladaptive forms. Degenerative joint disease is one of the most significant and under-diagnosed diseases of cats and dogs. Degenerative joint disease is ubiquitous, found in pets of all ages, and inevitably progresses over time; evidencebased strategies for management are established in dogs, and e ...
Calcium-Channel Blocker–Clarithromycin Drug Interactions and
... lovastatin) has been shown to be associated with a greater risk of hospitalization with rhabdomyolysis, hospitalization with acute kidney injury, and all-cause mortality compared with azithromycin coprescription.3 Calcium-channel blockers are a popular class of antihypertensive drugs that are metabo ...
... lovastatin) has been shown to be associated with a greater risk of hospitalization with rhabdomyolysis, hospitalization with acute kidney injury, and all-cause mortality compared with azithromycin coprescription.3 Calcium-channel blockers are a popular class of antihypertensive drugs that are metabo ...
product monograph
... Midazolam dosing should not be based on pharmacokinetic values; it should always be titrated to achieve a given clinical effect. This is especially important when used for long-term sedation in the Intensive Care Unit (ICU). The elimination half-life of midazolam is increased in congestive heart fai ...
... Midazolam dosing should not be based on pharmacokinetic values; it should always be titrated to achieve a given clinical effect. This is especially important when used for long-term sedation in the Intensive Care Unit (ICU). The elimination half-life of midazolam is increased in congestive heart fai ...
High plasma linezolid concentration and impaired renal function
... the drug and its metabolites. Pharmacokinetic studies of linezolid have indicated that 30% of linezolid is eliminated unchanged via the kidneys,23,30 – 34 while the majority is metabolized by the oxidation of its morpholino ring (mediated by ubiquitous reactive oxygen species) to create two metabol ...
... the drug and its metabolites. Pharmacokinetic studies of linezolid have indicated that 30% of linezolid is eliminated unchanged via the kidneys,23,30 – 34 while the majority is metabolized by the oxidation of its morpholino ring (mediated by ubiquitous reactive oxygen species) to create two metabol ...
Ephedra - Longwood Herbal Task Force
... randomized, controlled cross-over study of obese women who were on a low calorie diet (1000-1400 calories daily), treatment with ephedrine supplements (50 mg three times daily for two months) resulted in significantly greater weight loss than placebo treatment (2.4 vs. 0.6 kg weight loss, P<0.05); s ...
... randomized, controlled cross-over study of obese women who were on a low calorie diet (1000-1400 calories daily), treatment with ephedrine supplements (50 mg three times daily for two months) resulted in significantly greater weight loss than placebo treatment (2.4 vs. 0.6 kg weight loss, P<0.05); s ...
Interventional Spine and Pain Procedures in Patients - cmp
... lymphatics, and connective tissue (eg, plica mediana dorsalis and scar tissue after previous surgical intervention). The amount of epidural fat in the posterior epidural space is directly related to age and body weight.7,8 Epidural fat decreases with age. The amount of epidural fat according to spin ...
... lymphatics, and connective tissue (eg, plica mediana dorsalis and scar tissue after previous surgical intervention). The amount of epidural fat in the posterior epidural space is directly related to age and body weight.7,8 Epidural fat decreases with age. The amount of epidural fat according to spin ...
Antiarrhythmic effect of the Ca(2+)
... Dofetilide was, until recently, believed to be a specific IKr blocker; however, new data indicate that it also increases the late sodium current [39]. IKr is conducted through hERG1 channels, which are expressed in both atria and ventricle [15, 27]. Unlike other antiarrhythmic agents, dofetilide doe ...
... Dofetilide was, until recently, believed to be a specific IKr blocker; however, new data indicate that it also increases the late sodium current [39]. IKr is conducted through hERG1 channels, which are expressed in both atria and ventricle [15, 27]. Unlike other antiarrhythmic agents, dofetilide doe ...
THE WHOLE STORY ABOUT HEARTWORM
... When ingested by a mosquito, the microfilariae undergo a series of molts to the infective, or third, larval stage and then migrate to the mouth parts of the mosquito, where they wait to infect another host by being deposited on the skin of such. These changes inside a mosquito can occur in as littl ...
... When ingested by a mosquito, the microfilariae undergo a series of molts to the infective, or third, larval stage and then migrate to the mouth parts of the mosquito, where they wait to infect another host by being deposited on the skin of such. These changes inside a mosquito can occur in as littl ...
Product Monograph - Habitrol® Canada Support Program
... systems. However, since the plasma S(-)-nicotine concentrations reached with HABITROL are substantially lower and fluctuate less than those produced by smoking, nicotine related adverse reactions occurring during treatment with HABITROL can be expected to be less marked. If the user continues to smo ...
... systems. However, since the plasma S(-)-nicotine concentrations reached with HABITROL are substantially lower and fluctuate less than those produced by smoking, nicotine related adverse reactions occurring during treatment with HABITROL can be expected to be less marked. If the user continues to smo ...
A multiparameter test of clot formation and fibrinolysis for in
... not shown), and of thrombin alone (0.125–1 IU/ml) and with t-PA (30–1400 ng/ml), was investigated by the CL-test (Fig. 2a,b). We have experimentally found that the concentrations of 0.5 IU/ml thrombin and 60 ng/ml t-PA are optimal in in-vitro drug screening. Exogenous calcium ions were not added to ...
... not shown), and of thrombin alone (0.125–1 IU/ml) and with t-PA (30–1400 ng/ml), was investigated by the CL-test (Fig. 2a,b). We have experimentally found that the concentrations of 0.5 IU/ml thrombin and 60 ng/ml t-PA are optimal in in-vitro drug screening. Exogenous calcium ions were not added to ...
Microinjection of GABAergic agents into the anterior nucleus of the
... Muscimol (160 or 80 nmol; Research Biochemicals International) was dissolved in 0.5 or 0.2 ml of a 2% Evans blue saline solution. To dissolve bicuculline (Research Biochemicals International, Natick, MA) glacial acetic acid was used. The solution was titrated to pH 6.0 with 1 NaOH and subsequently b ...
... Muscimol (160 or 80 nmol; Research Biochemicals International) was dissolved in 0.5 or 0.2 ml of a 2% Evans blue saline solution. To dissolve bicuculline (Research Biochemicals International, Natick, MA) glacial acetic acid was used. The solution was titrated to pH 6.0 with 1 NaOH and subsequently b ...
Teratogenicity as a Consequence of Drug-Induced
... functional during a restricted period in rodent embryonic life (gestational days 10-14 in rats), but not thereafter. Single doses during this period caused stage-specific external, visceral and skeletal defects in rats. The later the treatment was during this period, the more caudal the site of the ...
... functional during a restricted period in rodent embryonic life (gestational days 10-14 in rats), but not thereafter. Single doses during this period caused stage-specific external, visceral and skeletal defects in rats. The later the treatment was during this period, the more caudal the site of the ...
Psychiatric Perspective Treating Steroid
... atoms. Hydroxy or ketone groups are found at C-3 and C17. Testosterone, the major androgen in humans, is secreted mainly by Leydig cells in testicular interstitial tissues. As a class, androgens are responsible for the male phenotype in utero. They stimulate the development of male sexual organs and ...
... atoms. Hydroxy or ketone groups are found at C-3 and C17. Testosterone, the major androgen in humans, is secreted mainly by Leydig cells in testicular interstitial tissues. As a class, androgens are responsible for the male phenotype in utero. They stimulate the development of male sexual organs and ...
Opioids - Waterloo Region Integrated Drugs Strategy
... Fentanyl is a potent opioid, used in anesthesia, for pain, chronic pain, pain in end of life care Typically administered as a patch placed on the skin Fentanyl is produced by pharmaceutical manufacturers Small chemical changes to fentanyl can result in drugs with very similar actions These “bootleg” ...
... Fentanyl is a potent opioid, used in anesthesia, for pain, chronic pain, pain in end of life care Typically administered as a patch placed on the skin Fentanyl is produced by pharmaceutical manufacturers Small chemical changes to fentanyl can result in drugs with very similar actions These “bootleg” ...
Pharmacological options for the management of refractory cancer pain
... Few studies have explored the possibility that refractory cancer pain responds to a rapid and intensive analgesic intervention. In a small open-label RCT assessing the use of parenteral morphine titration for pain exacerbations, pain was controlled in 77 % of the cases with no difference between the ...
... Few studies have explored the possibility that refractory cancer pain responds to a rapid and intensive analgesic intervention. In a small open-label RCT assessing the use of parenteral morphine titration for pain exacerbations, pain was controlled in 77 % of the cases with no difference between the ...
Botulinum Toxins A and B - UnitedHealthcareOnline.com
... This Drug Policy provides assistance in interpreting UnitedHealthcare benefit plans. When deciding coverage, the member specific benefit plan document must be referenced. The terms of the member specific benefit plan document [e.g., Certificate of Coverage (COC), Schedule of Benefits (SOB), and/or S ...
... This Drug Policy provides assistance in interpreting UnitedHealthcare benefit plans. When deciding coverage, the member specific benefit plan document must be referenced. The terms of the member specific benefit plan document [e.g., Certificate of Coverage (COC), Schedule of Benefits (SOB), and/or S ...
Piracetam - Rebound Health
... action (quite unlike most neurotransmitters), and its low toxicity.[15] GABA brain metabolism and GABA receptors are not affected by piracetam. It has been found to increase blood flow and oxygen consumption in parts of the brain but this may be a side effect of increased brain activity rather than ...
... action (quite unlike most neurotransmitters), and its low toxicity.[15] GABA brain metabolism and GABA receptors are not affected by piracetam. It has been found to increase blood flow and oxygen consumption in parts of the brain but this may be a side effect of increased brain activity rather than ...
Colloidal Submicron-Particle Curcumin Exhibits High Absorption
... Summary Curcumin is a major constituent of the spice turmeric and has various biological activities, including anticancer, antioxidant, and anti-inflammatory properties, as well as alcohol detoxification. However, because of its poor absorption efficiency, it is difficult for orally administered cur ...
... Summary Curcumin is a major constituent of the spice turmeric and has various biological activities, including anticancer, antioxidant, and anti-inflammatory properties, as well as alcohol detoxification. However, because of its poor absorption efficiency, it is difficult for orally administered cur ...
Review Articles` Abstracts - source url
... Psoriasis is a chronic disease that can have substantial psychological and social impact on patient's life. Psoriasis has been shown to affect health-related Quality of Life to an extent similar to the effects of other chronic diseases such as depression, myocardial infarction, hypertension, etc. Th ...
... Psoriasis is a chronic disease that can have substantial psychological and social impact on patient's life. Psoriasis has been shown to affect health-related Quality of Life to an extent similar to the effects of other chronic diseases such as depression, myocardial infarction, hypertension, etc. Th ...
Journal of Legal Medicine The Need for Ibogaine in
... phase has ended, the user then enters a reflective and neutral state that lasts 8 to 20 hours.46 The experiences during this stage may vary individual to individual, with some using this time to reflect on what they learned in the first stage.47 In the majority of cases, the user will be unable to s ...
... phase has ended, the user then enters a reflective and neutral state that lasts 8 to 20 hours.46 The experiences during this stage may vary individual to individual, with some using this time to reflect on what they learned in the first stage.47 In the majority of cases, the user will be unable to s ...
Polyethylene Glycol: A Game-Changer Laxative for Children
... only a few were randomized controlled trials. In these studies, patients used different doses of PEG and PEG þ E for different durations of therapy and had different outcome criteria. Two well-designed studies assessed the efficacy of PEG compared with a placebo for short-term treatment of constipat ...
... only a few were randomized controlled trials. In these studies, patients used different doses of PEG and PEG þ E for different durations of therapy and had different outcome criteria. Two well-designed studies assessed the efficacy of PEG compared with a placebo for short-term treatment of constipat ...
What are psychedelics?
... Both the parent compound tryptamine and the N-methyltransferase system which is capable of converting it to DMT, occur in humans, but there is as yet no evidence that DMT is formed in vivo. DMT has nonetheless been identified in trace amounts in the blood and urine of both normals and of schizophren ...
... Both the parent compound tryptamine and the N-methyltransferase system which is capable of converting it to DMT, occur in humans, but there is as yet no evidence that DMT is formed in vivo. DMT has nonetheless been identified in trace amounts in the blood and urine of both normals and of schizophren ...
Medications Development Research for Treatment of Amphetamine and Methamphetamine Addiction
... to amphetamines could potentially cause significant problems. Unfortunately, our knowledge of the effects of prenatal exposure is limited. The few human studies that exist have shown increased rates of premature delivery, placental abruption, fetal growth retardation, and cardiac and brain abnormali ...
... to amphetamines could potentially cause significant problems. Unfortunately, our knowledge of the effects of prenatal exposure is limited. The few human studies that exist have shown increased rates of premature delivery, placental abruption, fetal growth retardation, and cardiac and brain abnormali ...
Amoxicillin/clavulanate - a broad spectrum antimicrobial
... occur during treatment or up to 6 weeks after cessation. Risk factors include old age, male gender and long courses. ...
... occur during treatment or up to 6 weeks after cessation. Risk factors include old age, male gender and long courses. ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.