A comparison of intervention with losartan or captopril in acute
... Aim of study: Angiotensin-converting enzyme ŽACE. inhibitors prolong life, lower the progression of heart failure, and decrease the need for hospitalizations in patients after myocardial infarctions. It is still unclear whether these effects could also be achieved by blocking the angiotensin II ŽATI ...
... Aim of study: Angiotensin-converting enzyme ŽACE. inhibitors prolong life, lower the progression of heart failure, and decrease the need for hospitalizations in patients after myocardial infarctions. It is still unclear whether these effects could also be achieved by blocking the angiotensin II ŽATI ...
Central Nervous System Activity Studies of Baptisia tinctoria (L.) R
... employed in present study for the assessment of anticonvulsant potential of test drugs. Inhibition of tonic extension in mice using MES test suggest anticonvulsant activity against generalized tonicclonic and cortical focal seizures as shown by the standrad drug, phenytoin [18]. But the test substan ...
... employed in present study for the assessment of anticonvulsant potential of test drugs. Inhibition of tonic extension in mice using MES test suggest anticonvulsant activity against generalized tonicclonic and cortical focal seizures as shown by the standrad drug, phenytoin [18]. But the test substan ...
Brentuximab Vedotin in CD30-Positive Lymphomas: A SIE, SIES
... the placebo group (hazard ratio, 0.57; 95% confidence interval, 0.40-0.81; P ¼ .0013). Median PFS by was 42.9 months for patients in the BV group compared to 24.1 months for those in the placebo group. The most frequent adverse events in the BV group compared to placebo were peripheral sensory neurop ...
... the placebo group (hazard ratio, 0.57; 95% confidence interval, 0.40-0.81; P ¼ .0013). Median PFS by was 42.9 months for patients in the BV group compared to 24.1 months for those in the placebo group. The most frequent adverse events in the BV group compared to placebo were peripheral sensory neurop ...
Benefits, adverse effects and drug interactionsof herbal
... Because the use of herbal therapies in the U.S. is escalating, it is essential to be aware of clinical and adverse effects, doses and potential drug-herb interactions. A consumer poll in 1998 indicated that one-third of respondents use botanical remedies, and nearly one in five taking prescription m ...
... Because the use of herbal therapies in the U.S. is escalating, it is essential to be aware of clinical and adverse effects, doses and potential drug-herb interactions. A consumer poll in 1998 indicated that one-third of respondents use botanical remedies, and nearly one in five taking prescription m ...
Get the Facts about Zohydro™ ER
... during initiation of therapy or following a dose increase. Proper dosing and titration are essential. • Interactions with CNS Depressants: Concomitant use may cause profound sedation, respiratory depression, and death. If coadministration is required, consider dose reduction of one or both drugs. • ...
... during initiation of therapy or following a dose increase. Proper dosing and titration are essential. • Interactions with CNS Depressants: Concomitant use may cause profound sedation, respiratory depression, and death. If coadministration is required, consider dose reduction of one or both drugs. • ...
Product Monograph Template - Standard - GlaxoSmithKline
... Treatment of Initial Infection of Herpes Genitalis: 200 mg ( one teaspoonful of suspension [5 mL]) every 4 hours, 5 times daily for a total of 1 g daily for 10 days. Therapy should be initiated as early as possible following onset of signs and symptoms. Suppressive Therapy for Recurrent Herpes Genit ...
... Treatment of Initial Infection of Herpes Genitalis: 200 mg ( one teaspoonful of suspension [5 mL]) every 4 hours, 5 times daily for a total of 1 g daily for 10 days. Therapy should be initiated as early as possible following onset of signs and symptoms. Suppressive Therapy for Recurrent Herpes Genit ...
MicroDose Therapeutx and Moerae Matrix Announce
... MAPKAP kinase 2 (MK2), a key terminal kinase in the TGF‐beta/p38 pathway, with a high degree of specificity. Moerae Matrix’s first development candidate, MMI‐0100, shows excellent activity in multiple models of fibrosis and is IND‐ready for clinical development in acute fibrotic ind ...
... MAPKAP kinase 2 (MK2), a key terminal kinase in the TGF‐beta/p38 pathway, with a high degree of specificity. Moerae Matrix’s first development candidate, MMI‐0100, shows excellent activity in multiple models of fibrosis and is IND‐ready for clinical development in acute fibrotic ind ...
methadone and buprenorphine
... Biological, psychological, social and economic factors influence when and why a person starts taking illicit opioids. Use of opioids can quickly escalate to misuse (repeated use despite adverse consequences) and then dependence (opioid tolerance, withdrawal symptoms, compulsive drug-taking). The ‘Di ...
... Biological, psychological, social and economic factors influence when and why a person starts taking illicit opioids. Use of opioids can quickly escalate to misuse (repeated use despite adverse consequences) and then dependence (opioid tolerance, withdrawal symptoms, compulsive drug-taking). The ‘Di ...
Seizure Management in Dogs and Cats
... The term idiopathic epilepsy, also known as primary or asymptomatic epilepsy, is used when there is no identifiable cause of seizures. The term inherited epilepsy is used when there is a genetic cause of seizures. It is felt than genetics plays an underlying role in idiopathic epileptic dogs. Epilep ...
... The term idiopathic epilepsy, also known as primary or asymptomatic epilepsy, is used when there is no identifiable cause of seizures. The term inherited epilepsy is used when there is a genetic cause of seizures. It is felt than genetics plays an underlying role in idiopathic epileptic dogs. Epilep ...
Choosing a Skeletal Muscle Relaxant
... Skeletal muscle relaxants are widely used in treating musculoskeletal conditions. However, evidence of their effectiveness consists mainly of studies with poor methodologic design. In addition, these drugs have not been proven to be superior to acetaminophen or nonsteroidal anti-inflammatory drugs f ...
... Skeletal muscle relaxants are widely used in treating musculoskeletal conditions. However, evidence of their effectiveness consists mainly of studies with poor methodologic design. In addition, these drugs have not been proven to be superior to acetaminophen or nonsteroidal anti-inflammatory drugs f ...
terbutaline sulfate injection usp
... effect usually occurs within 30 to 60 minutes, and clinically significant bronchodilator activity may continue for 1.5 to 4 hours. The duration of clinically significant improvement is comparable to that observed with equimilligram doses of epinephrine. Preclinical Studies in laboratory animals (min ...
... effect usually occurs within 30 to 60 minutes, and clinically significant bronchodilator activity may continue for 1.5 to 4 hours. The duration of clinically significant improvement is comparable to that observed with equimilligram doses of epinephrine. Preclinical Studies in laboratory animals (min ...
Med-Psych Drug-Drug Interactions Update Triptans
... et al., no significant clinical events occurred, and the authors suggested that no dose adjustment was necessary. These modest findings reflect almotriptan’s multiple avenues of metabolism, which allow the drug to be biotransformed despite “roadblocks” at some of its metabolic sites. We could not fi ...
... et al., no significant clinical events occurred, and the authors suggested that no dose adjustment was necessary. These modest findings reflect almotriptan’s multiple avenues of metabolism, which allow the drug to be biotransformed despite “roadblocks” at some of its metabolic sites. We could not fi ...
Antidepressant Agents
... another drug, and approximately 80% or more will respond to at least one antidepressant drug. Antidepressants do not elevate mood in normal subjects ...
... another drug, and approximately 80% or more will respond to at least one antidepressant drug. Antidepressants do not elevate mood in normal subjects ...
product monograph - Ask Novartis Pharma
... convention, are numbered from the N-terminal end of the molecule. The sequence of amino-acid occupying positions 25 to 33 varies among species and it is this part of the molecule which is most antigenic when ACTH of foreign origin is administered to man. In contrast, the N-terminal 24 amino-acid seq ...
... convention, are numbered from the N-terminal end of the molecule. The sequence of amino-acid occupying positions 25 to 33 varies among species and it is this part of the molecule which is most antigenic when ACTH of foreign origin is administered to man. In contrast, the N-terminal 24 amino-acid seq ...
Buprenorphine Treatment of Refractory
... buprenorphine causes feelings of generalized contentment, but not the "rush" induced by heroin. [20] Even after prolonged administration of high daily doses of the drug, the withdrawal syndrome has been shown to be mild and quite delayed, [17,19,21] although addicts are aware of the absence of the d ...
... buprenorphine causes feelings of generalized contentment, but not the "rush" induced by heroin. [20] Even after prolonged administration of high daily doses of the drug, the withdrawal syndrome has been shown to be mild and quite delayed, [17,19,21] although addicts are aware of the absence of the d ...
Ketamine - Medicines Management
... is due to non-competitive antagonism of the NMDA receptor. Ketamine interacts with specific binding site on the NMDA receptor, blocking the influx of Na and Ca. Binding of ketamine will only occur when the ion channel has been opened though neuronal excitation. The analgesic activity is believed to ...
... is due to non-competitive antagonism of the NMDA receptor. Ketamine interacts with specific binding site on the NMDA receptor, blocking the influx of Na and Ca. Binding of ketamine will only occur when the ion channel has been opened though neuronal excitation. The analgesic activity is believed to ...
Zofran
... of the liver [see Clinical Pharmacology (12.3)]. Because ondansetron is metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes (CYP3A4, CYP2D6, CYP1A2), inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life of ondansetron. In patients treated with pote ...
... of the liver [see Clinical Pharmacology (12.3)]. Because ondansetron is metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes (CYP3A4, CYP2D6, CYP1A2), inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life of ondansetron. In patients treated with pote ...
AP-ZP - Edison Investment Research
... The development risks of Intec are largely centred on whether the AP technology can provide a definitive benefit over other controlled release (CR) formulations. The company has MRI evidence that APs are effectively retained in the stomach, but the question remains how this translates into a benefit ...
... The development risks of Intec are largely centred on whether the AP technology can provide a definitive benefit over other controlled release (CR) formulations. The company has MRI evidence that APs are effectively retained in the stomach, but the question remains how this translates into a benefit ...
Cocaine-Like Discriminative Stimulus Effects of
... resulted primarily in responding on the saline lever up to a dose (100 mg/kg) where all mice failed to complete the FR10 within the five-minute window. The potency differences among the tested compounds in the present study follow each compound’s transporter selectivity, such that METH (which more s ...
... resulted primarily in responding on the saline lever up to a dose (100 mg/kg) where all mice failed to complete the FR10 within the five-minute window. The potency differences among the tested compounds in the present study follow each compound’s transporter selectivity, such that METH (which more s ...
Effects of Antidepressants on Inhibitory Avoidance in
... (Monleón et al., 2008). These studies provide several valuable insights into the effects of antidepressants on memory: ...
... (Monleón et al., 2008). These studies provide several valuable insights into the effects of antidepressants on memory: ...
Cholinergic agonists
... Major contraindication to the use of muscarinic agonists Asthma Choline esters (muscarinic agonists) can produce bronchoconstriction. In the predisposed patient, an asthmatic attack may be induced. Hyperthyroidism Choline esters (muscarinic agonists) can induce atrial fibrillation in hyperthyroid p ...
... Major contraindication to the use of muscarinic agonists Asthma Choline esters (muscarinic agonists) can produce bronchoconstriction. In the predisposed patient, an asthmatic attack may be induced. Hyperthyroidism Choline esters (muscarinic agonists) can induce atrial fibrillation in hyperthyroid p ...
ZYBAN (bupropion hydrochloride) Sustained-Release
... ----------------------- DOSAGE AND ADMINISTRATION ----------------------• Starting dose: 150 mg per day for first 3 days. (2.1) • General: Increase dose gradually to reduce seizure risk. (2.1, 5.3) • Begin dosing one week before quit day. (2.1) • After 3 days, increase the dose to 300 mg per day, gi ...
... ----------------------- DOSAGE AND ADMINISTRATION ----------------------• Starting dose: 150 mg per day for first 3 days. (2.1) • General: Increase dose gradually to reduce seizure risk. (2.1, 5.3) • Begin dosing one week before quit day. (2.1) • After 3 days, increase the dose to 300 mg per day, gi ...
Evaluation of potential retinal toxicity of adalimumab (Humira)
... Intravitreal injections have emerged during the last years as a new very effective way for delivering therapeutic agents intraocularly [23–25], ameliorating the possible systemic effects of such agents. However, intravitreal administration poses also risks related both to the procedure of administra ...
... Intravitreal injections have emerged during the last years as a new very effective way for delivering therapeutic agents intraocularly [23–25], ameliorating the possible systemic effects of such agents. However, intravitreal administration poses also risks related both to the procedure of administra ...
Use of low-dose pregabalin in patients undergoing - STOP-Bang
... by a well-validated QoR-40, which measured five dimensions of recovery: physical comfort (12 items), emotional state (nine items), physical independence (five items), psychological support (seven items), and pain (seven items).23 Each item was rated on a five-point Likert scale. The QoR-40 has a pos ...
... by a well-validated QoR-40, which measured five dimensions of recovery: physical comfort (12 items), emotional state (nine items), physical independence (five items), psychological support (seven items), and pain (seven items).23 Each item was rated on a five-point Likert scale. The QoR-40 has a pos ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.