Acute and Chronic Effects of Inhalants in Intracranial Self
... Inhalants Defined Inhalants are a pharmacologically diverse group of compounds that have been ubiquitously defined through the exclusivity of the inhalational route by which humans abuse them. In addition, inhalants are associated with their legal, therapeutic and commercial availability in society. ...
... Inhalants Defined Inhalants are a pharmacologically diverse group of compounds that have been ubiquitously defined through the exclusivity of the inhalational route by which humans abuse them. In addition, inhalants are associated with their legal, therapeutic and commercial availability in society. ...
BIOCRYST PHARMACEUTICALS INC (Form: 10
... key enzymes involved in therapeutic areas of interest to us. Areas of interest for the Company are determined primarily by the scientific discoveries and the potential advantages that its experienced drug discovery group develops in the laboratory along with the potential commercial opportunity of t ...
... key enzymes involved in therapeutic areas of interest to us. Areas of interest for the Company are determined primarily by the scientific discoveries and the potential advantages that its experienced drug discovery group develops in the laboratory along with the potential commercial opportunity of t ...
EFFECTS OF COFFEE ON THE CENTRAL NERVOUS SYSTEM
... akinesia, rigidity and postural instability. It is presently treated by the precursor of dopamine, Ldopa,,not very active on tremor. However, this treatment leads to long term complications, including loss of drug efficacy and dyskinesia (Marsden, 1990) and psychic side effects at high doses (Montas ...
... akinesia, rigidity and postural instability. It is presently treated by the precursor of dopamine, Ldopa,,not very active on tremor. However, this treatment leads to long term complications, including loss of drug efficacy and dyskinesia (Marsden, 1990) and psychic side effects at high doses (Montas ...
Theranostics Improved Tumor Uptake by Optimizing Liposome
... has been found that pre-injection of empty liposomes may saturate macrophages reversibly, and thus decrease liver uptake of a subsequent dose of similar vesicles with little to no side effect on the liver function [22]. Since the RES clearance process of inorganic particles resembles the clearance r ...
... has been found that pre-injection of empty liposomes may saturate macrophages reversibly, and thus decrease liver uptake of a subsequent dose of similar vesicles with little to no side effect on the liver function [22]. Since the RES clearance process of inorganic particles resembles the clearance r ...
Pharmaceutical Water Screening Values Report (PDF)
... clinically effective outcome, from the most appropriate FDA label. The LTD served as the point of departure (POD) for deriving a screening reference dose. The lowest dose that would be considered for the general population, not including special dosing for individuals with certain conditions requiri ...
... clinically effective outcome, from the most appropriate FDA label. The LTD served as the point of departure (POD) for deriving a screening reference dose. The lowest dose that would be considered for the general population, not including special dosing for individuals with certain conditions requiri ...
Epidural Analgesia in Infants and Children
... albumin and α-1-acid glycoprotein and therefore reduced protein binding of amide local anesthetics and other protein-bound drugs. Preterm infants have even lower levels of α-1-acid glycoprotein than term infants making them particularly susceptible to local anesthetic toxicity. Decreased levels of ...
... albumin and α-1-acid glycoprotein and therefore reduced protein binding of amide local anesthetics and other protein-bound drugs. Preterm infants have even lower levels of α-1-acid glycoprotein than term infants making them particularly susceptible to local anesthetic toxicity. Decreased levels of ...
DOVOBET® Gel
... Known hypersensitivity to DOVOBET gel (calcipotriol and betamethasone dipropionate gel), to any ingredient in the formulation or to components of the container. For a complete listing, see the Dosage Forms, Composition and Packaging section of the product monograph. Ophthalmic use Patients wit ...
... Known hypersensitivity to DOVOBET gel (calcipotriol and betamethasone dipropionate gel), to any ingredient in the formulation or to components of the container. For a complete listing, see the Dosage Forms, Composition and Packaging section of the product monograph. Ophthalmic use Patients wit ...
The safety of carprofen, flunixin and phenylbutazone Gyps coprotheres study.
... the actual time of sample collection indicated in hours. .................................................. 39 Table 4-4: Average clinical pathology parameters (ALB, ALT, Ca2+, Na, K and UA) for each treatment group with the average actual time of sample collection indicated in hours. . 43 Table 4-5 ...
... the actual time of sample collection indicated in hours. .................................................. 39 Table 4-4: Average clinical pathology parameters (ALB, ALT, Ca2+, Na, K and UA) for each treatment group with the average actual time of sample collection indicated in hours. . 43 Table 4-5 ...
British Transplantation Society Guidelines for the Prevention and Management of
... results are seen (15). As positive results from broncheoalveolar lavage in lung transplant recipients may only indicate viral secretion and not disease (16) and as urine culture has very poor specificity (17) it is now rare for this test to be used to guide clinical management in those specimens. Th ...
... results are seen (15). As positive results from broncheoalveolar lavage in lung transplant recipients may only indicate viral secretion and not disease (16) and as urine culture has very poor specificity (17) it is now rare for this test to be used to guide clinical management in those specimens. Th ...
Management of Hypertension - Kementerian Kesihatan Malaysia
... projected to do so for the next few. Of all the risk factors contributing to CVD, hypertension confer the greatest disease burden. It is thus pertinent that all health care providers directly or indirectly involved with CVD knows what is latest in the management of hypertension. I will like to recor ...
... projected to do so for the next few. Of all the risk factors contributing to CVD, hypertension confer the greatest disease burden. It is thus pertinent that all health care providers directly or indirectly involved with CVD knows what is latest in the management of hypertension. I will like to recor ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... Stimulation of pulmonary receptors can trigger bronchospasm which induce or aggravate cough in individuals with bronchial hyperreactivity. Bronchodilators relieve cough in such individual and improve the effectiveness of cough in clearing secretions by increasing surface velocity of air flow during ...
... Stimulation of pulmonary receptors can trigger bronchospasm which induce or aggravate cough in individuals with bronchial hyperreactivity. Bronchodilators relieve cough in such individual and improve the effectiveness of cough in clearing secretions by increasing surface velocity of air flow during ...
Ethanol Reversal of Tolerance to the Respiratory Depressant Effects
... A 75-mg morphine alkaloid pellet or placebo pellet was implanted subcutaneously on the lower dorsal flank under isoflurane general anesthesia. We found no differences in the responses of placebo pellet-implanted mice and naive mice. Hence, to reduce the number of animals undergoing surgery the contr ...
... A 75-mg morphine alkaloid pellet or placebo pellet was implanted subcutaneously on the lower dorsal flank under isoflurane general anesthesia. We found no differences in the responses of placebo pellet-implanted mice and naive mice. Hence, to reduce the number of animals undergoing surgery the contr ...
Title: The effects of caffeine, taurine or caffeine-taurine co
... of cardiac output.15-16 Lastly, taurine and caffeine are known to act on the central nervous system (CNS) but have distinctly different mechanisms, with caffeine relying on antagonism of adenosine receptors17 to induce wakefulness, alertness18 and enhance information processing.19 This is in contras ...
... of cardiac output.15-16 Lastly, taurine and caffeine are known to act on the central nervous system (CNS) but have distinctly different mechanisms, with caffeine relying on antagonism of adenosine receptors17 to induce wakefulness, alertness18 and enhance information processing.19 This is in contras ...
renamed_ce891 - Spiral
... This VASST data was combined with data from a non-blinded hospital patient cohort (receiving vasopressin and/or noradrenaline) to determine the frequency, risk factors and outcomes of SAEs [14]. As might be expected this study reported that patients with SAEs had a higher adjusted mortality than tho ...
... This VASST data was combined with data from a non-blinded hospital patient cohort (receiving vasopressin and/or noradrenaline) to determine the frequency, risk factors and outcomes of SAEs [14]. As might be expected this study reported that patients with SAEs had a higher adjusted mortality than tho ...
product monograph
... and children. HPA axis suppression, Cushing’s syndrome, linear growth retardation, delayed weight gain, and intracranial hypertension have been reported in children receiving topical corticosteroids. Manifestations of adrenal suppression in children include low plasma cortisol levels and an absence ...
... and children. HPA axis suppression, Cushing’s syndrome, linear growth retardation, delayed weight gain, and intracranial hypertension have been reported in children receiving topical corticosteroids. Manifestations of adrenal suppression in children include low plasma cortisol levels and an absence ...
Madhuca Indica JF Gmel. (Sapotaceae): An Overview
... saponins, Flavonoids and glycosides. M. indica is reported to possess antioxidant, anti-inflammatory, antimicrobial, hepatoprotective, antiulcer, antihyperglycaemic activity, antinociceptive and antidiarrhoeal activities. This work gives an overview of the phytochemical and pharmacological evidence ...
... saponins, Flavonoids and glycosides. M. indica is reported to possess antioxidant, anti-inflammatory, antimicrobial, hepatoprotective, antiulcer, antihyperglycaemic activity, antinociceptive and antidiarrhoeal activities. This work gives an overview of the phytochemical and pharmacological evidence ...
Zolpidem Physical Dependence Assessed Across Increasing Doses
... were considered intermediate in severity were observed. Specifically, tremor, jerk and/or rigidly braced posture was observed in one baboon at 1.0 mg/kg, two baboons at the next two doses and all three baboons at 32.0 mg/kg. Vomit and/or retch also occurred in two baboons at dose conditions above 1. ...
... were considered intermediate in severity were observed. Specifically, tremor, jerk and/or rigidly braced posture was observed in one baboon at 1.0 mg/kg, two baboons at the next two doses and all three baboons at 32.0 mg/kg. Vomit and/or retch also occurred in two baboons at dose conditions above 1. ...
EAU Guidelines Male Sexual Dysfunction 2009
... in body mass index (BMI) and physical activity scores, as well as in erectile function, were observed in the lifestyle intervention group. These changes were highly correlated with both weight loss and activity levels. ...
... in body mass index (BMI) and physical activity scores, as well as in erectile function, were observed in the lifestyle intervention group. These changes were highly correlated with both weight loss and activity levels. ...
A Systematic Review of Modafinil: Potential
... mg/day are effective in a dose-independent manner.40 The most commonly reported side effects are headache, nausea, diarrhea, nervousness, anxiety, dyspepsia, and insomnia.15 In contrast to traditional stimulants, modafinil has shown no effect on sleep architecture, including rapid eye movement (REM) ...
... mg/day are effective in a dose-independent manner.40 The most commonly reported side effects are headache, nausea, diarrhea, nervousness, anxiety, dyspepsia, and insomnia.15 In contrast to traditional stimulants, modafinil has shown no effect on sleep architecture, including rapid eye movement (REM) ...
G6PD deficiency: a classic example of pharmacogenetics with
... favism (Sansone & Segni, 1958), an acute syndrome associated with anaemia, haemoglobinuria and jaundice, potentially fatal especially in children, intriguingly affecting only some of the many people who eat fava beans. Favism had been known for centuries (Fermi & Martinetti, 1905), but it had been m ...
... favism (Sansone & Segni, 1958), an acute syndrome associated with anaemia, haemoglobinuria and jaundice, potentially fatal especially in children, intriguingly affecting only some of the many people who eat fava beans. Favism had been known for centuries (Fermi & Martinetti, 1905), but it had been m ...
GHB - CAP Members
... GHB and its analogues are abused for their euphoric and calming effects and because some people believe they build muscles and cause weight loss. GHB and its analogues are also misused for their ability to increase libido, suggestibility, passivity, and to cause amnesia (no memory of events while un ...
... GHB and its analogues are abused for their euphoric and calming effects and because some people believe they build muscles and cause weight loss. GHB and its analogues are also misused for their ability to increase libido, suggestibility, passivity, and to cause amnesia (no memory of events while un ...
Lecture notes on Toxicology
... effect of another chemical without having the effect e .g Disulfiram at non-toxic doses potentiate the toxicity of alcohol & used in the treatment of alcohol abuse. Antagonism -is the phenomenon of opposing actions of two chemicals on the same system e .g paracetamol causes serious liver damage when ...
... effect of another chemical without having the effect e .g Disulfiram at non-toxic doses potentiate the toxicity of alcohol & used in the treatment of alcohol abuse. Antagonism -is the phenomenon of opposing actions of two chemicals on the same system e .g paracetamol causes serious liver damage when ...
T3 Not 4 Me
... 30 mg codeine in a UM has same effects as 45 mg in an EM (1.5 fold increase in morphine concentration) ~ 3% of many Caucasian populations Up to 30 to 45 x higher codeine metabolites conc than PM’s Good responders to codeine maybe UM’s! * www.cypalleles.ki.se The Pharmacogenomics Journal 2007 ...
... 30 mg codeine in a UM has same effects as 45 mg in an EM (1.5 fold increase in morphine concentration) ~ 3% of many Caucasian populations Up to 30 to 45 x higher codeine metabolites conc than PM’s Good responders to codeine maybe UM’s! * www.cypalleles.ki.se The Pharmacogenomics Journal 2007 ...
Ropinirole 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, 4 mg and 5 mg
... The applications for the 0.25, 0.5, 1, 2 and 5 mg strengths have been submitted as ‘generic applications’ under Article 10.1 of Directive 2001/83/EC, as amended. Since the brand leader does not hold licences for the 3 mg and 4 mg strengths, the applications for these strengths have been made under A ...
... The applications for the 0.25, 0.5, 1, 2 and 5 mg strengths have been submitted as ‘generic applications’ under Article 10.1 of Directive 2001/83/EC, as amended. Since the brand leader does not hold licences for the 3 mg and 4 mg strengths, the applications for these strengths have been made under A ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.