Seroquel - PI
... SEROQUEL is indicated for the acute treatment of manic episodes associated with bipolar I disorder, both as monotherapy and as an adjunct to lithium or divalproex. Efficacy was established in two 12-week monotherapy trials in adults, in one 3-week adjunctive trial in adults, and in one 3-week monoth ...
... SEROQUEL is indicated for the acute treatment of manic episodes associated with bipolar I disorder, both as monotherapy and as an adjunct to lithium or divalproex. Efficacy was established in two 12-week monotherapy trials in adults, in one 3-week adjunctive trial in adults, and in one 3-week monoth ...
Adverse drug reaction reports of patients and healthcare
... rendered anonymous and scored for the presence or absence of predefined elements of information. These elements can be objective (e.g. start date of the ADR) or subjective (e.g. the impact or severity of the ADR). A two-sided Pearson’s Chi-square test was used to detect statistically significant diffe ...
... rendered anonymous and scored for the presence or absence of predefined elements of information. These elements can be objective (e.g. start date of the ADR) or subjective (e.g. the impact or severity of the ADR). A two-sided Pearson’s Chi-square test was used to detect statistically significant diffe ...
name of the candidate and address
... effects in prescribed doses. Modafinil has been reported to cause increase in heart rate and blood pressure with sustained adreno-medullary activation [1]. However, it does not cause an increase in muscle sympathetic nerve activity (MSNA) at rest and even attenuates it during an orthostatic stress [ ...
... effects in prescribed doses. Modafinil has been reported to cause increase in heart rate and blood pressure with sustained adreno-medullary activation [1]. However, it does not cause an increase in muscle sympathetic nerve activity (MSNA) at rest and even attenuates it during an orthostatic stress [ ...
Duspatal/Duspatal Retard
... been shown to be porphyrinogenic in in-vitro systems. Pharmacokinetics Mebeverine is rapidly absorbed after oral doses with peak plasma concentrations occurring in 1 to 3 hours. It is 75% bound to albumin in plasma. Mebeverine is completely metabolised by hydrolysis to veratric acid and mebeverine a ...
... been shown to be porphyrinogenic in in-vitro systems. Pharmacokinetics Mebeverine is rapidly absorbed after oral doses with peak plasma concentrations occurring in 1 to 3 hours. It is 75% bound to albumin in plasma. Mebeverine is completely metabolised by hydrolysis to veratric acid and mebeverine a ...
Full Text - IDOSI Publications
... Abstract: This research investigated the effect of leaf extracts of Alchornea cordifolia on fertility hormones in albino rats. The dried leaf extracts were prepared with deionised water and ethylacetate. Chemical analyses of the extracts were performed using standard methods. The effects of the extr ...
... Abstract: This research investigated the effect of leaf extracts of Alchornea cordifolia on fertility hormones in albino rats. The dried leaf extracts were prepared with deionised water and ethylacetate. Chemical analyses of the extracts were performed using standard methods. The effects of the extr ...
Review of cough and cold medicines in children
... been in use for at least 40 years. Indications for the uses of these drugs were accepted at much lower levels of evidence than would now be required, and there is no comprehensive review system for ‘grandfathered’ uses of drugs. Use in children has usually been extrapolated from adult practice with ...
... been in use for at least 40 years. Indications for the uses of these drugs were accepted at much lower levels of evidence than would now be required, and there is no comprehensive review system for ‘grandfathered’ uses of drugs. Use in children has usually been extrapolated from adult practice with ...
Review Article Pro- and Anticonvulsant Effects of Anesthetics (Part 11)
... The occurrence of status epilepticus has been reported with diazepam (188-190). Although observed in one child with petit ma1 seizures (189), this paradoxical effect of diazepam usually occurs in patients with Lennox-Gastaut syndrome, a form of secondary generalized epilepsy (188,190). In these epil ...
... The occurrence of status epilepticus has been reported with diazepam (188-190). Although observed in one child with petit ma1 seizures (189), this paradoxical effect of diazepam usually occurs in patients with Lennox-Gastaut syndrome, a form of secondary generalized epilepsy (188,190). In these epil ...
Chemoprevention_review_final_revision_HMW_edit_title
... postmenopausal women who were administered Tamoxifen, other SERMs have been investigated in an attempt to improve upon the safety profile of tamoxifen. One example is Raloxifene. The initial idea of using Raloxifene as a chemopreventative agent came from the data of the 1999 MORE trial which was tes ...
... postmenopausal women who were administered Tamoxifen, other SERMs have been investigated in an attempt to improve upon the safety profile of tamoxifen. One example is Raloxifene. The initial idea of using Raloxifene as a chemopreventative agent came from the data of the 1999 MORE trial which was tes ...
Blood Pressure Response to Central and/or Peripheral Inhibition of
... detected in brain stem areas (Saavedra et al., 1974) such as in the A, region which represents the catecholaminergic cell bodies projecting their axons to the spinal cord and in the A2 region (Fuxe, 1965; Bolme et al., 1972) which includes the nucleus tractus solitarii, the terminal of the majority ...
... detected in brain stem areas (Saavedra et al., 1974) such as in the A, region which represents the catecholaminergic cell bodies projecting their axons to the spinal cord and in the A2 region (Fuxe, 1965; Bolme et al., 1972) which includes the nucleus tractus solitarii, the terminal of the majority ...
product monograph
... Loratadine is a long-acting tricyclic antihistamine with selective peripheral H1 receptor antagonistic activity. It exhibits a dose-related inhibition of the histamine-induced skin wheal and flare response in humans which is rapid in onset, is apparent at two hours and persists throughout the 24 hou ...
... Loratadine is a long-acting tricyclic antihistamine with selective peripheral H1 receptor antagonistic activity. It exhibits a dose-related inhibition of the histamine-induced skin wheal and flare response in humans which is rapid in onset, is apparent at two hours and persists throughout the 24 hou ...
ANTIBIOTICS A brief overview for DMAT PA-1
... complete cross-resistance exists among the group all are identical except for their route of administration commonly used for bacteremia, skin and soft tissue infections, respiratory tract infections, bone and joint infections, urinary tract infections ineffective against MRSA/MRSE ...
... complete cross-resistance exists among the group all are identical except for their route of administration commonly used for bacteremia, skin and soft tissue infections, respiratory tract infections, bone and joint infections, urinary tract infections ineffective against MRSA/MRSE ...
product information
... responsible for the beneficial effects of pravastatin in hypercholesterolaemic patients is not known. Atherosclerosis: In the Pravastatin Limitation of Atherosclerosis in the Coronary Arteries (PLAC I) study, the effect of pravastatin therapy on coronary atherosclerosis was assessed by coronary angi ...
... responsible for the beneficial effects of pravastatin in hypercholesterolaemic patients is not known. Atherosclerosis: In the Pravastatin Limitation of Atherosclerosis in the Coronary Arteries (PLAC I) study, the effect of pravastatin therapy on coronary atherosclerosis was assessed by coronary angi ...
Ultrasonic delivery of silica-gold nanoshells for photothermolysis of
... 2.6. Human clinical studies Approval was obtained from an Investigational Review Board for the human study. The inclusion criteria for the study subjects were: a) male or female, 18–40 years of age, with clinical diagnosis of acne vulgaris reported on face in the last 6 months, with Fitzpatrick skin ...
... 2.6. Human clinical studies Approval was obtained from an Investigational Review Board for the human study. The inclusion criteria for the study subjects were: a) male or female, 18–40 years of age, with clinical diagnosis of acne vulgaris reported on face in the last 6 months, with Fitzpatrick skin ...
Full PDF - IOSR Journal of Pharmacy
... between 22°C with 12 h each of dark and light cycle. The mice were fed with standard laboratory pelleted feed. The mice were fasted overnight before and 3 h after the administration .A single dose of plant extract 2000 mg/kg orally was administered to one of the animals included in the study. Based ...
... between 22°C with 12 h each of dark and light cycle. The mice were fed with standard laboratory pelleted feed. The mice were fasted overnight before and 3 h after the administration .A single dose of plant extract 2000 mg/kg orally was administered to one of the animals included in the study. Based ...
ABC Clinical Guide 2003 - American Botanical Council
... prospective MC study, and a R, PC study. Two OL studies found positive results, but another OL study failed to find significant improvement in objective measures of bladder outlet obstruction. Similarly, one DB, C study found no difference between saw palmetto and placebo. Several clinical trials ha ...
... prospective MC study, and a R, PC study. Two OL studies found positive results, but another OL study failed to find significant improvement in objective measures of bladder outlet obstruction. Similarly, one DB, C study found no difference between saw palmetto and placebo. Several clinical trials ha ...
Corticotropin-releasing factor-1 receptor activation mediates nicotine
... receptors. Substantial evidence suggests that CRF1 receptors play a role in alcohol and nicotine withdrawal-induced anxiety-like behavior and alcohol and nicotine intake in dependent animals (23–25).Conflicting findings have been reported with regard to the role of CRF2 receptors in negative emotion ...
... receptors. Substantial evidence suggests that CRF1 receptors play a role in alcohol and nicotine withdrawal-induced anxiety-like behavior and alcohol and nicotine intake in dependent animals (23–25).Conflicting findings have been reported with regard to the role of CRF2 receptors in negative emotion ...
Displacement value presentation in monographs
... A national survey undertaken in 2015 found the use of displacement values in paediatrics is commonplace in the UK. Standardising displacement value information in Medusa monographs was viewed as ‘very useful’ or ‘preferred’ by 95% of respondents; reasons for this preference were risk reduction due t ...
... A national survey undertaken in 2015 found the use of displacement values in paediatrics is commonplace in the UK. Standardising displacement value information in Medusa monographs was viewed as ‘very useful’ or ‘preferred’ by 95% of respondents; reasons for this preference were risk reduction due t ...
Efficacy of Antiviral Drugs against Feline Immunodeficiency Virus
... potential anticancer drug. In 1985 it was shown to be effective against HIV [12] and became the first drug approved for treatment of HIV infection [13]. The anti-FIV activity of zidovudine has been assessed in numerous in vitro studies in different cell systems [14,15–26]. The first in vitro study w ...
... potential anticancer drug. In 1985 it was shown to be effective against HIV [12] and became the first drug approved for treatment of HIV infection [13]. The anti-FIV activity of zidovudine has been assessed in numerous in vitro studies in different cell systems [14,15–26]. The first in vitro study w ...
Hallucinatory and rewarding effect of salvinorin A in zebrafish: κ
... Users, particularly teenagers, claim the drug is not addictive, but its potential abuse is not known. Salvinorin A is a potent and highly selective κ-agonist, with greater efficacy than that of the synthetic κ-agonist U-50488 and U-69593, as revealed by binding studies (Roth et al. 2002; Sheffler an ...
... Users, particularly teenagers, claim the drug is not addictive, but its potential abuse is not known. Salvinorin A is a potent and highly selective κ-agonist, with greater efficacy than that of the synthetic κ-agonist U-50488 and U-69593, as revealed by binding studies (Roth et al. 2002; Sheffler an ...
PRODUCT INFORMATION MS Contin® modified release tablets 5
... tolerance. Morphine alters the affective response to pain in that patients remain aware of its existence but are less distressed. Morphine relieves most types of pain but is more effective against dull, constant pain than sharp, intermittent pain. Pharmacokinetics Absorption Morphine is readily abso ...
... tolerance. Morphine alters the affective response to pain in that patients remain aware of its existence but are less distressed. Morphine relieves most types of pain but is more effective against dull, constant pain than sharp, intermittent pain. Pharmacokinetics Absorption Morphine is readily abso ...
![Nefazodone in the rat: mimicry and antagonism of [À]-DOM](http://s1.studyres.com/store/data/007839591_1-ac381daefe7f911d421bf0a90c9e2846-300x300.png)
Nefazodone in the rat: mimicry and antagonism of [À]-DOM
... altered, relative to dose, by pretreatment with the monoamine reuptake inhibitor, nefazodone. Similar to ( ± ) fluoxetine, fluvoxamine, and venlafaxine (Winter et al., 1999a), the enhancement of [ ]-DOM-induced stimulus control occurs in the presence of significant partial substitution by nefazodone ...
... altered, relative to dose, by pretreatment with the monoamine reuptake inhibitor, nefazodone. Similar to ( ± ) fluoxetine, fluvoxamine, and venlafaxine (Winter et al., 1999a), the enhancement of [ ]-DOM-induced stimulus control occurs in the presence of significant partial substitution by nefazodone ...
Experimental Treatments for Leptomeningeal Metastases From
... Lymphoma Kinase in Lung Cancer: The CNS is a frequent site of relapse among patients with ALK-rearranged NSCLC who have been treated with crizotinib.24 The poor penetration of crizotinib to the brain (“pharmacokinetic relapse”), rather than cellular resistance, has been suspected as the mechanism of ...
... Lymphoma Kinase in Lung Cancer: The CNS is a frequent site of relapse among patients with ALK-rearranged NSCLC who have been treated with crizotinib.24 The poor penetration of crizotinib to the brain (“pharmacokinetic relapse”), rather than cellular resistance, has been suspected as the mechanism of ...
PRODUCT MONOGRAPH CYPROTERONE Cyproterone Acetate
... the value apparently increases because the cyproterone acetate eliminated with the urine is also measured. Simultaneously, cyproterone acetate also reduces the reaction of the adrenal cortex to exogenous ACTH in patients; the baseline cortisol and ACTH values may also be reduced. Pharmacokinetic Stu ...
... the value apparently increases because the cyproterone acetate eliminated with the urine is also measured. Simultaneously, cyproterone acetate also reduces the reaction of the adrenal cortex to exogenous ACTH in patients; the baseline cortisol and ACTH values may also be reduced. Pharmacokinetic Stu ...
Linköping University Post Print CYP3A activity influences imatinib response in
... regarded as a pilot study. There might be a number of confounding factors such as different disease phase, that some patients were phenotyped during imatinib therapy and other factors might as well influence imatinib pharmacokinetics such as body weight and α-acid glycoprotein plasma levels [4, 6, 1 ...
... regarded as a pilot study. There might be a number of confounding factors such as different disease phase, that some patients were phenotyped during imatinib therapy and other factors might as well influence imatinib pharmacokinetics such as body weight and α-acid glycoprotein plasma levels [4, 6, 1 ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.