Neuropharmacology of timing and time perception
... the seconds-to-minutes range is the ability to decrease clock-speed with neuroleptic drugs such as haloperidol and to increase clock-speed with stimulant drugs such as methamphetamine [63]. Systematic changes in the subjective experience of event duration following the administration of these drugs ...
... the seconds-to-minutes range is the ability to decrease clock-speed with neuroleptic drugs such as haloperidol and to increase clock-speed with stimulant drugs such as methamphetamine [63]. Systematic changes in the subjective experience of event duration following the administration of these drugs ...
Job Aid 6 Table I – Medication Issues of Particular Relevance
... Daily doses greater than 4 grams/day from all sources (alone or as part of combination products) may increase risk of liver toxicity ...
... Daily doses greater than 4 grams/day from all sources (alone or as part of combination products) may increase risk of liver toxicity ...
A role for D2 but not D1 dopamine receptors in the cross
... A77636 (Sigma, St. Louis, MO) using methods adapted from Carr et al. (2001). Testing began with 30-min habituation sessions in the open field activity chamber once per day for three consecutive days. The baseline bars provided in Fig. 1A–C represent the first 15 min in the activity chambers during t ...
... A77636 (Sigma, St. Louis, MO) using methods adapted from Carr et al. (2001). Testing began with 30-min habituation sessions in the open field activity chamber once per day for three consecutive days. The baseline bars provided in Fig. 1A–C represent the first 15 min in the activity chambers during t ...
Research Protocol - Newcastle University
... Legal or otherwise, NPS may cause significant acute harms; the Office for National Statistics (ONS) reported 56 deaths in England and Wales in 2012 where an NPS was mentioned on the death certificate following a drug-related death, almost double the figure for 2011.27 ONS also reported increases in ...
... Legal or otherwise, NPS may cause significant acute harms; the Office for National Statistics (ONS) reported 56 deaths in England and Wales in 2012 where an NPS was mentioned on the death certificate following a drug-related death, almost double the figure for 2011.27 ONS also reported increases in ...
210066-Journal vol3-4
... Treatment-resistant obsessive-compulsive disorder Non-pharmacological treatment OCD in children and adolescents Summary of recommendations for the treatment of OCD Posttraumatic stress disorder (PTSD) ...
... Treatment-resistant obsessive-compulsive disorder Non-pharmacological treatment OCD in children and adolescents Summary of recommendations for the treatment of OCD Posttraumatic stress disorder (PTSD) ...
to the full guide
... adjusting for the amount of milk produced prior to medication, the mean amount of milk produced on medication was 31ml/24 hours greater for domperidone than the mean for those taking metoclopramide. There were small differences in milk output between the two groups and in the incidence of side effec ...
... adjusting for the amount of milk produced prior to medication, the mean amount of milk produced on medication was 31ml/24 hours greater for domperidone than the mean for those taking metoclopramide. There were small differences in milk output between the two groups and in the incidence of side effec ...
Pain management case studies Pharmacy
... Most respondents wanted to optimise paracetamol use. Recent FDA arguments9 have been to reduce paracetamol dosing in the elderly, rather than follow the usual 4gm per day for everyone. Her paracetamol clearance may be about half that of a 30 year old, so doses may need to reflect this (e.g. 500mg q6 ...
... Most respondents wanted to optimise paracetamol use. Recent FDA arguments9 have been to reduce paracetamol dosing in the elderly, rather than follow the usual 4gm per day for everyone. Her paracetamol clearance may be about half that of a 30 year old, so doses may need to reflect this (e.g. 500mg q6 ...
Anticoagulant Dosing Management
... Laboratory testing: PT/INR prolonged; PTT prolonged at higher concentrations; Changes in PT/PTT small at therapeutic doses and variable; Anti-Xa accurate if proper standard is used Non-Urgent: Hold further doses of Apixaban For at least 24 hours before surgery or procedures for a low risk of bleed ...
... Laboratory testing: PT/INR prolonged; PTT prolonged at higher concentrations; Changes in PT/PTT small at therapeutic doses and variable; Anti-Xa accurate if proper standard is used Non-Urgent: Hold further doses of Apixaban For at least 24 hours before surgery or procedures for a low risk of bleed ...
Headaches - Dkb
... headaches have real neurological mechanisms has prompted headache experts to urge that patients and doctors alike take the condition more seriously and treat it more aggressively. Unfortunately, many people who suffer frequent, debilitating headaches still fail to tell their doctor, while many docto ...
... headaches have real neurological mechanisms has prompted headache experts to urge that patients and doctors alike take the condition more seriously and treat it more aggressively. Unfortunately, many people who suffer frequent, debilitating headaches still fail to tell their doctor, while many docto ...
lactic acidosis with chloramphenicol treatment in a child with cystic
... developing countries where alternatives are not readily available.14 Exposure to chloramphenicol is extremely rare today and there are limited published data supporting its role in aerobic metabolism toxicity and lactic acidosis. This toxicity mechanism was probably under recognized at the time, thu ...
... developing countries where alternatives are not readily available.14 Exposure to chloramphenicol is extremely rare today and there are limited published data supporting its role in aerobic metabolism toxicity and lactic acidosis. This toxicity mechanism was probably under recognized at the time, thu ...
Behavioural analysis of the acute and chronic effects of MDMA
... MDMA (n=9) treatment groups. Over 3 days proceeding drug treatment the rats were habituated to IP injections and the locomotor apparatus (IP saline, 30-min locomotor assessment). Racemic MDMA HCl (Sigma) in saline, or vehicle alone, was then administered IP twice daily (0800 and 1800 hours) over 3 c ...
... MDMA (n=9) treatment groups. Over 3 days proceeding drug treatment the rats were habituated to IP injections and the locomotor apparatus (IP saline, 30-min locomotor assessment). Racemic MDMA HCl (Sigma) in saline, or vehicle alone, was then administered IP twice daily (0800 and 1800 hours) over 3 c ...
Labetalol to metoprolol conversion chart
... personal estate an any. Or playing on Sunday or keeping out of. Ing in loco parentis when the wish for 1887 and the second. ...
... personal estate an any. Or playing on Sunday or keeping out of. Ing in loco parentis when the wish for 1887 and the second. ...
The Potential Role of Therapeutic Drug Monitoring in the Treatment
... year, CD4 cell count is stable at ≥350 µL, and patient’s adherence is dependable (CIII). Monitoring is optional if viral load is suppressed consistently for more than 2 years, CD4 cell counts are persistently >500/µL, except in setting of virologic failure or immunosuppressive treatments or condit ...
... year, CD4 cell count is stable at ≥350 µL, and patient’s adherence is dependable (CIII). Monitoring is optional if viral load is suppressed consistently for more than 2 years, CD4 cell counts are persistently >500/µL, except in setting of virologic failure or immunosuppressive treatments or condit ...
A Review on Evidence Based Practice of Ginkgo biloba in Brain
... improving status in those with cerebrovascular insufficiency. In a double blind trial of 90 patients conducted by Vesper and Hansgen over a twelve-week course28. Ginkgo was found to improve several clinical parameters of measure including: 1) Patient attention in tasks requiring quick orientation an ...
... improving status in those with cerebrovascular insufficiency. In a double blind trial of 90 patients conducted by Vesper and Hansgen over a twelve-week course28. Ginkgo was found to improve several clinical parameters of measure including: 1) Patient attention in tasks requiring quick orientation an ...
PGX Test Monographs
... CYP286 enzyme activity defines a normal or an abnormal (intermediate or poor) metabolizer status for a given individual. Several variant alleles have been identified and result in different CYP286 isoforms that functionally are fully active, partially active, inactive, or have increased activity. Th ...
... CYP286 enzyme activity defines a normal or an abnormal (intermediate or poor) metabolizer status for a given individual. Several variant alleles have been identified and result in different CYP286 isoforms that functionally are fully active, partially active, inactive, or have increased activity. Th ...
Lucrin® PDs Depot 3.75 mg
... breast cancer over 12 weeks. Mean leuprorelin acetate levels were above 0.1 ng/mL after four weeks and remained stable after re-injection (at 8 and 12 weeks). There was no tendency for drug accumulation. Distribution The mean steady-state volume of distribution of leuprorelin following intravenous b ...
... breast cancer over 12 weeks. Mean leuprorelin acetate levels were above 0.1 ng/mL after four weeks and remained stable after re-injection (at 8 and 12 weeks). There was no tendency for drug accumulation. Distribution The mean steady-state volume of distribution of leuprorelin following intravenous b ...
Felbamate (PDF, 63KB, File is accessible)
... combination with carbamazepine, phenytoin, phenobarbital or valproic acid may increase the incidence of their characteristic adverse reactions (see section 4.5). Initiate /.../felbamate dosage at 600 mg to 1200 mg/day, administered in 2 or 3 divided doses. At onset of /.../felbamate therapy, reduce ...
... combination with carbamazepine, phenytoin, phenobarbital or valproic acid may increase the incidence of their characteristic adverse reactions (see section 4.5). Initiate /.../felbamate dosage at 600 mg to 1200 mg/day, administered in 2 or 3 divided doses. At onset of /.../felbamate therapy, reduce ...
Dapagliflozin (as propanediol monohydrate) / Metformin hydrochloride
... Absorption Dapagliflozin Dapagliflozin was rapidly and well absorbed after oral administration and can be administered with or without food. Maximum dapagliflozin plasma concentrations (Cmax) were usually attained within 2 hours after administration in the fasted state. The Cmax and AUC values incre ...
... Absorption Dapagliflozin Dapagliflozin was rapidly and well absorbed after oral administration and can be administered with or without food. Maximum dapagliflozin plasma concentrations (Cmax) were usually attained within 2 hours after administration in the fasted state. The Cmax and AUC values incre ...
A Look at Opioid Maintenance Therapy - ascls-nd
... Opioid Misuse • The nontherapeutic use of opioids • Taking in amounts not prescribed • Using alternative routes of administration • Obtaining illicitly ...
... Opioid Misuse • The nontherapeutic use of opioids • Taking in amounts not prescribed • Using alternative routes of administration • Obtaining illicitly ...
Dabigatran instead of warfarin in AF
... o The lower dose can also be used in patients where the bleeding risk is high and the embolic risk is low (one wonders whether aspirin might not be better in these individuals…?) • The higher dose of dabigatran (150mg) is more effective than the lower dose or warfarin. The lower dose of dabigatra ...
... o The lower dose can also be used in patients where the bleeding risk is high and the embolic risk is low (one wonders whether aspirin might not be better in these individuals…?) • The higher dose of dabigatran (150mg) is more effective than the lower dose or warfarin. The lower dose of dabigatra ...
Vol 10, Issue 2 - Utah Poison Control Center
... Secondary outcome measures were intubation, time ventilated, seizures, and cardiac dysrhythmias. No difference was seen in mortality or in any other outcome measure. The majority of patients in this study received the first dose of activated charcoal greater than two hours after ingestion which ma ...
... Secondary outcome measures were intubation, time ventilated, seizures, and cardiac dysrhythmias. No difference was seen in mortality or in any other outcome measure. The majority of patients in this study received the first dose of activated charcoal greater than two hours after ingestion which ma ...
EryTab PI 03-A919-R2 Rev. July 2013 Final2
... of theophylline may be associated with an increase in serum theophylline levels and potential theophylline toxicity. In case of theophylline toxicity and/or elevated serum theophylline levels, the dose of theophylline should be reduced while the patient is receiving concomitant erythromycin therapy. ...
... of theophylline may be associated with an increase in serum theophylline levels and potential theophylline toxicity. In case of theophylline toxicity and/or elevated serum theophylline levels, the dose of theophylline should be reduced while the patient is receiving concomitant erythromycin therapy. ...
Article - Archive ouverte UNIGE
... This retrospective study was approved by our hospital’s ethics comittee. Six patients, one woman and five men, who are followed in a psychiatric unit specialising in patients with intellectual deficiencies, participated in the study. They presented autism associated with mental retardation ranging fro ...
... This retrospective study was approved by our hospital’s ethics comittee. Six patients, one woman and five men, who are followed in a psychiatric unit specialising in patients with intellectual deficiencies, participated in the study. They presented autism associated with mental retardation ranging fro ...
DAVID E. McCLURE, Ph. D. 10654 Canyon
... Designed and executed single and multiple-dose Phase 1 studies through CRO. Prepared and packaged SIB-1508Y clinical trial formulation through appropriate CROs. Planned initial Phase 2 patient trial with the Parkinson’s Study Group (PSG) to evaluate safety, tolerability, and efficacy of SIB-1508Y, m ...
... Designed and executed single and multiple-dose Phase 1 studies through CRO. Prepared and packaged SIB-1508Y clinical trial formulation through appropriate CROs. Planned initial Phase 2 patient trial with the Parkinson’s Study Group (PSG) to evaluate safety, tolerability, and efficacy of SIB-1508Y, m ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.