Ping Zhao CV
... Summary of simulations Effect of ritonavir on sildenafil exposure Lack of CYP inhibition by cabazitaxel Effect of rifampicin co-administration Lack of CYP inhibition by topically applied ketoconazole Synergistic effect of drug-disease interaction Similar drug interaction by ketoconazole under differ ...
... Summary of simulations Effect of ritonavir on sildenafil exposure Lack of CYP inhibition by cabazitaxel Effect of rifampicin co-administration Lack of CYP inhibition by topically applied ketoconazole Synergistic effect of drug-disease interaction Similar drug interaction by ketoconazole under differ ...
Synthetic Drugs FAQ
... scheduling for a number of these compounds, however many of these substances are still not illegal at the federal level. According to the National Conference of State Legislatures, all 50 states have banned two types of the synthetic drugs - cannabinoids and cathinones - with the majority doing so v ...
... scheduling for a number of these compounds, however many of these substances are still not illegal at the federal level. According to the National Conference of State Legislatures, all 50 states have banned two types of the synthetic drugs - cannabinoids and cathinones - with the majority doing so v ...
Effects of UN and Russian Influence on Drug Policy in Central Asia
... The third part therefore analyzes regional cooperation on drug control, with a focus on the two model laws on drugs adopted by the Inter-Parliamentary Assembly of the Commonwealth of Independent States (CIS), which largely replicate Russian policy. In the fourth part, a brief analysis of national d ...
... The third part therefore analyzes regional cooperation on drug control, with a focus on the two model laws on drugs adopted by the Inter-Parliamentary Assembly of the Commonwealth of Independent States (CIS), which largely replicate Russian policy. In the fourth part, a brief analysis of national d ...
Signaled drug delivery and transport across the blood
... of the capillary endothelial cells, astrocytes, pericytes and neurons. Because of the presence of tight junctions and efflux transporters, this structure is far less permeable than non-brain capillaries [7] although it has carriers for the uptake of selected molecules (e.g. glucose, large aromatic a ...
... of the capillary endothelial cells, astrocytes, pericytes and neurons. Because of the presence of tight junctions and efflux transporters, this structure is far less permeable than non-brain capillaries [7] although it has carriers for the uptake of selected molecules (e.g. glucose, large aromatic a ...
Lyophilisates for drug delivery in ophthalmology: pharmacokinetics
... body sensation of preserved drugs upon instillation produces a higher rate of loss because of reflex tearing.20 About 90% of eye medications prescribed today contain preservatives which are cytotoxic to the ocular surface to different degrees.21 22 Their cytotoxicity leads to epithelial desquamation ...
... body sensation of preserved drugs upon instillation produces a higher rate of loss because of reflex tearing.20 About 90% of eye medications prescribed today contain preservatives which are cytotoxic to the ocular surface to different degrees.21 22 Their cytotoxicity leads to epithelial desquamation ...
Guidance for Industry ANDAs: Impurities in Drug Substances
... Analytical results should be provided for all batches of the drug substance used for stability testing, as well as for batches representative of the proposed commercial process. The content of individual impurities, both identified and unidentified, and total impurities observed in these batches of ...
... Analytical results should be provided for all batches of the drug substance used for stability testing, as well as for batches representative of the proposed commercial process. The content of individual impurities, both identified and unidentified, and total impurities observed in these batches of ...
EA_QA66.6_warfarin+ppis
... in the pharmacokinetics of warfarin was observed after single dose administration to healthy subjects who had been receiving rabeprazole 20mg daily for 7 days (4, 42). The American product literature says there have been reports of increased INR and prothrombin time in patients receiving proton pump ...
... in the pharmacokinetics of warfarin was observed after single dose administration to healthy subjects who had been receiving rabeprazole 20mg daily for 7 days (4, 42). The American product literature says there have been reports of increased INR and prothrombin time in patients receiving proton pump ...
the use and abuse of drugs a handbook for health educators
... Cultural and social factors are important in understanding the use of drugs, for drug abuse is largely a problem related to the community attitudes toward drugs. Every culture permits certain methods of tension reduction, e.g., alcohol is to many an approved way of reducing tension in our society. T ...
... Cultural and social factors are important in understanding the use of drugs, for drug abuse is largely a problem related to the community attitudes toward drugs. Every culture permits certain methods of tension reduction, e.g., alcohol is to many an approved way of reducing tension in our society. T ...
Is there an interaction between warfarin and proton pump inhibitors?
... check prothrombin times and INRs (international normalised ratio). Warfarin is a mixture of 2 active isomers – the R-isomer and the S-isomer. The S-isomer is more potent. The R- and S-isomers are both metabolised in the liver. The S-isomer is metabolised more rapidly than the R-isomer, mainly by the ...
... check prothrombin times and INRs (international normalised ratio). Warfarin is a mixture of 2 active isomers – the R-isomer and the S-isomer. The S-isomer is more potent. The R- and S-isomers are both metabolised in the liver. The S-isomer is metabolised more rapidly than the R-isomer, mainly by the ...
PDF - World Journal of Pharmaceutical Sciences
... of ketorolac microcapsules as one of the multi-particulate formulations and are prepared to obtain prolonged drug delivery in order to decrease ulcerogenicity , improve bioavailability and stability and also target a drug at specific sites. Microcapsules were prepared by air suspension technique usi ...
... of ketorolac microcapsules as one of the multi-particulate formulations and are prepared to obtain prolonged drug delivery in order to decrease ulcerogenicity , improve bioavailability and stability and also target a drug at specific sites. Microcapsules were prepared by air suspension technique usi ...
PUBLIC ASSESSMENT REPORT of the Medicines Evaluation Board
... manufactured in-house, consisting of calcium carbonate drug substance and pregelatinized maize starch (again with same ratio of 96% calcium carbonate and 4% pregelatinized maize starch). The CEP procedure is used for the active substance. Under the official Certification Procedures of the EDQM of th ...
... manufactured in-house, consisting of calcium carbonate drug substance and pregelatinized maize starch (again with same ratio of 96% calcium carbonate and 4% pregelatinized maize starch). The CEP procedure is used for the active substance. Under the official Certification Procedures of the EDQM of th ...
06/06/13 - Magellan Rx Management
... JUXTAPID™ (lomitapide mesylate) 5 mg, 10 mg and 20 mg capsule: JUXTAPID™ is a microsomal triglyceride transfer protein inhibitor indicated as an adjunct to a low-fat diet and other lipid-lowering treatments, including LDL apheresis where available, to reduce low-density lipoprotein cholesterol (LDL- ...
... JUXTAPID™ (lomitapide mesylate) 5 mg, 10 mg and 20 mg capsule: JUXTAPID™ is a microsomal triglyceride transfer protein inhibitor indicated as an adjunct to a low-fat diet and other lipid-lowering treatments, including LDL apheresis where available, to reduce low-density lipoprotein cholesterol (LDL- ...
2. Basic Principles of Stability Testing
... accelerated testing with the drug substance up to the running production the analytical procedure has to be developed accordingly. It is not possible, to optimise and validate the analytical procedure at the beginning and then starting analysing the samples. The analytical procedure has to be develo ...
... accelerated testing with the drug substance up to the running production the analytical procedure has to be developed accordingly. It is not possible, to optimise and validate the analytical procedure at the beginning and then starting analysing the samples. The analytical procedure has to be develo ...
Avoiding Errors in the Reconstitution of Dantrolene Sodium
... Dantrolene Sodium for Intravenous Injection (DS‐IV) is labeled as requiring reconstitution with sterile water for injection (WFI). Anesthesiologists may be unaware of the current clinical guidelines for the preparation of Dantrolene Sodium for Injection (DS‐IV). The package inserts, according to ...
... Dantrolene Sodium for Intravenous Injection (DS‐IV) is labeled as requiring reconstitution with sterile water for injection (WFI). Anesthesiologists may be unaware of the current clinical guidelines for the preparation of Dantrolene Sodium for Injection (DS‐IV). The package inserts, according to ...
A theory of drug tolerance and dependence I
... description of tolerance development has been discussed in a previous paper (Peper et al., 1988). Adaptation is often considered a relatively slow, continuous learning process. Drug tolerance, however, usually manifests itself as a relatively short lasting, but recurrent and triggered process and ma ...
... description of tolerance development has been discussed in a previous paper (Peper et al., 1988). Adaptation is often considered a relatively slow, continuous learning process. Drug tolerance, however, usually manifests itself as a relatively short lasting, but recurrent and triggered process and ma ...
Public Assessment Report
... Lindaxa 10 mg and 15 mg hard capsules are generic medicinal products containing sibutramine hydrochloride monohydrate as the active substance. Original products are Reductil 10 and 15 mg hard capsules from Abbott GmbH and Co. KG, Germany, first authorization was granted in Germany in 1999. The origi ...
... Lindaxa 10 mg and 15 mg hard capsules are generic medicinal products containing sibutramine hydrochloride monohydrate as the active substance. Original products are Reductil 10 and 15 mg hard capsules from Abbott GmbH and Co. KG, Germany, first authorization was granted in Germany in 1999. The origi ...
Application of Induced Infringement Law in Pharmaceutical Patent
... 378. The Federal Circuit affirmed the ruling on induced infringement, noting they “have long held that the sale of a product specifically labeled for use in a patented method constitutes inducement to infringe that patent . . . .” Eli Lilly & Co., 435 Fed. Appx. at 926. In AstraZeneca LP v. Apotex, ...
... 378. The Federal Circuit affirmed the ruling on induced infringement, noting they “have long held that the sale of a product specifically labeled for use in a patented method constitutes inducement to infringe that patent . . . .” Eli Lilly & Co., 435 Fed. Appx. at 926. In AstraZeneca LP v. Apotex, ...
10. review of literature
... compartments for simultaneous delivery of two poorly water-soluble drugs, Atenolol and Amlodipine Besylate, by using solubility modulation approach. Scanning electron microscopy (SEM) before dissolution showed presence of outer dense region and inner porous region for the prepared asymmetric membran ...
... compartments for simultaneous delivery of two poorly water-soluble drugs, Atenolol and Amlodipine Besylate, by using solubility modulation approach. Scanning electron microscopy (SEM) before dissolution showed presence of outer dense region and inner porous region for the prepared asymmetric membran ...
Perspectives in Drug Discovery A Collection of Essays on the History
... these come into contact with yeast or other micro-organism under appropriate conditions of temperature and time. However, the low solubility of ethanol in lipids and the high solubility in water meant that massive amounts must be ingested to bring about stupor and narcosis. The modern era of drug di ...
... these come into contact with yeast or other micro-organism under appropriate conditions of temperature and time. However, the low solubility of ethanol in lipids and the high solubility in water meant that massive amounts must be ingested to bring about stupor and narcosis. The modern era of drug di ...
In vitro and in vivo evaluation of a new sublingual tablet system for
... an analgesic effect was obtained after 10–15 min. However, some patients found it difficult to retain the solution under the tongue and swallowed it. Weinberg et al. (1988) used a solution of fentanyl with a pH of 6.5, which is the natural pH of saliva. The solution (1 ml corresponding to 50 g fent ...
... an analgesic effect was obtained after 10–15 min. However, some patients found it difficult to retain the solution under the tongue and swallowed it. Weinberg et al. (1988) used a solution of fentanyl with a pH of 6.5, which is the natural pH of saliva. The solution (1 ml corresponding to 50 g fent ...
Oral Therapies for Cancer - Oncology Nursing Society
... Copyright © 2011 by the Oncology Nursing Society. All rights reserved. ...
... Copyright © 2011 by the Oncology Nursing Society. All rights reserved. ...
Overview of drug-interactions between coumarin
... available without prescription (over-the-counter: OTC). Over-the-Counter drugs are extensively used in the Netherlands. These OTC drugs are categorized into three categories of legal status of supply, based on a mild to very low potential risk for the user. These categories are ‘Pharmacy only (PH)’ ...
... available without prescription (over-the-counter: OTC). Over-the-Counter drugs are extensively used in the Netherlands. These OTC drugs are categorized into three categories of legal status of supply, based on a mild to very low potential risk for the user. These categories are ‘Pharmacy only (PH)’ ...
Reflection paper on the data requirements for - EMA
... A well-defined manufacturing process with satisfactory process controls is required in order to assure that an acceptable product is produced on a consistent basis. At the same time it is known that small changes to liposomal products can significantly influence their performance. Approaches to dete ...
... A well-defined manufacturing process with satisfactory process controls is required in order to assure that an acceptable product is produced on a consistent basis. At the same time it is known that small changes to liposomal products can significantly influence their performance. Approaches to dete ...