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Action Potentials
Action Potentials

... • EPSP and IPSP travel to the base of the axon hillock where they are summed • Two EPSPs in rapid succession at one synapse are additive • Same for IPSPs ...
The Journal of Neuroscience
The Journal of Neuroscience

... Correction: In the April 9, 2008 issue’s “This Week in the Journal” summary of the Development/Plasticity/Repair article by Coate et al., there was an error in the third sentence. The term “DP cells” should have been “EP cells.” Thus, the sentence should have read “This week, Coate et al. report tha ...
Neuron, Impulse Generation, and Reflex Arc
Neuron, Impulse Generation, and Reflex Arc

... neurotransmitters stored in vesicles in the axon bulb. They are released when triggered by an action potential arriving at the axon bulb of the pre-synaptic neuron. The action potential causes an influx of Ca2+ into the axon bulb and Ca causes the vesicles to fuse with the pre-synaptic membrane (exo ...
Slide 1
Slide 1

... FIGURE 47.7 LTP at the CA3–CA1 synapse in the hippocampus. (A) Test stimuli are delivered repeatedly once every 10 s while the strength of the synaptic connection is monitored. Strength can be assessed by the amplitude of the extracellularly recorded EPSP or, as was done in this example, as the slo ...
Neural Pathways and Transmission
Neural Pathways and Transmission

... Ion channels specific for sodium open within the cell membrane, allowing sodium to move into the neuron This causes a very temporary reversal in charges, in which the interior is now positively charged, and the exterior is negatively charged Internal environment is, on average, 30 mV at this state T ...
chapter_12 - The Anatomy Academy
chapter_12 - The Anatomy Academy

... slow signals supply the stomach and dilate pupil fast signals supply skeletal muscles and transport sensory signals for vision and balance ...
What is a neuron?
What is a neuron?

... Centrally located nuclei ...
The biological Approach
The biological Approach

... • The axon carries impulses away from the cell body. It is covered in a fatty layer called the myelin sheath that protects the axon and speeds up transmission of the impulse. • At the end of the axon are terminal buttons that communicate with the next neuron in the chain across a gap known as the sy ...
Sensory neurons
Sensory neurons

... Myelin Sheath • Some important nerve cells have an axon that is covered in Myelin. • Myelin is a fatty substance that acts as an insulator and allows an nerve impulse to travel very quickly. • Multiple Sclerosis is a disease where the Myelin Sheath is damaged causing some signals to ‘short-circuit’ ...
Introduction to drugs and the brain
Introduction to drugs and the brain

... Drugs Can Change Brain Circuitry Drugs can “hijack” the brain’s natural connections and change them, which can cause a variety of consequences ...
AUTONOMIC REFLEX - Semmelweis University
AUTONOMIC REFLEX - Semmelweis University

... sympathetic trunk and form the splanchnic nerves, these fibers travel to a prevertebral gaglion 4. some preganglionic axons in the splanchnic nerve innervate chromaffin cells of the adrenal medulla ...
Invited Re vie W The distribution of cholinergic neurons in the
Invited Re vie W The distribution of cholinergic neurons in the

... ChAT, an in situ hybridization technique has been induced to detect ChAT mRNA in neurons for identifying authentic cholinergic neurons. The present article reviews immunohistochemical and in situ hybridization studies on the distribution of neurons expressing ChAT in the human central nervous system ...
Ch 2 Biology and Behavior
Ch 2 Biology and Behavior

... • Released by neurons & affects chemical reactions • Key to diverse functions; sexual performance to formation of ...
The Nervous System - Volunteer State Community College
The Nervous System - Volunteer State Community College

... 4) undershoot phase – membrane potential is temporarily more negative than the resting stage (hyperpolarized); Na+ channels remain closed but K+ channels remain open since the inactivation gates have not had time to respond to repolarization of the membrane. ...
ANATOMY OF A NEURON
ANATOMY OF A NEURON

... molecules will be removed from the receptor sites in one of the three ways: •Some neurotransmitters will be destroyed by the enzymes in the synaptic cleft. • Some neurotransmitters will be broken down into its component molecules which will be reclaimed by the axon terminal. •Some neurotransmitters ...
awl review q answers
awl review q answers

... In answering this, we can contextualize the issue by also revising some material from Chapter 2. Through sensory systems, the brain is informed of such things in the world as the presence of food and water. Through detectors within the body, it is informed of such internal states as dehydration, bod ...
The Nervous System
The Nervous System

... – 4. Myelin Sheath: covering that insulates the axon, sending the impulse faster and give it a whitish appearance (11) – Neurons with axons that have myelin make up “white matter” in the brain, while neurons without myelin are called “gray matter” ...
Autonomic Nervous System
Autonomic Nervous System

... • The functional and structural unit of the nervous system • Specialized to conduct information from one part of the body to another • There are many, many different types of neurons but most have certain structural and functional characteristics in common: - Cell body (soma) - One or more specializ ...
Neurons - MrsMcFadin
Neurons - MrsMcFadin

... • Neurons may have dozens of dendrites, but usually they have only one axon. ...
The Nervous System
The Nervous System

... a. Primary somatic sensory area b. Visual area in occipital lobe c. Complex memory in the temporal lobe d. Note close proximity to olfactory area e. Anterior association area-higher intellectual reasoning and ...
Navigating The Nervous System
Navigating The Nervous System

... b. The chemical secreted travels across the gap between the axon and the dendrite of the next neuron. c. This gap is called a synapse. The chemical signal triggers a nerve impulse in the dendrite, which travels to the end of that neuron’s axon. ...
Brain Anatomy
Brain Anatomy

... Alzheimer’s patients lose neurons that release Acetylcholine. ...
Lecture nerve
Lecture nerve

... • Saltatory conduction -depolarization happens only at Nodes of Ranvier - areas along the axon that are unmyelinated and where there is a high density of voltage-gated ion channels -action potential “jumps” from node to node ...
The Nervous System
The Nervous System

... I. Propagation of action potentials • 1. concentration difference of ions on either side of membrane represents potential energy-kind of like of cocked gun • 2. stacked dominoes waiting to fall over • 3. one domino falling over initiates a wave of action potentials spreading out like the ripples in ...
ARIEL LEVINE Postdoctoral Associate, The Salk Institute for
ARIEL LEVINE Postdoctoral Associate, The Salk Institute for

... developing new strategies, I approach this question with a variety of techniques, including cutting-edge viral tracing techniques, neuronal and synaptic labeling, optogenetics, large-scale gene expression database analysis, knock-in mouse genetics, and behavioral testing. Most recently, I identified ...
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Synaptic gating



Synaptic gating is the ability of neural circuits to gate inputs by either suppressing or facilitating specific synaptic activity. Selective inhibition of certain synapses has been studied thoroughly (see Gate theory of pain), and recent studies have supported the existence of permissively gated synaptic transmission. In general, synaptic gating involves a mechanism of central control over neuronal output. It includes a sort of gatekeeper neuron, which has the ability to influence transmission of information to selected targets independently of the parts of the synapse upon which it exerts its action (see also neuromodulation).Bistable neurons have the ability to oscillate between a hyperpolarized (down state) and a depolarized (up state) resting membrane potential without firing an action potential. These neurons can thus be referred to as up/down neurons. According to one model, this ability is linked to the presence of NMDA and AMPA glutamate receptors. External stimulation of the NMDA receptors is responsible for moving the neuron from the down state to the up state, while the stimulation of AMPA receptors allows the neuron to reach and surpass the threshold potential. Neurons that have this bistable ability have the potential to be gated because outside gatekeeper neurons can modulate the membrane potential of the gated neuron by selectively shifting them from the up state to the down state. Such mechanisms have been observed in the nucleus accumbens, with gatekeepers originating in the cortex, thalamus and basal ganglia.
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