What is Bioinformatics? A Proposed Definition and Overview of the Field
... A concept that underpins most research methods in bioinformatics is that much of the data can be grouped together based on biologically meaningful similarities. For example, sequence segments are often repeated at different positions of genomic DNA [27]. Genes can be clustered into those with partic ...
... A concept that underpins most research methods in bioinformatics is that much of the data can be grouped together based on biologically meaningful similarities. For example, sequence segments are often repeated at different positions of genomic DNA [27]. Genes can be clustered into those with partic ...
The Electrophoretic Movement of Proteins from Various
... strains. For example, f, i, k, m and p occurred in all five strains and g , h, j, n and q in four strains. For any named band, the frequency of occurrence and the intensity of staining (dark or light) was not the same for all isolates. The frequency of band k was low, only 18% for PD 04833,and high ...
... strains. For example, f, i, k, m and p occurred in all five strains and g , h, j, n and q in four strains. For any named band, the frequency of occurrence and the intensity of staining (dark or light) was not the same for all isolates. The frequency of band k was low, only 18% for PD 04833,and high ...
Ribosome - SRP - signal sequence interactions
... least in eukaryotes, but possibly also in prokaryotes [1,2]), thus targeting the ribosome to export sites on the membrane. Furthermore, once it binds to the ribosome, SRP seems to bring about a translational arrest or slowing down of chain elongation, that is lifted only upon a subsequent interactio ...
... least in eukaryotes, but possibly also in prokaryotes [1,2]), thus targeting the ribosome to export sites on the membrane. Furthermore, once it binds to the ribosome, SRP seems to bring about a translational arrest or slowing down of chain elongation, that is lifted only upon a subsequent interactio ...
Chapter 2 - Dr. Eric Schwartz
... present in large numbers, they play an extremely important role in molecular interactions and in determining the shape of large molecules. • Remember that the shape of large molecules often determines their functions and their ability to interact with other molecules. For example, some molecules int ...
... present in large numbers, they play an extremely important role in molecular interactions and in determining the shape of large molecules. • Remember that the shape of large molecules often determines their functions and their ability to interact with other molecules. For example, some molecules int ...
2.3 Carbon-Based Molecules
... • Carbohydrates can be broken down to provide energy for cells. • Some carbohydrates are part of cell structure. Polymer (starch) ...
... • Carbohydrates can be broken down to provide energy for cells. • Some carbohydrates are part of cell structure. Polymer (starch) ...
Go Nuts!
... Did you Know? “Scientific evidence suggests but does not prove that eating 1.5 ounces per day of most nuts, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease.” – U.S. Food and Drug Administration ...
... Did you Know? “Scientific evidence suggests but does not prove that eating 1.5 ounces per day of most nuts, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease.” – U.S. Food and Drug Administration ...
Untitled
... cargo and facilitate transport through the nuclear pore. Interestingly, proteins do not need to unfold to pass through the nuclear pore and can therefore cross while maintaining their higher order 3-dimensional shape. In contrast to nuclear transport, proteins that move into chloroplasts, the ER, an ...
... cargo and facilitate transport through the nuclear pore. Interestingly, proteins do not need to unfold to pass through the nuclear pore and can therefore cross while maintaining their higher order 3-dimensional shape. In contrast to nuclear transport, proteins that move into chloroplasts, the ER, an ...
GluR-A C-terminal 10 residues constitute a binding motif
... Bottom, Representation of RIL and the isolated RIL clones (numbers = amino residues). -Gal activity for the corresponding RIL clones is indicated: +++ = strong, ++ = good, += visible blue color. c, GluR-A but not GluR-B coimmunoprecipitates with FlagRIL. COS1 cells, transfected with plasmid DNA as ...
... Bottom, Representation of RIL and the isolated RIL clones (numbers = amino residues). -Gal activity for the corresponding RIL clones is indicated: +++ = strong, ++ = good, += visible blue color. c, GluR-A but not GluR-B coimmunoprecipitates with FlagRIL. COS1 cells, transfected with plasmid DNA as ...
Magic Numbers in Protein Structures
... lowering the temperature, we assume there is a phase transition to the unique native state. This is driven by the short ranged interactions fab sria 2 rjb d between the residues a and b at ria and rjb on the neighboring P elements as in the bead model. The energy gain DE ab fab sria 2 rjb d is lim ...
... lowering the temperature, we assume there is a phase transition to the unique native state. This is driven by the short ranged interactions fab sria 2 rjb d between the residues a and b at ria and rjb on the neighboring P elements as in the bead model. The energy gain DE ab fab sria 2 rjb d is lim ...
Our work was originally motivated my collaboration with Drs
... something that says that if you inject protein A into the body, the only tissue to which that protein can bind is tissue A. In vivo phage display is a technology used to reveal organ specific vascular ligand-receptor systems in animal models, and recently in patients, and also to validate them as po ...
... something that says that if you inject protein A into the body, the only tissue to which that protein can bind is tissue A. In vivo phage display is a technology used to reveal organ specific vascular ligand-receptor systems in animal models, and recently in patients, and also to validate them as po ...
Wilson`s disease and the copper ATPase transporters
... of information on protein families and domains. Examining the database, information on the Wilson’s disease protein and its homologues can be found in InterPro entries IPR001757 and its child entry IPR027256 (Table 1). From the description of IPR001757 , we know that ATP7B belongs to a broad family ...
... of information on protein families and domains. Examining the database, information on the Wilson’s disease protein and its homologues can be found in InterPro entries IPR001757 and its child entry IPR027256 (Table 1). From the description of IPR001757 , we know that ATP7B belongs to a broad family ...
Signaling by Serine/Threonine Kinase Receptors
... 2. Autophosphorylated α and β subunits are rendered Ca/CaM-independent (autonomous), but still retain substantial kinase activity. Both these consequences (calmodulin trapping and autonomy) allow the phosphorylated kinase subunits to remain active beyond the limited duration of a Ca2+ spike. Transge ...
... 2. Autophosphorylated α and β subunits are rendered Ca/CaM-independent (autonomous), but still retain substantial kinase activity. Both these consequences (calmodulin trapping and autonomy) allow the phosphorylated kinase subunits to remain active beyond the limited duration of a Ca2+ spike. Transge ...
The Play is the thing… - Biology Learning Center
... • Transcription – 1 strand => new RNA – => new protein ...
... • Transcription – 1 strand => new RNA – => new protein ...
Computational design of a pH-sensitive IgG binding
... ecombinant monoclonal antibodies and Fc-fusion proteins have become an important class of biological pharmaceuticals and are widely used as research reagents. Their manufacture typically involves mammalian cells as the expression host and affinity chromatography as a key purification step. Although ...
... ecombinant monoclonal antibodies and Fc-fusion proteins have become an important class of biological pharmaceuticals and are widely used as research reagents. Their manufacture typically involves mammalian cells as the expression host and affinity chromatography as a key purification step. Although ...
2.3 Carbon-Based Molecules
... • Carbohydrates can be broken down to provide energy for cells. • Some carbohydrates are part of cell structure. Polymer (starch) Starch is a polymer of glucose monomers that often has a branched structure. ...
... • Carbohydrates can be broken down to provide energy for cells. • Some carbohydrates are part of cell structure. Polymer (starch) Starch is a polymer of glucose monomers that often has a branched structure. ...
Chaperone-assisted protein folding: the path to discovery from a
... the chaperonin cage not only prevents aggregation but also can smooth rugged foldingenergy landscapes, allowing folding to occur within a biologically relevant time frame43. A chaperone relay for protein folding As the GroEL story developed, we were also busy trying to resolve another puzzle. In the ...
... the chaperonin cage not only prevents aggregation but also can smooth rugged foldingenergy landscapes, allowing folding to occur within a biologically relevant time frame43. A chaperone relay for protein folding As the GroEL story developed, we were also busy trying to resolve another puzzle. In the ...
Identification of cAMP-dependent phosphorylated proteins involved
... Fig. 1 cAMP-dependent protein phosphorylation detected by biotinylated Phos-tag/ECL assays (a),phosphoproteins isolated with Phos-tag agarose phosphate-affinity beads in encystment-induced C. cucullus (b). (a) ‘CBB’: Blots stained with CBB after the biotinylated Phos-tag/ECL detection. ‘P-tag’: Prot ...
... Fig. 1 cAMP-dependent protein phosphorylation detected by biotinylated Phos-tag/ECL assays (a),phosphoproteins isolated with Phos-tag agarose phosphate-affinity beads in encystment-induced C. cucullus (b). (a) ‘CBB’: Blots stained with CBB after the biotinylated Phos-tag/ECL detection. ‘P-tag’: Prot ...
8.5 Translation - Cloudfront.net
... • Translation converts mRNA messages into polypeptides which make ...
... • Translation converts mRNA messages into polypeptides which make ...
Measles virus M and F proteins associate with detergent
... yet neither of these protein species associated preferentially with the DRM or the detergent-soluble fractions. To investigate whether co-expression of F protein would alter DRM association of M proteins, pCG-M(ED) was transfected into 293 cells stably expressing authentic (EDderived) (Fig. 2c) or h ...
... yet neither of these protein species associated preferentially with the DRM or the detergent-soluble fractions. To investigate whether co-expression of F protein would alter DRM association of M proteins, pCG-M(ED) was transfected into 293 cells stably expressing authentic (EDderived) (Fig. 2c) or h ...
Protein (nutrient)
Proteins are essential nutrients for the human body. They are one of the building blocks of body tissue, and can also serve as a fuel source. As a fuel, proteins contain 4 kcal per gram, just like carbohydrates and unlike lipids, which contain 9 kcal per gram. The most important aspect and defining characteristic of protein from a nutritional standpoint is its amino acid composition.Proteins are polymer chains made of amino acids linked together by peptide bonds. During human digestion, proteins are broken down in the stomach to smaller polypeptide chains via hydrochloric acid and protease actions. This is crucial for the synthesis of the essential amino acids that cannot be biosynthesized by the body.There are nine essential amino acids which humans must obtain from their diet in order to prevent protein-energy malnutrition. They are phenylalanine, valine, threonine, tryptophan, methionine, leucine, isoleucine, lysine, and histidine. There are five dispensable amino acids which humans are able to synthesize in the body. These five are alanine, aspartic acid, asparagine, glutamic acid and serine. There are six conditionally essential amino acids whose synthesis can be limited under special pathophysiological conditions, such as prematurity in the infant or individuals in severe catabolic distress. These six are arginine, cysteine, glycine, glutamine, proline and tyrosine.Humans need the essential amino acids in certain ratios. Some protein sources contain amino acids in a more or less 'complete' sense. This has given rise to various ranking systems for protein sources, as described in the article.Animal sources of protein include meats, dairy products, fish and eggs. Vegan sources of protein include whole grains, pulses, legumes, soy, and nuts. Vegetarians and vegans can get enough essential amino acids by eating a variety of plant proteins. It is commonly believed that athletes should consume a higher-than-normal protein intake to maintain optimal physical performance.