• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Biological-Anthropology-2nd-Edition-Stanford-Test-Bank
Biological-Anthropology-2nd-Edition-Stanford-Test-Bank

... forensic sciences. It would be interesting to share several murder cases with students that were solved with these techniques or to show how these techniques have cleared many convicted felons of their supposed crimes. ...
A Serine/Proline-Rich Protein Is Fused To HRX in t(4
A Serine/Proline-Rich Protein Is Fused To HRX in t(4

... chimeric transcription factor consisting of an N-terminal portion of HRX fused to a novel serine/proline-rich protein from 1 9 ~ 1 3The . ~ predicted t(4;ll) products have not been completely characterized thus, it is unclear whether various HRX fusion partners might share significant similarities t ...
Standard Mutation Nomenclature in Molecular Diagnostics
Standard Mutation Nomenclature in Molecular Diagnostics

... As shown in Table 1, genetic sequence changes occur at the DNA level, and we usually identify mutations at the DNA level in a clinical genetic testing. Descriptions at the amino acid level are usually inferred with no experimental proof and are not unequivocal because amino acid codes are degenerate ...
w + gene is silenced in some cells
w + gene is silenced in some cells

... • Tandem repeats of 5 – 300 bp long, can extend over megabases of DNA • Have different chromatin structure and higher-order packaging than other chromosomal regions • Predominant human satellite DNA is a-satellite  171 bp repeat, present in > 1 Mb block of tandem repeats Copyright © The McGraw-Hill ...
Polypeptide Synthesis - Fairfax Senior High School
Polypeptide Synthesis - Fairfax Senior High School

...  Finished strand is shorter ...
METHODS TO DETECT SELECTION IN POPULATIONS WITH
METHODS TO DETECT SELECTION IN POPULATIONS WITH

... along a contiguous stretch of DNA in a population sample, the haplotypes defined by these variants, and homologous sequences from closely related species. The review has two components. The first is an exposition of available methods for testing data for evidence of selection. Some tests apply equal ...
What is an Epigenetic Mechanism and why is it
What is an Epigenetic Mechanism and why is it

... pencil markings (can be erased) ...
Genomic imprinting and human disease
Genomic imprinting and human disease

... of kilobases (kb) in size. Imprinted gene expression across these evolutionarily conserved clusters is regulated by ICRs (imprinting control regions), essential DNA sequence elements that are up to several kilobases in size. ICRs are CpG-rich regions that are methylated only on one of the two parent ...
GENETIC ANALYSIS OF THE FUNCTION OF THE DROSOPHILA
GENETIC ANALYSIS OF THE FUNCTION OF THE DROSOPHILA

... genital disc to the testis to form the coiled shape found in adults. Based on tissue-specific RT-PCR analysis, the head was identified as a non-sex specific tissue expressing dmrt93B. During the development of this dissertation I identified discrete expression of this gene in regions of the brain as ...
The Large Loop Repair and Mismatch Repair Pathways
The Large Loop Repair and Mismatch Repair Pathways

... Plasmids containing his4 alleles with varying length DNA sequence insertions were used to replace the wild-type HIS4 chromosomal sequence in AS13. Each plasmid was constructed by annealing two complementary oligonucleotides and inserting the oligos into the Sal I site in HIS4 on pDN9 (Nag et al. 198 ...
Document
Document

... Figure 8.10 Resolution of RNA polymerases that transcribe the spoVG gene from two different promoters. Losick and his colleagues purified polymerase from B. subtilis ceils that were running out of nutrients. The last purification step was DNA-cellutose column chromatography. The polymerase activity ...
Next generation sequencing
Next generation sequencing

... Ion torrent sequencing works much like 454 sequencing, except instead of detecting released PPi by conversion to a flash of light, the production of H+ ions is sensed using semiconductor technology. This makes the instrument much cheaper, essentially $50,000 instead of $500,000. ...
Breaking PCR - Integrated DNA Technologies
Breaking PCR - Integrated DNA Technologies

... Overall, we have to conclude that the polymerase chain reaction is an even more forgiving technique than we first assumed. The nature of some of the robust results we obtained, particularly for MgCl2 concentration, primer annealing temperatures, and polymerase extension step duration, suggest that a ...
patterns of linkage disequilibrium in the human genome
patterns of linkage disequilibrium in the human genome

... of LD, its numerical value is of little use for measuring the strength of and comparing levels of LD. This is due to the dependence of D on allele frequencies. As a result, several alternative measures based on D have been devised (reviewed in Devlin and Risch23). Comparing different reports on the ...
GCAT-SEEK Workshop - Prokaryotic Genomics Module – Jeff
GCAT-SEEK Workshop - Prokaryotic Genomics Module – Jeff

Biology OF CLONING VECTORS-III-B.SC - E
Biology OF CLONING VECTORS-III-B.SC - E

... phenotype is readily scorable, for in this way it is possible to distinguish chimeras from cleaved plasmid molecules which have self-annealed. Of course, readily detectable insertional inactivation is not essential if the vector and insert are to be joined by the hormopolymer tailing method or tif t ...
Archaeal Transcription Initiation - IMBB
Archaeal Transcription Initiation - IMBB

... fervidus [Sandman et al., 1990]) is shown below the consensus sequence for the histonefold domain of eucaryal histone H4. The additional N- and C-terminal domains of H4 have been omitted. Listed below each residue in the HMfB sequence are the different residues found at that position in one or more ...
Li 2001 Cancer Res
Li 2001 Cancer Res

... accordance with the 1997 revision of the International System for Staging Lung Cancer (9). SCC was divided into “limited” and “extensive” disease, based on the absence or presence, respectively, of distant metastases. For this analysis, stages I and II NSCC were defined as “limited disease,” stage I ...
Nanosep® Centrifugal Devices - Protocols for Use
Nanosep® Centrifugal Devices - Protocols for Use

... This value refers to the approximate molecular weight (MW) of a dilute globular solute (i.e., a typical protein) which is 90% retained by the membrane. However, a molecule’s shape can have a direct effect on its retention by a membrane. For example, linear molecules like DNA may find their way throu ...
Genetics of mammalian meiosis: regulation, dynamics and impact
Genetics of mammalian meiosis: regulation, dynamics and impact

... regulation of meiotic initiation by rA could involve germ­cell­intrinsic factors, such as the rNA­binding protein deleted in azoospermia­like (DAZl), which may act upstream of Stra8 in the pathway of meiotic induction19. The lack of obvious mechanistic conserva­ tion between yeast and mice in regula ...
AIDS Case Study Teacher Guide - URMC
AIDS Case Study Teacher Guide - URMC

... illustrate how to load a gel. Students will work in groups of 2-4 to complete the agarose gel electrophoresis activity. They will load 10L of each of the “DNA vaccines” into the well of an agarose gel and run the gel for about 15 minutes at 120 Volts. While the gels are running, use slides 19-25 to ...
Presentazione di PowerPoint
Presentazione di PowerPoint

... RNA-Seq Sequencing the transcriptome to investigate differentially expressed genes: - under different conditions, or - in different tissues - in different alleles ...
Lecture 7: Tetrad analysis
Lecture 7: Tetrad analysis

... determine map distance between the locus A and the centromere RF (A, CM) = ½ * MII asci / Total asci Why to multiply by ½ ? ...because in any MII ascus only ½ of the spores are recombinant ...
Motif Finding
Motif Finding

... An Introduction to Bioinformatics Algorithms ...
Methods - Research Repository UCD
Methods - Research Repository UCD

... determined, but no gene that might code for a halogenating enzyme was detected either within the gene cluster, or in the flanking sequences. Following further analysis of culture supernatants that were active against bacteria by liquid chromatography-mass spectrometry (LC-MS), it was not possible to ...
< 1 ... 72 73 74 75 76 77 78 79 80 ... 766 >

Cre-Lox recombination



In the field of genetics, Cre-Lox recombination is known as a site-specific recombinase technology, and is widely used to carry out deletions, insertions, translocations and inversions at specific sites in the DNA of cells. It allows the DNA modification to be targeted to a specific cell type or be triggered by a specific external stimulus. It is implemented both in eukaryotic and prokaryotic systems.The system consists of a single enzyme, Cre recombinase, that recombines a pair of short target sequences called the Lox sequences. This system can be implemented without inserting any extra supporting proteins or sequences. The Cre enzyme and the original Lox site called the LoxP sequence are derived from bacteriophage P1.Placing Lox sequences appropriately allows genes to be activated, repressed, or exchanged for other genes. At a DNA level many types of manipulations can be carried out. The activity of the Cre enzyme can be controlled so that it is expressed in a particular cell type or triggered by an external stimulus like a chemical signal or a heat shock. These targeted DNA changes are useful in cell lineage tracing and when mutants are lethal if expressed globally.The Cre-Lox system is very similar in action and in usage to the FLP-FRT recombination system.
  • studyres.com © 2026
  • DMCA
  • Privacy
  • Terms
  • Report