Solubility enhancement technique for an anti-malarial
... Solid dispersions represent a useful pharmaceutical technique for increasing the dissolution, absorption and therapeutic efficacy of drugs in dosage forms. The term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic matrix an ...
... Solid dispersions represent a useful pharmaceutical technique for increasing the dissolution, absorption and therapeutic efficacy of drugs in dosage forms. The term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic matrix an ...
01 Chapter 1644 - Pharmaceutical Press
... In this the core of the micelle represents a hydrophobic region into which the poorly water-soluble drugs may partition. The location in the micelle is related to the chemical structure of the drug. For example, if the therapeutic agent is poorly soluble the molecule will locate exclusively within t ...
... In this the core of the micelle represents a hydrophobic region into which the poorly water-soluble drugs may partition. The location in the micelle is related to the chemical structure of the drug. For example, if the therapeutic agent is poorly soluble the molecule will locate exclusively within t ...
navigating the fda
... • Clinical data not supportive of indications for use – need more data •Inadequacy on how people respond to various dosages – need more data •“Approvable” – probably be approved, provided certain issues get resolved •Labeling •Safety issues •Manufacturing issues – can delay or deny application. Prod ...
... • Clinical data not supportive of indications for use – need more data •Inadequacy on how people respond to various dosages – need more data •“Approvable” – probably be approved, provided certain issues get resolved •Labeling •Safety issues •Manufacturing issues – can delay or deny application. Prod ...
presentation source
... needs to be used cautiously because it lowers blood pressure. • Viagra should not be given to patients who are taking nitrates, because nitrates are also a strong vasodilator. The use of both could cause major heart problems. • Also, the use of CYP3A4 or P450 inhibitors (which are the cytochromes re ...
... needs to be used cautiously because it lowers blood pressure. • Viagra should not be given to patients who are taking nitrates, because nitrates are also a strong vasodilator. The use of both could cause major heart problems. • Also, the use of CYP3A4 or P450 inhibitors (which are the cytochromes re ...
ANSI HIBC 3.1 Positive Identification for Patient Safety: Part 1
... Massachusetts General Hospital (MGH), a hospital within the Partners Healthcare System. MGH embarked on a project in 2004 to develop a safer system for the administration of medication to patients. The proposed system and resulting specification requires the use of “barcodes”, “2-D” symbols or RFID ...
... Massachusetts General Hospital (MGH), a hospital within the Partners Healthcare System. MGH embarked on a project in 2004 to develop a safer system for the administration of medication to patients. The proposed system and resulting specification requires the use of “barcodes”, “2-D” symbols or RFID ...
The effect of topical benzamil and amiloride on nasal potential
... Consideration will also need to be given to its toxicity. No side-effects were seen of nasally administered benzamil in this study but the toxicological consequences of administration of this drug to the lungs are unknown. Benzamil is more lipophilic than amiloride and this could potentially increas ...
... Consideration will also need to be given to its toxicity. No side-effects were seen of nasally administered benzamil in this study but the toxicological consequences of administration of this drug to the lungs are unknown. Benzamil is more lipophilic than amiloride and this could potentially increas ...
an-update-of-taste-m.. - Scholars Research Library
... Inclusion complexes are ‘host-guest’ relationship in which complexing agent act as host and provide cavities in which foreign guest molecule may fit. Cyclodextrin form inclusion types of complexes with organic molecules both in solid state and in solution[64]. The complexing agent is capable of mask ...
... Inclusion complexes are ‘host-guest’ relationship in which complexing agent act as host and provide cavities in which foreign guest molecule may fit. Cyclodextrin form inclusion types of complexes with organic molecules both in solid state and in solution[64]. The complexing agent is capable of mask ...
Routine analysis of amphetamine class drugs as their
... and methamphetamine in urine have been described. Although the fluorescence and chemiluminescence techniques are highly sensitive for detection of amphetamine and methamphetamine in urine [14– 18], chemiluminescent methods require complex postcolumn detection procedures [14,15]. For fluorescence det ...
... and methamphetamine in urine have been described. Although the fluorescence and chemiluminescence techniques are highly sensitive for detection of amphetamine and methamphetamine in urine [14– 18], chemiluminescent methods require complex postcolumn detection procedures [14,15]. For fluorescence det ...
Drug-resistant leprosy: Monitoring and current status
... MB leprosy patients and rifampicin and dapsone for PB leprosy patients. Among these drugs, rifampicin is the most important anti-leprosy drug and, therefore, is included in the treatment of both types of leprosy. Experience strongly suggest that treatment of leprosy with either dapsone15,16 or rifam ...
... MB leprosy patients and rifampicin and dapsone for PB leprosy patients. Among these drugs, rifampicin is the most important anti-leprosy drug and, therefore, is included in the treatment of both types of leprosy. Experience strongly suggest that treatment of leprosy with either dapsone15,16 or rifam ...
Appropriate Timing of Fluoxetine and Statin Delivery Reduces the
... being used in on-going clinical trials [3,4]. ...
... being used in on-going clinical trials [3,4]. ...
Comparison of the Effects of Pilocarpine Solution and Tablet on
... Purpose: Pilocarpine has the effects on improvement of salivary flow and subjective symptoms for xerostomic patients. Because of unwanted side effects following its systemic administration, topical pilocarpine has been paid attention as an alternative. This study aimed to investigate effects of pilo ...
... Purpose: Pilocarpine has the effects on improvement of salivary flow and subjective symptoms for xerostomic patients. Because of unwanted side effects following its systemic administration, topical pilocarpine has been paid attention as an alternative. This study aimed to investigate effects of pilo ...
Combinations of antifungal agents in therapy–what value are they?
... interactions against fungal species.41,48 For Aspergillus species, pre-incubation with the polyene followed by miconazole or fluconazole showed significantly greater synergy than when the drugs were tested simultaneously.47 Finally, the combined effect in vitro of amphotericin B and azole agents aga ...
... interactions against fungal species.41,48 For Aspergillus species, pre-incubation with the polyene followed by miconazole or fluconazole showed significantly greater synergy than when the drugs were tested simultaneously.47 Finally, the combined effect in vitro of amphotericin B and azole agents aga ...
View/Open
... Malaria is a major worldwide health problem and the control of the disease is compromised by acquisition and spread of Plasmodium falciparum resistance to multiple antimalarial drugs, which has caused an increase in malaria related morbidity and mortality. In response, Artemisinin based Combination ...
... Malaria is a major worldwide health problem and the control of the disease is compromised by acquisition and spread of Plasmodium falciparum resistance to multiple antimalarial drugs, which has caused an increase in malaria related morbidity and mortality. In response, Artemisinin based Combination ...
introduction - KSU Faculty Member websites
... QTc intervals. There was no significant change in the QRS duration. As compared with the control values, the ∆HR max value was –19.3±3.0 beats/min (-6.8%) at 10 min, the ∆PR max value was 5.4±1.0 ms (9.3%) at 10 min, the ∆QT max value was 4.0±1.0 ms (3.3%) at 30 min, and the ∆QTc max value was 5.5±1 ...
... QTc intervals. There was no significant change in the QRS duration. As compared with the control values, the ∆HR max value was –19.3±3.0 beats/min (-6.8%) at 10 min, the ∆PR max value was 5.4±1.0 ms (9.3%) at 10 min, the ∆QT max value was 4.0±1.0 ms (3.3%) at 30 min, and the ∆QTc max value was 5.5±1 ...
Pharmacology Training Course - Medical Transcription at Home
... Gilman wrote this text. This reference is written for medical personnel who have a strong background in physiology and pharmacology. Indeed, it is not written for a reader who has a weak or limited background in the sciences. The clinical application of drug knowledge is the aim of the text. The boo ...
... Gilman wrote this text. This reference is written for medical personnel who have a strong background in physiology and pharmacology. Indeed, it is not written for a reader who has a weak or limited background in the sciences. The clinical application of drug knowledge is the aim of the text. The boo ...
Antiepileptic Drugs
... fussiness, lethargy, disobedience, and stubbornness; phenytoin with unsteadiness, involuntary movements, tiredness, and alterations of emotional state; carbamazepine with sleep disorders, agitation, irritability, and emotional liability; clonazepam with irritability, aggression, hyperactivity, disob ...
... fussiness, lethargy, disobedience, and stubbornness; phenytoin with unsteadiness, involuntary movements, tiredness, and alterations of emotional state; carbamazepine with sleep disorders, agitation, irritability, and emotional liability; clonazepam with irritability, aggression, hyperactivity, disob ...
new insights into the role of environmental context in the expression
... [3,6] or an isodirectional CR [7]. Despite these differences, however, all of these views attribute context dependency to an association between the environment in which the drug is given and the drug’s effect. For purposes of experimental control, environments used in studies of context-dependency ...
... [3,6] or an isodirectional CR [7]. Despite these differences, however, all of these views attribute context dependency to an association between the environment in which the drug is given and the drug’s effect. For purposes of experimental control, environments used in studies of context-dependency ...
sodium valproate in childhood epilepsy
... or over a defined interval of time such as a year (period prevalence). Again, like incidence rates, prevalence rates quoted can be influenced depending on whether persons with single seizures, febrile seizures, acute symptomatic seizures or only recurrent unprovoked seizures are counted as cases. Th ...
... or over a defined interval of time such as a year (period prevalence). Again, like incidence rates, prevalence rates quoted can be influenced depending on whether persons with single seizures, febrile seizures, acute symptomatic seizures or only recurrent unprovoked seizures are counted as cases. Th ...
(Soma): prescribing indications
... Treatment of Overdosage: Basic life support measures should be instituted as dictated by the clinical presentation. Induced emesis is not recommended due to the risk of CNS and respiratory depression. Gastric lavage should be considered soon after ingestion (usually within 1 hour.) In cases of sever ...
... Treatment of Overdosage: Basic life support measures should be instituted as dictated by the clinical presentation. Induced emesis is not recommended due to the risk of CNS and respiratory depression. Gastric lavage should be considered soon after ingestion (usually within 1 hour.) In cases of sever ...
Evaluation of the dead volume in intravenous short
... performed using ERP software (see Figure 1). A small discrepancy between the responses given in the questionnaire and the statistical analysis was found only on the surgical ward and concerned the use of 50 mL infusions. For the most part, 100 mL infusions were used, but on one internal medicine war ...
... performed using ERP software (see Figure 1). A small discrepancy between the responses given in the questionnaire and the statistical analysis was found only on the surgical ward and concerned the use of 50 mL infusions. For the most part, 100 mL infusions were used, but on one internal medicine war ...
Dear Sir/Madam - University of Michigan College of Pharmacy
... S. Caccia and M. R. Feng. Kinetics and distribution of the beta-adrenergic agonist salbutamol in rat brain. J Pharm Pharmacol. 1984, 36(3):200-2. S. Caccia, M.R. Feng, G. Guiso. Disposition of the psychotropic drugs buspirone, MJ13805 and piribedil, and of their common active metabolite 1-(2-pyrimid ...
... S. Caccia and M. R. Feng. Kinetics and distribution of the beta-adrenergic agonist salbutamol in rat brain. J Pharm Pharmacol. 1984, 36(3):200-2. S. Caccia, M.R. Feng, G. Guiso. Disposition of the psychotropic drugs buspirone, MJ13805 and piribedil, and of their common active metabolite 1-(2-pyrimid ...
... factor in asthma, because the infiltrated inflammatory cells, eosinophils in particular, in the airway, produce various chemical substances that may contribute to the bronchoconstriction, excess secretion of mucus, epithelial damage, and nonspecific hyperreactivity that is characteristic of asthma [ ...
FORMULATION AND CHARACTERIZATION OF MATRIX AND TRIPLE LAYER MATRIX
... matrix tablets is a drug delivery device, which comprises a matrix core containing the active solute and one, or more barriers (modulating layers) incorporated during tabletting process [1]. The barrier layers delay the interaction of active solute with dissolution medium, by limiting the surface av ...
... matrix tablets is a drug delivery device, which comprises a matrix core containing the active solute and one, or more barriers (modulating layers) incorporated during tabletting process [1]. The barrier layers delay the interaction of active solute with dissolution medium, by limiting the surface av ...
paracetamol, diphenhydramine hydrochloride
... The products contain the active ingredients paracetamol and diphenhydramine hydrochloride and are for the treatment of mild to moderate pain in infants and children, including teething pain, headache, sore throat, aches and pains and for the symptomatic relief of influenza, feverishness, and feveris ...
... The products contain the active ingredients paracetamol and diphenhydramine hydrochloride and are for the treatment of mild to moderate pain in infants and children, including teething pain, headache, sore throat, aches and pains and for the symptomatic relief of influenza, feverishness, and feveris ...
Pharmacognosy
Pharmacognosy is the study of medicinal drugs derived from plants or other natural sources. The American Society of Pharmacognosy defines pharmacognosy as ""the study of the physical, chemical, biochemical and biological properties of drugs, drug substances or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources.""It is also defined as the study of crude drugs.