DESIGN AND OPTIMISATION OF EXTENDED RELEASE METOPROLOL SUCCINATE
... based on phase-separation technique [7]. A multiunit system based on ionic interactions consisting of a drug layered, Eudragit® NEcoated salt core followed by coating with Eudragit® RS was attempted [8]. Sustained release microspheres formulation using chitosan polymer by cross-linking technique has ...
... based on phase-separation technique [7]. A multiunit system based on ionic interactions consisting of a drug layered, Eudragit® NEcoated salt core followed by coating with Eudragit® RS was attempted [8]. Sustained release microspheres formulation using chitosan polymer by cross-linking technique has ...
Hydrochlorothiazide - Developing Anaesthesia
... Hydrochlorothiazide is a thiazide diuretic, primarily used in the treatment of hypertension. It may be used alone but more commonly is used in combination formulations with other antihypertensive drugs. Electrolyte disturbances are the most common significant adverse side effect, hypokalemia in part ...
... Hydrochlorothiazide is a thiazide diuretic, primarily used in the treatment of hypertension. It may be used alone but more commonly is used in combination formulations with other antihypertensive drugs. Electrolyte disturbances are the most common significant adverse side effect, hypokalemia in part ...
The Influence of Conformational Isomerism on Drug
... occurs sequentially. In each discrete and successive step, small energy barriers are overcome as the molecule and receptor adjust their conformations to allow binding. In summary, the use of preferred conformations in making SAR determinations is very difficult since in many instances knowledge of t ...
... occurs sequentially. In each discrete and successive step, small energy barriers are overcome as the molecule and receptor adjust their conformations to allow binding. In summary, the use of preferred conformations in making SAR determinations is very difficult since in many instances knowledge of t ...
design and development of lornoxicam fast dissolving tablets by
... as hospitalized or bedridden patients suffering from a variety of disorders such as stroke, thyroid disorder, Parkinson’s disease and other neurological disorders also find difficulty in swallowing and require fast-melt tablets because of their physical condition. The convention and the ease of usin ...
... as hospitalized or bedridden patients suffering from a variety of disorders such as stroke, thyroid disorder, Parkinson’s disease and other neurological disorders also find difficulty in swallowing and require fast-melt tablets because of their physical condition. The convention and the ease of usin ...
Inhalant Abuse - American Psychological Association
... Basic Research in Solvent Intoxication • Ethical concerns prevent studies in people, especially juveniles • There are 100’s of chemicals to study • The strong odors of most solvents will make them easily distinguishable from other drugs and difficult to study ...
... Basic Research in Solvent Intoxication • Ethical concerns prevent studies in people, especially juveniles • There are 100’s of chemicals to study • The strong odors of most solvents will make them easily distinguishable from other drugs and difficult to study ...
Recommendations for TDM - Auburn University College of
... will accumulate until a steady-state is reached. Because of this long half-life, the sampling time for bromide can be any time during a dosing interval. Monitoring should occur at: Baseline: “Steady-state” should occur in 3 to 5 drug half-lives, or 2.5 to 3 months after dosing at the same dosing re ...
... will accumulate until a steady-state is reached. Because of this long half-life, the sampling time for bromide can be any time during a dosing interval. Monitoring should occur at: Baseline: “Steady-state” should occur in 3 to 5 drug half-lives, or 2.5 to 3 months after dosing at the same dosing re ...
Research Protocol - Newcastle University
... (NPS) or ‘legal highs.’ These are an increasing healthcare challenge, with 73 new substances reported to the Drugs Early Warning system in Europe in 2012 and 81 in 2013. These substances are associated with significant acute toxicity with 56 deaths reported in England and Wales during 2012 and numer ...
... (NPS) or ‘legal highs.’ These are an increasing healthcare challenge, with 73 new substances reported to the Drugs Early Warning system in Europe in 2012 and 81 in 2013. These substances are associated with significant acute toxicity with 56 deaths reported in England and Wales during 2012 and numer ...
An Overview of Cannabis
... this epoch and recognize it as another instance of the “madness of crowds.” Millions of marijuana users have already arrived at this understanding. For a short period in the ’70s, it was possible to believe that this popular delusion was beginning to lose its deeply embedded grip. Whatever the cultu ...
... this epoch and recognize it as another instance of the “madness of crowds.” Millions of marijuana users have already arrived at this understanding. For a short period in the ’70s, it was possible to believe that this popular delusion was beginning to lose its deeply embedded grip. Whatever the cultu ...
Juillerat et al, (2013) Nanotest paper online early
... localization and cell effects of these nanovectors. The therapeutic efficacy and biological effects depend on the chemical components of these NPs, their solubility in a biological environment and their intra-cellular localization. Transport of NPs across biological barriers (cell membranes and cell ...
... localization and cell effects of these nanovectors. The therapeutic efficacy and biological effects depend on the chemical components of these NPs, their solubility in a biological environment and their intra-cellular localization. Transport of NPs across biological barriers (cell membranes and cell ...
Over the Counter Medications
... The U.S. Food and Drug Administration (called the FDA, for short) regulates over-the-counter medications. When they approve an OTC drug for sale to the general public, they believe that: • The medication’s benefits outweigh its risks. • The potential for misuse and abuse of the product is low. • Con ...
... The U.S. Food and Drug Administration (called the FDA, for short) regulates over-the-counter medications. When they approve an OTC drug for sale to the general public, they believe that: • The medication’s benefits outweigh its risks. • The potential for misuse and abuse of the product is low. • Con ...
A Mechanistic Approach to Understanding the Factors Affecting
... less than or equal to 250 ml. Permeability (Peff, expressed in units of 104 cm per second) is defined as the effective human jejunal wall permeability of a drug. High-permeability drugs are generally those with an extent of absorption greater than or equal to 90% and are not generally associated wit ...
... less than or equal to 250 ml. Permeability (Peff, expressed in units of 104 cm per second) is defined as the effective human jejunal wall permeability of a drug. High-permeability drugs are generally those with an extent of absorption greater than or equal to 90% and are not generally associated wit ...
Antibiotics - DENTISTRY 2012
... potential to cause acute nephritis, thus Methicillin is no longer available. - All oral penicillins are best given on an empty stomach to avoid the absorption delay. Exception amoxicillin. ...
... potential to cause acute nephritis, thus Methicillin is no longer available. - All oral penicillins are best given on an empty stomach to avoid the absorption delay. Exception amoxicillin. ...
October
... recall of Rugby Laboratories label enteric-coated aspirin tablets, 81 mg (Lot 13A026; expiration date: January 2015) due to a complaint that a bottle labeled with this product name actually contained acetaminophen 500 mg tablets. This over-the-counter (OTC) product is packaged in bottles of 120 tabl ...
... recall of Rugby Laboratories label enteric-coated aspirin tablets, 81 mg (Lot 13A026; expiration date: January 2015) due to a complaint that a bottle labeled with this product name actually contained acetaminophen 500 mg tablets. This over-the-counter (OTC) product is packaged in bottles of 120 tabl ...
OVERVIEW OF CHIRALITY AND CHIRAL DRUGS
... other hand, stereoisomers are compounds that have the same atoms connected in the same order but differ from each other in the way that the atoms are oriented in space. They include enantiomers and diastereomers, the latter indicating compounds that contain two or more chiral centers and are not sup ...
... other hand, stereoisomers are compounds that have the same atoms connected in the same order but differ from each other in the way that the atoms are oriented in space. They include enantiomers and diastereomers, the latter indicating compounds that contain two or more chiral centers and are not sup ...
The Řie-Tozer Model of Drug D
... where RE/I is the extravascular/intravascular ratio of binding proteins, and VP, VE, and VR refer to the volumes of plasma, extracellular fluid, and remainder fluid, respectively. Both these equations derive from assumptions that the drug molecules in the body are distributed into kinetic pools tha ...
... where RE/I is the extravascular/intravascular ratio of binding proteins, and VP, VE, and VR refer to the volumes of plasma, extracellular fluid, and remainder fluid, respectively. Both these equations derive from assumptions that the drug molecules in the body are distributed into kinetic pools tha ...
Experimental animal studies on analgesic and anti
... for management of various painful conditions. The results obtained by this study cannot be directly extrapolated to humans; further studies are required to establish the effect on pain perception in humans. ...
... for management of various painful conditions. The results obtained by this study cannot be directly extrapolated to humans; further studies are required to establish the effect on pain perception in humans. ...
ORIGINAL ARTICLE Morpho-anatomy of leaf, stem and root of
... are similar, 2 but the present investigation shows that leaves can be distinguished on the basis of size and stomata type. We found two types of stomata viz., anomocytic and diacytic in Alternanthera sessilis whereas only anomocytic type of stomata for Alternanthera sessilis was previously reported. ...
... are similar, 2 but the present investigation shows that leaves can be distinguished on the basis of size and stomata type. We found two types of stomata viz., anomocytic and diacytic in Alternanthera sessilis whereas only anomocytic type of stomata for Alternanthera sessilis was previously reported. ...
Pobierz plik
... PknB. In vitro anti-TB studies demonstrated that the good anti-TB activities of YH-8 had no cross-resistance with the first-line anti-tuberculosis drugs with the minimum inhibitory concentration (MIC) value of 0.125 µg/mL against M. tuberculosis including MDR-TB (24). The anti-TB activity of YH-8 is ...
... PknB. In vitro anti-TB studies demonstrated that the good anti-TB activities of YH-8 had no cross-resistance with the first-line anti-tuberculosis drugs with the minimum inhibitory concentration (MIC) value of 0.125 µg/mL against M. tuberculosis including MDR-TB (24). The anti-TB activity of YH-8 is ...
Use of Neurotransmitter Precursors for Treatment of Depression
... beneficial symptom-relieving effect of antidepressant drugs suggests late-developing factors may be more relevant to these drugs’ clinical efficacy than their acute effect (inhibiting re-uptake of neurotransmitters). Imipramine (a tricyclic antidepressant) can block neurotransmitter re-uptake in a m ...
... beneficial symptom-relieving effect of antidepressant drugs suggests late-developing factors may be more relevant to these drugs’ clinical efficacy than their acute effect (inhibiting re-uptake of neurotransmitters). Imipramine (a tricyclic antidepressant) can block neurotransmitter re-uptake in a m ...
Drug Development Pipeline
... proteins. Biologics can be composed of sugars, proteins, or nucleic acids or complex combinations of these substances, or may be living entities such as cells and tissues. Biologics are isolated from a variety of natural sources - human, animal, or microorganism - and may be produced by biotechnolog ...
... proteins. Biologics can be composed of sugars, proteins, or nucleic acids or complex combinations of these substances, or may be living entities such as cells and tissues. Biologics are isolated from a variety of natural sources - human, animal, or microorganism - and may be produced by biotechnolog ...
... this paper deals with issues not real important to my current purpose, there is one important point in this regard. The paper notes that Z-l 03 has a variety of antioxidant actions in vitro. Besides the potential contribution of these properties to anti-ulcer actions, most antioxidants tend to be re ...
Speaker`s Notes
... The label should also contain the names and amounts of all active drug ingredients. Medicated feed labels also contain the withdrawal period. The withdrawal period is the amount of time required for the medication to be metabolized, broken down or otherwise rendered inactive by the animal’s body. Me ...
... The label should also contain the names and amounts of all active drug ingredients. Medicated feed labels also contain the withdrawal period. The withdrawal period is the amount of time required for the medication to be metabolized, broken down or otherwise rendered inactive by the animal’s body. Me ...
Drug-induced acute pancreatitis
... 0.2% developed AP. Most patients had other potential etiological risk factors for AP, such as cholelithiasis or other concomitant medications associated with AP. There was no significant difference between the valproic acid- and placebo-treated groups in reference to elevated amylase levels. The aut ...
... 0.2% developed AP. Most patients had other potential etiological risk factors for AP, such as cholelithiasis or other concomitant medications associated with AP. There was no significant difference between the valproic acid- and placebo-treated groups in reference to elevated amylase levels. The aut ...
JB-D - Pharmaceutical Press
... lung toxicity occurred owing to the accidental release of methyl isocyanate) had a reduced lung function that made them more sensitive to otherwise mild infections. Alhough the accident occurred over 20 years ago, people may still die because of that tragic incident. Clearly, drugs can induce a broa ...
... lung toxicity occurred owing to the accidental release of methyl isocyanate) had a reduced lung function that made them more sensitive to otherwise mild infections. Alhough the accident occurred over 20 years ago, people may still die because of that tragic incident. Clearly, drugs can induce a broa ...
Pharmacognosy
Pharmacognosy is the study of medicinal drugs derived from plants or other natural sources. The American Society of Pharmacognosy defines pharmacognosy as ""the study of the physical, chemical, biochemical and biological properties of drugs, drug substances or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources.""It is also defined as the study of crude drugs.