Emerging technologies to achieve oral delivery of GLP-1 and GLP
... Oral administration is often the most desirable and attractive choice for drugs due to convenience and patient adherence, especially when the drug of interest must be administered repeatedly [12]. However, the oral route for drug administration, especially for peptide and protein drugs constitutes a ...
... Oral administration is often the most desirable and attractive choice for drugs due to convenience and patient adherence, especially when the drug of interest must be administered repeatedly [12]. However, the oral route for drug administration, especially for peptide and protein drugs constitutes a ...
clinical course and cellular pathology of tardive dyskinesia
... identification of cellular and circuit determinants of dyskinesias in mammalian brain. The clinical course of TD varies by psychiatric diagnosis, age, sex, and concomitant medical or neurologic illness. Data from a prospective study of 971 young adult psychiatric patients followed for up to 20 years ...
... identification of cellular and circuit determinants of dyskinesias in mammalian brain. The clinical course of TD varies by psychiatric diagnosis, age, sex, and concomitant medical or neurologic illness. Data from a prospective study of 971 young adult psychiatric patients followed for up to 20 years ...
Clinical pharmacology of anti-infectives and nonsteroidal_англ
... A. occurs primarily in patients under 30 years of age B. occurs with increased frequency in patients receiving concomitant ethambutol therapy C. *is probably due to the formation of a toxic hydrazine metabolite that binds to liver protein D. is frequently associated with allergic manifestations such ...
... A. occurs primarily in patients under 30 years of age B. occurs with increased frequency in patients receiving concomitant ethambutol therapy C. *is probably due to the formation of a toxic hydrazine metabolite that binds to liver protein D. is frequently associated with allergic manifestations such ...
The study of antiepileptic activity of clove oil by MES model in mice
... respective standards. MES model is the most validated experimental method for evaluation of antiepileptic drug effective in generalized tonic-clonic seizures. Anticonvulsant drugs like valproate and phenytoin act by modulation of ion channels. Hence valproate was chosen as the standard drug in this ...
... respective standards. MES model is the most validated experimental method for evaluation of antiepileptic drug effective in generalized tonic-clonic seizures. Anticonvulsant drugs like valproate and phenytoin act by modulation of ion channels. Hence valproate was chosen as the standard drug in this ...
abstracts
... Research, Development and Application Center (MAGUM). MAGUM, a subunit of Hacettepe University, was established in 1996 for the purpose of realization of the drug design, structure-activity relationships, synthesis, analysis and molecular quality control of synthetic and natural drugs and drug raw m ...
... Research, Development and Application Center (MAGUM). MAGUM, a subunit of Hacettepe University, was established in 1996 for the purpose of realization of the drug design, structure-activity relationships, synthesis, analysis and molecular quality control of synthetic and natural drugs and drug raw m ...
Adverse Event Reporting and IND Safety Reports
... an Adverse Event is “any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment. An adverse event (AE) can therefore be any unfavourable and unintended sign (includ ...
... an Adverse Event is “any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment. An adverse event (AE) can therefore be any unfavourable and unintended sign (includ ...
Gastrokinetic and Gastroprotective Activity of Gasex
... Present study was aimed to evaluate the gastrokinetic and gastroprotective effect of Gasex a polyherbal formulation in experimental models of phenol red test meal method for gastrokinetic activity and acid-induced gastrointestinal lesions for gastroprotective activity. Gasex at a dose of 500 and 100 ...
... Present study was aimed to evaluate the gastrokinetic and gastroprotective effect of Gasex a polyherbal formulation in experimental models of phenol red test meal method for gastrokinetic activity and acid-induced gastrointestinal lesions for gastroprotective activity. Gasex at a dose of 500 and 100 ...
Comparing Treatments for Age-Related Macular Degeneration
... • The higher rate of adverse events in Avastin groups, without a typical doseresponse relationship and in organ systems not targeted by the drug, remains unexplained. It may be that the difference was the result of chance, unobserved differences in the groups at baseline, or truly higher risk. Resu ...
... • The higher rate of adverse events in Avastin groups, without a typical doseresponse relationship and in organ systems not targeted by the drug, remains unexplained. It may be that the difference was the result of chance, unobserved differences in the groups at baseline, or truly higher risk. Resu ...
The MHS pharmacy benefit efficacy of civilian cost saving strategies
... pharmacies and the TMOP are purchased at prices negotiated by the Defense Supply Center in Philadelphia and the Department of Veterans Affairs directly with drug manufacturers. These negotiated prices do not apply to retail pharmacies and as such the prices at retail pharmacies can be two and even t ...
... pharmacies and the TMOP are purchased at prices negotiated by the Defense Supply Center in Philadelphia and the Department of Veterans Affairs directly with drug manufacturers. These negotiated prices do not apply to retail pharmacies and as such the prices at retail pharmacies can be two and even t ...
to our information package
... on neuropathic pain is thought to involve voltage-gated calcium ion channels. Clinical uses Gabapentin has also been used in the treatment of bipolar disorder. However, its off-label use for this purpose is increasingly controversial. Some claim gabapentin acts as a mood stabilizer and has the advan ...
... on neuropathic pain is thought to involve voltage-gated calcium ion channels. Clinical uses Gabapentin has also been used in the treatment of bipolar disorder. However, its off-label use for this purpose is increasingly controversial. Some claim gabapentin acts as a mood stabilizer and has the advan ...
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... the results of which will be reported separately. The relationship between SEP-225289 plasma concentration and the primary and selected secondary clinical outcome measures, and SEP-225289 plasma concentration and DHPG/NE concentrations using population PKJPD methods will be explored. ...
... the results of which will be reported separately. The relationship between SEP-225289 plasma concentration and the primary and selected secondary clinical outcome measures, and SEP-225289 plasma concentration and DHPG/NE concentrations using population PKJPD methods will be explored. ...
Antibiotics - SeattleCloud
... neuritis (reduced with 10 mg/day of Pyridoxine). Administration: take on an empty stomach. Used in pregnant women with TB. Concomitant administration of Pyridoxine is necessary. Contraindications: liver disease and hypersensitivity. ...
... neuritis (reduced with 10 mg/day of Pyridoxine). Administration: take on an empty stomach. Used in pregnant women with TB. Concomitant administration of Pyridoxine is necessary. Contraindications: liver disease and hypersensitivity. ...
Bio-diversity Issues..
... • Protecting biological diversity is in our self interest. • Biological resources are the pillars upon which we build civilization. • Nature’s product supports such diverse industries as agriculture, cosmetics, pharmaceuticals, pulp and paper, horticulture, construction and waste treatment. • The lo ...
... • Protecting biological diversity is in our self interest. • Biological resources are the pillars upon which we build civilization. • Nature’s product supports such diverse industries as agriculture, cosmetics, pharmaceuticals, pulp and paper, horticulture, construction and waste treatment. • The lo ...
abstract book - Marmara Üniversitesi
... be used as indispensable tools in biomedical research. Many local folk medıcınes contain natural products of plant origin, which remain a largely untapped reservoir of natural compounds with novel chemical structures and biological activities. One common objective of practicing research in the field ...
... be used as indispensable tools in biomedical research. Many local folk medıcınes contain natural products of plant origin, which remain a largely untapped reservoir of natural compounds with novel chemical structures and biological activities. One common objective of practicing research in the field ...
Macrolids
... Clarithromycin is metabolized in the liver. The major metabolite is 14-hydroxyclarithromycin, which also has antibacterial activity. A portion of active drug and this major metabolite is eliminated in the urine, and dosage reduction (eg, a 500-mg loading dose, then 250 mg once or twice daily) is rec ...
... Clarithromycin is metabolized in the liver. The major metabolite is 14-hydroxyclarithromycin, which also has antibacterial activity. A portion of active drug and this major metabolite is eliminated in the urine, and dosage reduction (eg, a 500-mg loading dose, then 250 mg once or twice daily) is rec ...
Master-Thesis
... studies in drug development, with a particular focus on the translational process from animals to humans and the potential obstacles which are necessary to be overcome. Translational research is the interface between preclinical research and clinical development and tries to turn potential innovativ ...
... studies in drug development, with a particular focus on the translational process from animals to humans and the potential obstacles which are necessary to be overcome. Translational research is the interface between preclinical research and clinical development and tries to turn potential innovativ ...
etd-tamu-2003A-2003032721-Vaug-1 - OAKTrust Home
... and hepatic portal system, thus increasing the bioavailability of orally administered drugs that otherwise undergo hepatic first-pass metabolism; improved patient compliance due to the elimination of pain associated with injections; administration of drugs in unconscious or incapacitated patients; c ...
... and hepatic portal system, thus increasing the bioavailability of orally administered drugs that otherwise undergo hepatic first-pass metabolism; improved patient compliance due to the elimination of pain associated with injections; administration of drugs in unconscious or incapacitated patients; c ...
Research Article WISTAR RATS
... motility and microcirculation all play a role in the development of inflammation and ulcers. Plants have been proved to be powerful therapeutic agents for the treatment of various lumen suffering, including atherosclerosis, cancer, ulcer etc. Due to the lack of side effects compared to synthetic dru ...
... motility and microcirculation all play a role in the development of inflammation and ulcers. Plants have been proved to be powerful therapeutic agents for the treatment of various lumen suffering, including atherosclerosis, cancer, ulcer etc. Due to the lack of side effects compared to synthetic dru ...
Product Monograph - AstraZeneca Canada
... isoenzymes. In vitro studies also demonstrated that the plasma protein binding of desciclesonide was not affected by warfarin or salicylic acid, indicating that protein bindingbased drug interactions are unlikely. The serum levels of ciclesonide and des-ciclesonide, its active metabolite M1, are ne ...
... isoenzymes. In vitro studies also demonstrated that the plasma protein binding of desciclesonide was not affected by warfarin or salicylic acid, indicating that protein bindingbased drug interactions are unlikely. The serum levels of ciclesonide and des-ciclesonide, its active metabolite M1, are ne ...
LESSON 4.4 WORKBOOK Can caffeine treat narcolepsy?
... those of us who consume caffeine regularly do not experience the same stimulating effects as nonusers, and why those of us who regularly use caffeine need more of the it to get the same effects. Withdrawal is what happens if we try to stop using a drug we’ve become dependent on. People who suddenly ...
... those of us who consume caffeine regularly do not experience the same stimulating effects as nonusers, and why those of us who regularly use caffeine need more of the it to get the same effects. Withdrawal is what happens if we try to stop using a drug we’ve become dependent on. People who suddenly ...
The pharmacokinetic profile of fesoterodine
... measured at the prestudy examinations; during each period before dosing; 3, 6, 10, 15, 24, and 36 h after drug administration, and at the poststudy examination (each measure was obtained after three min. rest in a supine position). 12-lead ECGs were recorded prestudy; during each period before dosin ...
... measured at the prestudy examinations; during each period before dosing; 3, 6, 10, 15, 24, and 36 h after drug administration, and at the poststudy examination (each measure was obtained after three min. rest in a supine position). 12-lead ECGs were recorded prestudy; during each period before dosin ...
Multi-Drug Resistant Salmonella - American Meat Science Association
... identical pattern of resistance when compared to the 1997 isolate. In the same study, it was observed that the IncFI plasmids from 3 of the 1970 s strains and the 1997 strain contained a conserved integron (In-t2); the 1997 isolate contained a second integron (In-t1) in the IncFI plasmid. Hence, the ...
... identical pattern of resistance when compared to the 1997 isolate. In the same study, it was observed that the IncFI plasmids from 3 of the 1970 s strains and the 1997 strain contained a conserved integron (In-t2); the 1997 isolate contained a second integron (In-t1) in the IncFI plasmid. Hence, the ...
On-site testing of saliva and sweat with Drugwipe and determination
... law enforcement agencies for roadside testing of potentially intoxicated drivers [14–16]. The presence of certain drugs of abuse or their metabolites in urine can be interpreted as evidence of relatively recent exposure, except for cannabis. However, this does not necessarily mean that the subject w ...
... law enforcement agencies for roadside testing of potentially intoxicated drivers [14–16]. The presence of certain drugs of abuse or their metabolites in urine can be interpreted as evidence of relatively recent exposure, except for cannabis. However, this does not necessarily mean that the subject w ...
Article - The Probation Service
... frequency of injecting, improvement in physical, psychological health, reduction in needle sharing, reduction in sexual risk-taking, reduction in criminal activity, improvement in relationships and improvement in home stability. The findings from this study showed that at the end of the first year c ...
... frequency of injecting, improvement in physical, psychological health, reduction in needle sharing, reduction in sexual risk-taking, reduction in criminal activity, improvement in relationships and improvement in home stability. The findings from this study showed that at the end of the first year c ...
2009 drug tr en dr eport drug tr en dr eport
... Selected neurological, seizure, and antipsychotic drugs were the primary drivers of Medicare utilization. Although utilization growth accelerated for lipid-lowering drugs (3.5%), it was offset by a significant reduction in unit costs (-7.5%) due to the increased use of generics. ...
... Selected neurological, seizure, and antipsychotic drugs were the primary drivers of Medicare utilization. Although utilization growth accelerated for lipid-lowering drugs (3.5%), it was offset by a significant reduction in unit costs (-7.5%) due to the increased use of generics. ...
Pharmacognosy
Pharmacognosy is the study of medicinal drugs derived from plants or other natural sources. The American Society of Pharmacognosy defines pharmacognosy as ""the study of the physical, chemical, biochemical and biological properties of drugs, drug substances or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources.""It is also defined as the study of crude drugs.