Epigenetic and genetic factors affect transgene
... These data imply that the process of transgene methylation imprinting involves both cw-acting elements, which reflect the methylation state of the transgene in the previous generation, and trans-acting factors, which are supplied by the maternal genome after fertilization. Our data also demonstrate ...
... These data imply that the process of transgene methylation imprinting involves both cw-acting elements, which reflect the methylation state of the transgene in the previous generation, and trans-acting factors, which are supplied by the maternal genome after fertilization. Our data also demonstrate ...
New techniques in plant biotechnology
... regulations (see note 2), a product should be recognised as a GMO if in its development process use is made of genetic modification. This would mean that offspring of a GMO should also be recognised as genetically modified, even when the gene concerned is no longer present in the genome of succeedin ...
... regulations (see note 2), a product should be recognised as a GMO if in its development process use is made of genetic modification. This would mean that offspring of a GMO should also be recognised as genetically modified, even when the gene concerned is no longer present in the genome of succeedin ...
Life: The Science of Biology, 10e
... Expression? 16.4 How Do Epigenetic Changes Regulate Gene Expression? 16.5 How Is Eukaryotic Gene Expression Regulated After Transcription? ...
... Expression? 16.4 How Do Epigenetic Changes Regulate Gene Expression? 16.5 How Is Eukaryotic Gene Expression Regulated After Transcription? ...
Relationship between expression and methylation of obesity
... has been utilised for transcriptomics in studies investigating a variety of topics including cancer (18,19), infectious disease (20) and immunology (21), but has yet to be employed in the assessment of expression changes associated with obesity in humans. The nCounter Analysis System has a variety o ...
... has been utilised for transcriptomics in studies investigating a variety of topics including cancer (18,19), infectious disease (20) and immunology (21), but has yet to be employed in the assessment of expression changes associated with obesity in humans. The nCounter Analysis System has a variety o ...
Biological Theories of Aging
... function (at least one SD below the mean) ―absence of any other signs of dementia ...
... function (at least one SD below the mean) ―absence of any other signs of dementia ...
A plant dialect of the histone language
... considerable research interest because it is associated with transcriptional regulation and methyl transferases contain well conserved domains among different organisms. In contrast to other modifications, no histone demethylases have thus far been identified, although theoretical studies recently p ...
... considerable research interest because it is associated with transcriptional regulation and methyl transferases contain well conserved domains among different organisms. In contrast to other modifications, no histone demethylases have thus far been identified, although theoretical studies recently p ...
Parental Methamphetamine Exposure Affects Offspring`s Behavior and
... phenotypes: multigenerational inheritance • Studies suggest the transmission of behavioral traits acquired by one generation to subsequent generations through epigenetic processes Exposure to a drug of abuse Phenotype A Phenotype B (methamphetamine) Multigenerational persistence Phenotype B ...
... phenotypes: multigenerational inheritance • Studies suggest the transmission of behavioral traits acquired by one generation to subsequent generations through epigenetic processes Exposure to a drug of abuse Phenotype A Phenotype B (methamphetamine) Multigenerational persistence Phenotype B ...
Original 2013 answers page as a complete
... endocrinology, 354, 3-8. http://www.ncbi.nlm.nih.gov/pubmed/22020198 Environmental epigenetics has an important role in regulating phenotype formation or disease etiology. The ability of environmental factors and exposures early in life to alter somatic cell epigenomes and subsequent development is ...
... endocrinology, 354, 3-8. http://www.ncbi.nlm.nih.gov/pubmed/22020198 Environmental epigenetics has an important role in regulating phenotype formation or disease etiology. The ability of environmental factors and exposures early in life to alter somatic cell epigenomes and subsequent development is ...
Comings et al. (1996)
... The D2 Receptor Gene in Gambling Both prevalence and frequency were higher in pathological gamblers than in controls. When the 102 pathological gamblers who had completed the gambling questionnaire were divided according to their gambling scores, those scoring in the upper half had higher prevalenc ...
... The D2 Receptor Gene in Gambling Both prevalence and frequency were higher in pathological gamblers than in controls. When the 102 pathological gamblers who had completed the gambling questionnaire were divided according to their gambling scores, those scoring in the upper half had higher prevalenc ...
Exclusion of the neuronal nicotinic acetylcholine receptor 7 subunit
... respectively. Genotyping led to the exclusion of CHRNA7 together with the duplication of exons 5–10 of this gene15 from the region of interest due to a recombination event between D15S144 and D15S1040 in one branch of the pedigree (Figure 2), narrowing further down the region to approximately 20.3 c ...
... respectively. Genotyping led to the exclusion of CHRNA7 together with the duplication of exons 5–10 of this gene15 from the region of interest due to a recombination event between D15S144 and D15S1040 in one branch of the pedigree (Figure 2), narrowing further down the region to approximately 20.3 c ...
When epigenetics meets alternative splicing: the roles of DNA
... exon 5 of the CD45 gene is methylation sensitive; exon 5 is included in the mRNA only when it is not methylated [16]. Since CTCF binds to a specific sequence in a small subset of exons, there must be other splicing regulatory proteins that are recruited by methyl binding proteins and deposited on th ...
... exon 5 of the CD45 gene is methylation sensitive; exon 5 is included in the mRNA only when it is not methylated [16]. Since CTCF binds to a specific sequence in a small subset of exons, there must be other splicing regulatory proteins that are recruited by methyl binding proteins and deposited on th ...
Histone H3 Lysine 9 Methylation Occurs Rapidly at the Onset
... Metaphase spreads were prepared from undifferentiated PGK12.1 XX ES cells and at various times after induction of differentiation. Efc-1 XY ES cells were used as a control. In undifferentiated XX ES cells there was staining of pericentromeric regions of the chromosomes (Figure 1A), consistent with a ...
... Metaphase spreads were prepared from undifferentiated PGK12.1 XX ES cells and at various times after induction of differentiation. Efc-1 XY ES cells were used as a control. In undifferentiated XX ES cells there was staining of pericentromeric regions of the chromosomes (Figure 1A), consistent with a ...
Gene Therapy, Genetics and Epigenetics in Child Neurology
... Blood, Brain, etc. It can be noted that one paper is in positive revision in Nature Medicine, two other papers in preparation to be submitted in top-ranked journals. In addition, the team has three patents. For team 2, if the analysis is restricted to the group working on the genetics and epigenetic ...
... Blood, Brain, etc. It can be noted that one paper is in positive revision in Nature Medicine, two other papers in preparation to be submitted in top-ranked journals. In addition, the team has three patents. For team 2, if the analysis is restricted to the group working on the genetics and epigenetic ...
Supplementary Material Legends
... within 5 kb adjacent to the target transgene insertion site and the non-silenced NPTII RNA levels (left panel, grey diamonds; Spearman rank order correlation coefficient -0.024, P=0.907; Pearson product moment correlation coefficient -0.048, P=0.816) or the relative NPTII levels in F1 plants in pres ...
... within 5 kb adjacent to the target transgene insertion site and the non-silenced NPTII RNA levels (left panel, grey diamonds; Spearman rank order correlation coefficient -0.024, P=0.907; Pearson product moment correlation coefficient -0.048, P=0.816) or the relative NPTII levels in F1 plants in pres ...
2nd IDARS Special Conference Report
... code for alcohol-metabolizing enzymes, and also for the effectors of neurotransmission – receptors, transporters and signal-transduction components – for a variety of transmitter classes, including dopamine, serotonin, glutamate, and GABA. Some genes are associated with general aspects of addiction. ...
... code for alcohol-metabolizing enzymes, and also for the effectors of neurotransmission – receptors, transporters and signal-transduction components – for a variety of transmitter classes, including dopamine, serotonin, glutamate, and GABA. Some genes are associated with general aspects of addiction. ...
Assessment of Fetal Growth and Development
... Pregnancy is a period of psychologic preparation for the profound demands of parenting. Women may experience ambivalence, particularly (but not exclusively) if the pregnancy was unplanned. If financial worries, physical illness, prior miscarriages or stillbirths, or other crises interfere with psych ...
... Pregnancy is a period of psychologic preparation for the profound demands of parenting. Women may experience ambivalence, particularly (but not exclusively) if the pregnancy was unplanned. If financial worries, physical illness, prior miscarriages or stillbirths, or other crises interfere with psych ...
Several recent reports have suggested a relationship between
... However, taken together, the research data and population studies suggesting that epigenetic changes with deleterious consequences could result from the application of ART techniques in the human must be taken seriously. Though we must be careful considering technological and etiological causes sepa ...
... However, taken together, the research data and population studies suggesting that epigenetic changes with deleterious consequences could result from the application of ART techniques in the human must be taken seriously. Though we must be careful considering technological and etiological causes sepa ...
Genome demethylation and imprinting in the endosperm
... Angiosperm seeds are composed of the seed coat, the mature embryo, and the endosperm. The endosperm, which serves as a conduit to store and transport nutrients to the embryo during initial phases of seed growth, is a major food source for most of the world. With one exception [1], all known plant g ...
... Angiosperm seeds are composed of the seed coat, the mature embryo, and the endosperm. The endosperm, which serves as a conduit to store and transport nutrients to the embryo during initial phases of seed growth, is a major food source for most of the world. With one exception [1], all known plant g ...
William’s syndrome: gene expression is related to ORIGINAL ARTICLE
... features. Previous work from this laboratory also used molecular cytogenetic, microsatellite and DNA sequencing analyses to characterize the structure and variation of the WS deletion in a cohort of 83 families. Testing of the hypothesis that differences in cognitive phenotypes would be in part rela ...
... features. Previous work from this laboratory also used molecular cytogenetic, microsatellite and DNA sequencing analyses to characterize the structure and variation of the WS deletion in a cohort of 83 families. Testing of the hypothesis that differences in cognitive phenotypes would be in part rela ...
The Inheritance of Phenotypes: an Adaptation to
... are known: in the chromatin marking system chromatin marks such as DNA methylation patterns, or patterns of proteins associated with DNA are carried and transmitted on the chromosomes through cell divisions; in a steady-state system inheritance is based on the self-perpetuating properties of reactio ...
... are known: in the chromatin marking system chromatin marks such as DNA methylation patterns, or patterns of proteins associated with DNA are carried and transmitted on the chromosomes through cell divisions; in a steady-state system inheritance is based on the self-perpetuating properties of reactio ...
209 Original Scientific Article THE INFLUENCE OF
... ooplasm (iSCNTp) only the primers for bovine DNMTs (bDNMT1, bDNMT3a) showed positive signals (Fig. 2A; Fig. 2B). Considering the different timing of EGA during the embryonic development in bovine and porcine embryos, the intense effect of ooplasm on transferred fibroblast was expected. Despite the m ...
... ooplasm (iSCNTp) only the primers for bovine DNMTs (bDNMT1, bDNMT3a) showed positive signals (Fig. 2A; Fig. 2B). Considering the different timing of EGA during the embryonic development in bovine and porcine embryos, the intense effect of ooplasm on transferred fibroblast was expected. Despite the m ...
non-Mendelian inheritance
... Maternal effect genes encode RNA or proteins that play important roles in the early steps of embryogenesis ...
... Maternal effect genes encode RNA or proteins that play important roles in the early steps of embryogenesis ...
2016 Poster Abstracts - Molecular Psychiatry Association
... Deletions in the 16.5kb mitochondrial genome have been implicated in a number of mitochondrial disorders, many of which are phenotypically complex but often display overlapping symptoms associated with muscle and/or neurological dysfunction due to the high energy demands of these tissues. While ther ...
... Deletions in the 16.5kb mitochondrial genome have been implicated in a number of mitochondrial disorders, many of which are phenotypically complex but often display overlapping symptoms associated with muscle and/or neurological dysfunction due to the high energy demands of these tissues. While ther ...
Trans-HHS Workshop: Diet, DNA Methylation
... is considered a key enzyme in the one-carbon metabolism because it catalyzes the irreversible conversion of 5,10-methylenetetrahydrofolate to methyl-THF (31). In 1988 Kang and colleagues identified a variant of the MTHFR that causes enzyme thermolability and reduced activity (32). The mutant enzyme ...
... is considered a key enzyme in the one-carbon metabolism because it catalyzes the irreversible conversion of 5,10-methylenetetrahydrofolate to methyl-THF (31). In 1988 Kang and colleagues identified a variant of the MTHFR that causes enzyme thermolability and reduced activity (32). The mutant enzyme ...
In vitro fertilization (IVF) in mammals: epigenetic and developmental
... He named this process Epigenetics, which is now understood as the conditions that control the expression of genes that are highly influenced by environment. A more precise definition is: “The study of changes in gene function that are mitotically and/or meiotically heritable and that do not entail a ...
... He named this process Epigenetics, which is now understood as the conditions that control the expression of genes that are highly influenced by environment. A more precise definition is: “The study of changes in gene function that are mitotically and/or meiotically heritable and that do not entail a ...
Behavioral epigenetics
Behavioral epigenetics is the field of study examining the role of epigenetics in shaping animal (including human) behaviour. It is an experimental science that seeks to explain how nurture shapes nature, where nature refers to biological heredity and nurture refers to virtually everything that occurs during the life-span (e.g., social-experience, diet and nutrition, and exposure to toxins). Behavioral epigenetics attempts to provide a framework for understanding how the expression of genes is influenced by experiences and the environment to produce individual differences in behaviour, cognition personality, and mental health.Epigenetic gene regulation involves changes other than to the sequence of DNA and includes changes to histones (proteins around which DNA is wrapped) and DNA methylation. These epigenetic changes can influence the growth of neurons in the developing brain as well as modify activity of the neurons in the adult brain. Together, these epigenetic changes on neuron structure and function can have a marked influence on an organism's behavior.