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Transcription part (10/2/2015)
Transcription part (10/2/2015)

... 11. Splicing of exons in pre-mRNA is done by Spliceosome. How does spliceosome recognize introns in pre-mRNA? What is the role of U1 and U2 particles in this process? Which end of intron is easier to recognize? Why do we have introns in our genomes? 12. How is the branching A in intron defined durin ...
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... found 4.624 genes, which showed differences in gene expression and 19.261 different DNA methylation sites. Between closer related cells like naive and activated/memory cells of the same lymphocyte subtype (CD4+ T-cells) the number decrease to 638 genes and 9.412 sites. Comparing monocytes against T- ...
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Document

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Epigenetics of depression

Depression is a serious behavioral disorder causing long lasting feelings of sadness and loss of interest. One form of depression is Major Depressive Disorder (MDD), in which symptoms of depression are present most days a week for 2 weeks or longer. Depression affects a large aspect of day-to-day activities such as thought process, sleep, and appetite. It can be accompanied by anxiety and decreased energy. According to the World Health Organization, depression affects about 350 million people worldwide and is the major cause of disability. Depression can be caused by the interaction of environmental and genetic factors. These factors include epigenetic modification of the genome in which there is a persistent change in gene expression without a change in the actual DNA sequence.
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