Epigenetics and Inheritance
... polymorphisms in the DNMT1 gene which have been associated with an increased risk of cancer, especially of the breast and stomach. In addition, overexpression of the DNMT1 gene has been identified in certain brain cancers called gliomas. (12, 13) 2) Human DNMT2, called DNA (cytosine-5)-methyltransfe ...
... polymorphisms in the DNMT1 gene which have been associated with an increased risk of cancer, especially of the breast and stomach. In addition, overexpression of the DNMT1 gene has been identified in certain brain cancers called gliomas. (12, 13) 2) Human DNMT2, called DNA (cytosine-5)-methyltransfe ...
Clustering Time-Series Gene Expression Data Using Smoothing
... 44 mice were subjected to 11 different fasting periods ranging from 0 to 72 hours. At each time points(0, 3, 6, 9, 12, 18, 24, 36, 48, 60, 70), 4 mice were euthanized and their livers were used for RNA extraction. The experiment was measured with a decreasing ...
... 44 mice were subjected to 11 different fasting periods ranging from 0 to 72 hours. At each time points(0, 3, 6, 9, 12, 18, 24, 36, 48, 60, 70), 4 mice were euthanized and their livers were used for RNA extraction. The experiment was measured with a decreasing ...
Chapter 15 – psychological disorders
... Mood Disorders • Predisposition depends on a variety of genes. • One identified gene leads to an 80% decrease in the brain’s ability to produce serotonin. – Most depressed people do not have this gene. – Those who have the gene have a higher predisposition. ...
... Mood Disorders • Predisposition depends on a variety of genes. • One identified gene leads to an 80% decrease in the brain’s ability to produce serotonin. – Most depressed people do not have this gene. – Those who have the gene have a higher predisposition. ...
Computational Biology
... Typically, unmethylated clusters of CpG pairs are located in tissue-specific genes and in essential housekeeping genes. (House-keeping genes are involved in routine maintenance roles and are expressed in most tissues.) ...
... Typically, unmethylated clusters of CpG pairs are located in tissue-specific genes and in essential housekeeping genes. (House-keeping genes are involved in routine maintenance roles and are expressed in most tissues.) ...
GENE REGULATION IN PROKARYOTES AND EUKARYOTES
... mRNA must be exported from the nucleus before it can be translated. This means that other factors being equal, protein synthesis in a prokaryote can be faster than in a eukaryote. It also means that the primary mRNA transcript can be processed before it is exported from the nucleus, with translation ...
... mRNA must be exported from the nucleus before it can be translated. This means that other factors being equal, protein synthesis in a prokaryote can be faster than in a eukaryote. It also means that the primary mRNA transcript can be processed before it is exported from the nucleus, with translation ...
Document
... Interferon gamma (IFNγ), a cytokine involved in multiple aspects of iron metabolism and the immune response , has been shown to increase frataxin levels in both cell and animal models of FRDA It has been reported that in vivo treatment of YG8R mice with IFNγ enhances both locomotor activity and moto ...
... Interferon gamma (IFNγ), a cytokine involved in multiple aspects of iron metabolism and the immune response , has been shown to increase frataxin levels in both cell and animal models of FRDA It has been reported that in vivo treatment of YG8R mice with IFNγ enhances both locomotor activity and moto ...
Document
... - Lower expression of MeCP2 in females results in reduced gene silencing. Theory 1 for female bias: Males are hemizygous for X chromosome gene expression, and a mutation of MeCP2 will lead to a loss or partial inactivation of the MeCP2 function. The severe phenotype in males results in early lethali ...
... - Lower expression of MeCP2 in females results in reduced gene silencing. Theory 1 for female bias: Males are hemizygous for X chromosome gene expression, and a mutation of MeCP2 will lead to a loss or partial inactivation of the MeCP2 function. The severe phenotype in males results in early lethali ...
Running Head: ADOLESCENT DPD - Psychology
... differentiates DPD from dysthymia is a lack of depressed mood in DPD individuals. The Millon Adolescent Clinical Inventory (MACI, Millon, 1993) was developed to assess Axis I and II disorders in adolescents using Millon’s theoretical model of personality and psychopatholgy. The MACI Doleful (2B) sca ...
... differentiates DPD from dysthymia is a lack of depressed mood in DPD individuals. The Millon Adolescent Clinical Inventory (MACI, Millon, 1993) was developed to assess Axis I and II disorders in adolescents using Millon’s theoretical model of personality and psychopatholgy. The MACI Doleful (2B) sca ...
Day and Sweatt
... campal synaptic plasticity and hippocampal neuron function13,16,18. Although the hippocampus is critical for memory consolidation, it is not essential for long-term memory storage. Thus, the observations of plasticity of DNA methylation in the hippocampus are consistent with the behavioral and syste ...
... campal synaptic plasticity and hippocampal neuron function13,16,18. Although the hippocampus is critical for memory consolidation, it is not essential for long-term memory storage. Thus, the observations of plasticity of DNA methylation in the hippocampus are consistent with the behavioral and syste ...
view
... • As a result, common alleles will typically be old and will have only short-range LD. • Rare alleles may be either young or old and thus may have long- or short range LD • Positive selection causes an unusually rapid rise in allele frequency, occurring over a short enough time that recombination do ...
... • As a result, common alleles will typically be old and will have only short-range LD. • Rare alleles may be either young or old and thus may have long- or short range LD • Positive selection causes an unusually rapid rise in allele frequency, occurring over a short enough time that recombination do ...
Postpartum Depression and Perinatal Mood Disorders in the DSM
... (Vice-Chair), and a task force comprised of 13 work-groups: each comprised of a chair and work group members who were key experts in psychiatric treatment, research and epidemiology. (See following url for more information on the committee: http://www.dsm5.org/Pages/Default.aspx ) The DSM, which has ...
... (Vice-Chair), and a task force comprised of 13 work-groups: each comprised of a chair and work group members who were key experts in psychiatric treatment, research and epidemiology. (See following url for more information on the committee: http://www.dsm5.org/Pages/Default.aspx ) The DSM, which has ...
Results
... domain-containing proteins from C. lavandulifolium, Arabidopsis and Oryza sativa. Amino acid sequences were aligned using ClustalW and a neighbor-joining tree was constructed with a 1000-bootstrap replication support. The subfamilies within the NAC family, as designated by Ooka et al. [8] were group ...
... domain-containing proteins from C. lavandulifolium, Arabidopsis and Oryza sativa. Amino acid sequences were aligned using ClustalW and a neighbor-joining tree was constructed with a 1000-bootstrap replication support. The subfamilies within the NAC family, as designated by Ooka et al. [8] were group ...
Relationship between expression and methylation of obesity
... POMC, PCSK1 and MC4R can lead to obesity, these variants are rare and therefore explain only a fraction of obesity’s observed 40–70% heritability (8,10). It is possible that a portion of this unexplained heritability, an example of the ‘missing heritability problem’ (11), is due to epigenetic change ...
... POMC, PCSK1 and MC4R can lead to obesity, these variants are rare and therefore explain only a fraction of obesity’s observed 40–70% heritability (8,10). It is possible that a portion of this unexplained heritability, an example of the ‘missing heritability problem’ (11), is due to epigenetic change ...
single nucleotide polymorphisms and suicidal behaviour
... enzyme activity, thus reducing the effect of COMT genotype in women relative to men (Dickinson & Elvevag 2009). ...
... enzyme activity, thus reducing the effect of COMT genotype in women relative to men (Dickinson & Elvevag 2009). ...
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... Rett syndrome, an X-linked progressive neurodevelopmental disorder associated with mental retardation, is believed to result from loss of methyl CpG binding protein-2 (MeCP2) in neurons [28, 29]. In a typical case, MeCP2 expression increases as neurons differentiate prior to synaptogenesis. MeCP2 ha ...
... Rett syndrome, an X-linked progressive neurodevelopmental disorder associated with mental retardation, is believed to result from loss of methyl CpG binding protein-2 (MeCP2) in neurons [28, 29]. In a typical case, MeCP2 expression increases as neurons differentiate prior to synaptogenesis. MeCP2 ha ...
Postpartum Depression
... Are the prevalence and incidence of PPD different across racial and ethnic lines? What is the mechanism of disease? Are the rates of perinatal depression greater than the general population? Effectiveness and cost effectiveness of screening? Timing of screening and disease occurrence? ...
... Are the prevalence and incidence of PPD different across racial and ethnic lines? What is the mechanism of disease? Are the rates of perinatal depression greater than the general population? Effectiveness and cost effectiveness of screening? Timing of screening and disease occurrence? ...
Transgenerational Epigenetic Inheritance in Plants - 文献云下载
... In eukaryotic DNA, 5-methylcytosine is prevailing, comprising up to 4 and 30 % of total cytosine residues in mammals and plants, respectively (Kappler 1971; Finnegan et al. 1998). The location of 5-methylcytosine also differs between mammalian and plant DNAs, being found only in CpG in the former, b ...
... In eukaryotic DNA, 5-methylcytosine is prevailing, comprising up to 4 and 30 % of total cytosine residues in mammals and plants, respectively (Kappler 1971; Finnegan et al. 1998). The location of 5-methylcytosine also differs between mammalian and plant DNAs, being found only in CpG in the former, b ...
Gene silencing in mammalian cells and the spread of DNA
... outcome for each translocated allele. DNA methylation occurs at extremely low levels in the fly (Gowher et al., 2000; Lyko et al., 2000) and thus is unlikely to be involved in gene repression. This suggests that allelic battles for expression can occur in the absence of DNA methylation, and by exten ...
... outcome for each translocated allele. DNA methylation occurs at extremely low levels in the fly (Gowher et al., 2000; Lyko et al., 2000) and thus is unlikely to be involved in gene repression. This suggests that allelic battles for expression can occur in the absence of DNA methylation, and by exten ...
Cognitvie Psychology
... transporter gene is “switched on” by attentive mothering so, a vulnerable pup with two short copies of the promoter for the serotonin transporter gene is cured by its mother’s licking (short gene works better) this environmental effect is passed along to the pup’s ...
... transporter gene is “switched on” by attentive mothering so, a vulnerable pup with two short copies of the promoter for the serotonin transporter gene is cured by its mother’s licking (short gene works better) this environmental effect is passed along to the pup’s ...
Analyzing Expression Data: Clustering and Stats
... • In order to cluster the points (genes or conditions), we need some concept of which points are “close” to each other. • So we need a measure of distance (or, conversely,) similarity between two rows (or columns) in our n by m matrix. • We can then compute all the pair-wise distances between rows ( ...
... • In order to cluster the points (genes or conditions), we need some concept of which points are “close” to each other. • So we need a measure of distance (or, conversely,) similarity between two rows (or columns) in our n by m matrix. • We can then compute all the pair-wise distances between rows ( ...
Supplementary Information (doc 7548K)
... Supplementary Figure 7 | Transcription factor binding site enrichment by community. Sets of genes from within the positively correlated GATA2 network that were identified as belonging to sub-networks (using the algorithm of (Blondel et al., 2008)) were generated. Ref_seq identifiers for these gene ...
... Supplementary Figure 7 | Transcription factor binding site enrichment by community. Sets of genes from within the positively correlated GATA2 network that were identified as belonging to sub-networks (using the algorithm of (Blondel et al., 2008)) were generated. Ref_seq identifiers for these gene ...