Physical Models for Protein Folding and Drug Design
... acids, but also to design a novel class of drugs which interfere with the folding mechanism and whose inhibitor effect cannot be neutralized through mutations, as it is the case with standard drugs acting, as a rule, on the active site of enzymes. ...
... acids, but also to design a novel class of drugs which interfere with the folding mechanism and whose inhibitor effect cannot be neutralized through mutations, as it is the case with standard drugs acting, as a rule, on the active site of enzymes. ...
Cellular Respiration
... The electron transport chain is in the cristae of the mitochondrion Most of the chain’s components are proteins, which exist in multi-protein complexes The carriers alternate reduced and oxidized states as they accept and donate electrons Electrons drop in free energy as they go down the chain and a ...
... The electron transport chain is in the cristae of the mitochondrion Most of the chain’s components are proteins, which exist in multi-protein complexes The carriers alternate reduced and oxidized states as they accept and donate electrons Electrons drop in free energy as they go down the chain and a ...
Naming Covalently Bonded Molecules
... Covalent bond – chemical bond that occurs when valence electrons are shared, not transferred Molecule – product of a covalent bond Usually occurs between nonmetals and elements that are close to each other on the periodic table ...
... Covalent bond – chemical bond that occurs when valence electrons are shared, not transferred Molecule – product of a covalent bond Usually occurs between nonmetals and elements that are close to each other on the periodic table ...
Proton n.m.r, spectroscopic evidence for sulfur
... of the "bioactive confirmation" ofOT and this could be the reason for the higher in vitro biological activity of analogs containing sulfur in position 6 (dearnino-carba-l-O'I') compared to analogs with sulfur in position 1 (deaminocarba-6-0T)(36, 37). The ill vivo biological activity of oxytocin car ...
... of the "bioactive confirmation" ofOT and this could be the reason for the higher in vitro biological activity of analogs containing sulfur in position 6 (dearnino-carba-l-O'I') compared to analogs with sulfur in position 1 (deaminocarba-6-0T)(36, 37). The ill vivo biological activity of oxytocin car ...
Dual Luminescence and Long-Lived Charge
... and A. Such triads, composed of tetrathiafulvalene, porphyrins and fullerenes have been successfully used in the creation of artificial photosynthetic systems.[6] Tertrathiafulvalene derivatives, on the one hand, constitute a class of versatile electron donors for a number of interesting application ...
... and A. Such triads, composed of tetrathiafulvalene, porphyrins and fullerenes have been successfully used in the creation of artificial photosynthetic systems.[6] Tertrathiafulvalene derivatives, on the one hand, constitute a class of versatile electron donors for a number of interesting application ...
Volatile Secretions in Three Species of Dufourea
... to eicosanol, respectively. The esters are found in all three species; not all of them , however, are present in all species. Esters constitute one of the most com mon group of natural products. In insects they occur frequently either as volatile signals or as wax con stituents, covering a wide ra ...
... to eicosanol, respectively. The esters are found in all three species; not all of them , however, are present in all species. Esters constitute one of the most com mon group of natural products. In insects they occur frequently either as volatile signals or as wax con stituents, covering a wide ra ...
AMINO ACIDS METABOLISM ** Dr. Mohammed Abdullateef **
... Bi peptides are hydrolysed by the mucosal cells and only free amino acids enter the portal circulation. Amino acids are actively taken up by all cells and use 7 types of ATP dependent Active pumps to do that. Cystinuria is a disease where cysteine is excreted in urine as its uptake mechanism i ...
... Bi peptides are hydrolysed by the mucosal cells and only free amino acids enter the portal circulation. Amino acids are actively taken up by all cells and use 7 types of ATP dependent Active pumps to do that. Cystinuria is a disease where cysteine is excreted in urine as its uptake mechanism i ...
Increasing the thermostability of sucrose
... cluster of three aspartate residues at positions 445– 447 was found to be the most flexible region. This cluster is located in a loop segment of the C-terminal domain, far away from both the active site and dimer interface. The top 10 positions were then examined in the 3DM-database (Kuipers et al., ...
... cluster of three aspartate residues at positions 445– 447 was found to be the most flexible region. This cluster is located in a loop segment of the C-terminal domain, far away from both the active site and dimer interface. The top 10 positions were then examined in the 3DM-database (Kuipers et al., ...
PBI 6 Features on Teacher`s Map 2-08.qxp
... The Translation Start Site (AUG) is located at nucleotides 62,187- 62,189. All proteins begin with the amino acid methionine, Met, encoded by nucleotides AUG. This rule is a consequence of the mechanism that cells use to begin protein synthesis; a special Met-tRNA initiates assembly of the two subun ...
... The Translation Start Site (AUG) is located at nucleotides 62,187- 62,189. All proteins begin with the amino acid methionine, Met, encoded by nucleotides AUG. This rule is a consequence of the mechanism that cells use to begin protein synthesis; a special Met-tRNA initiates assembly of the two subun ...
No Slide Title
... C Cys Cysteine Cysteine is a small till intermediately large hydrophobic residue. It doesn’t like the alpha helix, but doesn’t mind strand and turn. It can form Cys-Cys bridges with other cysteines. It can bind metals (especially Zn and Cu). The S-H group is very reactive. ...
... C Cys Cysteine Cysteine is a small till intermediately large hydrophobic residue. It doesn’t like the alpha helix, but doesn’t mind strand and turn. It can form Cys-Cys bridges with other cysteines. It can bind metals (especially Zn and Cu). The S-H group is very reactive. ...
Regioselectivity and Activity of Cytochrome P450 BM-3 and
... proton transfer to the active site for formation of the reactive intermediate(s), two processes which are likely to coincide with conformational fluctuations that affect regioselectivity. Peroxygenase reactions were initiated by addition of 10 mM H2O2 and were extremely slow relative to hydroxylatio ...
... proton transfer to the active site for formation of the reactive intermediate(s), two processes which are likely to coincide with conformational fluctuations that affect regioselectivity. Peroxygenase reactions were initiated by addition of 10 mM H2O2 and were extremely slow relative to hydroxylatio ...
Fall 2013 Final practice questions w/o solution
... 17. How many atoms of nitrogen are in 20.85 g Ba(NO3)2 ? The molar mass of Ba(NO3)2 is 261.337 g/mol. A) 8.84 x 1024 atoms B) 4.80 x 1022 atoms C) 9.60 x 1022 atoms D) 1.92 x 1023 atoms E) 8.13 x 1026 atoms 18. What is the solid produced when Li3PO4 reacts with calcium nitrate? A) LiNO3 B) Ca3(PO4) ...
... 17. How many atoms of nitrogen are in 20.85 g Ba(NO3)2 ? The molar mass of Ba(NO3)2 is 261.337 g/mol. A) 8.84 x 1024 atoms B) 4.80 x 1022 atoms C) 9.60 x 1022 atoms D) 1.92 x 1023 atoms E) 8.13 x 1026 atoms 18. What is the solid produced when Li3PO4 reacts with calcium nitrate? A) LiNO3 B) Ca3(PO4) ...
heme
... ● globin → AAs → metabolism ● heme → bilirubin 2+ → transport with transferrin and used in the next ● Fe heme biosynthesis ...
... ● globin → AAs → metabolism ● heme → bilirubin 2+ → transport with transferrin and used in the next ● Fe heme biosynthesis ...
Protein prediction methods – steps of analysis
... helices, β-sheets and coils. It is determined by the amino acid side chains. The α helices typically are formed from contiguous stretches of 4-10 amino acids residues in length. The β sheets are formed from adjacent β strands composed of 5-10 residues. They are arranged in parallel or antiparallel o ...
... helices, β-sheets and coils. It is determined by the amino acid side chains. The α helices typically are formed from contiguous stretches of 4-10 amino acids residues in length. The β sheets are formed from adjacent β strands composed of 5-10 residues. They are arranged in parallel or antiparallel o ...
Chemistry in Everyday Life
... Non-competitive inhibitor inhibits the catalyic activity of enzyme by binding with its active site. ...
... Non-competitive inhibitor inhibits the catalyic activity of enzyme by binding with its active site. ...
Pharmacophore screening of the Protein Data Bank for specific
... required residue types, but also the relative geometry. The number of unique sites selected using various radius (Qm/n) and direction (Qv) b-factors is shown in Fig. 3 (results from the individual pharmacophore queries were merged and redundant hits were clustered). Ultimately, the objective is not ...
... required residue types, but also the relative geometry. The number of unique sites selected using various radius (Qm/n) and direction (Qv) b-factors is shown in Fig. 3 (results from the individual pharmacophore queries were merged and redundant hits were clustered). Ultimately, the objective is not ...
Ch 8 Cellular Respiration
... • break C-C bonds • strip off electrons from C-H bonds by removing H atoms – C6H12O6 CO2 = the fuel has been oxidized • electrons attracted to more electronegative atoms – in biology, the most electronegative atom? – O2 H2O = oxygen has been reduced ...
... • break C-C bonds • strip off electrons from C-H bonds by removing H atoms – C6H12O6 CO2 = the fuel has been oxidized • electrons attracted to more electronegative atoms – in biology, the most electronegative atom? – O2 H2O = oxygen has been reduced ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008.
... change may be a result of changes in the activity of enzymes. The activity of plant polyphenoloxidases can cause enzymatic browning of fruits and vegetables and render food unfit for consumption due to formation of benzoquinone. Proteases degrade polypeptides and facilitate seed germination, leaf se ...
... change may be a result of changes in the activity of enzymes. The activity of plant polyphenoloxidases can cause enzymatic browning of fruits and vegetables and render food unfit for consumption due to formation of benzoquinone. Proteases degrade polypeptides and facilitate seed germination, leaf se ...
Enzymes - HKEdCity
... Properties of enzyme : 1. It speeds up chemical reactions but remain undestroyed at the end of the reaction. i.e. it has the catalytic properties. 2. It works in either direction. i.e. it catalyses the forward and backward reaction to the same extent. The direction in which the reaction goes depends ...
... Properties of enzyme : 1. It speeds up chemical reactions but remain undestroyed at the end of the reaction. i.e. it has the catalytic properties. 2. It works in either direction. i.e. it catalyses the forward and backward reaction to the same extent. The direction in which the reaction goes depends ...
Protein Synthesis I
... PROTEIN SYNTHESIS [S1]: a. This process is called translation, which is sometimes compared and contrasted to transcription i. Transcription is when DNA is used to make an RNA molecule ii. In transcription, there is no new element involved except for the change in oxygen (deoxy vs oxygenated molecule ...
... PROTEIN SYNTHESIS [S1]: a. This process is called translation, which is sometimes compared and contrasted to transcription i. Transcription is when DNA is used to make an RNA molecule ii. In transcription, there is no new element involved except for the change in oxygen (deoxy vs oxygenated molecule ...
Ni recovery using KOH, NaOH, and NH4OH in the presence of
... During production of the platinum group metals (PGMs) in South Africa, base metals are leached first. A significant amount of iron is also co-leached, which in turn is removed by precipitation as ammonium jarosite. Substantial amounts of nickel have been found entrained in this precipitate, which is ...
... During production of the platinum group metals (PGMs) in South Africa, base metals are leached first. A significant amount of iron is also co-leached, which in turn is removed by precipitation as ammonium jarosite. Substantial amounts of nickel have been found entrained in this precipitate, which is ...
Metalloprotein
Metalloprotein is a generic term for a protein that contains a metal ion cofactor. A large number of all proteins are part of this category.