Document
... Cancer cells produce most of their ATP by glycolysis (Warburg effect) Why do proliferating cells switch to a less efficient ...
... Cancer cells produce most of their ATP by glycolysis (Warburg effect) Why do proliferating cells switch to a less efficient ...
Chemical formulae and chemical equations
... Objective 1: Constructing chemical equations, with state symbols, including ionic equations • An equation can be written in words – a word equation. sodium + chlorine sodium chloride • An equation can also be written with symbols and formulae instead of words – a chemical equation. 2Na + Cl2 2N ...
... Objective 1: Constructing chemical equations, with state symbols, including ionic equations • An equation can be written in words – a word equation. sodium + chlorine sodium chloride • An equation can also be written with symbols and formulae instead of words – a chemical equation. 2Na + Cl2 2N ...
21_Pentose phosphate pathway of carbohydrates metabolism
... action of the tripeptide glutathione (GSH) (maintains it in the reduced state). GSH in erythrocytes maintains hemoglobin in the reduced Fe(II) state necessary for oxygen binding. GSH also functions to eliminate H2O2 and organic peroxides. Peroxides can cause irreversible damage to hemoglobin and des ...
... action of the tripeptide glutathione (GSH) (maintains it in the reduced state). GSH in erythrocytes maintains hemoglobin in the reduced Fe(II) state necessary for oxygen binding. GSH also functions to eliminate H2O2 and organic peroxides. Peroxides can cause irreversible damage to hemoglobin and des ...
Enzymes
... Some enzymes require coenzymes • Some enzymes require a coenzyme (another compound) to be bound to them before they can catalyze reactions. • Coenzymes are non-protein organic compounds. • Eg. of coenzymes: Vitamin B complex ...
... Some enzymes require coenzymes • Some enzymes require a coenzyme (another compound) to be bound to them before they can catalyze reactions. • Coenzymes are non-protein organic compounds. • Eg. of coenzymes: Vitamin B complex ...
Goat Milk - Mt. Capra
... our past—our very distant past. This legendary patriarch is Hippocrates, the father of Western Medicine who lived over 2400 years ago. Now, when a man has been deemed the “father” of an entire Joe Stout hemisphere, it would be wise to listen to what he has to say. Here are the words of Hippocrates: ...
... our past—our very distant past. This legendary patriarch is Hippocrates, the father of Western Medicine who lived over 2400 years ago. Now, when a man has been deemed the “father” of an entire Joe Stout hemisphere, it would be wise to listen to what he has to say. Here are the words of Hippocrates: ...
Evolution of the citric acid cycle and respiratory
... organisms as an "electron sink" device and the reduction of fumarate, which involves participation of cytochrome b, is frequently associated with phosphorylation of A D P [1,3]. (iii) In prokaryotes capable of obtaining energy from the aerobic CAC or some alternative anaerobic process, mutants no lo ...
... organisms as an "electron sink" device and the reduction of fumarate, which involves participation of cytochrome b, is frequently associated with phosphorylation of A D P [1,3]. (iii) In prokaryotes capable of obtaining energy from the aerobic CAC or some alternative anaerobic process, mutants no lo ...
Hydrogen Ion Buffers and Enzymatic Activity: Myosin B
... Received May 6, 1968; accepted July 4, 1968 The production of hydrogen ions during the hydrolysis of ATP by myosin B and the consequent fall in pH can produce alterations in enzymatic activity directly, or by influencing Ca ion concentrations controlled by metal-chelate systems. Adequate hydrogen io ...
... Received May 6, 1968; accepted July 4, 1968 The production of hydrogen ions during the hydrolysis of ATP by myosin B and the consequent fall in pH can produce alterations in enzymatic activity directly, or by influencing Ca ion concentrations controlled by metal-chelate systems. Adequate hydrogen io ...
Liver Physiology - e-safe
... and anabolism. It removes amino acids from blood for gluco-neogenesis and protein synthesis. It also releases amino acids into the blood for utilisation by peripheral tissues and plays a major role in breakdown of amino acids, removing nitrogen in the form of urea. The liver synthesizes many importa ...
... and anabolism. It removes amino acids from blood for gluco-neogenesis and protein synthesis. It also releases amino acids into the blood for utilisation by peripheral tissues and plays a major role in breakdown of amino acids, removing nitrogen in the form of urea. The liver synthesizes many importa ...
New concepts of cellular fatty acid uptake: role of fatty acid transport
... Efficient uptake and channelling of long-chain fatty acids (LCFA) are critical cell functions. Evidence is emerging that proteins are important mediators of LCFA-trafficking into cells and various proteins have been suggested to be involved in this process. Amongst these proteins is a family of memb ...
... Efficient uptake and channelling of long-chain fatty acids (LCFA) are critical cell functions. Evidence is emerging that proteins are important mediators of LCFA-trafficking into cells and various proteins have been suggested to be involved in this process. Amongst these proteins is a family of memb ...
Methemoglobinemia: a Puzzling Case Study
... methemoglobinemia in patients with glucose-6phosphate dehydrogenase (G6PD) deficiency • Ascorbic acid should be given instead ...
... methemoglobinemia in patients with glucose-6phosphate dehydrogenase (G6PD) deficiency • Ascorbic acid should be given instead ...
Lecture 12 –Octahedral Substitution Reactions
... Consider the following two reactions: [CoCl2(en)2]+ + H2O [CoCl(H2O)(en)2]+ + Cl[CoCl2(Me4en)2]+ + H2O H2N ...
... Consider the following two reactions: [CoCl2(en)2]+ + H2O [CoCl(H2O)(en)2]+ + Cl[CoCl2(Me4en)2]+ + H2O H2N ...
CM22555559
... and membrane proteins, is possible with considerably high accuracy. Transmembrane protein is a protein that goes from one side of a membrane through to other side of the membrane. They permit the transport of specific substances across the biological membrane The classification of all amino acid seq ...
... and membrane proteins, is possible with considerably high accuracy. Transmembrane protein is a protein that goes from one side of a membrane through to other side of the membrane. They permit the transport of specific substances across the biological membrane The classification of all amino acid seq ...
Amidinate Ligands in Zinc coordination sphere: Synthesis and
... coordination polymers using various flexible ligands.16 In our ongoing work too, we are working with zinc, supported by various mixed N-/O- donors17 and NHC based ligands.18 However, to the best of our knowledge, there are no reports on any direct synthesis of zinc amidinate complexes while using one ...
... coordination polymers using various flexible ligands.16 In our ongoing work too, we are working with zinc, supported by various mixed N-/O- donors17 and NHC based ligands.18 However, to the best of our knowledge, there are no reports on any direct synthesis of zinc amidinate complexes while using one ...
Ligand Binding and Allosteric Regulation
... Heme: iron protoporphyrin IX, with bound Fe2+ 1 heme per Mb = 1 O2 binding site per Mb molecule 1 heme per Hb subunit, so maximum of 4 O2 can bind to Hb tetramer. ...
... Heme: iron protoporphyrin IX, with bound Fe2+ 1 heme per Mb = 1 O2 binding site per Mb molecule 1 heme per Hb subunit, so maximum of 4 O2 can bind to Hb tetramer. ...
P. Mignon, J. Steyaert, R. Loris, P. Geerlings, and S. Loverix, J. Biol
... Because RNase-catalyzed phosphodiester cleavage is not a dissociative process (16), the nucleophilic attack contributes largely to the rate-limiting step of the reaction. The nucleophilic attack on hard centers such as phosphates involves the donation of electrons from a nucleophile to a phosphorus, ...
... Because RNase-catalyzed phosphodiester cleavage is not a dissociative process (16), the nucleophilic attack contributes largely to the rate-limiting step of the reaction. The nucleophilic attack on hard centers such as phosphates involves the donation of electrons from a nucleophile to a phosphorus, ...
The Johan Kjeldahl Method
... From a historical perspective, the official analytical methods used to determine nitrogen are certainly old. Johan Kjeldahl (Fig. 1) published his “New method for the determination of nitrogen in organic substances” in 1883, revolutionising nitrogen analysis [1]. The versatility of the method and si ...
... From a historical perspective, the official analytical methods used to determine nitrogen are certainly old. Johan Kjeldahl (Fig. 1) published his “New method for the determination of nitrogen in organic substances” in 1883, revolutionising nitrogen analysis [1]. The versatility of the method and si ...
Title: Rescuing discarded spectra: Full - e
... of information due to the high percentage of unassigned spectra. To determine the causes behind this loss we have analyzed the proteome of one of the smallest living bacteria that can be grown axenically, Mycoplasma pneumoniae (729 ORFs). The proteome of M. pneumoniae cells, grown in defined media, ...
... of information due to the high percentage of unassigned spectra. To determine the causes behind this loss we have analyzed the proteome of one of the smallest living bacteria that can be grown axenically, Mycoplasma pneumoniae (729 ORFs). The proteome of M. pneumoniae cells, grown in defined media, ...
Characterization of the Plasmid-Encoded Arsenic Salts Resistance
... homology, possibly due to gene duplication and fusion of a gene ancestral to the arsA gene [4]. It was also shown that ArsA was 32% identical to the sequence of MinD, which is a membrane-associated protein capable of binding and hydrolyzing ATP [7]. MinD functions to activate the division inhibition ...
... homology, possibly due to gene duplication and fusion of a gene ancestral to the arsA gene [4]. It was also shown that ArsA was 32% identical to the sequence of MinD, which is a membrane-associated protein capable of binding and hydrolyzing ATP [7]. MinD functions to activate the division inhibition ...
An Investigation into the Minimum Requirements for
... A series of variants was constructed containing D102N and either alanine, aspartic acid, lysine, leucine, or histidine at position 57. The k,,, values for the H57A/D102N and H57L/D102N variants a t pH 8.0 were slightly higher and at pH 10.1 were much higher than those for the analogous H57A and H57L ...
... A series of variants was constructed containing D102N and either alanine, aspartic acid, lysine, leucine, or histidine at position 57. The k,,, values for the H57A/D102N and H57L/D102N variants a t pH 8.0 were slightly higher and at pH 10.1 were much higher than those for the analogous H57A and H57L ...
Nickel(II) cis- and trans-Dimethyl Complexes of
... decomposition products. The 1H NMR spectra display resonances attributable to 3, of which the most indicative are two doublets centered at δ 4.47 and 6.65 ppm assigned to the diastereotopic bridging methylene protons and a singlet at δ 0.13 ppm ascribed to the NiCH3 protons. After standing at room t ...
... decomposition products. The 1H NMR spectra display resonances attributable to 3, of which the most indicative are two doublets centered at δ 4.47 and 6.65 ppm assigned to the diastereotopic bridging methylene protons and a singlet at δ 0.13 ppm ascribed to the NiCH3 protons. After standing at room t ...
ligand design - UZH - Department of Chemistry
... containing pi acceptor ligands These are electrophilic at the alpha carbon count as neutral two containing pi‐acceptor ligands. These are electrophilic at the alpha‐carbon, count as neutral two‐ electron donor ligands, their ligation being similar to CO. We can draw a resonance structure as follows ...
... containing pi acceptor ligands These are electrophilic at the alpha carbon count as neutral two containing pi‐acceptor ligands. These are electrophilic at the alpha‐carbon, count as neutral two‐ electron donor ligands, their ligation being similar to CO. We can draw a resonance structure as follows ...
Structural Analyses of Nucleotide Binding to an Aminoglycoside
... 3′-hydroxyl position. One member of this class, APH(3′)IIIa, is found in Gram-positive cocci such as Staphylococci and Enterococci. This enzyme has the broadest substrate specificity of the APH(3′) isozymes, phosphorylating at least nine different aminoglycoside substrates and carrying out additiona ...
... 3′-hydroxyl position. One member of this class, APH(3′)IIIa, is found in Gram-positive cocci such as Staphylococci and Enterococci. This enzyme has the broadest substrate specificity of the APH(3′) isozymes, phosphorylating at least nine different aminoglycoside substrates and carrying out additiona ...
Poster - MSOE Center for BioMolecular Modeling
... The active site amino acids involved in cleaving the peptide bonds in fibrinogen are His-57, Asp102, and Ser-195. Defective thrombin can either lead to too few or too many blood clots. Too little clotting could result in a disorder called hemophilia; too much could result in deep vein thrombosis (DV ...
... The active site amino acids involved in cleaving the peptide bonds in fibrinogen are His-57, Asp102, and Ser-195. Defective thrombin can either lead to too few or too many blood clots. Too little clotting could result in a disorder called hemophilia; too much could result in deep vein thrombosis (DV ...
ppt-file
... glucose as a substrate (yield: ¾), five modes only use acetate, and 29 use both. The optimal lysine over glucose yield of ¾ coincides with earlier results obtained by metabolite balancing in [3]. It is understandable that the yield is lower than when ATP and ADP are external (cf. first reaction sche ...
... glucose as a substrate (yield: ¾), five modes only use acetate, and 29 use both. The optimal lysine over glucose yield of ¾ coincides with earlier results obtained by metabolite balancing in [3]. It is understandable that the yield is lower than when ATP and ADP are external (cf. first reaction sche ...
Metalloprotein
Metalloprotein is a generic term for a protein that contains a metal ion cofactor. A large number of all proteins are part of this category.