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biotransformation
biotransformation

... Sites of drug metabolism:  The liver is the major organ of drug metabolism, although other sites (lungs, kidneys, plasma, small intestine. Placenta, skin and brain) may contribute.  Cytochrome P450 monooxygenase or mixed function oxidase (M.F.O) system is the major catalyst of drug biotransformati ...
Recent advances in enzyme promiscuity | SpringerLink
Recent advances in enzyme promiscuity | SpringerLink

... a protein’s original function and structure, where each and every variant is folded and functional and maintains a certain degree of the enzyme’s existing function. For making neutral libraries, several iterative rounds of mutagenesis and selection are applied to maintain the protein’s original func ...
Ultimate removal mechanisms of elements from the ocean*
Ultimate removal mechanisms of elements from the ocean*

... for manganese and iron oxides, especially for high valent, low ionic radius cations (e.g. transition metals). This may explain why aluminosilicate phases in the ocean mostly absorb alkaline and alkaline earth elements and not transition metals. For neutral ion species, tlC'olv is zero. In short, con ...
Amino acid residues that determine functional specificity of NADP
Amino acid residues that determine functional specificity of NADP

... in protein on average and in each comparison. Experimental data collected for all proteins of the family, contacts calculated for IDH from E. coli, 1ai2. (B) Fraction of amino acid residues of different functional types: specificity determinants are described in the literature as essential for the en ...


... A phospholipid replaces the fatty acid at position 1 with a phosphate group that may link to other groups (such as choline) 5. (10 pts) Please do any one of the following three questions: Choice A: Briefly describe the role of the hydrophobic effect on the formation of phospholipid bilayers and mice ...
Erythroid Iron Metabolism
Erythroid Iron Metabolism

... Each chain is non-covalently bound to a single heme molecule that sits in a hydrophobic pocket. Since the ferrous iron of each heme group can bind a single oxygen molecule, the hemoglobin tetramer can reversibly bind and transport four molecules of oxygen. In addition to transporting oxygen and carb ...
Quantum Mechanical Model for Information Transfer from DNA to
Quantum Mechanical Model for Information Transfer from DNA to

... Hydrogen bond sites are characterized as “donors” or “acceptors” of hydrogen. Figure 2 shows a schematic representation of the four nucleotides and their bond sites. Donor sites are marked with “1” and acceptor sites with “0”. The upper bond is the first bond. The following three assumptions about t ...
High pKa variability of cysteine residues in structural databases and
High pKa variability of cysteine residues in structural databases and

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support material
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Synthesis and Characterization of Mononuclear, Pseudotetrahedral
Synthesis and Characterization of Mononuclear, Pseudotetrahedral

... configurations, and cobalt(III) centers prefer low-spin octahedral geometries.5 Square-planar coordination environments are also readily observed for four-coordinate cobalt(III) complexes, but small molecules with cobalt(III) centers in tetrahedral environments are significantly scarce. The cobalt(III ...
Muscles
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... • Botulinum toxin is produced by bacterium Clostridium botulinum. The toxin is a two-chain polypeptide with a heavy chain joined by a disulphide bond to a light chain. • The light chain is a protease that attacks one of the fusion proteins at a neuromuscular junction, preventing vesicles from anchor ...
Solubility and Complex-ion Equilibria
Solubility and Complex-ion Equilibria

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report on HMM

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Bennett, Eric: Utilization of primary and secondary structure elements to predict a protein's propensity to form amyloids
Bennett, Eric: Utilization of primary and secondary structure elements to predict a protein's propensity to form amyloids

... neurofibrillar tangles (6). All of these diseases point to a common feature. These aggregation prone proteins are normally soluble with a variety of three-dimensional structures that are stable until some mutation or cellular event triggers a conformational change leading to amyloid formation (7-9). ...
electrochemistry
electrochemistry

... exothermic reaction is normally lost as heat. However, it can be trapped and converted into electrical energy if the reactants involved are not in direct contact with each other. In galvanic cells redox reactions is split into two halfreactions, each occurring in two separate compartments, called ha ...
Theoretical Studies of the Coordination and Stability of Divalent
Theoretical Studies of the Coordination and Stability of Divalent

... listed in Table 5. The closer this sum is to 360°, the closer the metal is to a planar orientation and the better the overlap of orbitals between the metal and the four O atoms associated with the two Al atoms in the ring. If the ring is too small to accommodate the metal, as is the case for the Z4 ...
CHE-120 Test 4
CHE-120 Test 4

... 7) The side chain for histidine is classified as a ________ side chain. A) acidic B) polar C) nonpolar D) neutral ...
Regulation of carbohydrate metabolism
Regulation of carbohydrate metabolism

... 2. 3 key sites for the regulation of gluconeogenesis (their activation). 3. The signal pathway for the activation of glycogen degradation by glucagon. 4. Main regulators of glycogen degradation in liver and muscle. 5. Pathways preventing hypoglycemia and hyperglycemia. ...
Solubility and Complex-ion Equilibria
Solubility and Complex-ion Equilibria

... • The solubility of an insoluble salt can be manipulated by adding a species that reacts with either the cation or the anion. • Effect of pH on Solubility • When a salt contains the conjugate base of a weak acid, the pH will affect the solubility of the salt. ...
BIOC*4540 ENZYMOLOGY Winter 2015
BIOC*4540 ENZYMOLOGY Winter 2015

... to  answer  questions  (independent  study/seminar  is  worth  20%  of  the  course  grade).    It  is  important to remember that anything that you include or say during your presentation is open to  questions from the audience and so you should ensure that you fully understand it.  Each student  i ...
JOURNAL OF APPLIED SCIENCE AND AGRICULTURE
JOURNAL OF APPLIED SCIENCE AND AGRICULTURE

... studies that have proven its ability to extract high amount of high-quality protein (Hamada, 1998; Hamada, 2000; Hanmoungjai et al., 2001; Hanmoungjai et al., 2002; Tang et al., 2003), this process is not economically efficient due to the high cost of enzymes. Nevertheless, there are a few novel met ...
Presentation
Presentation

... ATP synthesis can be uncoupled: if a different H+ diffusion channel is inserted into the mitochondrial membrane, the energy of the diffusion is lost as heat. The protein thermogenin occurs in human ...
Cellular Respiration Powerpoint
Cellular Respiration Powerpoint

... 2. Alcohol Fermentation - a form of anaerobic respiration used primarily by yeasts & bacteria ...
From The Building Blocks to Life
From The Building Blocks to Life

... Contemporary life on Earth stores genetic information in the sequences of DNA and RNA and it evolves through changes in these sequences. Protein enzymes catalyze most of the chemical reactions essential for life. The biological basic functions of information storage and catalysis are fulfilled by bi ...
PDF - Biochemical Journal
PDF - Biochemical Journal

... A 3CI isotope-dilution method which provides an Institute of Animal Phy8iology, Babraham, Camadequate standard of reference for evaluation of bridge) other methods has been developed (Cotlove & The effects on glutamate dehydrogenase of Green, 1958). The present method involves comacetate (PMA) (Hell ...
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Metalloprotein



Metalloprotein is a generic term for a protein that contains a metal ion cofactor. A large number of all proteins are part of this category.
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