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Improved Tolerance to Salt and Water Stress in
Improved Tolerance to Salt and Water Stress in

... The brine shrimp A. franciscana has served as an important model for animal desiccation tolerance, and multiple LEA proteins that belong to group 1 (PF00477), 3 (PF02987), and 4 (PF04927) are found in developmental stages that survive severe desiccation (Hand et al., 2007; Sharon et al., 2009; Wu et ...
Evolutionary Rate in the Protein Interaction Network
Evolutionary Rate in the Protein Interaction Network

... with their rate of evolution. Proteins with more interactors evolve more slowly not because they are more important to the organism, but because a greater proportion of the protein is directly involved in its function. At sites important for interaction between proteins, evolutionary changes may occ ...
4.5 Regulation and Variability of Signaling by Nuclear Receptors
4.5 Regulation and Variability of Signaling by Nuclear Receptors

... are lipophilic hormones, among which the steroid hormones, the thyroid hormone T3, and derivatives of vitamin A and D have long been known as central regulators.  These hormones play a significant role in metabolic regulation, organ function, and development and differentiation processes. Following ...
Figure 2 - Trace: Tennessee Research and Creative Exchange
Figure 2 - Trace: Tennessee Research and Creative Exchange

... In order to ensure their survival, bacteria must sense and adapt to a variety of environmental signals. Motile bacteria are able to orient their movement in a chemical gradient by chemotaxis. During chemotaxis, environmental signals are detected by chemotaxis receptors and are propagated via a signa ...
Thoughts on Vitamin A, IBD and PSC
Thoughts on Vitamin A, IBD and PSC

... “The epithelial barrier is determined primarily by intercellular tight junctions (TJs). We have demonstrated previously that all-trans retinoic acid (atRA) plays an important role in forming functional TJs through a specific retinoic acid receptor (RAR)/retinoid X receptor (RXR) heterodimer in epith ...
Trafficking of phosphatidylinositol by phosphatidylinositol transfer
Trafficking of phosphatidylinositol by phosphatidylinositol transfer

... membrane traffic [8–10]. Despite a detailed knowledge of the biochemical activities of PITPs in vitro, a molecular understanding of how PITPs fulfil their functions in intact cells and in complex organisms remains poor. The current view is that it is unlikely that PITPs are passive mediators of phos ...
Hemoglobin as the main protein of erythrocytes. Its structure and
Hemoglobin as the main protein of erythrocytes. Its structure and

... hemoglobin polymorphism. The hemoglobinopathies. Synthesis of heme. The most important proteins of myofibrils: myosin, actin, tropomyosin, troponin. Their molecular organization and their role in a muscular contraction. The chemical character of the muscular contraction and relaxation. The role of C ...
Metabolic Pathways and Energy Production
Metabolic Pathways and Energy Production

... • Chromosomes in the nucleus contain genetic material • Cytoplasm is material between nucleus and cell membrane • Mitochondria are where energy-producing reactions occur ...
Metabolic Pathways a..
Metabolic Pathways a..

... • Chromosomes in the nucleus contain genetic material • Cytoplasm is material between nucleus and cell membrane • Mitochondria are where energy-producing reactions occur ...
1 - u.arizona.edu
1 - u.arizona.edu

... - ribose-5-P produced from glycolytic intermediates; oxidative pathway shutdown by NADPH feedback inhibition Cell requires both NADPH and ribose-5-P - cell operates only oxidative branch of pentose pathway - all ribulose-5-P converted to ribose-5-P 2. REACTIVE OXYGEN SPECIES (ROS) - toxic ROS gener ...
Membrane Proteins
Membrane Proteins

Biological importance of Uronic Acid Pathway
Biological importance of Uronic Acid Pathway

... Glucose-6-phosphate dehydrogenase deficiency (sometimes also called G6PD deficiency, or favism) is a hereditary disease. As it is linked to the X chromosome, most people who suffer from it are male. Sufferers can not make the enzyme glucose-6phosphate dehydrogenase. This will mean the circulation o ...
lec27_2013 - Andrew.cmu.edu
lec27_2013 - Andrew.cmu.edu

... Citric acid (TCA, Krebs) cycle Electron transport Oxidative phosphorylation (ATP synthesis) ...
Evolution of Cellular Data Processing
Evolution of Cellular Data Processing

... 3.2.2 Group translocation systems: primeval forms of dataprocessing networks combining food uptake with gene regulation The best-known representatives of this family of membrane transporters are the PEP (phosphoenol pyruvate)-powered phosphotransferase systems, abbreviated as PTS. They combine membr ...
HORMONE OF MIDDLE LOBE OF PITUITARY MELANOCYTE
HORMONE OF MIDDLE LOBE OF PITUITARY MELANOCYTE

... protrudes into the lumen of rough ER and a signal peptidase of rER membrane hydrolyzes the molecules to split off 25 a.a and thus pre-pro PTH is changed to proPTH having 90 amino acids. PTH: pro-PTH is transferred to rER lumen end moves to Golgi cisternae. A trypsin like enzymes called lipase B hydr ...
Respiration
Respiration

2. - Blue Ridge Institute for Medical Research
2. - Blue Ridge Institute for Medical Research

... receptor different superantigens interact with, and polyreactive antibodies made by CD5÷B cells. Two colours, black and red (and tints thereof), are used throughout, producing a visual range that will not satisfy all. In places, such as in densely painted cell masses, the coiour rather dominates the ...
Digestion of Dietary Proteins
Digestion of Dietary Proteins

... Inability to digest lactose of milk due to deficiency of lactase enzyme So, diarrhea will occur on ingestion of milk or milk products For infants (up to two years old): are treated by lactose-free milk 2- Intestinal diseases or drugs that injure the mucosa of the small intestine ...
Lehninger Principles of Biochemistry Fourth Edition David L. Nelson
Lehninger Principles of Biochemistry Fourth Edition David L. Nelson

... the chemical components of a living organism is dynamic; changes in one component cause coordinating or compensating changes in another, with the whole ensemble displaying a character beyond that of its individual parts. The collection of molecules carries out a program, the end result of which is r ...
advanced placement biology - Freehold Regional High School District
advanced placement biology - Freehold Regional High School District

... considerable amount of studying, memorizing, and analyzing the structure and function of living organisms. The rigor of the course is equivalent to an entry-level college course, and students are expected to rise to the challenge of the College Board AP Biology exam. Students are expected to apply t ...
Metabolic Pathway Flux Enhancement by Synthetic
Metabolic Pathway Flux Enhancement by Synthetic

... titers may be improved by colocalizing consecutive metabolic enzymes to produce a higher local concentration of metabolite in close proximity to the downstream enzyme (Conrado et al., 2008; Welch, 1977). This has been the subject of debate in early papers in which consecutive enzymes, b-galactosidas ...
Oncogenic regulation of tumor metabolic reprogramming
Oncogenic regulation of tumor metabolic reprogramming

... reprogramming closely related to the acquisition of most of cancer hallmarks. In fact, key oncogenic pathways converge to adapt the metabolism of carbohydrates, proteins, lipids and nucleic acids to the dynamic tumor microenvironment, conferring a selective advantage to cancer cells. Therefore, meta ...
CHAPTER 6
CHAPTER 6

... • Energy transduction and energy storage in the adenylate system – ATP, ADP, and AMP – lie at the very heart of metabolism – The regulation of metabolism by adenylates in turn requires close control of the relative concentrations of ATP, ADP, and AMP – ATP, ADP, and AMP are all important effectors i ...
Cyclic AMP and Hormone Action
Cyclic AMP and Hormone Action

... Hormones are important regulators of biological processes. Those that work through the action of 3’-5’-cyclic AMP (cAMP) control enzymes by using ATP to phosphorylate serine and threonine groups on target enzymes. These so-called protein kinases represent a sequel of catalytic steps designed to ampl ...
Carbohydrate metabolism in cultured animal cells
Carbohydrate metabolism in cultured animal cells

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Biochemical cascade

A biochemical cascade (or a signaling pathway) is a series of chemical reactions which are initiated by a stimulus (first messenger) acting on a receptor that is transduced to the cell interior through second messengers (which amplify the initial signal) and ultimately to effector molecules, resulting in a cell response to the initial stimulus. At each step of the signaling cascade, various controlling factors are involved to regulate cellular actions, responding effectively to cues about their changing internal and external environments.
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