![Architecture of the trypanosome RNA editing accessory complex](http://s1.studyres.com/store/data/017803596_1-cedbd1530351ef3ccf285b56cc278ee4-300x300.png)
Architecture of the trypanosome RNA editing accessory complex
... Both MRB8180/MRB4150 and MRB8170/MRB4160 are the result of a chromosomal duplication in T. brucei (but not L. major), and therefore these two proteins have the same single L. major homolog. g Some of the predicted sizes for the T. brucei proteins are different from those listed on TriTrypDB because ...
... Both MRB8180/MRB4150 and MRB8170/MRB4160 are the result of a chromosomal duplication in T. brucei (but not L. major), and therefore these two proteins have the same single L. major homolog. g Some of the predicted sizes for the T. brucei proteins are different from those listed on TriTrypDB because ...
294_2005_38_MOESM43_ESM - Springer Static Content Server
... Cdc24: Likely orthologues of the Cdc42 GTP/GDP exchange factor (GEF) were found in all species. Sequence identity, however, drops to about 20% for filamentous fungi. There is a significant size difference between yeasts, 81646, and filamentous fungi, 101992 (p=0.0059, t-test). Ste50: This Ste20-S ...
... Cdc24: Likely orthologues of the Cdc42 GTP/GDP exchange factor (GEF) were found in all species. Sequence identity, however, drops to about 20% for filamentous fungi. There is a significant size difference between yeasts, 81646, and filamentous fungi, 101992 (p=0.0059, t-test). Ste50: This Ste20-S ...
Plant serine/arginine-rich proteins and their role in pre
... introns and ligation of exons, is an important step in the regulation of gene expression in all eukaryotes. Selection of alternative splice sites in a pre-mRNA generates multiple mRNAs from a single gene that encode structurally and functionally distinct proteins. Alternative splicing of pre-mRNAs c ...
... introns and ligation of exons, is an important step in the regulation of gene expression in all eukaryotes. Selection of alternative splice sites in a pre-mRNA generates multiple mRNAs from a single gene that encode structurally and functionally distinct proteins. Alternative splicing of pre-mRNAs c ...
Detonator of the population explosion
... of the steel industry. It should be risked.” And he did it: he solved some unprecedented engineering problems, and commercial production of ammonia began on 9 September 1913, just four years and two months after Haber’s laboratory demonstration. Today’s ammonia synthesis has been improved in many de ...
... of the steel industry. It should be risked.” And he did it: he solved some unprecedented engineering problems, and commercial production of ammonia began on 9 September 1913, just four years and two months after Haber’s laboratory demonstration. Today’s ammonia synthesis has been improved in many de ...
Structure and assembly of the spliceosomal small nuclear
... nucleotides of stem–loop II, AUUGCAC, and the loop-closing C⋅G base pair form an intricate hydrogen-bond network with the sidechains and the mainchain of the U1A protein. These nucleotides show stacking interactions with either an adjacent RNA base or a protein sidechain, or both, that stabilise the ...
... nucleotides of stem–loop II, AUUGCAC, and the loop-closing C⋅G base pair form an intricate hydrogen-bond network with the sidechains and the mainchain of the U1A protein. These nucleotides show stacking interactions with either an adjacent RNA base or a protein sidechain, or both, that stabilise the ...
Molecular Chaperones - Cellular Machines for Protein Folding
... and groES genes encode proteins of 57 kDa and 10 kDa size, respectively, which are both required for the viability of E. coli.[25] Thus, at least one essential E. coli protein cannot fold without assistance from the GroE chaperone. 2.1.1. Structure of the GroE Chaperone The most striking feature of ...
... and groES genes encode proteins of 57 kDa and 10 kDa size, respectively, which are both required for the viability of E. coli.[25] Thus, at least one essential E. coli protein cannot fold without assistance from the GroE chaperone. 2.1.1. Structure of the GroE Chaperone The most striking feature of ...
Amino Acids
... Does Lactose Intolerance Have a Genetic Basis? • Observation: Most lactose-intolerant people have a normal version of the lactase gene. • Question: What is the genetic basis for lactose intolerance? • Hypothesis: Lactose-intolerant people have a mutation but not within the lactase gene. ...
... Does Lactose Intolerance Have a Genetic Basis? • Observation: Most lactose-intolerant people have a normal version of the lactase gene. • Question: What is the genetic basis for lactose intolerance? • Hypothesis: Lactose-intolerant people have a mutation but not within the lactase gene. ...
Antigenic Properties of Mycoplasma Organisms and Membranes
... Agglutination of whole cell. This was carried out either on glass slides at room temperature or in test-tubes at 52O according to Bailey et al. (1961). Double difliion in agar. The test was done according to Ouchterlony (1964). Noble agar 1% (w/v) was prepared in veronal+HCl buffer (PH = 8.2; ionic ...
... Agglutination of whole cell. This was carried out either on glass slides at room temperature or in test-tubes at 52O according to Bailey et al. (1961). Double difliion in agar. The test was done according to Ouchterlony (1964). Noble agar 1% (w/v) was prepared in veronal+HCl buffer (PH = 8.2; ionic ...
The role of cytosolic proteins in the insertion of tail
... proteins and their salt-resistant association to the cytosolic leaflet of the bilayer (Brambillasca et al., 2005), has led to important advances in our understanding of the mechanisms used by this class of proteins to insert into the ER membrane. The analysis of the membrane components involved and ...
... proteins and their salt-resistant association to the cytosolic leaflet of the bilayer (Brambillasca et al., 2005), has led to important advances in our understanding of the mechanisms used by this class of proteins to insert into the ER membrane. The analysis of the membrane components involved and ...
Effect of Dependency Relationships and Ordered Co
... – Aimed to extract information concerning the roles of amino acids in protein molecules, and to create a database of protein active sites from both scientific journal abstracts and full articles. – New protein structures are being reported at very high rates and the number of co-ordinate sets (curre ...
... – Aimed to extract information concerning the roles of amino acids in protein molecules, and to create a database of protein active sites from both scientific journal abstracts and full articles. – New protein structures are being reported at very high rates and the number of co-ordinate sets (curre ...
12551_2008_5_MOESM1_ESM - Springer Static Content Server
... Polypeptides. Academic, New York At the time this was the most comprehensive compilation of data available on both fibrous proteins and the methodology used to study them. It still provides an excellent summary on the structures of many of the synthetic polypeptides that were used as model protein s ...
... Polypeptides. Academic, New York At the time this was the most comprehensive compilation of data available on both fibrous proteins and the methodology used to study them. It still provides an excellent summary on the structures of many of the synthetic polypeptides that were used as model protein s ...
In vivo hepatic localized proton magnetic resonance spectroscopy at
... accumulation of liver fatty acids (steatosis). The phenotype of GSD I results from a defect in the glucose-6 phosphatase complex (G6pc). Despite of a strict diet, patients with GSD 1 develop, with age, multiple hepatocellular adenoma (HCA), ultimately transforming into hepatocellular carcinoma (HCC) ...
... accumulation of liver fatty acids (steatosis). The phenotype of GSD I results from a defect in the glucose-6 phosphatase complex (G6pc). Despite of a strict diet, patients with GSD 1 develop, with age, multiple hepatocellular adenoma (HCA), ultimately transforming into hepatocellular carcinoma (HCC) ...
Protein Interactions Techniques and Challenges
... produce similar scores In some cases the correct solution is not among the first ranked results Thessaloniki, October 2009 ...
... produce similar scores In some cases the correct solution is not among the first ranked results Thessaloniki, October 2009 ...
On The Determination of Enzyme Structure, Function, and
... The polypeptide chain of lignin peroxidase is folded into mainly alpha-helical secondary structures, and it also contains a heme molecule as a cofactor (thicker lines in the middle). Right: magnification of a small portion of the polypeptide chain indicating two amino acids (phenylalanine and aspart ...
... The polypeptide chain of lignin peroxidase is folded into mainly alpha-helical secondary structures, and it also contains a heme molecule as a cofactor (thicker lines in the middle). Right: magnification of a small portion of the polypeptide chain indicating two amino acids (phenylalanine and aspart ...
Bioinformatics tools as JAWB (Just another Western Blot)
... Caveats of using protein docking to predict interaction ...
... Caveats of using protein docking to predict interaction ...
Supplementary Figure 1 Details of PIQED Automated Qualitative
... output from the previous module. These modules are broadly divided into three sections: (1) file conversions and DIAUmpire signal extraction, (2) database searches, and (3) post processing, quantification and significance testing. The leftmost section is used to specify parameters for file conversio ...
... output from the previous module. These modules are broadly divided into three sections: (1) file conversions and DIAUmpire signal extraction, (2) database searches, and (3) post processing, quantification and significance testing. The leftmost section is used to specify parameters for file conversio ...
Tupai eBusiness Systems
... predict future behavior - we make the model out of structure so we can combine it with other structure - we pass complex messages through the structure Orion technology does all these things too... ...
... predict future behavior - we make the model out of structure so we can combine it with other structure - we pass complex messages through the structure Orion technology does all these things too... ...
Name Molecules in our world project Goal: The idea for this project
... Choose 1 small and two medium molecules OR 1 small and 1 large molecule: Small molecules should have at least 2 elements and fewer than 5 non-hydrogen atoms. Medium molecules should have at least 3 elements and between 5 and 12 non-hydrogen atoms. Large molecules should have at least 4 element ...
... Choose 1 small and two medium molecules OR 1 small and 1 large molecule: Small molecules should have at least 2 elements and fewer than 5 non-hydrogen atoms. Medium molecules should have at least 3 elements and between 5 and 12 non-hydrogen atoms. Large molecules should have at least 4 element ...
Sequence identity and homology
... A statistical perturbation analysis can be used to characterize this covariation. An alignment of related sequences is “perturbed” by only considering sequences at which, for example, the first position is Y. The effect of this perturbation on the residue distribution observed at other positions is ...
... A statistical perturbation analysis can be used to characterize this covariation. An alignment of related sequences is “perturbed” by only considering sequences at which, for example, the first position is Y. The effect of this perturbation on the residue distribution observed at other positions is ...
The Roles of Moonlighting Proteins in Bacteria
... been shown to bind with HEp-2 and A549 cells, and to adhere to aldolase, GAPDH and cyclophilin A inside epithelial cells (Reddy and Suleman, 2004). It is generally thought that by binding to host components these surface-located proteins help pathogens to adhere to host cells, and facilitate their c ...
... been shown to bind with HEp-2 and A549 cells, and to adhere to aldolase, GAPDH and cyclophilin A inside epithelial cells (Reddy and Suleman, 2004). It is generally thought that by binding to host components these surface-located proteins help pathogens to adhere to host cells, and facilitate their c ...
Systemic Delivery of siRNA by a Plant PHLOEM SMALL RNA
... plants in which c-Myc4-His8 tagged rbcS, GFP, CmPSRP1 WT, Qm and ∆C were expressed using a ZYMV vector. Total proteins extracted from infected tissues (10 µg) and phloem exudate (40 µg) were separated on 13% SDS-PAGE gels and analyzed by protein gel blot analysis using anti-c-Myc mAb. (b) CmPSRP1, Q ...
... plants in which c-Myc4-His8 tagged rbcS, GFP, CmPSRP1 WT, Qm and ∆C were expressed using a ZYMV vector. Total proteins extracted from infected tissues (10 µg) and phloem exudate (40 µg) were separated on 13% SDS-PAGE gels and analyzed by protein gel blot analysis using anti-c-Myc mAb. (b) CmPSRP1, Q ...
Lecture 15, Feb 26
... the shape of a sheet of paper folded back and forth; it is called the betasheet (or pleated sheet or beta pleated sheet) conformation. The polypeptide chain may fold back again to allow three (or more) regions of the polypeptide chain to align in a thicker pleated sheet conformation. Note the oxygen ...
... the shape of a sheet of paper folded back and forth; it is called the betasheet (or pleated sheet or beta pleated sheet) conformation. The polypeptide chain may fold back again to allow three (or more) regions of the polypeptide chain to align in a thicker pleated sheet conformation. Note the oxygen ...
minervini
... Europe (EGEE) and China (CNGrid) Grid infrastructures The goals of the EUChinaGRID are: ...
... Europe (EGEE) and China (CNGrid) Grid infrastructures The goals of the EUChinaGRID are: ...
PDF - Oxford Academic - Oxford University Press
... antiserum in mock-transfected cells (Fig. 1C, left panel). The appearance of similar granular structures in both cases indicates that the tagged and endogenous proteins have similar behaviours and that the tagged protein can be used as a marker of the normal one. To improve the yield of tagged prote ...
... antiserum in mock-transfected cells (Fig. 1C, left panel). The appearance of similar granular structures in both cases indicates that the tagged and endogenous proteins have similar behaviours and that the tagged protein can be used as a marker of the normal one. To improve the yield of tagged prote ...
Sure, some prions can cause diseases, but others are
... HHMI investigator David Eisenberg, a protein structure specialist at the University of California, Los Angeles, uses various types of x-ray crystallography techniques to study the structure of the amyloid proteins produced by prions. In 2005, Eisenberg showed that when a protein converts to a prion, ...
... HHMI investigator David Eisenberg, a protein structure specialist at the University of California, Los Angeles, uses various types of x-ray crystallography techniques to study the structure of the amyloid proteins produced by prions. In 2005, Eisenberg showed that when a protein converts to a prion, ...
Cyclol
![](https://commons.wikimedia.org/wiki/Special:FilePath/Cyclol_reaction.png?width=300)
The cyclol hypothesis is the first structural model of a folded, globular protein. It was developed by Dorothy Wrinch in the late 1930s, and was based on three assumptions. Firstly, the hypothesis assumes that two peptide groups can be crosslinked by a cyclol reaction (Figure 1); these crosslinks are covalent analogs of non-covalent hydrogen bonds between peptide groups. These reactions have been observed in the ergopeptides and other compounds. Secondly, it assumes that, under some conditions, amino acids will naturally make the maximum possible number of cyclol crosslinks, resulting in cyclol molecules (Figure 2) and cyclol fabrics (Figure 3). These cyclol molecules and fabrics have never been observed. Finally, the hypothesis assumes that globular proteins have a tertiary structure corresponding to Platonic solids and semiregular polyhedra formed of cyclol fabrics with no free edges. Such ""closed cyclol"" molecules have not been observed either.Although later data demonstrated that this original model for the structure of globular proteins needed to be amended, several elements of the cyclol model were verified, such as the cyclol reaction itself and the hypothesis that hydrophobic interactions are chiefly responsible for protein folding. The cyclol hypothesis stimulated many scientists to research questions in protein structure and chemistry, and was a precursor of the more accurate models hypothesized for the DNA double helix and protein secondary structure. The proposal and testing of the cyclol model also provides an excellent illustration of empirical falsifiability acting as part of the scientific method.