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Investigator`s Brochure
Investigator`s Brochure

... imidazole, or [18F]FMISO, is a radiolabeled imaging agent that has been used for  investigating tumor hypoxia with positron emission tomography (PET). The University of  Washington pioneered the development and biodistribution evaluation of [18F]FMISO.   An ideal hypoxia‐imaging agent should distrib ...
RBFM v5n1.indb
RBFM v5n1.indb

... ICMP 2011, in Porto Alegre, enabled the reunion of medical physicists, engineers and other professionals that work in this field for different activities, such as symposiums, workshops, courses and meetings that started a few days before the conference, from April 15 to 17. One of these events was t ...
Cone beam computed tomography: Adding three dimensions to
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... Nobel Prize in medicine in 1979.[4] Hounsfield used image ...
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ecr today 2012
ecr today 2012

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... e) Tmax: the time at which the deconvolved residue function reaches its maximal value.3 CBF represents the maximal value of the deconvolved residue function in each voxel. f) Peak height: the maximal drop in signal intensity from precontrast baseline during the first-pass bolus phase of GBCA.4-6 Thi ...
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... that has low spatial resolution but high sensitivity (PET or SPECT).1, 12 In this manner, fusion of morphological and functional data can improve operator guidance and confidence during all phases of IR procedures. With the ongoing development of novel tracers, targeted molecular imaging techniques ...
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... physics, and radiation therapy physics is the main area of activity of medical physicists worldwide. These physicists are trained to use special concepts and methods of physics to help diagnose and treat human disease, and they have collected practical experience dealing with medical problems and us ...
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Use of Cross-Sectional Imaging in Predicting Surgical
Use of Cross-Sectional Imaging in Predicting Surgical

... counsel the patient. Proper localization of a parotid space lesion is difficult to assess based on palpation. The surgeon may feel the mass but is unable to identify the deep extent. This information directly impacts the surgical approach of parotid neoplasms. In addition, patients should be informe ...
Clinical Use of Electronic Portal Imaging : Report of AAPM Radiation
Clinical Use of Electronic Portal Imaging : Report of AAPM Radiation

... exposed under a metal plate, with no phosphor, has a quantum efficiency of ~1%. Figure 2 shows that the quantum efficiency increases as the thickness of the phosphor screen increases, because the incident x-ray quanta can also interact directly within the phosphor screen36. Therefore, somewhat fortu ...
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CLINICAL IMPLEMENTATION OF IMAGE

... eventual treatment planning. The tools to facilitate this modeling were developed in NIRFAST, which is a finite‐element based open‐source package for modeling near‐ infrared light transport in tissue for medical applications. It includes full‐featured segmentation and mesh creat ...
Using Cone Beam CT in Clinical Practice
Using Cone Beam CT in Clinical Practice

... Provider Disclosure: PennWell does not have a leadership position or a commercial interest in any products or services discussed or shared in this educational activity nor with the commercial supporter. No manufacturer or third party has had any input into the development of course content. Requirem ...
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Radiosurgery

Radiosurgery is surgery using radiation, that is, the destruction of precisely selected areas of tissue using ionizing radiation rather than excision with a blade. Like other forms of radiation therapy, it is usually used to treat cancer. Radiosurgery was originally defined by the Swedish neurosurgeon Lars Leksell as “a single high dose fraction of radiation, stereotactically directed to an intracranial region of interest”. In stereotactic radiosurgery (SRS), the word stereotactic refers to a three-dimensional coordinate system that enables accurate correlation of a virtual target seen in the patient's diagnostic images with the actual target position in the patient anatomy.Technological improvements in medical imaging and computing have led to increased clinical adoption of stereotactic radiosurgery and have broadened its scope in recent years. Notwithstanding these improvements, the localization accuracy and precision that are implicit in the word “stereotactic” remain of utmost importance for radiosurgical interventions today. Stereotactic accuracy and precision are significantly increased by using a device known as the N-localizer that was invented by the American physician and computer scientist Russell Brown and that has achieved widespread clinical use in several stereotactic surgical and radiosurgical systems.Recently, the original concept of radiosurgery has been expanded to include treatments comprising up to five fractions, and stereotactic radiosurgery has been redefined as a distinct neurosurgical discipline that utilizes externally generated ionizing radiation to inactivate or eradicate defined targets in the head or spine without the need for a surgical incision. Irrespective of the similarities between the concepts of stereotactic radiosurgery and fractionated radiotherapy, and although both treatment modalities are reported to have identical outcomes for certain indications, the intent of both approaches is fundamentally different. The aim of stereotactic radiosurgery is to destroy target tissue while preserving adjacent normal tissue, where fractionated radiotherapy relies on a different sensitivity of the target and the surrounding normal tissue to the total accumulated radiation dose. Historically, the field of fractionated radiotherapy evolved from the original concept of stereotactic radiosurgery following discovery of the principles of radiobiology: repair, reassortment, repopulation, and reoxygenation. Today, both treatment techniques are complementary as tumors that may be resistant to fractionated radiotherapy may respond well to radiosurgery and tumors that are too large or too close to critical organs for safe radiosurgery may be suitable candidates for fractionated radiotherapy.
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