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Effects of Cannabinoids on Synaptic Transmission in the Frog
Effects of Cannabinoids on Synaptic Transmission in the Frog

... 2-arachidonoylglycerol are formed, in some cases they target the CB1 receptors in the same cell where they are formed, via diffusion within the plasmalemma, or they can be released from the extracellular fluid, where they reach presynaptic terminals (Piomelli, 2003; Rodriguez de Fonseca et al., 2005 ...
Basic Science Award Recipients 2003
Basic Science Award Recipients 2003

... Cells with extensive DNA damage are typically eliminated via apoptosis, but pre¬- and early-gastrulation embryos of most organisms cannot induce apoptosis. What happens to damaged cells in early embryogenesis? I profiled zebrafish embryos by single-cell RNAseq and discovered a new cellular expressio ...
Chapter 16 Cholinesterase Inhibitors
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... At the same receptor • Almost always inhibitory (antagonist/agonist) At separate sites • May be potentiative (morphine and diazepam) OR • Inhibitory (HCTZ and spironolactone) ...
FREE Sample Here
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... REF: The Nervous System: Control of Behavior and Physiological Functions 27. Which lobe of the cerebral cortex processes auditory information and supports language comprehension and production? a. occipital lobe c. parietal lobe b. temporal lobe d. frontal lobe ANS: B PTS: 1 REF: The Nervous System: ...
Harris KD. Neural signatures of cell assembly organization. Nat Rev
Harris KD. Neural signatures of cell assembly organization. Nat Rev

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NIPS/Dec99/notebook3

... nisms enhance the activity of second-order neurons with overlapping receptive fields and inhibit other second-order cells with different receptive fields. These mechanisms include efferent control by the cerebral cortex and positive feedback by collaterals of second-order cells on other second-orde ...
A Medicinal Chemistry Perspec8ve on Picking the Right
A Medicinal Chemistry Perspec8ve on Picking the Right

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IBRO 2008
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... On the one hand, it seems obvious that studying the brain should be useful if one is interested in the mind. The phrase one often hears is that knowledge of the brain “provides constraints” on theories of the mind. But how, specifically, do these data provide constraints, and how do you figure out w ...
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... ability to quickly and accurately evaluate the cause of the patient’s discomfort or impairment. • Magnetic resonance imaging is a non-invasive procedure. • The patient is not exposed to any x-ray radiation during an MRI procedure. • The contrast material (dye) used in MRIs is less likely to cause a ...
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... these neurotransmitters originate in the brain stem and mid-brain regions but radiate widely around the cerebral cortex. Most anti-depressant drugs operate by amplifying the effect of these monoamines. Currently, the most widely used antidepressants (like Prozac) are selective serotonin re-uptake in ...
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Determinants of Neonatal Cardiac Output

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New proposal form February 2015
New proposal form February 2015

... 4. That is rarely used, such that individual GPs are unlikely to see sufficient patients and acquire a working knowledge of the drug 5. NICE guidance 6. Products without a UK product licence would normally be classified as ‘red’ but may, in exceptional circumstances, be classified as ‘amber’. Shared ...
Cell Cycle Events as Triggers of Nerve Cell Death
Cell Cycle Events as Triggers of Nerve Cell Death

... however, because clearance of A␤ plaque peptide by immunization seems to result in a behavioral “cure” within days, although the plaques themselves linger for weeks (Dodart et al., 2002; Kotilinek et al., 2002). But what does all this have to do with the cell cycle? The absence of neurodegeneration ...
The GABAergic system in schizophrenia
The GABAergic system in schizophrenia

... mechanism whereby an abnormality in the GABAergic system could be involved in the dopaminergic dysfunction of schizophrenia (Carlsson, 1988 ; Fuxe et al., 1977 ; Garbutt and van Kammen, 1983 ; Stevens et al., 1974 ; van Kammen, 1979). Squires and Saederup (1991) postulated that schizophrenia involve ...
Suppression of Noxious Stimulus-Evoked Activity in the Ventral
Suppression of Noxious Stimulus-Evoked Activity in the Ventral

... decrease neurotransmission in the output pathways of the basal ganglia (Miller and Walker, 1995), raising questions about the interpretation of results from behavioral tests of pain sensitivity (Cartmell et al., 1991). Several recent studies suggest that cannabinoids suppress nociceptive processing ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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