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1 - A patient allergic to penicillin group of antibiotics has to avoid
1 - A patient allergic to penicillin group of antibiotics has to avoid

... 75-The time of peak serum concentration gives indication of the relative rate of: a. absorption d- elimination b. distribution e. biotransformation c. metabolism 76-The area under the serum concentration vs. time curve (AUC) represents the: a. biologic half-time of the drug b. amount of the drug th ...
Phenotypic Characterization of Mitochondria in Breast Cancer Cells
Phenotypic Characterization of Mitochondria in Breast Cancer Cells

... It has long been thought that mitochondrial defects play an important role in the development and progression of cancer, and many of the cell growth and survival pathways targeted by anti-cancer drugs are mediated through mitochondria. However, it is not known how changes in mitochondrial shape and ...
New antiepileptic drugs
New antiepileptic drugs

... of the spread of epileptic discharges. This is believed to be mediated through action at voltage-sensitive sodium channels. It is currently indicated for people with focal seizures with or without secondary generalisation but it is likely to be a broad-spectrum drug. It can be effective in generalis ...
Date Rape Drugs
Date Rape Drugs

... Rohypnol may cause users to feel intoxicated; they may have slurred speech, impaired judgment, and difficulty walking. The effects are often felt within 10 minutes and can last up to 8 hours. Rohypnol can cause deep sedation, respiratory distress, and blackouts that can last up to 24 hours. ...
Regulation of Action-Potential Firing in Spiny Neurons of the Rat
Regulation of Action-Potential Firing in Spiny Neurons of the Rat

... Intracellular records were obtained from 23 striatal cells that were identified as spiny projection neurons by histological examination after the experiment (Fig. 1). Five cells in the sample were identified as striatonigral neurons by antidromic activation from the substantia nigra. All neurons in ...
Regulation of Action-Potential Firing in Spiny Neurons of the Rat
Regulation of Action-Potential Firing in Spiny Neurons of the Rat

... Intracellular records were obtained from 23 striatal cells that were identified as spiny projection neurons by histological examination after the experiment (Fig. 1). Five cells in the sample were identified as striatonigral neurons by antidromic activation from the substantia nigra. All neurons in ...
Art.-Schoenbaum (R) - UCSD Cognitive Science
Art.-Schoenbaum (R) - UCSD Cognitive Science

... amygdala may provide a critical circuit for the learning that underlies goal-directed behavior. We examined neural activity in rat orbitofrontal cortex and basolateral amygdala during instrumental learning in an olfactory discrimination task. Neurons in both regions fired selectively during the anti ...
Electrical Activity of a Membrane Resting Potential
Electrical Activity of a Membrane Resting Potential

... • Voltage-Sensitive Ion Channels – Gated protein channel that opens or closes only at specific membrane voltages – Sodium (Na+) and potassium (K+) – Closed at membrane’s resting potential – Na+ channels are more sensitive than K+ channels and therefore open sooner ...
M100,907, a selective 5-HT antagonist, attenuates dopamine
M100,907, a selective 5-HT antagonist, attenuates dopamine

... receptors regulate DA function in the mPFC. For example, administration of the atypical antipsychotic drug clozapine, a potent 5-HT 2 antagonist [20], increases extracellular DA concentrations in vivo when administered either systemically or directly into the mPFC [15,21,28]. In addition, systemic a ...
The Central Nervous System
The Central Nervous System

... pupils, tachycardia. • Used by ophthalmologist to dilate the pupils for exam. • Pre-op drug to suppress salivation and respiratory secretions during surgery. ...
Computational models of reinforcement learning
Computational models of reinforcement learning

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File

... • Secondline regimens for MDR-TB (TB resistant to at least isoniazid and rifampin) normally include an aminoglycoside (streptomycin, kanamycin, or amikacin) or capreomycin (all injectable agents), • Fluoroquinolone (typically levofloxacin or moxifloxacin). • Any first-line drugs that remain active, ...
Oncostatin`s LIFR sentence
Oncostatin`s LIFR sentence

... the tightly related processes of bone formation and resorption. Now, a group of Australian researchers has found a ligand, oncostatin M, that can elicit bone formation when it binds to a receptor called LIFR or bone resorption when it binds to another receptor called OSMR.1 The challenge will be to ...
Chapter_02 Edited
Chapter_02 Edited

... – An electric nerve impulse that travels through a neuron, changing the cell’s charge from negative to positive ...
LiuPoster - Department of Mathematics
LiuPoster - Department of Mathematics

... Phase delayed inhibition is a mechanism that enables the detection of synchrony in a group of neurons. This mechanism is found in many parts of the brain such as the neocortex, the hippocampus, the cerebellum, and the amygdala (Bruno, 2011). The project I worked on dealt specifically with the rat ba ...
diencephalon - Loyola University Medical Education Network
diencephalon - Loyola University Medical Education Network

... cholinergic, noradrenergic, serotonergic and dopaminergic). • Thalamic projection neurons have two physiological states o The role of the thalamus as a “gateway” to the cortex depends on a combination of ion channels o Tonic mode – Action potential train frequency of a thalamic neuron is a function ...
multiple choice questions (MCQs)
multiple choice questions (MCQs)

... effects, should be a tip-off that we are dealing with a drug that interacts with dopamine receptorsspecifically D2, by blocking them. Amoxapine, the correct answer, is a tricyclic antidepressant (secondary amine). It is rather unique among all the tricyclics (other secondary amines, and tertiary ami ...
PDF
PDF

... Regions nearer the surface of the brain stem stained better than deeper regions, likely due to issues of penetration. Adequate staining was also achieved, however, for structures located deep within the brain when vacuum immersion was used. Included are examples from the dentate nucleus of the cereb ...
Gastrointestinal Disorders and Medication Management Drugs for
Gastrointestinal Disorders and Medication Management Drugs for

... o Diarrhea with magnesium based products o Constipation with aluminum & calcium based products o May contain Simethicone, an anti-gas agent Dosing o 1-3 hours pc & hs o Follow with water o Space antacids 1-2 hours apart from other medications Cautious Use o Electrolyte imbalance o Renal insufficienc ...
INFORMATION PROCESSING WITH POPULATION CODES
INFORMATION PROCESSING WITH POPULATION CODES

... architecture of the brain. What are the units of computation and how is information represented at the neural level? An important part of the answers to these questions is that individual elements of information are encoded not by single cells, but rather by populations or clusters of cells. This en ...
shands - UF Health Professionals
shands - UF Health Professionals

... leukemia (AML). Binding of gemtuzumab ozogamicin to leukemia cells results in cellular internalization of calicheamicin and cell death. The most recent data documenting the efficacy and safety of gemtuzumab ozogamicin in patients with CD33positive AML in first relapse showed an overall rate of remis ...
Powerpoint
Powerpoint

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AntiretroviralAgents..
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The Role of Selective Transport in Neuronal Protein
The Role of Selective Transport in Neuronal Protein

... To assess whether selective microtubule-based vesicle transport underlies the polarized distribution of neuronal proteins, we expressed green fluorescent protein– (GFP-) tagged chimeras of representative axonal and dendritic membrane proteins in cultured hippocampal neurons and visualized the transp ...
Comparison of Drug Approval Process in United States
Comparison of Drug Approval Process in United States

... This topic aims at reviewing the drug filing and different aspects of obtaining United States Food & Drug Administration (USFDA) and European Medicines Agency (EMA) approval for a drug in order to get a Marketing Authorization in US & Europe and their effective role in improving the standards laid d ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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