Orexinergic Input to Dopaminergic Neurons of the Human Ventral
... profoundly influenced by an orexinergic input from the lateral hypothalamus to the VTA. Because the existence and significance of an analogous orexigenic regulatory mechanism acting in the human VTA have been elusive, here we addressed the possibility that orexinergic neurons provide direct input to ...
... profoundly influenced by an orexinergic input from the lateral hypothalamus to the VTA. Because the existence and significance of an analogous orexigenic regulatory mechanism acting in the human VTA have been elusive, here we addressed the possibility that orexinergic neurons provide direct input to ...
Effexor/Effexor XR (venlafaxine)
... The combination of psychotherapy and antidepressants is very effective in treating moderate to severe depression. The medications improve mood, sleep, energy, and appetite, while therapy strengthens coping skills, deals with possible underlying issues, and improves thought patterns and behavior. Eff ...
... The combination of psychotherapy and antidepressants is very effective in treating moderate to severe depression. The medications improve mood, sleep, energy, and appetite, while therapy strengthens coping skills, deals with possible underlying issues, and improves thought patterns and behavior. Eff ...
Corticothalamic feedback and sensory processing
... Whether or not corticothalamic feedback serves a similar role in egocentric selection in the visual and somatosensory systems is an open question, however, results from recent work in the visual system may support the idea of egocentric selection [17]. Although this line of thinking is certainly sp ...
... Whether or not corticothalamic feedback serves a similar role in egocentric selection in the visual and somatosensory systems is an open question, however, results from recent work in the visual system may support the idea of egocentric selection [17]. Although this line of thinking is certainly sp ...
Fibronectin-like lmmunoreactivity in the Developing Cerebral Cortex
... Recent evidence indicates that ECM componentsmight also play a role in the development of the CNS. Fibronectin-like immunoreactivity is presentin the initial parts of the migratory pathway of granule cell precursorsover the surfaceof the cerebellum (Hatten et al., 1982), but it has thus far not been ...
... Recent evidence indicates that ECM componentsmight also play a role in the development of the CNS. Fibronectin-like immunoreactivity is presentin the initial parts of the migratory pathway of granule cell precursorsover the surfaceof the cerebellum (Hatten et al., 1982), but it has thus far not been ...
When thinking about toxicity, we can think about drug metabolizing... a xenobiotic encounters during both phase I and phase II... 20.201 Take-home exam, October 2013
... Question 2 When thinking about toxicity, we can think about drug metabolizing enzymes that a xenobiotic encounters during both phase I and phase II of metabolism, which generally consists of hydrolysis, reduction, oxidation and conjugation reactions. If the drug encounters an enzyme that can convert ...
... Question 2 When thinking about toxicity, we can think about drug metabolizing enzymes that a xenobiotic encounters during both phase I and phase II of metabolism, which generally consists of hydrolysis, reduction, oxidation and conjugation reactions. If the drug encounters an enzyme that can convert ...
BIOFEEDBACK AND YOGA
... onsistent with the idea that mind affects body, and that body affects mind, and possibly related to the fact that emotional upsets often trigger seizures in epileptics, researchers from four laboratories reported at the February, 1974, meeting of the Biofeedback Research Society that a number of epi ...
... onsistent with the idea that mind affects body, and that body affects mind, and possibly related to the fact that emotional upsets often trigger seizures in epileptics, researchers from four laboratories reported at the February, 1974, meeting of the Biofeedback Research Society that a number of epi ...
Article - Archive ouverte UNIGE
... patients with intellectual deficiencies, participated in the study. They presented autism associated with mental retardation ranging from moderate to severe according to the diagnostic criteria of the International Classification of Diseases, 10th edition (ICD-10) [29]. These patients presented the fo ...
... patients with intellectual deficiencies, participated in the study. They presented autism associated with mental retardation ranging from moderate to severe according to the diagnostic criteria of the International Classification of Diseases, 10th edition (ICD-10) [29]. These patients presented the fo ...
Morphological and Functional Types of Neurons
... have been used for cells in the dorsal lateral geniculate nucleus (Guillery, 1966; Updyke, 1979) and a class of interneurons (Tiimbol, 1967; Rainey and Jones, 1983; Spreafico et al., 1983) which appear to be identical to ceils that stain immunocytochemically for glutamic acid decarboxylase, the rate ...
... have been used for cells in the dorsal lateral geniculate nucleus (Guillery, 1966; Updyke, 1979) and a class of interneurons (Tiimbol, 1967; Rainey and Jones, 1983; Spreafico et al., 1983) which appear to be identical to ceils that stain immunocytochemically for glutamic acid decarboxylase, the rate ...
Synapse
... regulation of motor behavior. This distinct characteristic in the pharmacology of cocaethylene provides an opportunity to study the relative contribution(s) of DA and 5-HT molecules on cocaethylene-stimulated behaviors, particularly those associated with stereotypy and exploratory behavior. Indeed, ...
... regulation of motor behavior. This distinct characteristic in the pharmacology of cocaethylene provides an opportunity to study the relative contribution(s) of DA and 5-HT molecules on cocaethylene-stimulated behaviors, particularly those associated with stereotypy and exploratory behavior. Indeed, ...
Nicotine and the adolescent brain
... perturbations of cholinergic systems during this time with nicotine, via tobacco or e-cigarettes, have unique consequences on adolescent development. In this review, we highlight recent clinical and preclinical data examining the adolescent brain’s distinct neurobiology and unique sensitivity to nic ...
... perturbations of cholinergic systems during this time with nicotine, via tobacco or e-cigarettes, have unique consequences on adolescent development. In this review, we highlight recent clinical and preclinical data examining the adolescent brain’s distinct neurobiology and unique sensitivity to nic ...
structure of Macromolecular complexes - CNB
... and highly intertwined research areas with the ultimate scientific goal of identifying specific therapeutic targets potentially useful for disease prevention and control. The first research area is focussed to the dissection of virus-host interactions of highly relevant human and veterinary pathogen ...
... and highly intertwined research areas with the ultimate scientific goal of identifying specific therapeutic targets potentially useful for disease prevention and control. The first research area is focussed to the dissection of virus-host interactions of highly relevant human and veterinary pathogen ...
antibacterial agents - NC State Veterinary Medicine
... Modification of the antibiotic or its target may involve various methodologies, such as production of antibiotic-inactivating or altering enzymes, chemical alterations (such as acetylation or phosphorylation) to the antibiotic or its binding site, or chromosomal or DNA changes that induce protein st ...
... Modification of the antibiotic or its target may involve various methodologies, such as production of antibiotic-inactivating or altering enzymes, chemical alterations (such as acetylation or phosphorylation) to the antibiotic or its binding site, or chromosomal or DNA changes that induce protein st ...
Emergence of Sense-Making Behavior by the Stimulus Avoidance
... 1 Providing external stimuli to cultured neuronal cells. 2 Connection between each neuron is changed by the external stimuli, and thus a behavior represented through the external body is also changed (modifiability). 3 If a behavior that can stop the external stimuli occurs, stimulation is finished ...
... 1 Providing external stimuli to cultured neuronal cells. 2 Connection between each neuron is changed by the external stimuli, and thus a behavior represented through the external body is also changed (modifiability). 3 If a behavior that can stop the external stimuli occurs, stimulation is finished ...
Catabasis Pharmaceuticals Presents Positive Data for CAT
... acid (DHA) using the company’s SMART linker drug discovery platform to enhance the intracellular activity of the bioactive components. CAT-5571 allows sustained intracellular delivery of the two bioactive components leading to activation of autophagy through two different pathways. Autophagy is a pr ...
... acid (DHA) using the company’s SMART linker drug discovery platform to enhance the intracellular activity of the bioactive components. CAT-5571 allows sustained intracellular delivery of the two bioactive components leading to activation of autophagy through two different pathways. Autophagy is a pr ...
Chapter 1: Literature review 1.1. Introduction
... A significant advance in the field of early medicine was Paracelsus’ recognition that all compounds have the capacity to be poisonous depending upon dosage. This has made toxicity testing a necessary and critical industry practice to identify and define safety thresholds for all new potential chemot ...
... A significant advance in the field of early medicine was Paracelsus’ recognition that all compounds have the capacity to be poisonous depending upon dosage. This has made toxicity testing a necessary and critical industry practice to identify and define safety thresholds for all new potential chemot ...
Status Epilepticus was defined by the International Classification of
... should take folic acid 5 mg/day in the preconception period and throughout the pregnancy; vitamin K should be used in the last month of pregnancy in women on enzyme-inducing AEDs. The use of phenytoin, valproate, carbamazepine, lamotrigine, and phenobarbital has been associated with an increased ris ...
... should take folic acid 5 mg/day in the preconception period and throughout the pregnancy; vitamin K should be used in the last month of pregnancy in women on enzyme-inducing AEDs. The use of phenytoin, valproate, carbamazepine, lamotrigine, and phenobarbital has been associated with an increased ris ...
BIOASSAY SCREENINGS- IMPORTANCE IN DRUG RESEARCH
... directed isolation of natural products- Strategies Bioassay-guided fractionation (BGF) and isolation ...
... directed isolation of natural products- Strategies Bioassay-guided fractionation (BGF) and isolation ...
BIOL241 Lab tips Labs17-22
... Activity 3 is to learn the anatomy of the 12 cranial nerves, which can be studied from models or links. http://www.wisc-online.com/objects/ViewObject.aspx?ID=AP11504 The MAJOR part of Lab 19 is the SHEEP BRAIN DISSECTION. Detailed info for this can be found in the Lab 19 handout. Tips for Lab 21- An ...
... Activity 3 is to learn the anatomy of the 12 cranial nerves, which can be studied from models or links. http://www.wisc-online.com/objects/ViewObject.aspx?ID=AP11504 The MAJOR part of Lab 19 is the SHEEP BRAIN DISSECTION. Detailed info for this can be found in the Lab 19 handout. Tips for Lab 21- An ...
Facilitating adverse drug event detection in pharmacovigilance
... limitations: the system captures only approximately 10% of events,3 the number of patients taking any drug is uncertain, and therefore the number of patients actually at risk is unknown. In addition, there are data quality issues preventing its effective use.4 The limitations imply that many serious ...
... limitations: the system captures only approximately 10% of events,3 the number of patients taking any drug is uncertain, and therefore the number of patients actually at risk is unknown. In addition, there are data quality issues preventing its effective use.4 The limitations imply that many serious ...
Full Text - Discovery Publication
... The efficacy of many drugs is often limited by their potential to reach the site of therapeutic action due to various problems such as - poor bioavailability, in vivo stability, solubility, intestinal absorption, sustained and targeted delivery to site of action, therapeutic effectiveness. In most c ...
... The efficacy of many drugs is often limited by their potential to reach the site of therapeutic action due to various problems such as - poor bioavailability, in vivo stability, solubility, intestinal absorption, sustained and targeted delivery to site of action, therapeutic effectiveness. In most c ...
Print PDF - CiplaMed
... Citicoline has been investigated as a therapy for stroke patients. Three mechanisms are postulated: (1) ability to repair neuronal membranes via increased synthesis of phosphatidylcholine; (2) repair of damaged cholinergic neurons via potentiation of acetylcholine production; and, (3) reduction of f ...
... Citicoline has been investigated as a therapy for stroke patients. Three mechanisms are postulated: (1) ability to repair neuronal membranes via increased synthesis of phosphatidylcholine; (2) repair of damaged cholinergic neurons via potentiation of acetylcholine production; and, (3) reduction of f ...
Toxicology Common poisonings and Drugs of Abuse
... the Chinese government attempted to prohibit the importation of opium by the British East India Company in 2001, 404,000 Americans age 12 and older had used heroin; 3.7 million have used heroin at least once euphoric and addictive potential of the opioids is immortalized in the works of several famo ...
... the Chinese government attempted to prohibit the importation of opium by the British East India Company in 2001, 404,000 Americans age 12 and older had used heroin; 3.7 million have used heroin at least once euphoric and addictive potential of the opioids is immortalized in the works of several famo ...
New frontiers in neuroimaging applications to inborn errors of
... Most inborn errors of metabolism (IEMs) are associated with potential for injury to the developing central nervous system resulting in chronic encephalopathy, though the etiopathophysiology of neurological injury have not been fully established in many disorders. Shared mechanisms can be envisioned ...
... Most inborn errors of metabolism (IEMs) are associated with potential for injury to the developing central nervous system resulting in chronic encephalopathy, though the etiopathophysiology of neurological injury have not been fully established in many disorders. Shared mechanisms can be envisioned ...
Table 48-1a - JeromeIBBiology
... neurotransmitter they have the same effect but are not broken down as easily so the effect is stronger because they stay longer in the synapse) • example- nicotine mimics acetylcholine (Ach) - acts on synapses in the brain to cause a calming effect • -enzyme that breaks down acetylcholine cannot b ...
... neurotransmitter they have the same effect but are not broken down as easily so the effect is stronger because they stay longer in the synapse) • example- nicotine mimics acetylcholine (Ach) - acts on synapses in the brain to cause a calming effect • -enzyme that breaks down acetylcholine cannot b ...