Auto-structure of presynaptic activity defines postsynaptic firing
... We have studied then the Fano factor F FC as a measure of clustering of synchronous activity for renewal processes with Gamma- and log-normal -distributed interspike intervals. The Fano factor of the coincidence count distribution for pairs of processes with identical spike-rates is represented in F ...
... We have studied then the Fano factor F FC as a measure of clustering of synchronous activity for renewal processes with Gamma- and log-normal -distributed interspike intervals. The Fano factor of the coincidence count distribution for pairs of processes with identical spike-rates is represented in F ...
Inhibition of Bladder Activity by 5 - Duke Statistical
... In a recent cystometric study of the 5-HT1A receptor agonist (R)-(⫹)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (Thor et al., 2002), normal cat bladders were filled either with saline to innocuously initiate micturition via activation of myelinated A␦ fibers or with dilute acetic acid to noc ...
... In a recent cystometric study of the 5-HT1A receptor agonist (R)-(⫹)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (Thor et al., 2002), normal cat bladders were filled either with saline to innocuously initiate micturition via activation of myelinated A␦ fibers or with dilute acetic acid to noc ...
A Fast, Reciprocal Pathway between the Lateral Geniculate Nucleus
... can drive responses. In the cat, where LGN input to layer 6 may differ in density compared with the primate, physiological studies report that all layer 6 neurons, including corticogeniculate neurons, receive subthreshold geniculocortical input that rarely drives suprathreshold spikes (Ferster and L ...
... can drive responses. In the cat, where LGN input to layer 6 may differ in density compared with the primate, physiological studies report that all layer 6 neurons, including corticogeniculate neurons, receive subthreshold geniculocortical input that rarely drives suprathreshold spikes (Ferster and L ...
Slide 1
... Maps can be generated by intracortical microstimulation Sites controlling individual muscles are distributed over a wide area of motor cortex Muscle representations overlap in cortex Stimulation of single sites activates several muscles (diverging innervation) Many motor cortical neurons contribute ...
... Maps can be generated by intracortical microstimulation Sites controlling individual muscles are distributed over a wide area of motor cortex Muscle representations overlap in cortex Stimulation of single sites activates several muscles (diverging innervation) Many motor cortical neurons contribute ...
The Development of Neural Synchrony and Large
... perception of squares and circles in children (10–12 y), young adults (20–26 y), and older adults (70–76 y). Evoked oscillations in children were significantly reduced between 30 and 148 Hz over occipital electrodes relative to adults and did not show a modulation by the size of the stimulus. Moreov ...
... perception of squares and circles in children (10–12 y), young adults (20–26 y), and older adults (70–76 y). Evoked oscillations in children were significantly reduced between 30 and 148 Hz over occipital electrodes relative to adults and did not show a modulation by the size of the stimulus. Moreov ...
CS 561a: Introduction to Artificial Intelligence
... Increasing the Realism of Neuron Models • The McCulloch-Pitts neuron of 1943 is important as a basis for ...
... Increasing the Realism of Neuron Models • The McCulloch-Pitts neuron of 1943 is important as a basis for ...
What Is A Dietary Supplement?
... • antidepressants • alcohol, sedatives • pain relievers • anxiety medicines • muscle relaxants Overdose Symptoms • tiredness • Sleepiness • poor coordination ...
... • antidepressants • alcohol, sedatives • pain relievers • anxiety medicines • muscle relaxants Overdose Symptoms • tiredness • Sleepiness • poor coordination ...
Corticofugal Modulation of Initial Sound
... onto glass slides and stained using the Nissl method. The electrolytic neurons were measured, two experimental protocols were applied to lesion was examined under a light microscope. An example is shown evaluate the influence of the cortex on the activities of CN neurons. in Figure 1, B and C. One e ...
... onto glass slides and stained using the Nissl method. The electrolytic neurons were measured, two experimental protocols were applied to lesion was examined under a light microscope. An example is shown evaluate the influence of the cortex on the activities of CN neurons. in Figure 1, B and C. One e ...
product information
... The volume of distribution of eletriptan following IV administration is 138L indicating distribution into the tissues. Eletriptan is only moderately protein bound (approximately 85%). Metabolism In-vitro studies indicate that eletriptan is primarily metabolised by cytochrome P-450 enzyme CYP3A4. Thi ...
... The volume of distribution of eletriptan following IV administration is 138L indicating distribution into the tissues. Eletriptan is only moderately protein bound (approximately 85%). Metabolism In-vitro studies indicate that eletriptan is primarily metabolised by cytochrome P-450 enzyme CYP3A4. Thi ...
Oral Fluoroquinolones
... increased bleeding risk; mechanism of this interaction not identified; changes in PT/INR may occur 2-16 days after addition of FQ to warfarin therapy concurrent administration may cause decreased FQ bioavailability and potential for reduced pharmacologic effects concurrent administration may decreas ...
... increased bleeding risk; mechanism of this interaction not identified; changes in PT/INR may occur 2-16 days after addition of FQ to warfarin therapy concurrent administration may cause decreased FQ bioavailability and potential for reduced pharmacologic effects concurrent administration may decreas ...
A Practical Approach to Discontinuing NSAID Therapy Prior to a
... approach using 5 half-lives as a standard.28-30 However, these guidelines do not explain the reasons for using pharmacokinetic principles to aid in clinical decision-making, or provide a quick resource for easy access to relevant pharmacokinetic parameters. In general, to determine when to discontin ...
... approach using 5 half-lives as a standard.28-30 However, these guidelines do not explain the reasons for using pharmacokinetic principles to aid in clinical decision-making, or provide a quick resource for easy access to relevant pharmacokinetic parameters. In general, to determine when to discontin ...
Skeletal Muscle Relaxant
... • Histamine release (by d-tubocurarine) • CVS – Significant fall in BP – Increase in Heart rate – Vagal gangionic blockade (also ‘ve’ and ‘pan’) ...
... • Histamine release (by d-tubocurarine) • CVS – Significant fall in BP – Increase in Heart rate – Vagal gangionic blockade (also ‘ve’ and ‘pan’) ...
Department of Clinical Laboratory Diagnostics
... to the functional diagnostic tests and methods. It describes the most common modern functional diagnostic medical systems and the methodology of the data analysis in pulmonary, cardiac, and Vscan function tests. This discipline is focused on etiology and pathogenesis of organic diseases with the emp ...
... to the functional diagnostic tests and methods. It describes the most common modern functional diagnostic medical systems and the methodology of the data analysis in pulmonary, cardiac, and Vscan function tests. This discipline is focused on etiology and pathogenesis of organic diseases with the emp ...
ANTIDIABETIC ACTIVITY OF SOME HERBAL DRUG
... Jain, S., Gaurav, B., Rakesh, B., Praveen, K., Avnish, J. and Vinod, K. D. (2010). Antidiabetic activity of Paspalum scrobiculatum (Linn). In alloxan induced diabetic rats. Journal of Ethnopharmacology, 127: pp 325-328. Kareru, P. G. (2008). Ethnomedicine Practices, Analysis and Standardization of H ...
... Jain, S., Gaurav, B., Rakesh, B., Praveen, K., Avnish, J. and Vinod, K. D. (2010). Antidiabetic activity of Paspalum scrobiculatum (Linn). In alloxan induced diabetic rats. Journal of Ethnopharmacology, 127: pp 325-328. Kareru, P. G. (2008). Ethnomedicine Practices, Analysis and Standardization of H ...
Strategies for In Vitro Metabolic Stability Testing
... Loss of parent method used most frequently in Discovery Stage (HTS assays) Measure disappearance of low concentration of drug (<5 or 10 µM) When S << Km…..T1/2 = ln2/-k (or 0.693/-k) Terminal elimination rate constant (-k): slope of linear regression from natural log percentage substrate remaining v ...
... Loss of parent method used most frequently in Discovery Stage (HTS assays) Measure disappearance of low concentration of drug (<5 or 10 µM) When S << Km…..T1/2 = ln2/-k (or 0.693/-k) Terminal elimination rate constant (-k): slope of linear regression from natural log percentage substrate remaining v ...
Anti HER2 mAbs
... Ireland, starring Harry Connick, Jr. The film is based on the true life story of Dr. Dennis Slamon. New York (NY): Random House, 1998. 214 pp., illus. ISBN 0-679-45702-X ...
... Ireland, starring Harry Connick, Jr. The film is based on the true life story of Dr. Dennis Slamon. New York (NY): Random House, 1998. 214 pp., illus. ISBN 0-679-45702-X ...
Guidance for Industry Drug Metabolism/Drug Interaction Studies in the Drug Development
... Even for drugs that are not substantially metabolized, the potential effect of that drug on the metabolism of concomitant drugs could be important. Large differences in blood levels can occur because of individual differences in metabolism. Some drugs, such as tricyclic antidepressants, exhibit ord ...
... Even for drugs that are not substantially metabolized, the potential effect of that drug on the metabolism of concomitant drugs could be important. Large differences in blood levels can occur because of individual differences in metabolism. Some drugs, such as tricyclic antidepressants, exhibit ord ...
assembly committee on public safety
... effects of alcohol. Certain generalizations can be made: high doses generally have a larger effect than small doses; well-learned tasks are less affected than novel tasks; and certain variables, such as prior exposure to a drug, can either reduce or accentuate expected effects, depending on circumst ...
... effects of alcohol. Certain generalizations can be made: high doses generally have a larger effect than small doses; well-learned tasks are less affected than novel tasks; and certain variables, such as prior exposure to a drug, can either reduce or accentuate expected effects, depending on circumst ...
Evolution of Association Pallial Areas: In Birds E
... obtain a reward. The animals were able to use this information, memorizing only relevant stimuli. Most importantly, this selectivity was reflected in the memory-period activity of NCL neurons. The vast majority of neurons showed memory related activity when the birds chose to remember; however, this ...
... obtain a reward. The animals were able to use this information, memorizing only relevant stimuli. Most importantly, this selectivity was reflected in the memory-period activity of NCL neurons. The vast majority of neurons showed memory related activity when the birds chose to remember; however, this ...
EVEKEO® (amphetamine sulfate tablets, USP) DESCRIPTION
... potent in causing CNS excitatory effects. The racemic mixture also is less effective as an appetite suppressant when compared to dextroamphetamine. There is neither specific evidence which clearly establishes the mechanism whereby amphetamines produce mental and behavioral effects in children, nor c ...
... potent in causing CNS excitatory effects. The racemic mixture also is less effective as an appetite suppressant when compared to dextroamphetamine. There is neither specific evidence which clearly establishes the mechanism whereby amphetamines produce mental and behavioral effects in children, nor c ...
Why is marijuana illegal
... cigarette smokers, but yet cigs are still legal? What about alcohol? MJ has been around for over 5000 years, and until recently nobody had a problem with it. Government propaganda has trained the American society to believe that this drug is so detrimental to progress in society and users should be ...
... cigarette smokers, but yet cigs are still legal? What about alcohol? MJ has been around for over 5000 years, and until recently nobody had a problem with it. Government propaganda has trained the American society to believe that this drug is so detrimental to progress in society and users should be ...
Lineage origins of GABAergic versus glutamatergic neurons in the
... neurons, and also in a mosaic in the cortical VZ. Fezf2 is required for the specification of subcerebral projection neurons of layer V [38,39], while Tbr1, which is expressed in layer VI neurons is required to specify corticothalamic projection neurons [36,40,41]. In contrast, Satb2 is expressed in ...
... neurons, and also in a mosaic in the cortical VZ. Fezf2 is required for the specification of subcerebral projection neurons of layer V [38,39], while Tbr1, which is expressed in layer VI neurons is required to specify corticothalamic projection neurons [36,40,41]. In contrast, Satb2 is expressed in ...
Neurocircuitry of Addiction
... that result in relapse. The purpose of current neurobiological drug abuse research is to understand the genetic/ epigenetic, cellular, and molecular mechanisms that mediate the transition from occasional, controlled drug use to the loss of behavioral control over drug-seeking and drugtaking and to c ...
... that result in relapse. The purpose of current neurobiological drug abuse research is to understand the genetic/ epigenetic, cellular, and molecular mechanisms that mediate the transition from occasional, controlled drug use to the loss of behavioral control over drug-seeking and drugtaking and to c ...
The use of beta-lactamase inhibitors to reconquer resistance
... against beta-lactamase producing methicillin susceptible staphylococci as well as Haemophilus spp, Moraxella spp and many others. Tazobactam as an addition to piperacillin is another widely used combination. Both clavulanic acid and tazobactam, as well as sulbactam, another betalactamase inhibitor, ...
... against beta-lactamase producing methicillin susceptible staphylococci as well as Haemophilus spp, Moraxella spp and many others. Tazobactam as an addition to piperacillin is another widely used combination. Both clavulanic acid and tazobactam, as well as sulbactam, another betalactamase inhibitor, ...
Cnidarians and the evolutionary origin of the nervous system Review
... nervous system and eye-bearing sensory complex (Rhopalia) of cnidarians, an increasing number of examples indicating the evolutionary convergence in both nervous and sensory systems (Nishikawa 2002) make it difficult to simply compare cnidarian and bilaterian neural structures and to place the evolu ...
... nervous system and eye-bearing sensory complex (Rhopalia) of cnidarians, an increasing number of examples indicating the evolutionary convergence in both nervous and sensory systems (Nishikawa 2002) make it difficult to simply compare cnidarian and bilaterian neural structures and to place the evolu ...