Pathophysiology of Paresthesia
... sensitization and alleviate chronic pain. Various protein regulation is seen in peripheral sensitization, peripheral nerve injury induced by various animal studies changes transient receptor potential (TRP) channel expression. TRP channels are a family of nonselective cation-permeable channels that ...
... sensitization and alleviate chronic pain. Various protein regulation is seen in peripheral sensitization, peripheral nerve injury induced by various animal studies changes transient receptor potential (TRP) channel expression. TRP channels are a family of nonselective cation-permeable channels that ...
D2 receptor overexpression in the striatum leads to a deficit in
... that SKF-81297 at a concentration of 1 μM significantly enhanced NMDA receptor (NMDAR) currents and trafficking in the PFC neurons (25, 26). We found that bath application of SKF-81297 (1 μM) for 10 min caused significant depression in IPSCs trains recorded from both D2R-OE and control mice. Fig. 4 A a ...
... that SKF-81297 at a concentration of 1 μM significantly enhanced NMDA receptor (NMDAR) currents and trafficking in the PFC neurons (25, 26). We found that bath application of SKF-81297 (1 μM) for 10 min caused significant depression in IPSCs trains recorded from both D2R-OE and control mice. Fig. 4 A a ...
Periodicity and Pitch - Auditory Neuroscience
... The observed orientation of their periodotopic map (mediodorsal to latero-ventral for high to low) appears to differ from that described by Schreiner & Langner (1988) in the cat (predimonantly caudal to ...
... The observed orientation of their periodotopic map (mediodorsal to latero-ventral for high to low) appears to differ from that described by Schreiner & Langner (1988) in the cat (predimonantly caudal to ...
Drugs for constipation and Diarrhoea
... stool, accumulates fluids and fatty substance thus softening the stool. • Administered orally or as retention enema. • Should not be given with liquid paraffin, because increase absorption of it. ...
... stool, accumulates fluids and fatty substance thus softening the stool. • Administered orally or as retention enema. • Should not be given with liquid paraffin, because increase absorption of it. ...
Pharmacogenomics
... We are all different. Some of our differences translate into how we react to drugs as individuals. This is why personalized medicine is important to everyone. ...
... We are all different. Some of our differences translate into how we react to drugs as individuals. This is why personalized medicine is important to everyone. ...
Pharmacokinetics and doses of anti-TB drugs in children
... – Efficacy of Mfx in adults with TB shown in several studies • Cmax was higher than the mutant prevention concentration 90% (MPC90) of in vitro studies for MFX (1.2μg/mL) • Limited data on Mfx use in children with MDR-TB, but current recommended dose of 7.5-10mg/kg may be too low. Studies in younger ...
... – Efficacy of Mfx in adults with TB shown in several studies • Cmax was higher than the mutant prevention concentration 90% (MPC90) of in vitro studies for MFX (1.2μg/mL) • Limited data on Mfx use in children with MDR-TB, but current recommended dose of 7.5-10mg/kg may be too low. Studies in younger ...
VetACE Bioavailability and Pharmacodynamic Effect
... individual dog’s percentage reduction in ACE activity compared to their baseline value for Fortekor and VetACE at 3 and 23 hours after each dose, respectively. ...
... individual dog’s percentage reduction in ACE activity compared to their baseline value for Fortekor and VetACE at 3 and 23 hours after each dose, respectively. ...
Brain Part
... Most basic functions (sensory & motor) are equally controlled by both left & right hemispheres (remember communication exists through corpus callosum). o However, for some association functions, one hemisphere has greater control over language-related activities including speech, writing, reading, m ...
... Most basic functions (sensory & motor) are equally controlled by both left & right hemispheres (remember communication exists through corpus callosum). o However, for some association functions, one hemisphere has greater control over language-related activities including speech, writing, reading, m ...
E(R) - Consciousness Online
... Uninformative stimuli bring less information but elicit a higher response than the 55% cues. It is not the information per se! It is its utility to the organism. After all, attention MUST be selective! ...
... Uninformative stimuli bring less information but elicit a higher response than the 55% cues. It is not the information per se! It is its utility to the organism. After all, attention MUST be selective! ...
Mirror neurons and the social nature of language
... anti-anthropomorphism, according to which human traits are a priori uniquely human. By following the anti-anthropomorphism bias, many scholars in the cognitive sciences exclusively focus on clarifying differences between humans and other primates with respect to the use of propositional attitudes. A ...
... anti-anthropomorphism, according to which human traits are a priori uniquely human. By following the anti-anthropomorphism bias, many scholars in the cognitive sciences exclusively focus on clarifying differences between humans and other primates with respect to the use of propositional attitudes. A ...
Challenges Associated with Current and Future TB
... that is, the hypothesis that there are subpopulations of organisms that span the spectrum from actively growing bacteria to metabolically quiescent ones. It appears that one or more of these bacterial subpopulations, although they are genetically drug-sensitive, can display phenotypic drug-resistanc ...
... that is, the hypothesis that there are subpopulations of organisms that span the spectrum from actively growing bacteria to metabolically quiescent ones. It appears that one or more of these bacterial subpopulations, although they are genetically drug-sensitive, can display phenotypic drug-resistanc ...
Suggestion from clinicians
... duloxetine is indicated for neuropathic pain and for pain associated with fibromyalgia. Isolated cases of hepatic injury have been reported but there is no requirement for routine monitoring of liver enzymes. Desvenlafaxine, an SNRI, is the active metabolite of venlafaxine. The recommended dose is 5 ...
... duloxetine is indicated for neuropathic pain and for pain associated with fibromyalgia. Isolated cases of hepatic injury have been reported but there is no requirement for routine monitoring of liver enzymes. Desvenlafaxine, an SNRI, is the active metabolite of venlafaxine. The recommended dose is 5 ...
A C , Oct. 2005, p. 4358–4361 Vol. 49, No. 10
... Cryptococcus neoformans is an encapsulated yeast-like fungus of worldwide distribution that is a relatively frequent cause of serious disease in immunocompromised patients. Amphotericin B (AMB) is recommended in combination with flucytosine for the treatment of cryptococcosis (16). AMB is purported ...
... Cryptococcus neoformans is an encapsulated yeast-like fungus of worldwide distribution that is a relatively frequent cause of serious disease in immunocompromised patients. Amphotericin B (AMB) is recommended in combination with flucytosine for the treatment of cryptococcosis (16). AMB is purported ...
CHAPTER 41
... changes in arterial Po2 in the range of 60 down to 30 mm Hg, a range in which hemoglobin saturation with oxygen decreases rapidly. Effect of Carbon Dioxide and Hydrogen Ion Concentration on Chemoreceptor Activity. ...
... changes in arterial Po2 in the range of 60 down to 30 mm Hg, a range in which hemoglobin saturation with oxygen decreases rapidly. Effect of Carbon Dioxide and Hydrogen Ion Concentration on Chemoreceptor Activity. ...
How Do Neurons Convey Information?
... electrons) to a body that contains a lower charge (fewer electrons). The body with the higher electrical charge is called the negative pole, because electrons are negatively charged and this body has more of them. The body with the lower electrical charge is called the positive pole. Electricity is ...
... electrons) to a body that contains a lower charge (fewer electrons). The body with the higher electrical charge is called the negative pole, because electrons are negatively charged and this body has more of them. The body with the lower electrical charge is called the positive pole. Electricity is ...
Thieme: Brain Imaging
... Frequency: 1–2:100 000 Peak age: 3–5 years The disorder can manifest itself at any age. Etiology, pathophysiology, pathogenesis Histopathology resembles multiple sclerosis, with acute demyelinating inflammation of the brain and spinal cord In contrast to MS, the course is monophasic Acute disseminat ...
... Frequency: 1–2:100 000 Peak age: 3–5 years The disorder can manifest itself at any age. Etiology, pathophysiology, pathogenesis Histopathology resembles multiple sclerosis, with acute demyelinating inflammation of the brain and spinal cord In contrast to MS, the course is monophasic Acute disseminat ...
The Serotonin Syndrome - Department of Psychiatry
... Downloaded from www.nejm.org at UNIVERSITY OF TORONTO on August 18, 2010. For personal use only. No other uses without permission. Copyright © 2005 Massachusetts Medical Society. All rights reserved. ...
... Downloaded from www.nejm.org at UNIVERSITY OF TORONTO on August 18, 2010. For personal use only. No other uses without permission. Copyright © 2005 Massachusetts Medical Society. All rights reserved. ...
Purves ch. 8 + Kandel ch. 23 - Weizmann Institute of Science
... nerve endings, which in turn affects the ionic permeability of the receptor cell membrane. Changes in permeability generate a depolarizing current in the nerve ending, thus producing a receptor (or generator) potential that triggers action potentials, as described in Chapters 2 and 3. This overall p ...
... nerve endings, which in turn affects the ionic permeability of the receptor cell membrane. Changes in permeability generate a depolarizing current in the nerve ending, thus producing a receptor (or generator) potential that triggers action potentials, as described in Chapters 2 and 3. This overall p ...
FULL TEXT PDF - An International Journal of Experimental and
... by extension neuronal dysfunction, are tightly modulated, in fact controlled, by a number of non-neuronal cells. Many of these are glial cells including astrocytes, microglial cells, and oligodendrocytes. ...
... by extension neuronal dysfunction, are tightly modulated, in fact controlled, by a number of non-neuronal cells. Many of these are glial cells including astrocytes, microglial cells, and oligodendrocytes. ...
Tau pathology does not affect experience-driven single
... tau in neurodegenerative disease, little data directly test the hypothesis that tangles, per se, impair neuronal function. In fact, there is no conclusive evidence for a mechanistic role of NFTs in dysregulation of nervous system, either on a single-neuron or neuronal network level. We hypothesized ...
... tau in neurodegenerative disease, little data directly test the hypothesis that tangles, per se, impair neuronal function. In fact, there is no conclusive evidence for a mechanistic role of NFTs in dysregulation of nervous system, either on a single-neuron or neuronal network level. We hypothesized ...
perspective - IMBB
... A comparison of the gene sets given precedence from samples analyzed on Affymetrix and spotted platforms is given in Tables 1 and 2. Of the 89 genes of Table 1 and the 49 genes of Table 2, only 8 genes are common to both gene sets (Fig. 1a). Surprisingly, expression of 7 of the 8 common genes is fou ...
... A comparison of the gene sets given precedence from samples analyzed on Affymetrix and spotted platforms is given in Tables 1 and 2. Of the 89 genes of Table 1 and the 49 genes of Table 2, only 8 genes are common to both gene sets (Fig. 1a). Surprisingly, expression of 7 of the 8 common genes is fou ...
Should My Loved One Be Taking the Alzheimer`s Medicines?
... Researchers and a number of neurologists have recommended that patients with Alzheimer’s take one of the medicines for early stage and the medicine for middle stage together (during the same day), if they can tolerate the side effects of the medicines. The most common side effects of these medicines ...
... Researchers and a number of neurologists have recommended that patients with Alzheimer’s take one of the medicines for early stage and the medicine for middle stage together (during the same day), if they can tolerate the side effects of the medicines. The most common side effects of these medicines ...
Highly Specific Olfactory Receptor Neurons for Types of Amino
... response range (EMRR) to amino acids (i.e., Group I units), we initially failed to document the occurrence of units that exhibited a broader response specificity. However, to obtain an estimate of the percentage of Group I units, we performed a subset of experiments consisting of 164 different elect ...
... response range (EMRR) to amino acids (i.e., Group I units), we initially failed to document the occurrence of units that exhibited a broader response specificity. However, to obtain an estimate of the percentage of Group I units, we performed a subset of experiments consisting of 164 different elect ...
Lecture Presentation for Chapter 17
... store information in the nervous system. New learning and memory formation can involve new neurons, new synapses, or changes in synapses in response to biochemical signals. Neuroplasticity (or neural plasticity) is the ability of neurons and neural circuits to be remodeled by experience or the ...
... store information in the nervous system. New learning and memory formation can involve new neurons, new synapses, or changes in synapses in response to biochemical signals. Neuroplasticity (or neural plasticity) is the ability of neurons and neural circuits to be remodeled by experience or the ...
Structure–function relationship of working memory activity with
... (2) to investigate whether there was any evidence for differential structure–function relationships between subject groups. Accordingly, we used two different models to identify relevant regions and investigate the possibility of group differences. In one approach (‘‘main effect’’ model), we first i ...
... (2) to investigate whether there was any evidence for differential structure–function relationships between subject groups. Accordingly, we used two different models to identify relevant regions and investigate the possibility of group differences. In one approach (‘‘main effect’’ model), we first i ...