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神经系统传导通路
神经系统传导通路

... The auditory impulsion is conducing of two sides. If one side path above lateral lemniscus is damaged, the obvious symptom wouldn’t happen. But if the cochlear nerve, internal ear or middle ear is damaged, auditory handicap will be induced. ...
Alpha-2 Adrenergic Regulation of Melatonin Release in Chick
Alpha-2 Adrenergic Regulation of Melatonin Release in Chick

... rhythm of melatonin biosynthesis, with elevated levels at night and low levels during the day. The rhythm of melatonin is regulated both by circadian oscillators located within the gland itself and by adrenergic input from the sympathetic nervous system. Previous work has shown that norepinephrine a ...
and clinical implications Chantal Guillemette1,3
and clinical implications Chantal Guillemette1,3

... evidence linking UGT1A1*28 allele and dose-limiting toxicities, and a number of studies supporting that genotyping of the UGT1A1*28 allele prior to irinotecan administration in CRC patients would be cost-effective.19 This marker thus falls into the category of pharmacogenetic markers associated with ...
Orthotopic transplantation of immortalized
Orthotopic transplantation of immortalized

... Here we examined whether CSM14.1 cells grafted bilaterally orthotopically in the substantia nigra of hemiparkinsonian rats have the potential to differentiate into dopaminergic neurons. Adult male rats received 6-hydroxydopamine into the right medial forebrain bundle, and successful lesions were eva ...
Transcripts/01_15 11
Transcripts/01_15 11

... (except olfaction) is relayed to the cortex via the thalamus. The recurring theme is that almost everything on its way to the cortex goes through the thalamus, not just sensory but other things as well. ii. Motor: The descending motor pathways and the corticospinal tract don’t go through the thalamu ...
MS Word DOC - AvianBrain.org
MS Word DOC - AvianBrain.org

... major histogenetic divisions: the pallium and the subpallium. The existence of these two divisions is based on developmental, molecular, and connectivity data explained below. If we consider the telencephalon isolated from the rest of the brain, the pallium is located at the top of the telencephalic ...
7 - Down Web
7 - Down Web

... Medication must be used with particular care in the elderly. The definition of elderly is difficult because until a generation ago people in their 60s would have been considered elderly, now its more likely to be those over 75. It also depends on the individual, how lucky they have been to have rema ...
Prosjektoppgave - Mirror neurons_ver4.2
Prosjektoppgave - Mirror neurons_ver4.2

... from the hand field of the F1 area (primary motor cortex) were recorded, the thinking being that if the observation of the experimenter's actions would trigger some comparable movement in the monkey's F5 region, it should also activate the neurons in the F1 region that control them. None of the neu ...
The role of the hypothalamic dorsomedial nucleus in the central
The role of the hypothalamic dorsomedial nucleus in the central

... Major projections relay vagus-mediated signals from the gastrointestinal tract, and humoral signals to the hypothalamus from the nucleus of the solitary tract (NTS), a viscerosensory cell group in the dorsomedial medulla. In contrast to tonically active adiposity signals providing ongoing messages, ...
Tutorial on Pattern Classification in Cell Recording
Tutorial on Pattern Classification in Cell Recording

... neural data. We assume that neural recordings have been made from a number of trials in which different conditions were present, and our procedure produces an estimate of how accurately we can predict the labels of these conditions in a new set of data. We call this estimate of future prediction the ...
Chirally Pure NoN-Steroidal aNti
Chirally Pure NoN-Steroidal aNti

... and S(+)Ibuprofen. R-Ibuprofen and Dexibuprofen differ in their physicochemical, pharmacological and metabolic properties. S-Ibuprofen or Dexibuprofen is the pharmacologically active enantiomer of racemic Ibuprofen. Dexibuprofen is the S(+) (dextrorotatory)-enantiomer of Ibuprofen and accounts for v ...
Basic Concepts in Medicinal Chemistry - Review
Basic Concepts in Medicinal Chemistry - Review

... with references) might enhance the book. Assessment This is an excellent introduction to the fundamental principles of medicinal chemistry, focusing primarily on the physicochemical properties of functional groups, the broad concept of structure-activity relationships, the basics of drug metabolism, ...
The habenular nuclei - Philosophical Transactions of the Royal
The habenular nuclei - Philosophical Transactions of the Royal

... The LHb is a point of convergence for neural information from the basal ganglia and limbic forebrain. A major source of innervation of the LHb in the rat derives from the entopeduncular nucleus (EP, which is the non-primate equivalent of the internal segment of the globus pallidus). In the rat, virt ...
Children's intellectual ability is associated with structural network integrity
Children's intellectual ability is associated with structural network integrity

... Recent structural and functional neuroimaging studies of adults suggest that efficient patterns of brain connectivity are fundamental to human intelligence. Specifically, whole brain networks with an efficient small-world organization, along with specific brain regions (i.e., Parieto-Frontal Integration ...
file
file

... lysosomal storage disorders primarily affecting children. Patients share common features like accumulation of autofluorescent storage material, neuronal degeneration, and suffer from motor disturbances, progressive loss of vision and premature death. To date, nine genes have been detected to cause N ...
Novel approaches to explore mechanisms of
Novel approaches to explore mechanisms of

... Epilepsy comprises a family of neurological disorders characterized by recurrent seizures, which can be highly debilitating. Up to 30% of patients with temporal lobe epilepsy, the most common form of the disorder in adults, arising in the hippocampus, cannot be effectively treated by current pharmac ...
07-Managing Pain
07-Managing Pain

... – Changes in the spinal column and brain control the flow of neural impulses – Parts of spinal column can either • increase (open the gate) or ...
Contribution of Pedunculopontine Tegmental Nucleus Neurons to
Contribution of Pedunculopontine Tegmental Nucleus Neurons to

... The correlation between the tonic discharges or the responses to the FP and RTFP was also examined. To examine motivation toward the task, we classified error trials into three types depending on which portion of the task the monkey failed to perform and analyzed the relationship between the error t ...
Cytochrome P450
Cytochrome P450

... Many drugs may increase or decrease the activity of various CYP isozymes in a phenomenon known as enzyme induction and inhibition. This is a major source of adverse drug interactions, since changes in CYP enzyme activity may affect the metabolism and clearance of various drugs. For example, if one d ...
Presynaptic proteins involved in exocytosis in <Emphasis Type
Presynaptic proteins involved in exocytosis in

... The fundamental aspects of neurotransmission have tong been studied at the electrophysiological level and were expounded upon by Katz (1969), who introduced the 'calcium hypothesis' of neurotransmitter release. This model is now widely accepted and can be summarized as follows. Following the integra ...
Artificial Neural Networks - A Science in Trouble
Artificial Neural Networks - A Science in Trouble

... notions of this field. Under this notion, it is construed that individual cells modify their synaptic strengths (connection weights) solely on the basis of their "input and output behavior." The input and output information of a cell may include information about the error in the performance of a gi ...
Reflex Activity/Lab
Reflex Activity/Lab

...  Effector: the quadriceps femoris muscle group (agonists) contracts and extends the leg when stimulated Activity: Testing the Patellar Reflex 1) Choose one member of your group to be the subject. Have the subject sit on the edge of a table or tall lab chair with the knees off the table or chair and ...
Epistatic interaction of CREB1 and KCNJ6 on rumination and
Epistatic interaction of CREB1 and KCNJ6 on rumination and

... al., 1993, 1994, 1997; Just and Alloy, 1997). As rumination is a relatively stable trait, regardless of the current depression level (Nolen-Hoeksema and Davis, 1999; Watkins, 2009), a genetic determination is probable. However, up to now only two studies have addressed this question. Hilt et al. rep ...
David Hunter Hubel. 27 February 1926 — 22 September 2013
David Hunter Hubel. 27 February 1926 — 22 September 2013

... time of their experiments, there was little idea, much less experimental evidence, about how this reconstruction came about. What was known about the neuronal mechanisms of the cat retina was largely based on the investigations of Steve Kuffler on the output neurons of the retina, the ganglion cells ...
Chapter 7: Consciousness
Chapter 7: Consciousness

... Biofeedback • It provides awareness of systems people are not normally aware of (such as heart rate) – Allows control of physical responses not normally under conscious control • Greatest success is in treating chronic headaches (especially migraines) • Many benefits are related to relaxation ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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