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Neural Correlates of Object-Associated Choice Behavior
Neural Correlates of Object-Associated Choice Behavior

... Task-factor analysis and multicollinearity control. Neurons that significantly modulated their activity during the task events were further subjected to a two-way ANOVA with the object category (toy and egg) and spatial choice (left and right touch responses) as main factors. If the ANOVA showed sig ...
Strychnine
Strychnine

... metabolites accounted for less than 1%. The major enzyme responsible for metabolism was the cytochrome P450 mono-oxygenase [8]. Excretion: strychnine is excreted in the urine and can be detected there 24 h or more following ingestion [3]. Only 20% or less is excreted unchanged in the urine (reviewed ...
Structural brain MRI studies in eye diseases: are they clinically
Structural brain MRI studies in eye diseases: are they clinically

... Many eye diseases reduce visual acuity or are associated with visual field defects. Because of the well-defined retinotopic organization of the connections of the visual pathways, this may affect specific parts of the visual pathways and cortex, as a result of either deprivation or transsynaptic degener ...
$doc.title

... mediated by proteins synthesised by the parasite and exported into the host RBC as well as by host-derived proteins (Leech et.al, 1984; Johnson et.al, 1994). The ring stage of infection is characterised by minimal alterations or deformations in the gross anatomy of the erythrocyte membrane. The ring ...
HD CAG Repeat Is Sufficient to Cause a Progressive
HD CAG Repeat Is Sufficient to Cause a Progressive

... a number of components to the motor disorder including a resting tremor, movements described as resembling chorea, stereotypic involuntary movements, and in some cases a mild ataxia manifesting as dysmetria. One of the first symptoms is a dyskinesia of the limbs when held by the tail. This progresse ...
new-local anaethetic
new-local anaethetic

... It prevents the conduction by blocking the sodium ion channels. Blocking is achieved either by  The drug causing a physical block in the channel like a cork in a bottle  The drug molecule distorting the channels ...
Understanding Circuit Dynamics Using the Stomatogastric Nervous
Understanding Circuit Dynamics Using the Stomatogastric Nervous

... Recent years have seen a rebirth of interest in understanding how neural circuits generate behavior. Therefore, it is a particularly good time to review and critically examine what we know about the stomatogastric nervous system (STNS), one of the premier systems for analyzing how circuit dynamics a ...
PowerPoint Document - Minnesota Brain Injury Alliance
PowerPoint Document - Minnesota Brain Injury Alliance

... of TBI with rates estimated between 11 and 34%. • Aggression can result from delirium, mood disorder, or personality change secondary to TBI. • Individuals who demonstrate aggression following TBI have been found to have higher prevalence of newonset major depressive symptoms, poorer pre-and postinj ...
Salvinorin A, an Active Component of the Hallucinogenic Sage
Salvinorin A, an Active Component of the Hallucinogenic Sage

... The work was supported by U.S. Public Health Service Grant RO1 DA04123 from National Institute on Drug Abuse (to C.C.) and by the National Institute of Mental Health Psychoactive Drug Screening Program and KO2MH01366 and RO1DA017204 (to B.L.R.). Article, publication date, and citation information ca ...
Part B
Part B

A COMMON REFERENCE FRAME FOR MOVEMENT PLANS IN
A COMMON REFERENCE FRAME FOR MOVEMENT PLANS IN

... ahead. On the other hand, relative to your left arm, which is by your side, the coffee is to the right. The cup’s location can also be described in a reference frame that depends on the external world rather than the location of your body; for example, relative to its position on the table. Being ab ...
Quality Assessment of the Commonly Prescribed Antimicrobial Drug
Quality Assessment of the Commonly Prescribed Antimicrobial Drug

... bioequivalence of drug products, and drug product selection have emerged as critical issues in pharmacy and medicine during the last three decades. Concern about lowering health care costs has resulted in a tremendous increase in the use of generic drug products; currently about one half of all pres ...
Kevin Schuer
Kevin Schuer

... 3. McFarlin DE, McFarland HF. Multiple sclerosis (first of two parts). N Engl J Med 1982;307(19):1183-8. 4. Inglese M, van Waesberghe JH, Rovaris M, et al. The effect of interferon beta-1b on quantities derived from MT MRI in secondary progressive MS. Neurology 2003;60(5):853-60. 5. Lublin FD. The d ...
Concurrent Disorders - Saskatoon Health Region
Concurrent Disorders - Saskatoon Health Region

... treatment settings have revealed prevalence rates of 40-60% for substance use disorders in subjects presenting with a mental disorder. Numerous factors can make the identification and successful treatment of these individuals difficult including symptom overlap between the disorders, finite treatmen ...
Regional anaesthesia in patients on newer
Regional anaesthesia in patients on newer

... P2Y12 receptor. It is a cyclopentyl-triazolo-pyrimidine, which is administered orally in its active form and does not need the metabolic activation required with thienopyridines. Ticagrelor targets the P2Y12 receptor via a mechanism that is noncompetitive with ADP, suggesting the existence of a bind ...
Evaluation of analgesic activity of Evodia lunu-ankenda
Evaluation of analgesic activity of Evodia lunu-ankenda

... marked analgesic activity and is equipotent to standard analgesic drugs. The present study establishes the effectiveness and pharmacological rationale for use of Evodia lunu-ankenda as an analgesic drug. the drug may be further explored for its phytochemical profile to identify the active constituen ...
Action, time and the basal ganglia - Philosophical Transactions of
Action, time and the basal ganglia - Philosophical Transactions of

... system is converted into a reference signal for the body configuration control system. With integration in the output function of the velocity control system, the velocity error signal is proportional to the rate of change in the body configuration reference. The higher the velocity reference, the f ...
Nervous System: Spinal Cord and Spinal Nerves
Nervous System: Spinal Cord and Spinal Nerves

... Trauma and disorders: -often result from damage or pressure Paralysis = loss of motor function: disorder of ventral root or anterior gray horn Paresthesias = sensory loss: disorder of dorsal root or posterior gray horn -complete transection results in loss of both motor and sensory below injury Par ...
Innovative approaches to anti-arrhythmic drug
Innovative approaches to anti-arrhythmic drug

... are abnormal depolarizations falling during AP phases 2 or 3 (early after-depolarizations (EADs)), or phase 4 (delayed after-depolarizations (DADs)) (FIG. 2B,C). EADs are caused by factors that impair repolarization, allowing for re-activation of inward currents that depolarize the cell prematurely. ...
Activity in the Lateral Prefrontal Cortex Reflects Multiple Steps of
Activity in the Lateral Prefrontal Cortex Reflects Multiple Steps of

... start display changed its color after delay periods, the monkeys initiated the first movement. Thereafter, they performed the second and third movements, each after a delay period, to capture the goal. Our previous behavioral study demonstrated that this task provides a behavioral model in which mon ...
The Pedunculopontine Tegmental Nucleus as a Motor and
The Pedunculopontine Tegmental Nucleus as a Motor and

... As an important component of ascending activating systems, brainstem cholinergic neurons in the pedunculopontine tegmental nucleus (PPTg) are involved in the regulation of motor control (locomotion, posture and gaze) and cognitive processes (attention, learning and memory). The PPTg is highly interc ...
T2 - Center for Neural Basis of Cognition
T2 - Center for Neural Basis of Cognition

... Remapping in humans produces activity in the hemisphere ipsilateral to the stimulus. Remapped activity is present in human parietal, extrastriate and striate cortex. Remapped visual signals are more prevalent at higher levels of the visual system hierarchy. Remapping occurs in parietal and visual co ...
Bain 2006 - American Geriatrics Society
Bain 2006 - American Geriatrics Society

... -has no potential for abuse, tolerance, or rebound insomnia after discontinuation -is safe in overdose -has fixed dosing with no need to reduce the optimal dose in elderly patients -addresses the physiologic condition underlying insomnia General recommendations -risk benefit analysis of potential ag ...
I in the Pacing of Subthreshold Oscillations h
I in the Pacing of Subthreshold Oscillations h

... in vitro slices to investigate the specific biophysical and pharmacological properties of the current underlying this inward rectification and to clarify its potential role in the genesis of the subthreshold oscillations. In voltage-clamp conditions, hyperpolarizing voltage steps evoked a slow, noni ...
Exercise and Anxiety Take Home Messages
Exercise and Anxiety Take Home Messages

... i. Higher after 45 min of treadmill running 1) In males who run at least 4 times a week for the previous 6 months b. Cycling i. Higher after 45 min of stationary cycling 1) In males who cycle at least 4 times a week for the previous 6 months c. As endocannabinoids are rapidly degraded, exercise caus ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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