Neurosurgery: Functional Regeneration after Laser Axotomy
... light depends on its polarization. A fast mechanical shutter is used to select the desired number of pulses for the ablation experiments. The laser beam is tightly focused inside the sample through an oil-immersion high numerical aperture objective lens (Zeiss 64×, NA=1.4). The fluorescence imaging ...
... light depends on its polarization. A fast mechanical shutter is used to select the desired number of pulses for the ablation experiments. The laser beam is tightly focused inside the sample through an oil-immersion high numerical aperture objective lens (Zeiss 64×, NA=1.4). The fluorescence imaging ...
Toxicologic Pathology - Ocular Therapeutix, Inc.
... while maintaining a sustained drug delivery to the anterior and posterior segment during a prolonged period of time. Hydrophilic drugs, which penetrate through the sclera, are more effective when given by the subconjunctival route, because they do not have to penetrate the conjunctival epithelium. T ...
... while maintaining a sustained drug delivery to the anterior and posterior segment during a prolonged period of time. Hydrophilic drugs, which penetrate through the sclera, are more effective when given by the subconjunctival route, because they do not have to penetrate the conjunctival epithelium. T ...
Synaesthesia: reconciling the subjective with the objective
... began. Behaviourism had banished reference to mental states from scientific language, but, with the rise of cognitivism, mental phenomena once more became legitimate targets for scientific study. As a probable consequence, within the last 20 years, research into synaesthesia has enjoyed something of ...
... began. Behaviourism had banished reference to mental states from scientific language, but, with the rise of cognitivism, mental phenomena once more became legitimate targets for scientific study. As a probable consequence, within the last 20 years, research into synaesthesia has enjoyed something of ...
NutraSweet
... assimilation of whole-food proteins containing these amino acids AND aspartame. There is no unbalanced flooding of single amino acids into the system when proteins are slowly digested to produce single amino acids. Consuming phenylalanine as dietary protein does not significantly elevate plasma or b ...
... assimilation of whole-food proteins containing these amino acids AND aspartame. There is no unbalanced flooding of single amino acids into the system when proteins are slowly digested to produce single amino acids. Consuming phenylalanine as dietary protein does not significantly elevate plasma or b ...
The role of sodium channels in neuropathic pain
... decreases in Nav1.1, Nav1.2, and Nav1.7 expression in axotomised DRG neurons [38,40,52], it would appear that Nav1.3 becomes the predominant TTX-S channel in injured DRG neurons. Significantly, the ectopic discharges and mechanical allodynia associated with the SNL model of neuropathic pain are both ...
... decreases in Nav1.1, Nav1.2, and Nav1.7 expression in axotomised DRG neurons [38,40,52], it would appear that Nav1.3 becomes the predominant TTX-S channel in injured DRG neurons. Significantly, the ectopic discharges and mechanical allodynia associated with the SNL model of neuropathic pain are both ...
Contacts among non-sister dendritic branches at
... of dendritic segments composing the contact (shown in Fig. 3A, left panel). The radius of 3.75 μm was selected as sufficient to include the combined length of a spine and bouton, and thence reflect enrichment of synapses around the structures, but not including other synapses further away. BDIs had ...
... of dendritic segments composing the contact (shown in Fig. 3A, left panel). The radius of 3.75 μm was selected as sufficient to include the combined length of a spine and bouton, and thence reflect enrichment of synapses around the structures, but not including other synapses further away. BDIs had ...
Spike Timing-Dependent Plasticity: From Synapse to Perception
... blocked by Mg2⫹ at hyperpolarized membrane potentials, but the block can be relieved by depolarization (69, 83), leading to the idea that the NMDAR serves as the coincidence detector for pre/post activity. For LTP and LTD induced by conventional protocols, different cascades of signaling events are ...
... blocked by Mg2⫹ at hyperpolarized membrane potentials, but the block can be relieved by depolarization (69, 83), leading to the idea that the NMDAR serves as the coincidence detector for pre/post activity. For LTP and LTD induced by conventional protocols, different cascades of signaling events are ...
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... When analyzing architectonic organization in the PFC, Barbas and Pandya (21) found two distinct trends in gradual changes in laminar characteristics that can be traced from the limbic periallocortex toward the isocortical areas. Based on cytoarchitectonic and myeloarchitectonic analysis, they observ ...
... When analyzing architectonic organization in the PFC, Barbas and Pandya (21) found two distinct trends in gradual changes in laminar characteristics that can be traced from the limbic periallocortex toward the isocortical areas. Based on cytoarchitectonic and myeloarchitectonic analysis, they observ ...
What Is The “Safest” Non-Steroidal Anti
... adverse reaction profile; “safety” priorities should be individualized based upon patient’s concurrent illnesses. This review will discuss the potential adverse reactions of both conventions (non-selective) and selective NSAIDs according to specific organ systems. Cardiovascular effect: During the l ...
... adverse reaction profile; “safety” priorities should be individualized based upon patient’s concurrent illnesses. This review will discuss the potential adverse reactions of both conventions (non-selective) and selective NSAIDs according to specific organ systems. Cardiovascular effect: During the l ...
Neuronal Regulation Implements Efficient Synaptic Pruning
... By studying NR-driven synaptic modification in the framework of associative memory networks, we show that NR prunes the weaker synapses and modifies the remaining synapses in a sigmoidal manner. The critical variables that govern the pruning process are the degradation dimension and the upper synapt ...
... By studying NR-driven synaptic modification in the framework of associative memory networks, we show that NR prunes the weaker synapses and modifies the remaining synapses in a sigmoidal manner. The critical variables that govern the pruning process are the degradation dimension and the upper synapt ...
Drug - HAL
... quasi-species. Both replication-competent and replication-deficient clones could be mixed and used for transfection. The analysis of intracellular viral DNA replicative intermediates, synthesized in the presence or absence of antivirals, enabled to determine the drugs’ IC50 and IC90 for each clinica ...
... quasi-species. Both replication-competent and replication-deficient clones could be mixed and used for transfection. The analysis of intracellular viral DNA replicative intermediates, synthesized in the presence or absence of antivirals, enabled to determine the drugs’ IC50 and IC90 for each clinica ...
University of Groningen Species and strain differences in drug
... Animal models are commonly used in the preclinical development of new drugs to predict the metabolic behaviour of new compounds in human. It is however important to realize that humans differ from animals with regard to isoform composition, expression and catalytic activities of drug metabolizing en ...
... Animal models are commonly used in the preclinical development of new drugs to predict the metabolic behaviour of new compounds in human. It is however important to realize that humans differ from animals with regard to isoform composition, expression and catalytic activities of drug metabolizing en ...
abstracts
... I would like to invite you to attend and contribute to the International Symposium on Drug Research and Development “From Chemistry to Medicine” DRD 2011 and New Horizons and Job Opportunities for Young Scientists which is organized by Hacettepe University, Medicinal Chemistry Research, Development ...
... I would like to invite you to attend and contribute to the International Symposium on Drug Research and Development “From Chemistry to Medicine” DRD 2011 and New Horizons and Job Opportunities for Young Scientists which is organized by Hacettepe University, Medicinal Chemistry Research, Development ...
Guidelines on the quality, safety, and efficacy of biotherapeutic
... These guidelines are intended to provide national regulatory authorities (NRAs) and manufacturers with guidance on the quality, safety and efficacy of biotherapeutic protein products prepared by recombinant deoxyribonucleic acid (DNA) technology (rDNAderived biotherapeutics) and intended for use in ...
... These guidelines are intended to provide national regulatory authorities (NRAs) and manufacturers with guidance on the quality, safety and efficacy of biotherapeutic protein products prepared by recombinant deoxyribonucleic acid (DNA) technology (rDNAderived biotherapeutics) and intended for use in ...
Perception Spike Timing-Dependent Plasticity: From Synapse to
... blocked by Mg2" at hyperpolarized membrane potentials, but the block can be relieved by depolarization (69, 83), leading to the idea that the NMDAR serves as the coincidence detector for pre/post activity. For LTP and LTD induced by conventional protocols, different cascades of signaling events are ...
... blocked by Mg2" at hyperpolarized membrane potentials, but the block can be relieved by depolarization (69, 83), leading to the idea that the NMDAR serves as the coincidence detector for pre/post activity. For LTP and LTD induced by conventional protocols, different cascades of signaling events are ...
Inositol: A Scientific Evaluation Of Its Clinical Ef F E C T
... stimulator, activates phospholipase C in order to produce inositol-1,4,5triphosphate which releases calcium from intracellular stores and stimulates uterine contractions (Colodny L et al, 1998). Calcium agonists such as inositol have been shown to affect dose-related myometrial contractions in labor ...
... stimulator, activates phospholipase C in order to produce inositol-1,4,5triphosphate which releases calcium from intracellular stores and stimulates uterine contractions (Colodny L et al, 1998). Calcium agonists such as inositol have been shown to affect dose-related myometrial contractions in labor ...
Pharma Drugs Isolated from Plants
... it as the important ingredient in medicines, although it is important to note that their chemical structure was often not fully elucidated until many years later. Serturner isolated the painkiller morphine, and other alkaloids such as codeine and narcotine, from opium (the dried latex of the poppy P ...
... it as the important ingredient in medicines, although it is important to note that their chemical structure was often not fully elucidated until many years later. Serturner isolated the painkiller morphine, and other alkaloids such as codeine and narcotine, from opium (the dried latex of the poppy P ...
Phage Therapy
... conducted in vitro, as well as a number in vivo; usually in mice. One such study by H. Williams Smith and M. B. Huggins at the Houghton Poultry Research Station focused specifically on comparing the effectiveness of phage therapy against traditional antibiotics in live mice infected with Escherichia ...
... conducted in vitro, as well as a number in vivo; usually in mice. One such study by H. Williams Smith and M. B. Huggins at the Houghton Poultry Research Station focused specifically on comparing the effectiveness of phage therapy against traditional antibiotics in live mice infected with Escherichia ...
Opioid Induced Hyperalgesia
... Activation of descending fibers from the RVM after chronic morphine administration facilitates nociceptive ...
... Activation of descending fibers from the RVM after chronic morphine administration facilitates nociceptive ...
Astaxanthin - Pure Encapsulations
... Skin Support: Initial trials with astaxanthin suggest that it may boost the skin’s natural antioxidant defenses against ultraviolet induced free radicals. In a human clinical evaluation, supplementation with astaxanthin for two weeks provided significant antioxidant protection for the skin. In cell ...
... Skin Support: Initial trials with astaxanthin suggest that it may boost the skin’s natural antioxidant defenses against ultraviolet induced free radicals. In a human clinical evaluation, supplementation with astaxanthin for two weeks provided significant antioxidant protection for the skin. In cell ...
Rebamipide Delivered by Brushite Cement Enhances Osteoblast and Macrophage Proliferation
... While many studies have successfully improved bone regrowth by delivering various therapeutic agents, only BMP-2 is widely used clinically. Most biological agents are expensive to purify, even in small quantities, and stimulation of new bone growth requires large amounts[17]. Furthermore, it is diff ...
... While many studies have successfully improved bone regrowth by delivering various therapeutic agents, only BMP-2 is widely used clinically. Most biological agents are expensive to purify, even in small quantities, and stimulation of new bone growth requires large amounts[17]. Furthermore, it is diff ...
Neuron
... 2001; Rushworth et al., 2001; Sohn et al., 2000) have identified brain regions apparently involved in set shifting. These regions include the posterior parietal cortex (PPC) and the prefrontal cortex (PFC), both of which showed larger activation during trials in which subjects shifted their cognitiv ...
... 2001; Rushworth et al., 2001; Sohn et al., 2000) have identified brain regions apparently involved in set shifting. These regions include the posterior parietal cortex (PPC) and the prefrontal cortex (PFC), both of which showed larger activation during trials in which subjects shifted their cognitiv ...
Introduction to Data Communication Networks - DSpace
... •Eg . Measurement of blood PH from blood samples. ...
... •Eg . Measurement of blood PH from blood samples. ...
Multicentric Lymphoma in the Dog
... Arriving at a diagnosis of lymphoma is typically fairly straightforward. Fine needle aspirate (FNA) of an enlarged lymph node often provides the initial or presumptive diagnosis of the most common lymphomas. The mandibular lymph nodes are often reactive, so cytologic samples should target other lymp ...
... Arriving at a diagnosis of lymphoma is typically fairly straightforward. Fine needle aspirate (FNA) of an enlarged lymph node often provides the initial or presumptive diagnosis of the most common lymphomas. The mandibular lymph nodes are often reactive, so cytologic samples should target other lymp ...
NIH Public Access - Medicinal Genomics
... The epilepsies are a diverse collection of neurological disorders involving recurrent and unprovoked seizures that are the manifestation of abnormal electrical activity in the central nervous system (CNS), and they represent one of the most common neurological diseases, with a lifetime incidence of ...
... The epilepsies are a diverse collection of neurological disorders involving recurrent and unprovoked seizures that are the manifestation of abnormal electrical activity in the central nervous system (CNS), and they represent one of the most common neurological diseases, with a lifetime incidence of ...