Brca1 is required for embryonic development of the mouse cerebral
... To examine the effects of conditional Brca1 ablation on the neocortex, we first analyzed the size and gross morphology of the P4.5 brain. Compared with the control, Brca1-ablated brains showed a reduction in size specific to the cerebral cortex (Fig. 1C). The whole-brain weight of Brca1-ablated mice ...
... To examine the effects of conditional Brca1 ablation on the neocortex, we first analyzed the size and gross morphology of the P4.5 brain. Compared with the control, Brca1-ablated brains showed a reduction in size specific to the cerebral cortex (Fig. 1C). The whole-brain weight of Brca1-ablated mice ...
Chapter 14b - Dr. Jerry Cronin
... Neurons innervate smooth muscles in walls of blood vessels in skeletal muscles and the brain Produce vasodilation and increased blood flow ...
... Neurons innervate smooth muscles in walls of blood vessels in skeletal muscles and the brain Produce vasodilation and increased blood flow ...
Hit discovery and hit-to-lead approaches
... for prioritizing structures for focused screening [12,13] or fragment-based lead discovery [14,15]. In vitro biochemical and cellular assays have long been used for HTS of approximately a million drug-like molecules in miniaturized formats [16]. Typically, single-point experiments are performed with ...
... for prioritizing structures for focused screening [12,13] or fragment-based lead discovery [14,15]. In vitro biochemical and cellular assays have long been used for HTS of approximately a million drug-like molecules in miniaturized formats [16]. Typically, single-point experiments are performed with ...
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... 䡲 OBJECTIVE: Tinnitus is a distressing symptom that affects up to 15% of the population; no satisfactory treatment exists. We present a novel surgical approach for the treatment of intractable tinnitus based on electrical extradural stimulation of the dorsolateral prefrontal cortex via an electrode ...
... 䡲 OBJECTIVE: Tinnitus is a distressing symptom that affects up to 15% of the population; no satisfactory treatment exists. We present a novel surgical approach for the treatment of intractable tinnitus based on electrical extradural stimulation of the dorsolateral prefrontal cortex via an electrode ...
P otective effects of inhaled ipratropium ... on bronchoconstriction induced by adenosine
... provoked by adenosine and AMP occurs through the enhanced release of histamine from preactivated airway mast cells. Recently, PEACHELL et al. [6) have demonstrated that in immunologically stimulated human lung mast cells adenosine not only enhances histamine release, but also potentiates prostanoid ...
... provoked by adenosine and AMP occurs through the enhanced release of histamine from preactivated airway mast cells. Recently, PEACHELL et al. [6) have demonstrated that in immunologically stimulated human lung mast cells adenosine not only enhances histamine release, but also potentiates prostanoid ...
Phase Precession and Variable Spatial Scaling in a Periodic
... HD component (see Fig. 1A for a 1D diagram of this connectivity). Thus, the intermediate, conjunctive cell layer moved the position of the activity bump in the chart, and translated the rat’s movement in the environment into a movement through a 2D continuum of attractors or neural states. Each of t ...
... HD component (see Fig. 1A for a 1D diagram of this connectivity). Thus, the intermediate, conjunctive cell layer moved the position of the activity bump in the chart, and translated the rat’s movement in the environment into a movement through a 2D continuum of attractors or neural states. Each of t ...
imaging in multiple sclerosis
... have been detected by diffusion measures. As with MTI changes, these can occur early in the clinical course of MS and can precede new lesion formation. Several studies have reported a relation between DWI changes in normal appearing brain tissue and disability in different MS subtypes. DWI has not y ...
... have been detected by diffusion measures. As with MTI changes, these can occur early in the clinical course of MS and can precede new lesion formation. Several studies have reported a relation between DWI changes in normal appearing brain tissue and disability in different MS subtypes. DWI has not y ...
Visual function before and after the removal of bilateral congenital
... and 21 months (when they were clearly present). At that stage PD’s visual system seems to have still been relatively plastic: our paper documents a wide range of neural adaptations resulting from the peculiarities of his visual input. In contrast, PD’s post-operative re-adaptation over time has thus ...
... and 21 months (when they were clearly present). At that stage PD’s visual system seems to have still been relatively plastic: our paper documents a wide range of neural adaptations resulting from the peculiarities of his visual input. In contrast, PD’s post-operative re-adaptation over time has thus ...
Kuzbanian Controls Proteolytic Processing of Notch
... the extracellular domains encode constitutively active receptors, and in some instances are found to be localized in the nucleus (reviewed in Artavanis-Tsakonas et al., 1995). These observations led to the hypothesis that upon ligand activation, Notch is proteolytically processed to release its cyto ...
... the extracellular domains encode constitutively active receptors, and in some instances are found to be localized in the nucleus (reviewed in Artavanis-Tsakonas et al., 1995). These observations led to the hypothesis that upon ligand activation, Notch is proteolytically processed to release its cyto ...
Neuronal responses to face-like and facial stimuli in the monkey
... Since it has been reported that individual sSC neurons are not sensitive to shape (Schiller and Koerner, 1971; Goldberg and Wurtz, 1972), we hypothesized that population activity of sSC neurons could better discriminate these prototypical facial stimuli than activity of individual sSC neurons. It is ...
... Since it has been reported that individual sSC neurons are not sensitive to shape (Schiller and Koerner, 1971; Goldberg and Wurtz, 1972), we hypothesized that population activity of sSC neurons could better discriminate these prototypical facial stimuli than activity of individual sSC neurons. It is ...
Feedforward and feedback frequency
... of electrode recording arrays and other techniques, experimental studies in recent years have not only yielded increasing information about dynamical interactions between pairs of cortical areas but also begun to reveal the complex FF and FB signaling flow among many cortical regions in a large-scal ...
... of electrode recording arrays and other techniques, experimental studies in recent years have not only yielded increasing information about dynamical interactions between pairs of cortical areas but also begun to reveal the complex FF and FB signaling flow among many cortical regions in a large-scal ...
a review on the pharmacology of embelia ribes burm.f.
... Though the new era has seen advances in chemistry, which have paved the way to reproduce the active ingredients found in plants, but plants still will continue to have the medicinal importance in their own right. Their active components may be slightly modified to improve their efficacy or to reduce ...
... Though the new era has seen advances in chemistry, which have paved the way to reproduce the active ingredients found in plants, but plants still will continue to have the medicinal importance in their own right. Their active components may be slightly modified to improve their efficacy or to reduce ...
Bayesian Spiking Neurons II: Learning
... time about events in the external world or the body. We proceed to develop a theory of Bayesian learning in spiking neural networks, where the neurons learn to recognize temporal dynamics of their synaptic inputs. Meanwhile, successive layers of neurons learn hierarchical causal models for the senso ...
... time about events in the external world or the body. We proceed to develop a theory of Bayesian learning in spiking neural networks, where the neurons learn to recognize temporal dynamics of their synaptic inputs. Meanwhile, successive layers of neurons learn hierarchical causal models for the senso ...
Differential effects of 10-Hz and 40
... one to assess exogenous attention. Experimental sessions were conducted in an electrically-shielded, sound-attenuated booth, and stimuli were presented on a cathode ray tube (CRT) monitor positioned 75 cm from the participant, using Presentation software (v.18.1; www.neurobs.com). The trial sequence ...
... one to assess exogenous attention. Experimental sessions were conducted in an electrically-shielded, sound-attenuated booth, and stimuli were presented on a cathode ray tube (CRT) monitor positioned 75 cm from the participant, using Presentation software (v.18.1; www.neurobs.com). The trial sequence ...
Toxicologic Pathology - Ocular Therapeutix, Inc.
... while maintaining a sustained drug delivery to the anterior and posterior segment during a prolonged period of time. Hydrophilic drugs, which penetrate through the sclera, are more effective when given by the subconjunctival route, because they do not have to penetrate the conjunctival epithelium. T ...
... while maintaining a sustained drug delivery to the anterior and posterior segment during a prolonged period of time. Hydrophilic drugs, which penetrate through the sclera, are more effective when given by the subconjunctival route, because they do not have to penetrate the conjunctival epithelium. T ...
2009 Gout Pharmacology
... •gastrointestinal (nausea, vomiting, cramping, diarrhea, abdominal pain) •hematologic (agranulocytosis, aplastic anemia, thrombocytopenia) •muscular weakness adverse effects dose-related & more common when patient has renal or hepatic disease ...
... •gastrointestinal (nausea, vomiting, cramping, diarrhea, abdominal pain) •hematologic (agranulocytosis, aplastic anemia, thrombocytopenia) •muscular weakness adverse effects dose-related & more common when patient has renal or hepatic disease ...
Synaesthesia: reconciling the subjective with the objective
... began. Behaviourism had banished reference to mental states from scientific language, but, with the rise of cognitivism, mental phenomena once more became legitimate targets for scientific study. As a probable consequence, within the last 20 years, research into synaesthesia has enjoyed something of ...
... began. Behaviourism had banished reference to mental states from scientific language, but, with the rise of cognitivism, mental phenomena once more became legitimate targets for scientific study. As a probable consequence, within the last 20 years, research into synaesthesia has enjoyed something of ...
Neurosurgery: Functional Regeneration after Laser Axotomy
... light depends on its polarization. A fast mechanical shutter is used to select the desired number of pulses for the ablation experiments. The laser beam is tightly focused inside the sample through an oil-immersion high numerical aperture objective lens (Zeiss 64×, NA=1.4). The fluorescence imaging ...
... light depends on its polarization. A fast mechanical shutter is used to select the desired number of pulses for the ablation experiments. The laser beam is tightly focused inside the sample through an oil-immersion high numerical aperture objective lens (Zeiss 64×, NA=1.4). The fluorescence imaging ...
RATIONALIZATION OF TWO DOSAGE FORMS OF A MODEL COMPOUND ALPRAZOLAM,
... effects are influenced by environmental factors such as age, disease, drug interactions due to co-administration etc [3,4,11]. Based on these pharmaco-metabonomic phenotyping has been used in the individualization of drug dosages [5]and metabolic signatures have been used for prediction of efficacie ...
... effects are influenced by environmental factors such as age, disease, drug interactions due to co-administration etc [3,4,11]. Based on these pharmaco-metabonomic phenotyping has been used in the individualization of drug dosages [5]and metabolic signatures have been used for prediction of efficacie ...
Regional and laminar distribution of the vesicular glutamate
... (Barroso-Chinea et al., 2007). In the MGC, VGluT1 mRNA expression was confined to the MGv, whereas neurons expressing VGluT2 were widely distributed in all divisions. In consideration of all of these findings, then, it appears that VGluT2-ir is a general marker of the glutamatergic thalamocortical pro ...
... (Barroso-Chinea et al., 2007). In the MGC, VGluT1 mRNA expression was confined to the MGv, whereas neurons expressing VGluT2 were widely distributed in all divisions. In consideration of all of these findings, then, it appears that VGluT2-ir is a general marker of the glutamatergic thalamocortical pro ...
An evaluation of the anti-inflammatory activity auranofin
... 20th century as a disease modifying anti-rheumatic drug. Auranofin, an oral antirheumatic drug, has been used for many years in the treatment of rheumatoid arthritis (RA). Although the drug has been successful in treating the symptoms of RA, many patients discontinue its use due to severe toxicity o ...
... 20th century as a disease modifying anti-rheumatic drug. Auranofin, an oral antirheumatic drug, has been used for many years in the treatment of rheumatoid arthritis (RA). Although the drug has been successful in treating the symptoms of RA, many patients discontinue its use due to severe toxicity o ...
Full Text - Harvard University
... The notion of the generalized drive D, in particular, has been extremely controversial and has largely fallen out of use. Prominent figures in psychology such as Bolles argued that specific drive alone may be sufficient to explain motivated behaviors, as 'by the time we have discovered what the asso ...
... The notion of the generalized drive D, in particular, has been extremely controversial and has largely fallen out of use. Prominent figures in psychology such as Bolles argued that specific drive alone may be sufficient to explain motivated behaviors, as 'by the time we have discovered what the asso ...