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syllabus - option b(human biochemistry)
syllabus - option b(human biochemistry)

... RNA has ribose as its pentose sugar; DNA has deoxyribose. Deoxyribose lacks an oxygen atom on C2. RNA has uracil instead of thymine as its base. RNA is a single‑strand nucleic acid; DNA is a doublestrand nucleic acid. The structure has two nucleic acid strands that spiral around an axis. Students sh ...
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Genetics and Heredity

... Tay-Sachs disease is caused by a dysfunctional enzyme that fails to break down brain lipids of a certain class. Is proportionately high incidence of TaySachs disease among Ashkenazic Jews, Jewish people whose ancestors lived in central Europe Sickle-cell disease, which affects one out of 400 Africa ...
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... a | Nuclease-induced double-strand breaks (DSBs) can lead to sequence insertion, nucleotide correction or change (red box) through homology-directed repair (HDR) in the presence of a donor DNA or a single-strand oligodeoxynucleotide (ssODN), both of which contain homology arms. DSBs can also be repa ...
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Identification and Characterization of the Potato Leafroll Virus
Identification and Characterization of the Potato Leafroll Virus

... The start codons used for the 23K ORF and 17K ORF are the first A U G codons following a stop codon ('k) in the same frame. ...
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SP12+ P12 (1+2) Urease: determination of inhibitor

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SP12+ P12 (1+2) Urease: determination of inhibitor
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... scroll over the first nucleotide of the new start codon to obtain the coordinate value. Note that there should be no stop codons between the original and proposed alternative start codon. In the example shown in Figure5.4, there are no start codons upstream of the proposed start codon, and there is ...
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... We have identified 15 CYP1B1 mutations, five of which have not been previously reported: E173K, D291G, G329V, R368C, I399V. We used bioinformatics tools and did protein homology modeling of the CYP1B1 protein using information at databases and located our mutations and other known CYP1B1 mutations i ...
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What is a gene mutation and how do mutations occur

... Different forms of a gene (e.g., normal and mutant) are referred to as alleles. Since diploid organisms carry two copies of each gene, they may carry identical alleles, that is, be homozygous for a gene, or carry different alleles, that is, be heterozygous for a gene. A recessive mutation is one in ...
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Glossary Excerpted with modification from the Glossary in Genes V

... indirectly) by linkage relationships; equivalent to a chromosome. Linking number is the number of times the two strands of a closed DNA duplex cross over each other. Locus is the position on a chromosome at which the gene for a particular trait resides; locus may be occupied by any one of the allele ...
Are nonessential amino acids not so redundant for Chinese hamster
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... ishing phosphorylation of the mTOR signaling effectors, 4E-BP1 and S6, and increasing phosphorylation of the AAR sensor, eIF2α [13] . In addition to regulation of protein stability and translation rates, amino acid depletion enhances translation of a subset of mRNA molecules, including certain trans ...
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Genetic code



The genetic code is the set of rules by which information encoded within genetic material (DNA or mRNA sequences) is translated into proteins by living cells. Biological decoding is accomplished by the ribosome, which links amino acids in an order specified by mRNA, using transfer RNA (tRNA) molecules to carry amino acids and to read the mRNA three nucleotides at a time. The genetic code is highly similar among all organisms and can be expressed in a simple table with 64 entries.The code defines how sequences of these nucleotide triplets, called codons, specify which amino acid will be added next during protein synthesis. With some exceptions, a three-nucleotide codon in a nucleic acid sequence specifies a single amino acid. Because the vast majority of genes are encoded with exactly the same code (see the RNA codon table), this particular code is often referred to as the canonical or standard genetic code, or simply the genetic code, though in fact some variant codes have evolved. For example, protein synthesis in human mitochondria relies on a genetic code that differs from the standard genetic code.While the genetic code determines the protein sequence for a given coding region, other genomic regions can influence when and where these proteins are produced.
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