王青青_Tumor Immunology
... • Cell-mediated immunity plays a key role in tumor rejection. • Humoral immunity (antibodies) and innate immunity also play a role in the defense against tumors. ...
... • Cell-mediated immunity plays a key role in tumor rejection. • Humoral immunity (antibodies) and innate immunity also play a role in the defense against tumors. ...
T Cell Differentiation - The Journal of Immunology
... and memory B cells (precursors); and 2) the observation that in vitro, several days of culture are required to generate effector CTL from the CTL precursors (16, 17). This model was intensively used in theoretical research by several authors studying the dynamics of CTL responses to viral infections ...
... and memory B cells (precursors); and 2) the observation that in vitro, several days of culture are required to generate effector CTL from the CTL precursors (16, 17). This model was intensively used in theoretical research by several authors studying the dynamics of CTL responses to viral infections ...
Phagocytosis in Teleosts. Implications of the New Cells Involved
... intruder in the second step. The last three decades of study greatly improved our knowledge of how the immune system initiated and developed the refined immune mechanisms actually present on invertebrates and vertebrates. Among these mechanisms, phagocytosis is always seen as crucial. Phagocytosis i ...
... intruder in the second step. The last three decades of study greatly improved our knowledge of how the immune system initiated and developed the refined immune mechanisms actually present on invertebrates and vertebrates. Among these mechanisms, phagocytosis is always seen as crucial. Phagocytosis i ...
T cell
... recognized by lymphocytes and elicits a response from them • A lymphocyte actually recognizes and binds to just a small, accessible portion of the antigen called an epitope or an antigenic determinant (4-5 a.a). ...
... recognized by lymphocytes and elicits a response from them • A lymphocyte actually recognizes and binds to just a small, accessible portion of the antigen called an epitope or an antigenic determinant (4-5 a.a). ...
Dendritic Cells: A Basic Review
... against cancer needs to continue. Since each cancer is heterogeneous, it is likely that immunity against multiple antigens may be required for complete, effective immunity against cancer. In the future, it may be possible to screen each cancer and determine which “cocktail” of antigens is required t ...
... against cancer needs to continue. Since each cancer is heterogeneous, it is likely that immunity against multiple antigens may be required for complete, effective immunity against cancer. In the future, it may be possible to screen each cancer and determine which “cocktail” of antigens is required t ...
Relevance of sexual dimorphism to regulatory T cells: estradiol
... cells to sense their antigenic environment with a predilection for lipids and glycolipid ligands presented by the nonpolymorphic ...
... cells to sense their antigenic environment with a predilection for lipids and glycolipid ligands presented by the nonpolymorphic ...
Discriminating between Different Pathways of Memory CD8 T Cell
... and memory B cells (precursors); and 2) the observation that in vitro, several days of culture are required to generate effector CTL from the CTL precursors (16, 17). This model was intensively used in theoretical research by several authors studying the dynamics of CTL responses to viral infections ...
... and memory B cells (precursors); and 2) the observation that in vitro, several days of culture are required to generate effector CTL from the CTL precursors (16, 17). This model was intensively used in theoretical research by several authors studying the dynamics of CTL responses to viral infections ...
Evaluation of the Cell-mediated Immune
... reactivity was also observed when the cellular response was In this study, in addition to CRA and MCA, the measured by a visual microcytotoxicity assay, although emphasis was placed on an assay in which cytotoxicity was reactivity dropped off more rapidly and became undetecta measured by the release ...
... reactivity was also observed when the cellular response was In this study, in addition to CRA and MCA, the measured by a visual microcytotoxicity assay, although emphasis was placed on an assay in which cytotoxicity was reactivity dropped off more rapidly and became undetecta measured by the release ...
Mature Dendritic Cells Derived from Human Monocytes
... the yield of isolated cells (13), most experimental and clinical studies currently rely on the in vitro development of DC-like cells from CD34⫹ progenitor cells or blood monocytes (14 –16). Commonly, monocytes are cultured for 5–7 days with GM-CSF and IL-4 to generate immature DCs that have to be ac ...
... the yield of isolated cells (13), most experimental and clinical studies currently rely on the in vitro development of DC-like cells from CD34⫹ progenitor cells or blood monocytes (14 –16). Commonly, monocytes are cultured for 5–7 days with GM-CSF and IL-4 to generate immature DCs that have to be ac ...
Cells - HAL
... APC. After 2 hours, cells were stained with FITC-conjugated CD11b, to discriminate APC. In order to distinguish internalization of cellular material from conjugates, B cells were stained with phycocyanin-5-coupled CD19 and CD20. Endocytosis was assessed by the percentage of PKH26+ cells within the C ...
... APC. After 2 hours, cells were stained with FITC-conjugated CD11b, to discriminate APC. In order to distinguish internalization of cellular material from conjugates, B cells were stained with phycocyanin-5-coupled CD19 and CD20. Endocytosis was assessed by the percentage of PKH26+ cells within the C ...
Epiligrin, A Component of Epithelial Basement Membranes, Is An
... Dako Corp. (Carpinteria, CA). mAbs to epiligrin (P1E1, P3H9-2, P3E4) and fibronectin (PIHll, P3D4) were produced by the methods of Oi and Herzenberg (1980) and Taggart and Samloff (1983) as described (Wayner and Carter, 1987; Wayner et al., 1988, 1989; Garcia-Pardo et al., 1992) using cultured kerat ...
... Dako Corp. (Carpinteria, CA). mAbs to epiligrin (P1E1, P3H9-2, P3E4) and fibronectin (PIHll, P3D4) were produced by the methods of Oi and Herzenberg (1980) and Taggart and Samloff (1983) as described (Wayner and Carter, 1987; Wayner et al., 1988, 1989; Garcia-Pardo et al., 1992) using cultured kerat ...
Evasion of Immunity I
... releasing toxic components which kill the cell. Cells involved in cellular immunity must be able to recognise self, especially as many of their targets are cells infected by agents that are within them. This means killing ones own cells in an effort to rid the infection. Self recognition is mediated ...
... releasing toxic components which kill the cell. Cells involved in cellular immunity must be able to recognise self, especially as many of their targets are cells infected by agents that are within them. This means killing ones own cells in an effort to rid the infection. Self recognition is mediated ...
Expression of NTRK1/TrkA affects immunogenicity of neuroblastoma
... High expression of the neurotrophic tyrosine kinase type 1 receptor, NTRK1, also named TrkA, is associated with a favorable prognosis in neuroblastoma.8 TrkA activation by binding of the specific ligand, nerve growth factor (NGF), inhibits angiogenesis, induces differentiation and growth arrest and m ...
... High expression of the neurotrophic tyrosine kinase type 1 receptor, NTRK1, also named TrkA, is associated with a favorable prognosis in neuroblastoma.8 TrkA activation by binding of the specific ligand, nerve growth factor (NGF), inhibits angiogenesis, induces differentiation and growth arrest and m ...
Chapter 43
... Amplifying Lymphocytes by Clonal Selection • In the body there are few lymphocytes with antigen receptors for any particular epitope ...
... Amplifying Lymphocytes by Clonal Selection • In the body there are few lymphocytes with antigen receptors for any particular epitope ...
Understanding the Immune System: How it works
... chains and two light chains. The variable region, which differs from one antibody to the next, allows an antibody to recognize its matching antigen. ...
... chains and two light chains. The variable region, which differs from one antibody to the next, allows an antibody to recognize its matching antigen. ...
Section VIII - BC Centre for Disease Control
... of cells and molecules that make up the immune system. Immunity is the ability of the human body to tolerate the presence of material indigenous to the body (self), and to eliminate foreign (non-self) material. Foreign substances such as viruses, bacteria, toxins, and parasites are surrounded by ant ...
... of cells and molecules that make up the immune system. Immunity is the ability of the human body to tolerate the presence of material indigenous to the body (self), and to eliminate foreign (non-self) material. Foreign substances such as viruses, bacteria, toxins, and parasites are surrounded by ant ...
The three families of innate lymphoid cells
... The three families of innate lymphoid cells Group 1 ILC Natural killer cells are the prototypical group 1 ILC and are characterized by the production of IFN-γ and the murine surface markers CD27, CD11b, CD127, KLRG-1, the natural cytotoxicity receptor (NCR) NKp46 and in some mouse strains NK1.1 (9, ...
... The three families of innate lymphoid cells Group 1 ILC Natural killer cells are the prototypical group 1 ILC and are characterized by the production of IFN-γ and the murine surface markers CD27, CD11b, CD127, KLRG-1, the natural cytotoxicity receptor (NCR) NKp46 and in some mouse strains NK1.1 (9, ...
Review Article The Role of Th17 in Neuroimmune
... gastritis induced by ATPase from gastric parietal cells as the target antigen. They found that while each injection of Th1, Th2 and Th17 cells induced gastritis, the transfer of Th17 effector cells caused the most dramatic pathology. At 4 weeks of cell injection, 20% of Th1 recipient, 60% of the Th2 ...
... gastritis induced by ATPase from gastric parietal cells as the target antigen. They found that while each injection of Th1, Th2 and Th17 cells induced gastritis, the transfer of Th17 effector cells caused the most dramatic pathology. At 4 weeks of cell injection, 20% of Th1 recipient, 60% of the Th2 ...
Paracrine control of tissue regeneration and cell proliferation by
... receptor activation by enhancing the phosphorylation of receptor-interacting protein (RIP) 1 and RIP3.27 Even though cell death may not absolutely require Caspase-3 and Caspase-7, activation of these specific proteases is still of significant biological importance in the context of tissue homeostasi ...
... receptor activation by enhancing the phosphorylation of receptor-interacting protein (RIP) 1 and RIP3.27 Even though cell death may not absolutely require Caspase-3 and Caspase-7, activation of these specific proteases is still of significant biological importance in the context of tissue homeostasi ...
Compartmentalizing intestinal epithelial cell toll
... intestinal epithelia critically influences epithelial cell proliferation and differentiation, maintenance of tight junctions, synthesis and release of antimicrobial peptides, and induction of pro- or anti-inflammatory responses, respectively [15, 16]. As the intestinal epithelial cells are at the fr ...
... intestinal epithelia critically influences epithelial cell proliferation and differentiation, maintenance of tight junctions, synthesis and release of antimicrobial peptides, and induction of pro- or anti-inflammatory responses, respectively [15, 16]. As the intestinal epithelial cells are at the fr ...
Stem cell biology is population biology: differentiation of
... Thus, organismal performance is intimately connected to HSCs and their products [6-9]. The myeloid products of the HSC system are particularly important for antipredator and foraging behaviors and general immune response and the lymphoid products of the HSC system are essential for specific immune re ...
... Thus, organismal performance is intimately connected to HSCs and their products [6-9]. The myeloid products of the HSC system are particularly important for antipredator and foraging behaviors and general immune response and the lymphoid products of the HSC system are essential for specific immune re ...
Anatomy of the Lymphatic and Immune Systems
... chemical structure on the surface of a pathogen that binds to T or B lymphocyte antigen receptors. Once activated by binding to antigen, B cells dierentiate into cells that secrete a soluble form of their surface antibodies. These activated B cells are known as plasma cells. ...
... chemical structure on the surface of a pathogen that binds to T or B lymphocyte antigen receptors. Once activated by binding to antigen, B cells dierentiate into cells that secrete a soluble form of their surface antibodies. These activated B cells are known as plasma cells. ...
Cytochrome P450s in human immune cells regulate IL-22
... The environmentally sensitive transcription factor aryl hydrocarbon receptor (AHR) has immunemodulating functions and responds to small molecules. Cytochrome P4501 enzymes (CYP1) act downstream of the AHR and metabolize small molecules. However, it is currently unknown whether CYP1 activity is relev ...
... The environmentally sensitive transcription factor aryl hydrocarbon receptor (AHR) has immunemodulating functions and responds to small molecules. Cytochrome P4501 enzymes (CYP1) act downstream of the AHR and metabolize small molecules. However, it is currently unknown whether CYP1 activity is relev ...
Blood vessels: the endothelium
... transport albumin conjugated to lipids into tissues. To accomplish this, endothelial cells express a receptor that binds more tightly to albumin-lipid than unbound albumin. Unlike endocytosis in other cells that utilize clathrin, endothelial cells employ a membrane proteins called caveolin. Caveolin ...
... transport albumin conjugated to lipids into tissues. To accomplish this, endothelial cells express a receptor that binds more tightly to albumin-lipid than unbound albumin. Unlike endocytosis in other cells that utilize clathrin, endothelial cells employ a membrane proteins called caveolin. Caveolin ...
T cell
T cells or T lymphocytes are a type of lymphocyte (in turn, a type of white blood cell) that plays a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. They are called T cells because they mature in the thymus (although some also mature in the tonsils). The several subsets of T cells each have a distinct function. The majority of human T cells rearrange their alpha/beta T cell receptors and are termed alpha beta T cells and are part of adaptive immune system. Specialized gamma delta T cells, which comprise a minority of T cells in the human body (more frequent in ruminants), have invariant TCR (with limited diversity), can effectively present antigens to other T cells and are considered to be part of the innate immune system.