Increased hematopoietic stem cell mobilization in aged
... cell interactions are dynamic over a lifetime and result in physiologically relevant changes in the biology of primitive hematopoietic cells with age. (Blood. 2006;108: ...
... cell interactions are dynamic over a lifetime and result in physiologically relevant changes in the biology of primitive hematopoietic cells with age. (Blood. 2006;108: ...
Stem cells: you can`t tell a cell by its cover
... and with the ability to give rise to multiple tissue types (Thomson et al., 1998). Both of these parameters are subject to wide interpretation and depend to some degree on whether the stem cell is present in situ (in its normal environment) or in an experimental setting. For example, embryonic stem ...
... and with the ability to give rise to multiple tissue types (Thomson et al., 1998). Both of these parameters are subject to wide interpretation and depend to some degree on whether the stem cell is present in situ (in its normal environment) or in an experimental setting. For example, embryonic stem ...
Dynamics of the Immune Reaction to Pancreatic Cancer from
... foreign antigen have been well characterized and directly visualized in elegant studies (22, 23), and although theories abound regarding the naturally occurring in vivo immune responses to tumor cells during the course of disease progression, these responses have never been studied directly. Mouse m ...
... foreign antigen have been well characterized and directly visualized in elegant studies (22, 23), and although theories abound regarding the naturally occurring in vivo immune responses to tumor cells during the course of disease progression, these responses have never been studied directly. Mouse m ...
STING Contributes to Antiglioma Immunity via Triggering Type I IFN
... Although type I IFNs play critical roles in antiviral and antitumor activity, it remains to be elucidated how type I IFNs are produced in sterile conditions of the tumor microenvironment and directly affect tumor-infiltrating immune cells. Mouse de novo gliomas show increased expression of type I IFN ...
... Although type I IFNs play critical roles in antiviral and antitumor activity, it remains to be elucidated how type I IFNs are produced in sterile conditions of the tumor microenvironment and directly affect tumor-infiltrating immune cells. Mouse de novo gliomas show increased expression of type I IFN ...
Treatment of Sickle Cell Anemia Mouse Model with iPS Cells
... encoding a 2-lox c-Myc cDNA (Fig. 2B). Twentyfour clones were isolated on day 16 after infection, expanded on feeder cells, and iPS line #3 was randomly selected for further experiments. To reduce the potential risk of tumor formation due to c-Myc transgene expression (13), iPS cells were infected w ...
... encoding a 2-lox c-Myc cDNA (Fig. 2B). Twentyfour clones were isolated on day 16 after infection, expanded on feeder cells, and iPS line #3 was randomly selected for further experiments. To reduce the potential risk of tumor formation due to c-Myc transgene expression (13), iPS cells were infected w ...
The role of Th1/Th2 polarization in mucosal immunity
... (IgA)-committed B cells (Fig. 1). There tions. However, large mucosal surfaces (for example, greater than 300 m2 in human gut) are continu- are two different important outcomes of immune responses ously exposed to millions of potentially harmful antigens from generated by organized lymphoid structur ...
... (IgA)-committed B cells (Fig. 1). There tions. However, large mucosal surfaces (for example, greater than 300 m2 in human gut) are continu- are two different important outcomes of immune responses ously exposed to millions of potentially harmful antigens from generated by organized lymphoid structur ...
Chapter 43
... • Antigen receptors are generated by random rearrangement of DNA • As lymphocytes mature in bone marrow or the thymus, they are tested for self-reactivity • Lymphocytes with receptors specific for the body’s own molecules are destroyed by apoptosis, or rendered nonfunctional ...
... • Antigen receptors are generated by random rearrangement of DNA • As lymphocytes mature in bone marrow or the thymus, they are tested for self-reactivity • Lymphocytes with receptors specific for the body’s own molecules are destroyed by apoptosis, or rendered nonfunctional ...
The Immuno-Endocrine System: Hormones, Receptors and
... store and secrete them. In addition these cells have receptors for hormones and signal transduction pathways. These functions are under the control of the central nervous system (neuro-immune regulation), and there is a dynamic multi-directional interaction within the neuroimmune circuitry. Consider ...
... store and secrete them. In addition these cells have receptors for hormones and signal transduction pathways. These functions are under the control of the central nervous system (neuro-immune regulation), and there is a dynamic multi-directional interaction within the neuroimmune circuitry. Consider ...
Blood vessels: the endothelium
... One of the most important functions of the endothelial cells is to prevent diffusion of proteins from the blood into the surrounding tissue. In most of the circulatory system, endothelial cells form the only cellular layer that separates blood from the tissue. Blood is under hydrostatic pressure tha ...
... One of the most important functions of the endothelial cells is to prevent diffusion of proteins from the blood into the surrounding tissue. In most of the circulatory system, endothelial cells form the only cellular layer that separates blood from the tissue. Blood is under hydrostatic pressure tha ...
The Immune System
... D. Memory Cells: cells that are made during an immune response but are kept in storage for a future attack by the same QuickTime™ and a decompressor antigen - these cells are needed to see this picture. contain the “recipe” for making a specific type of antibody ...
... D. Memory Cells: cells that are made during an immune response but are kept in storage for a future attack by the same QuickTime™ and a decompressor antigen - these cells are needed to see this picture. contain the “recipe” for making a specific type of antibody ...
Document
... between DPSCs and UCSCs, which could indicate divergent propensity to differentiate into various lineages. Dental and oral-derived stem cells have a number of advantages over other more commonly utilized sources of adult stem cells. Compared to the invasive surgical procedure required for obtaining ...
... between DPSCs and UCSCs, which could indicate divergent propensity to differentiate into various lineages. Dental and oral-derived stem cells have a number of advantages over other more commonly utilized sources of adult stem cells. Compared to the invasive surgical procedure required for obtaining ...
Antigen Presentation and Dendritic Cells
... 3. Overview of Dendritic Cells: A. Basic Concepts: 1. DCs are the most effective professional APCs -Only professional APCs are capable activation of naïve T cells -Amateur APCs lack the ability to elicit signal 2 and therefore only recognize previously activated T cells. Most cells that become infec ...
... 3. Overview of Dendritic Cells: A. Basic Concepts: 1. DCs are the most effective professional APCs -Only professional APCs are capable activation of naïve T cells -Amateur APCs lack the ability to elicit signal 2 and therefore only recognize previously activated T cells. Most cells that become infec ...
9 Innate and acquired immunity
... and inflammation, whereas mast cells are similar to basophils but are found in tissues. ...
... and inflammation, whereas mast cells are similar to basophils but are found in tissues. ...
Sample Syllabus - Graduate School of Biomedical Sciences
... This course presents principles of innate and acquired (adaptive) immunity, including descriptions of the development and functions of cells that participate in immune responses, as well as the role of important soluble mediators. In addition, disorders of impaired or inappr ...
... This course presents principles of innate and acquired (adaptive) immunity, including descriptions of the development and functions of cells that participate in immune responses, as well as the role of important soluble mediators. In addition, disorders of impaired or inappr ...
New families of bioactive oxidized phospholipids generated by
... Early studies on esterified eicosanoid generation by immune cells During immune cell activation, PLA2 hydrolysis of phospholipids releases free arachidonate, which is oxidized by LOX, COX, or cytochrome P450 (CYP) to generate eicosanoids, including prostaglandins E2 and D2, thromboxane A2, leukotrie ...
... Early studies on esterified eicosanoid generation by immune cells During immune cell activation, PLA2 hydrolysis of phospholipids releases free arachidonate, which is oxidized by LOX, COX, or cytochrome P450 (CYP) to generate eicosanoids, including prostaglandins E2 and D2, thromboxane A2, leukotrie ...
Role of T Follicular Helper (Tfh) Cells Plasticity in
... Ag-presenting DCs can acquire expression of Bcl-6. However, their flexibility to specific effector lineages is governed by additional signals and the coordinated and antagonistic actions of different transcription factors [34]. Sufficient levels of T-bet or GATA3, or potentially RORγt, willoverride ...
... Ag-presenting DCs can acquire expression of Bcl-6. However, their flexibility to specific effector lineages is governed by additional signals and the coordinated and antagonistic actions of different transcription factors [34]. Sufficient levels of T-bet or GATA3, or potentially RORγt, willoverride ...
T cell receptor-transgenic mouse models for studying cellular
... TCR-transgenic systems use arti¢cially high T cell precursor frequencies, which could result in non-physiological responses due to T cell competition. However, data for the GFP_OVA system suggest that this might not be a limitation at least of this particular model. Another potential disadvantage of ...
... TCR-transgenic systems use arti¢cially high T cell precursor frequencies, which could result in non-physiological responses due to T cell competition. However, data for the GFP_OVA system suggest that this might not be a limitation at least of this particular model. Another potential disadvantage of ...
Macrophages induce an allergen-specific and long-term suppression in a mouse asthma model
... period between treatment and challenge to 4 weeks it was examined whether OVA-Mw exerted an immunosuppressive memory response. Strikingly, CMFDA-labelled Mw were not trapped in the lungs, but migrated to the spleen. ISSODN-stimulated KLH-Mw failed to suppress OVA-induced airway manifestations of ast ...
... period between treatment and challenge to 4 weeks it was examined whether OVA-Mw exerted an immunosuppressive memory response. Strikingly, CMFDA-labelled Mw were not trapped in the lungs, but migrated to the spleen. ISSODN-stimulated KLH-Mw failed to suppress OVA-induced airway manifestations of ast ...
A simulation study on photoacoustic signals from red blood cells
... Such an aggregate was repeated and randomly placed within the region of interest (abbreviated as ROI hereafter and refers to the region illuminated by the optical radiation) to simulate non-overlapping, isotropic, and identical RBC clusters representing an aggregated blood sample. This is a very sim ...
... Such an aggregate was repeated and randomly placed within the region of interest (abbreviated as ROI hereafter and refers to the region illuminated by the optical radiation) to simulate non-overlapping, isotropic, and identical RBC clusters representing an aggregated blood sample. This is a very sim ...
The promise of cd T cells and the cd T cell receptor for cancer
... used in rearrangement leading to ab and cd TCRs were discovered almost at the same time,1 the elucidation of ab T cell biology progressed rapidly, while the complexities of cd T cells have been slower to emerge. Nevertheless, the tripartite organisation of the lymphocytic immune system appears to be ...
... used in rearrangement leading to ab and cd TCRs were discovered almost at the same time,1 the elucidation of ab T cell biology progressed rapidly, while the complexities of cd T cells have been slower to emerge. Nevertheless, the tripartite organisation of the lymphocytic immune system appears to be ...
Chapter 1 - University of Amsterdam
... Department of Pathology, Academic Medical Center, Amsterdam (NL) ...
... Department of Pathology, Academic Medical Center, Amsterdam (NL) ...
Conserved CTL epitopes on the adenovirus hexon protein expand
... We have established a system for generating adenovirus-specific, cytotoxic, and helper T-cell responses from healthy human seropositive donors in vitro using replication-incompetent Ad vectors to stimulate viral specificity.15 These CTLs recognize and kill target cells infected with multiple wild-ty ...
... We have established a system for generating adenovirus-specific, cytotoxic, and helper T-cell responses from healthy human seropositive donors in vitro using replication-incompetent Ad vectors to stimulate viral specificity.15 These CTLs recognize and kill target cells infected with multiple wild-ty ...
Increased frequencies of pulmonary regulatory T-cells in latent Mycobacterium tuberculosis infection
... of active TB due to a high percentage of falsenegative results [9]. Mechanisms that govern local containment versus the development of active disease are still incompletely understood. It would be advantageous if biomarkers that correlate either with maintenance of effective immune control of the my ...
... of active TB due to a high percentage of falsenegative results [9]. Mechanisms that govern local containment versus the development of active disease are still incompletely understood. It would be advantageous if biomarkers that correlate either with maintenance of effective immune control of the my ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.