Monoclonal Antibody Use in Inflammatory Bowel disease
... stimulating the production of cell adhesion molecules by endothelial cells.1 Therapeutic targets have focused on immunologic mechanisms that trigger inflammation in IBD. The use of corticosteroids, antibiotics, and anti-inflammatory agents such as 5-aminosalicylates (5-ASA), has improved the managem ...
... stimulating the production of cell adhesion molecules by endothelial cells.1 Therapeutic targets have focused on immunologic mechanisms that trigger inflammation in IBD. The use of corticosteroids, antibiotics, and anti-inflammatory agents such as 5-aminosalicylates (5-ASA), has improved the managem ...
CSA Biopharm - Moodle Lille 2
... Matthew P Baker et Al. Immunogenicity of protein therapeutics:The key causes, consequences and challenges. Self/Nonself 1:4, 314-322; October/November/December 2010 © 2010 Landes Bioscience ...
... Matthew P Baker et Al. Immunogenicity of protein therapeutics:The key causes, consequences and challenges. Self/Nonself 1:4, 314-322; October/November/December 2010 © 2010 Landes Bioscience ...
Amino Acids, Amino Sugars and Sugars Present in the Cell Wall of
... tested contained lysine, glutamic acid, alanine, glucosamine and muramic acid ; this finding is in keeping with other reports (Cummins & Harris, 1956). When it was seen that in addition to these amino acids a few other ninhydrin-positive minor spots were also present on some of the paper chromatogra ...
... tested contained lysine, glutamic acid, alanine, glucosamine and muramic acid ; this finding is in keeping with other reports (Cummins & Harris, 1956). When it was seen that in addition to these amino acids a few other ninhydrin-positive minor spots were also present on some of the paper chromatogra ...
Full Text
... quite different from presentation of mycobacterial glycolipids. Glycosphingolipids are presented to T cells without being internalized by the antigen-presenting cell (APC) and bind to intact CD1 molecules on the cell surface (14). On the contrary, mycobacterial ligands require internalization in lat ...
... quite different from presentation of mycobacterial glycolipids. Glycosphingolipids are presented to T cells without being internalized by the antigen-presenting cell (APC) and bind to intact CD1 molecules on the cell surface (14). On the contrary, mycobacterial ligands require internalization in lat ...
無投影片標題
... Serum Why use serum ? Advantages of using serum 1. Serum represent a cocktail of most of the factors 2. Required for cell proliferation and maintenance. 3. An universal growth supplement which is effective with most cells. 4. Serum buffers the cell culture system against a variety of perturbation ...
... Serum Why use serum ? Advantages of using serum 1. Serum represent a cocktail of most of the factors 2. Required for cell proliferation and maintenance. 3. An universal growth supplement which is effective with most cells. 4. Serum buffers the cell culture system against a variety of perturbation ...
Vaccine
... either in yeast, bacteria or cell cultures. 2. Release and isolation of the antigen: The aim of this second step is to release as much virus or bacteria as possible. To achieve this, the antigen will be separated from the cells and isolated from the proteins and other parts of the growth medium that ...
... either in yeast, bacteria or cell cultures. 2. Release and isolation of the antigen: The aim of this second step is to release as much virus or bacteria as possible. To achieve this, the antigen will be separated from the cells and isolated from the proteins and other parts of the growth medium that ...
Modulation of the immune system by Boswellia serrata extracts and
... century AD) as a remedy for the treatment of a variety of inflammatory diseases. In 1986 Singh and Atal reported anti-inflammatory activity of an extract of the gum resin of B. serrata in animal experiments. Wagner et al. (1987) observed inhibition of guinea pig complement system by ␣- and -boswellic ...
... century AD) as a remedy for the treatment of a variety of inflammatory diseases. In 1986 Singh and Atal reported anti-inflammatory activity of an extract of the gum resin of B. serrata in animal experiments. Wagner et al. (1987) observed inhibition of guinea pig complement system by ␣- and -boswellic ...
Anti-Rat Ciliary Neurotrophic Factor (CNTF) Developed in Goat IgG
... consists of one intron. 1 The amino acid sequence of rat CNTF has 85% homology to human and rabbit CNTF.1 Ciliary Neurotrophic Factor (CNTF) is produced in E. coli by a DNA sequence encoding the rat CNTF protein. 2 Performance Anti-Rat CNTF is tested for its ability to neutralize the biological acti ...
... consists of one intron. 1 The amino acid sequence of rat CNTF has 85% homology to human and rabbit CNTF.1 Ciliary Neurotrophic Factor (CNTF) is produced in E. coli by a DNA sequence encoding the rat CNTF protein. 2 Performance Anti-Rat CNTF is tested for its ability to neutralize the biological acti ...
Amino Acids, Amino Sugars and Sugars Present in
... tested contained lysine, glutamic acid, alanine, glucosamine and muramic acid ; this finding is in keeping with other reports (Cummins & Harris, 1956). When it was seen that in addition to these amino acids a few other ninhydrin-positive minor spots were also present on some of the paper chromatogra ...
... tested contained lysine, glutamic acid, alanine, glucosamine and muramic acid ; this finding is in keeping with other reports (Cummins & Harris, 1956). When it was seen that in addition to these amino acids a few other ninhydrin-positive minor spots were also present on some of the paper chromatogra ...
Lecture 12
... 1. What are the parts of your average phage? What do each of them do for the phage life? 2. How would restriction enzymes protect a bacterial host? 3. What would be the fate of the T4 virus if the host cell were killed at 18 min. post infection? 4. Why is transcription of the T4 phage DNA under such ...
... 1. What are the parts of your average phage? What do each of them do for the phage life? 2. How would restriction enzymes protect a bacterial host? 3. What would be the fate of the T4 virus if the host cell were killed at 18 min. post infection? 4. Why is transcription of the T4 phage DNA under such ...
Immunesystem - Child Early Intervention Medical Center
... Omega-3 fatty acids (fish oil, flax seed oil) are antiinflammatory - can have marked influence on both specific and nonspecific immune responses in modifying inflammatory precursors and replacing Omega-6 FAs in cell membranes. 1 - 2 grams a day can be given safely. Start with a low dose and work up. ...
... Omega-3 fatty acids (fish oil, flax seed oil) are antiinflammatory - can have marked influence on both specific and nonspecific immune responses in modifying inflammatory precursors and replacing Omega-6 FAs in cell membranes. 1 - 2 grams a day can be given safely. Start with a low dose and work up. ...
Document
... Nuprin®), and naproxen (Aleve®), as well as some prescription-strength NSAIDs • Selective NSAIDs — Selective NSAIDs (also called COX-2 inhibitors) are as effective in relieving pain and inflammation as nonselective NSAIDs and are less likely to cause gastrointestinal injury. Celecoxib (Celebrex®) is ...
... Nuprin®), and naproxen (Aleve®), as well as some prescription-strength NSAIDs • Selective NSAIDs — Selective NSAIDs (also called COX-2 inhibitors) are as effective in relieving pain and inflammation as nonselective NSAIDs and are less likely to cause gastrointestinal injury. Celecoxib (Celebrex®) is ...
Neuronal differentiation and long
... 1997). All these effects are due to RA induction of numerous gene products, including transcription factors, structural proteins, neurotransmitters, neuropeptide hormones, growth factors, enzymes and cell surface receptors (Maden and Hind, 2003). After treatment with RA, cells arrest in the G1-phase ...
... 1997). All these effects are due to RA induction of numerous gene products, including transcription factors, structural proteins, neurotransmitters, neuropeptide hormones, growth factors, enzymes and cell surface receptors (Maden and Hind, 2003). After treatment with RA, cells arrest in the G1-phase ...
Hook effect in radioligand assay for Anti
... antibody in the second, with the already pointed result that the calibration graphs are decreasing in the first case and increasing in the second. It has been described in some cases a decrease of the curves at high concentrations called "hook effect", which is interpreted as a blockade affecting th ...
... antibody in the second, with the already pointed result that the calibration graphs are decreasing in the first case and increasing in the second. It has been described in some cases a decrease of the curves at high concentrations called "hook effect", which is interpreted as a blockade affecting th ...
Commensal-Specific CD4+ Cells From Patients
... that is thought to result from a loss of tolerance to commensal microorganisms. This view is supported strongly by studies conducted in animal models of intestinal inflammation, in which pathogenic CD4þ T-cell responses are directed against the enteric microbiota.1–4 In CD patients, antibodies to sev ...
... that is thought to result from a loss of tolerance to commensal microorganisms. This view is supported strongly by studies conducted in animal models of intestinal inflammation, in which pathogenic CD4þ T-cell responses are directed against the enteric microbiota.1–4 In CD patients, antibodies to sev ...
Review Article Thyroid dysfunction: an autoimmune aspect
... inflammatory cytokines. IL-12, IFN-γ, TNF-α play an important role in initiating adaptive immune response [42]. IL-1β has variety of effects on other cells, like it can alter cell signaling, migration, cytokine production, break peripheral tolerance and implicate autoimmune disease. Not only the pro ...
... inflammatory cytokines. IL-12, IFN-γ, TNF-α play an important role in initiating adaptive immune response [42]. IL-1β has variety of effects on other cells, like it can alter cell signaling, migration, cytokine production, break peripheral tolerance and implicate autoimmune disease. Not only the pro ...
Expression and purification of proteins using Strep
... The Strep-tag® II is a short peptide tag with negligible effect on the recombinant protein due to its chemically balanced amino acid composition (8 amino acids, WSHPQFEK) which can be fused to the protein as either N- or C-terminal tag. A two amino acid spacer (SerAla) between the protein and the ta ...
... The Strep-tag® II is a short peptide tag with negligible effect on the recombinant protein due to its chemically balanced amino acid composition (8 amino acids, WSHPQFEK) which can be fused to the protein as either N- or C-terminal tag. A two amino acid spacer (SerAla) between the protein and the ta ...
CIR Annual Report for 2009
... detection molecules are needed. Soluble T-cell receptors are new tools for such studies in health and disease. Furthermore, they may block the binding of specific peptide-MHC, be used as diagnostics or as immunotoxins. Phage display has been instrumental for the success of antibody technology. We ha ...
... detection molecules are needed. Soluble T-cell receptors are new tools for such studies in health and disease. Furthermore, they may block the binding of specific peptide-MHC, be used as diagnostics or as immunotoxins. Phage display has been instrumental for the success of antibody technology. We ha ...
Understanding Revlimid
... which cancer cells depend. Revlimid® is structurally related to thalidomide but has been modified by researchers to take advantage of the anticancer properties, and at the same time substantially reduce the likelihood of nerve or neurologic toxic side effects (peripheral neuropathy). Revlimid® has d ...
... which cancer cells depend. Revlimid® is structurally related to thalidomide but has been modified by researchers to take advantage of the anticancer properties, and at the same time substantially reduce the likelihood of nerve or neurologic toxic side effects (peripheral neuropathy). Revlimid® has d ...
Antigen Presenting Cells
... b. macrophages – most efficient during secondary response c. B cells 3. antigen is presented on major histocompatibility complex (MHC) 4. all APCs require: a. MHC II b. Costimulatory molecules (B7, CD40) 5. Cells that present antigen to CD8+ T cells are called target cells because these cells are ta ...
... b. macrophages – most efficient during secondary response c. B cells 3. antigen is presented on major histocompatibility complex (MHC) 4. all APCs require: a. MHC II b. Costimulatory molecules (B7, CD40) 5. Cells that present antigen to CD8+ T cells are called target cells because these cells are ta ...
PURPOSE:
... the control dots. These results will report C. diff Interpretation as C. diff positive. A test cannot be interpreted as negative or invalid until 10 minutes following the addition of Substrate. A single blue dotted line is visible in the middle of the Reaction Window, below the “C” and no test lines ...
... the control dots. These results will report C. diff Interpretation as C. diff positive. A test cannot be interpreted as negative or invalid until 10 minutes following the addition of Substrate. A single blue dotted line is visible in the middle of the Reaction Window, below the “C” and no test lines ...
Specific Antibody-Dependent Responses in HIV
... Based on this, 13 (50%) of the 26 subjects studied consecutively displayed antigen-specific non-T-lymphocyte responses to at least one of the HIV-1 peptide pools studied (Table 1). The majority of NK cell-mediated HIV-specific responses in the cohort of 26 subjects were to the Env peptide pool, rang ...
... Based on this, 13 (50%) of the 26 subjects studied consecutively displayed antigen-specific non-T-lymphocyte responses to at least one of the HIV-1 peptide pools studied (Table 1). The majority of NK cell-mediated HIV-specific responses in the cohort of 26 subjects were to the Env peptide pool, rang ...
Origins of antinuclear antibodies
... period during which the major autoantibodyeautoantigen systems associated with systemic autoimmune diseases were identified and characterized. Over the past 10 years, the pathogenesis of these autoantibodies has been partially elucidated with the discovery that the nucleic acid components of lupus a ...
... period during which the major autoantibodyeautoantigen systems associated with systemic autoimmune diseases were identified and characterized. Over the past 10 years, the pathogenesis of these autoantibodies has been partially elucidated with the discovery that the nucleic acid components of lupus a ...
B lymphocyte activation by contact
... CD40 mediated IgM production but, as both full-length and truncated (‘dominant-negative’) versions of TRAF3 have this effect, it is likely that TRAF3 overexpression disrupts the stoichiometry of the signaling complex to inhibit CD40-mediated function [37••]. Thus, TRAF3 may also have positive regula ...
... CD40 mediated IgM production but, as both full-length and truncated (‘dominant-negative’) versions of TRAF3 have this effect, it is likely that TRAF3 overexpression disrupts the stoichiometry of the signaling complex to inhibit CD40-mediated function [37••]. Thus, TRAF3 may also have positive regula ...
“Best o Best o f DDW” f DDW
... CCX282-B (T Traficet-EN ®) • Oral CCR9 antagonist for mod derate-to-severe Crohn’s • Methods: Randomized, double e-blind, placebo-controlled trial • Maintenance 36 weeks after 12-week induction and 4-week open-label – Endpoints: CDAI response and Remission at 36 weeks ...
... CCX282-B (T Traficet-EN ®) • Oral CCR9 antagonist for mod derate-to-severe Crohn’s • Methods: Randomized, double e-blind, placebo-controlled trial • Maintenance 36 weeks after 12-week induction and 4-week open-label – Endpoints: CDAI response and Remission at 36 weeks ...
Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.