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Slide 1
Slide 1

... Hendra and Nipah are viral zoonoses first recognized in the mid and late 1990’s and now comprise the genus Henipavirus within the paramyxovirus family. Their broad species tropism together with their capacity to cause severe and often fatal disease in both humans and animals make them significant tr ...
Kuby Immunology 6/e
Kuby Immunology 6/e

...  Can be used by leukocytes to interact with tissues  For leukocytes to enter inflamed tissues, cells must ...
(Western) Blotting
(Western) Blotting

... Analysis Date: Thursday May 6th 2010 ...
The Immune System
The Immune System

...  Some antigens exist on red blood cells (which helps determine type), so blood transfusions can be rejected if the host body has non-self blood antibodies to attack these foreign blood cells based on their antigens ...
Forensic Serology - Faculty Web Sites
Forensic Serology - Faculty Web Sites

... Antibodies have two reactive sites allowing them to attach to two of the same antigens ...
6. ABO and H Blood Groups
6. ABO and H Blood Groups

... potent clinically significant anti H which reacts well over a wide thermal range and with all RBCs except those of other Oh people. ...
Gilead
Gilead

... infected cell or cancer cells • Activated by cytokines from helper T cells • “Clone” themselves into attack cells and memory cells • Attack by producing proteins that open holes in infected cells ...
Tissue effector memory T cells Lymphoid central memory T cells
Tissue effector memory T cells Lymphoid central memory T cells

... 1. Life-long protection can be induced against some viruses 2. Presence of the virus is not needed for the maintenance of ...
The immune system
The immune system

... Cells, tissues and organs of the immune system • Immune cells are bone marrow-derived, & distributed through out the body ...
Lecture 1: The immune system: an overview
Lecture 1: The immune system: an overview

... Cells, tissues and organs of the immune system • Immune cells are bone marrow-derived, & distributed through out the body ...
Study Guide - Communicable Diseases, Ch
Study Guide - Communicable Diseases, Ch

... helper cells, which aid the activity of the B cells and killer T cells. (Killer T cells attach to abnormal body cells and release toxins that help destroy the abnormal cells.) ...
6. ABO and H Blood Groups
6. ABO and H Blood Groups

... a potent clinically significant anti H which reacts well over a wide thermal range and with all RBCs except those of other Oh people. ...
ANTIVIRAL ANTIBODY-PRODUCING CELLS IN
ANTIVIRAL ANTIBODY-PRODUCING CELLS IN

... accumulations of mononuclear cells (29-31) that may be so extensive as to resemble lymphomas . We now report that these infiltrates contain numerous plasma cells but also lymphocytes and mononuclear phagocytes, and, by use of a recently developed procedure (32, 33), we have demonstrated in the same ...
Physiology (Immunity) Lec.(5) Dr.Rafah Sami
Physiology (Immunity) Lec.(5) Dr.Rafah Sami

... system are 11 proteins designated C1 through C9, B, and D, shown in Figure All these are present normally among the plasma proteins in the blood as well as among the proteins that leak out of the capillaries into the tissue spaces. The enzyme precursors are normally inactive, but they can be activat ...
innate (non-specific) immunity
innate (non-specific) immunity

... Killing in the Phago-lysosome Effector Molecule ...
Molecular Oncology
Molecular Oncology

...  Cytotoxic and noncytotoxic methods with flow cytometry detection.  Enzyme-linked immunosorbent assay (ELISA) with solubilized HLA antigens.  Mixed lymphocyte culture measuring growth of lymphocytes activated by cross-reactivity.  Measure of HLA-protein mobility differences in one-dimensional ge ...
No T cells
No T cells

... an identical MHC gene locus T-cells recognize products of MHC genes as self or non-self If any cell of an individual starts to produce foreign (viral or bacterial) or abnormal (tumor associated) proteins, the T-cells recognize these antigen presenting cells as altered self cells and respond against ...
Antigen
Antigen

... • This gives rise to cells that secrete a soluble form of the protein called an antibody or immunoglobulin (Ig) • Secreted antibodies are similar to B cell receptors but lack transmembrane regions that anchor receptors in the plasma membrane ...
BD Pharmingen™ Polyclonal Rabbit Anti-Human
BD Pharmingen™ Polyclonal Rabbit Anti-Human

... smaller subunits of 40/36 kDa (doublet) and 23 kDa subunits. These subunits form a proteolytically active heterodimer capable of cleaving other caspase family members, as well as substrates such as PARP. This polyclonal antibody recognizes both the proform of caspase-8 as a 55/50 kDa doublet as well ...
This is the accepted version of the following article:
This is the accepted version of the following article:

... specific providing high yields and purity without the risk of structural or functional modification of isolated protein. Purifications based on affinity chromatography represent the most powerful tool available in term of the selectivity and recovery. Batch separation with specific antibodies as af ...
CLASS REVIEW...in the form of Jeopardy!
CLASS REVIEW...in the form of Jeopardy!

... Lymphocytes that persistently receive a primary stimulatory signal without a costimulatory signal are likely to end up in this inactive state. ...
Characterization of the mycobacterial lipids presented by
Characterization of the mycobacterial lipids presented by

... Mycobacteria, including Mycobacterium tuberculosis (Mtb) - a causative agent of tuberculosis, are characterized by exceptionally high content of lipids in their cell walls. Several mycobacterial lipid antigens have been found to be associated with group I CD1 molecules - non-polymorphic, MHC class I ...
Dr. JL Jarry
Dr. JL Jarry

... Activation of T-cells • T-cells have receptors • Macrophages present fragments of broken down pathogens to T-cells through a HLA antigen • This sensitizes the T-cell, which acquires specific receptors on its surface that enables them to recognize the invader • The T-cell undergoes clonal expansion • ...
B. True or False/Edit
B. True or False/Edit

... ___ 31. If allowed to go untreated, local infections may result in a fever when endogenous pyrogen molecules are released from leukocytes and macrophages. ___ 32. In certain diseases such as Alzheimer’s disease, asthma, or type 1 diabetes mellitus, the inflammatory processes required to protect the ...
SUPPLEMENT/ANCILLARY TITLE
SUPPLEMENT/ANCILLARY TITLE

... ___ 31. If allowed to go untreated, local infections may result in a fever when endogenous pyrogen molecules are released from leukocytes and macrophages. ___ 32. In certain diseases such as Alzheimer’s disease, asthma, or type 1 diabetes mellitus, the inflammatory processes required to protect the ...
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Monoclonal antibody



Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.
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