Prof
... respond in fundamentally different ways to two widely-used model vaccines (OVA and ßgal). Gene vaccines encoding the antigen were used to ensure identical conditions for the used antigens. Under these conditions, it became obvious that skin DCs can have different selectivity for different protein an ...
... respond in fundamentally different ways to two widely-used model vaccines (OVA and ßgal). Gene vaccines encoding the antigen were used to ensure identical conditions for the used antigens. Under these conditions, it became obvious that skin DCs can have different selectivity for different protein an ...
Granulocyte-Macrophage Colony Stimulating Factor, human
... 14.6 kDa globular protein consisting of 128 amino acids, containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites. It is lyophilized from a 10 mM sodium citrate solution, pH 3.5. The protein is sterile filtered through a 0.2 µm filter. The biological activity of r ...
... 14.6 kDa globular protein consisting of 128 amino acids, containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites. It is lyophilized from a 10 mM sodium citrate solution, pH 3.5. The protein is sterile filtered through a 0.2 µm filter. The biological activity of r ...
BIOC39H – Immunology Winter 2015 Course Syllabus
... Dr. Bebhinn Treanor Immunology is a discipline that overlaps with many other biological disciplines including physiology, cell and molecular biology, genetics, biochemistry, and microbiology, parasitology, and virology. The concepts and methods of these disciplines are fundamental to the study of th ...
... Dr. Bebhinn Treanor Immunology is a discipline that overlaps with many other biological disciplines including physiology, cell and molecular biology, genetics, biochemistry, and microbiology, parasitology, and virology. The concepts and methods of these disciplines are fundamental to the study of th ...
Module 2: Antibodies and Antigens
... Lecture 8: Antibodies and Antigens (part II) 8.1 Characteristics of biologic antigens 1) One of the most important characters of antigen is to bind specifically to an antibody. 2) Almost all the antigens are identified by specific antibodies but very few have the ability to stimulate the antibodies. ...
... Lecture 8: Antibodies and Antigens (part II) 8.1 Characteristics of biologic antigens 1) One of the most important characters of antigen is to bind specifically to an antibody. 2) Almost all the antigens are identified by specific antibodies but very few have the ability to stimulate the antibodies. ...
ppt
... foreign antigen of a RBC, second arm can fit with another antigen on another RBC – Causes clumping – If occurs in a blood transfusion, clumping can cause blood to cease flow due to obstruction, resulting in death ...
... foreign antigen of a RBC, second arm can fit with another antigen on another RBC – Causes clumping – If occurs in a blood transfusion, clumping can cause blood to cease flow due to obstruction, resulting in death ...
cells
... Variable regions, or idiotypes (ids),of antibodies ,BCRs and TCRs represent novel molecules not previously experienced by the immune system. Tolerance will not have been induced against them and ,if present in sufficient quantity, as occurs during a clonally expanded immune response, they will be im ...
... Variable regions, or idiotypes (ids),of antibodies ,BCRs and TCRs represent novel molecules not previously experienced by the immune system. Tolerance will not have been induced against them and ,if present in sufficient quantity, as occurs during a clonally expanded immune response, they will be im ...
7 T cell
... CHARACTERISTICS OF T-CELL ANTIGEN RECOGNITION 1. The TCR is not able to interact directly with soluble or cell-bound antigen 2. T-cell activation can be induced by antigen in the presence of acessory cells, only 3. T-cells recognize virus-infected cells ...
... CHARACTERISTICS OF T-CELL ANTIGEN RECOGNITION 1. The TCR is not able to interact directly with soluble or cell-bound antigen 2. T-cell activation can be induced by antigen in the presence of acessory cells, only 3. T-cells recognize virus-infected cells ...
protein
... Pure proteins are required to study enzyme function. Pure proteins can be used to determine what other proteins or molecules they might interact with. Pure proteins are needed for studies of protein function (e.g. Are there regulatory subunits? Is it phosphorylated? Is the protein regulated by its i ...
... Pure proteins are required to study enzyme function. Pure proteins can be used to determine what other proteins or molecules they might interact with. Pure proteins are needed for studies of protein function (e.g. Are there regulatory subunits? Is it phosphorylated? Is the protein regulated by its i ...
CARBOHYDRATES B: Polysaccharides Learning Goals/Objectives
... to be involved in recognition of other binding molecules, prevention of aggregation during protein folding, protection from proteolysis, and increases half-life of the proteins. In contrast to a protein sequence which is determined by a DNA template, sugars are attached to proteins by enzymes which ...
... to be involved in recognition of other binding molecules, prevention of aggregation during protein folding, protection from proteolysis, and increases half-life of the proteins. In contrast to a protein sequence which is determined by a DNA template, sugars are attached to proteins by enzymes which ...
2-2 immunity F11
... A contagious viral disease of the upper respiratory track Primarily caused by rhinoviruses ...
... A contagious viral disease of the upper respiratory track Primarily caused by rhinoviruses ...
Lecture Notes: Immune System (Part I)
... lipid and carbohydrate sequences unique to bacterial cell walls and to other substances characteristic of tumor and transplant cells. They exert their effects by way of the complement and other systems, with the cells they attack frequently dying by osmotic lysis or apoptosis. Their cytokines also a ...
... lipid and carbohydrate sequences unique to bacterial cell walls and to other substances characteristic of tumor and transplant cells. They exert their effects by way of the complement and other systems, with the cells they attack frequently dying by osmotic lysis or apoptosis. Their cytokines also a ...
The Body Defenses
... • Innate, nonspecific, responses work immediately when the body is exposed to a threatening agent. They nonselectively defend against foreign invaders. They provide a first line of defense, with rapid but limited responses. • Adaptive, or acquired, immunity specifically targets foreign material to w ...
... • Innate, nonspecific, responses work immediately when the body is exposed to a threatening agent. They nonselectively defend against foreign invaders. They provide a first line of defense, with rapid but limited responses. • Adaptive, or acquired, immunity specifically targets foreign material to w ...
Defense mechanism against pathogens
... 1) Innate immune system (non-specific) Defense system present at birth Protect against foreign cells or matters regardless what they are Doesn’t require prior exposure to invaders ...
... 1) Innate immune system (non-specific) Defense system present at birth Protect against foreign cells or matters regardless what they are Doesn’t require prior exposure to invaders ...
Click to view PowerPoint Presentation
... cancer demonstrated a response to Doxil1 In addition to causing DNA damage, Doxil increases the vulnerability of ovarian cancer cells to T cell attack Immunophenotypic changes in response to Doxil are more pronounced in BRCA-/- cells BRCA-/- tumors recruit higher numbers of T cells after Doxil expos ...
... cancer demonstrated a response to Doxil1 In addition to causing DNA damage, Doxil increases the vulnerability of ovarian cancer cells to T cell attack Immunophenotypic changes in response to Doxil are more pronounced in BRCA-/- cells BRCA-/- tumors recruit higher numbers of T cells after Doxil expos ...
An investigation of the mechanism of destruction by mammalian
... antibiotic resistance to current treatment methods.1 Thus, there is an essential need for alternative therapeutics to slow the infection rate around the world. H. pylori pathogenesis is directly linked to its ability to glycosylate proteins.2 These glycoproteins are not present in mammalian cells, a ...
... antibiotic resistance to current treatment methods.1 Thus, there is an essential need for alternative therapeutics to slow the infection rate around the world. H. pylori pathogenesis is directly linked to its ability to glycosylate proteins.2 These glycoproteins are not present in mammalian cells, a ...
Antibodies determine virulence of Dengue viruses
... secondary DF vs secondary DHF 1.DHF (enhanced infection) has stronger influence on the gene expression profile than DF (partially protected secondary infection). 2. 17 genes in immune response category are more strongly upregulated in DF PBMCs than in DHF PBMCs. 40% of them are genes of the interfer ...
... secondary DF vs secondary DHF 1.DHF (enhanced infection) has stronger influence on the gene expression profile than DF (partially protected secondary infection). 2. 17 genes in immune response category are more strongly upregulated in DF PBMCs than in DHF PBMCs. 40% of them are genes of the interfer ...
ThaoSpr2013
... glycosylation the core protein is exposed allowing antibodies to develop against the core tumor mucin protein, which then signals the immune system to kill off the infected cancer cell. However, over expression of MUC1 mucin exhibits immunosuppression by inhibiting cell lysis, thus rendering the imm ...
... glycosylation the core protein is exposed allowing antibodies to develop against the core tumor mucin protein, which then signals the immune system to kill off the infected cancer cell. However, over expression of MUC1 mucin exhibits immunosuppression by inhibiting cell lysis, thus rendering the imm ...
type I
... • One T helper epitope can provide help to multiple antibody epitopes in the same particle ...
... • One T helper epitope can provide help to multiple antibody epitopes in the same particle ...
Immunology
... proliferation of other T cell populations in vitro. The suppression by these regulatory cells is antigen specific because it depends upon activation through the TCR. Cell contact between the suppressing cells and their targets is required, if the regulatory cells are activated by antigen but separat ...
... proliferation of other T cell populations in vitro. The suppression by these regulatory cells is antigen specific because it depends upon activation through the TCR. Cell contact between the suppressing cells and their targets is required, if the regulatory cells are activated by antigen but separat ...
Lymphatic System and Immunity
... • Immune- body reacts to the presence of a pathogen by destroying it or rendering it harmless • Antigen (antibody generator)- any foreign substance (usually a protein) to which the body responds by making chemicals or specialized cells that eliminate that antigen, could be produced by a pathogen or ...
... • Immune- body reacts to the presence of a pathogen by destroying it or rendering it harmless • Antigen (antibody generator)- any foreign substance (usually a protein) to which the body responds by making chemicals or specialized cells that eliminate that antigen, could be produced by a pathogen or ...
B cells
... Antibodies as Tools • Antibody specificity and antigen-antibody binding have been harnessed in research, diagnosis, and therapy • Polyclonal antibodies, produced following exposure to a microbial antigen, are products of many different clones of plasma cells, each specific for a different epitope • ...
... Antibodies as Tools • Antibody specificity and antigen-antibody binding have been harnessed in research, diagnosis, and therapy • Polyclonal antibodies, produced following exposure to a microbial antigen, are products of many different clones of plasma cells, each specific for a different epitope • ...
Downstream Processes - Biological Engineering
... Protein-Cu(II) complexes react with Folin-Phenol reagent (phosphotungstic acid + phospomolybdic acid + phenol) Product is blue and can be detected at 630 nm Less sensitive than the Bradford method ...
... Protein-Cu(II) complexes react with Folin-Phenol reagent (phosphotungstic acid + phospomolybdic acid + phenol) Product is blue and can be detected at 630 nm Less sensitive than the Bradford method ...
Harmless Derivatives of Cancer Cells Induce Adaptive Immune
... USA Scientific, Ocala, FL) in tissue culture flasks under conditions described previously(1). Cells are harvested when confluent or cover more than 90% area of the tissue culture flask, as seen under an inverted microscope (PhotoZoom, Cambridge Instruments, Cambridge, MA). Cancer vaccines are made f ...
... USA Scientific, Ocala, FL) in tissue culture flasks under conditions described previously(1). Cells are harvested when confluent or cover more than 90% area of the tissue culture flask, as seen under an inverted microscope (PhotoZoom, Cambridge Instruments, Cambridge, MA). Cancer vaccines are made f ...
Microbiology_Ch_23,24, 26 W2010 - Cal State LA
... Coats antigen, eases engulfment by phagocytes (opsonization) ...
... Coats antigen, eases engulfment by phagocytes (opsonization) ...
ENHANCEMENT OF ANTI-KLH IgG ANTIBODY PRODUCTION IN
... stress, physical stressors such as inadequate sleep or athletic overtraining, environmental and occupational chemical exposure, UV and other types of radiation, common viral or bacterial infections, certain drug therapies, blood transfusions and surgery (9-13). In all cases immunostimulation using m ...
... stress, physical stressors such as inadequate sleep or athletic overtraining, environmental and occupational chemical exposure, UV and other types of radiation, common viral or bacterial infections, certain drug therapies, blood transfusions and surgery (9-13). In all cases immunostimulation using m ...
Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.