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Copying our Genes
Copying our Genes

PARENT #2
PARENT #2

... We can now translate the mRNA. Each codon equals an amino acid. We will get practice with pedigrees and protein synthesis during our gallery walk next! ...
A1985ASW1100001
A1985ASW1100001

... the amino acids was bound to the new RNA reversibly and at a separate site. The clincher as to its role in protein synthesis was that after it was charged with amino acids and reisolated, its bound amino acids were rapidly and quantitatively transferred to peptide linkages in protein on ribosomes~An ...
Gene Cloning
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Fundamentals of Cell Biology

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Genetic Engineering of Mammalian Cells
Genetic Engineering of Mammalian Cells

PPT File
PPT File

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Study Guide for Biology mid-term Exam
Study Guide for Biology mid-term Exam

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Bacterial Transformation - Baldwinsville Central School
Bacterial Transformation - Baldwinsville Central School

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It`s Alive! ...Or Not!

... which a new organism is produced from one organism and has DNA identical to the parent. • Sexual reproduction- reproduction in which two cells join in order to form a new cell which will have DNA similar to the parents. ...
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... using enzymes (proteins that catalyze reactions in organisms) to cut and join DNA from different sources into one stretch. To make a GM plant, say, that has a built-in insecticide to kill insect pests, for example, a gene coding for a protein that kills the insect is included, along with signals to ...
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Darwin`s Ideas and Natural Selection

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1-2 Student

... Producing New Kinds of Plants Mutations in some plant cells produce cells that have double or triple the normal number of chromosomes. This condition, known as polyploidy, produces new species of plants that are often larger and stronger than their diploid relatives. Polyploidy in animals is usually ...
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... mutations that change the protein and mutation that do not This provide us with a powerful “internal control” – we are comparing two different types of evolutionary events at the same loci, so all sources of variation in the mutational process are not ...
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Deoxyribozyme



Deoxyribozymes, also called DNA enzymes, DNAzymes, or catalytic DNA, are DNA oligonucleotides that are capable of catalyzing specific chemical reactions, similar to the action of other biological enzymes, such as proteins or ribozymes (enzymes composed of RNA).However, in contrast to the abundance of protein enzymes in biological systems and the discovery of biological ribozymes in the 1980s,there are no known naturally occurring deoxyribozymes.Deoxyribozymes should not be confused with DNA aptamers which are oligonucleotides that selectively bind a target ligand, but do not catalyze a subsequent chemical reaction.With the exception of ribozymes, nucleic acid molecules within cells primarily serve as storage of genetic information due to its ability to form complementary base pairs, which allows for high-fidelity copying and transfer of genetic information. In contrast, nucleic acid molecules are more limited in their catalytic ability, in comparison to protein enzymes, to just three types of interactions: hydrogen bonding, pi stacking, and metal-ion coordination. This is due to the limited number of functional groups of the nucleic acid monomers: while proteins are built from up to twenty different amino acids with various functional groups, nucleic acids are built from just four chemically similar nucleobases. In addition, DNA lacks the 2'-hydroxyl group found in RNA which limits the catalytic competency of deoxyribozymes even in comparison to ribozymes.In addition to the inherent inferiority of DNA catalytic activity, the apparent lack of naturally occurring deoxyribozymes may also be due to the primarily double-stranded conformation of DNA in biological systems which would limit its physical flexibility and ability to form tertiary structures, and so would drastically limit the ability of double-stranded DNA to act as a catalyst; though there are a few known instances of biological single-stranded DNA such as multicopy single-stranded DNA (msDNA), certain viral genomes, and the replication fork formed during DNA replication. Further structural differences between DNA and RNA may also play a role in the lack of biological deoxyribozymes, such as the additional methyl group of the DNA base thymidine compared to the RNA base uracil or the tendency of DNA to adopt the B-form helix while RNA tends to adopt the A-form helix. However, it has also been shown that DNA can form structures that RNA cannot, which suggests that, though there are differences in structures that each can form, neither is inherently more or less catalytic due to their possible structural motifs.
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