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Structure and Function of Macromolecules
Structure and Function of Macromolecules

... just a few small monomers, by varying number, sequence and bonding arrangements. Our biological macromolecules are grouped into four categories: proteins, nucleic acids, lipids and carbohydrates. We shall discuss structure and functions of each group. Most of our biological molecules are assembled o ...
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A Database of Peak Annotations of Empirically Derived Mass Spectra
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The Necessities of Life
The Necessities of Life

< 1 ... 491 492 493 494 495 496 497 498 499 ... 693 >

Proteolysis



Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Low pH or high temperatures can also cause proteolysis non-enzymatically.Proteolysis in organisms serves many purposes; for example, digestive enzymes break down proteins in food to provide amino acids for the organism, while proteolytic processing of a polypeptide chain after its synthesis may be necessary for the production of an active protein. It is also important in the regulation of some physiological and cellular processes, as well as preventing the accumulation of unwanted or abnormal proteins in cells. Consequently, dis-regulation of proteolysis can cause diseases, and is used in some venoms to damage their prey.Proteolysis is important as an analytical tool for studying proteins in the laboratory, as well as industrially, for example in food processing and stain removal.
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