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Jmol answers
Jmol answers

... Additional background information and web tutorials: http://jmol.sourceforge.net/ http://www.bluffton.edu/~bergerd/classes/jmol.html ...
Enzyme Structure and Function
Enzyme Structure and Function

... – Less collisions between substrate & enzyme = decreased reaction rate • Bubbling slows due to less hydrogen peroxide molecules colliding with liver enzymes. (Remember the toothpicks) ...
Functional decorations: post-translational modifications and heart
Functional decorations: post-translational modifications and heart

... identical sites and the functional basis (for example, which PTM is the positive and which is the negative regulator of function) for those that have been identified is generally not known. O-GlcNAc attachment and removal are mediated through the actions of O-GlcNAc transferase and OGlcNAcase, respe ...
Genome-Scale Modeling of the Protein Secretory Machinery
Genome-Scale Modeling of the Protein Secretory Machinery

... transmembrane, ERADM; cytosolic ERADC, ERAD C) pathways have been proposed as ER quality control system to detect and degrade the mis-folded protein to ensure the fidelity of proper folding., [30-34]. It has been also been shown that large amounts of the wild-type proteins can be degraded by the ERA ...
91.510_ch8_part1
91.510_ch8_part1

... Definition of a motif A motif (or fingerprint) is a short, conserved region of a protein. Its size is often 10 to 20 amino acids. Simple motifs include transmembrane domains and phosphorylation sites. These do not imply homology when found in a group of proteins. PROSITE (www.expasy.org/prosite) is ...
Unit 3 - Madison Public Schools
Unit 3 - Madison Public Schools

... natural by-product of cellular metabolism. Enzymes in peroxisomes break hydrogen peroxide into water and oxygen gas.  Prevalent in cells that are synthesizing and breaking down lipids.  In germinating seeds the peroxisomes break down fatty acids into sugars needed by the growing plant. ...
投影片下載 - 資訊科學與工程學系
投影片下載 - 資訊科學與工程學系

... sequences are the same. (3) Residues common at rat imidase and proteins of group3 or group4 but differ from that of group2, the score is set to 3. (4) Residues common at imidase and group2 proteins but differ from that of group3 or group4, the score is set to –2. (5) Residues common at sequence rela ...
SAMIE: STATISTICAL ALGORITHM FOR MODELING
SAMIE: STATISTICAL ALGORITHM FOR MODELING

... Many important biological processes depend on such accurate identi cation: DNA replication, methylation, and cell defense are among them. However, the most extensively studied such process is gene transcription, which is one of the ...
PPT
PPT

... • The results for the genomes of six archaea, 19 bacteria, and the eukaryotic organisms. • Using two different approaches, several factors – Determine amino acid composition can be deduced ...
- Academy Test Bank
- Academy Test Bank

... 41) In eukaryotes, which of the following properties is TRUE for both DNA and RNA? A) involved in translation B) contain the bases uracil and thymine C) follow the law of complementary base pairing D) propagation through semi-conservative replication E) double-stranded ...
answers_ch04
answers_ch04

... Chapter 4: Proteins as drug targets – enzymes 4) A mechanism similar to that described for the hydrolysis of peptide bonds by chymotrypsin (section 4.5.3) would be feasible, involving a catalytic triad of serine, histidine and aspartate. Serine would serve as a nucleophile, histidine as an acid/base ...
proteins
proteins

... ■ A protein is made as a result of transcription and translation in the cell. – During transcription, DNA is copied by RNA polymerase, which produces a copy of DNA called mRNA. – This mRNA copy then leaves the nucleus and moves to the ribosome. ■ During translation, the ribosome reads the mRNA in gr ...
Understanding conserved amino acids in proteins
Understanding conserved amino acids in proteins

... acids are universally conserved within each family of proteins having that fold. Such positions are localized in structure, and their unusually strong conservatism may be due to functional reason (e.g. super-site), or folding kinetics (folding nucleus) [5 –8]. In contrast to function and folding kin ...
Hemoglobin binding curve: causes of shift to right
Hemoglobin binding curve: causes of shift to right

... And tryptophan(W) has indole double ring thing. Sulfur in Cysteine; it loves to bond Sulfur Methionine is much more a snob Alcoholic Serine, well wouldn't you know, And Threonine's OH gives a warm glow. Acid-aspartic(D) and glutamic(E) are ionized With pK of 4, their protons are lysed, asparagine(N) ...
Investigation of the enzymatic processes depending on the ty
Investigation of the enzymatic processes depending on the ty

... Isoenzymes are important for diagnosis of different diseases ...
Download PDF
Download PDF

... may suffice for that purpose, there is no attempt to cover the full range of topics that will be found on those exams. ...
A Proteomics Approach to Membrane Trafficking1
A Proteomics Approach to Membrane Trafficking1

Dissecting protein structure and function using directed evolution
Dissecting protein structure and function using directed evolution

... discussed here demonstrate its value for studying protein structure and interactions. The contributions of individual amino acids to structure and protein complex formation can be interdependent, and their characterization can require the generation and analysis of many mutations without prior knowl ...
Sequence-Function Relationships
Sequence-Function Relationships

Tackling Unwanted Proteolysis in Plant Production Hosts Used for
Tackling Unwanted Proteolysis in Plant Production Hosts Used for

... heavy chains, whereas the light chains usually remain intact. It has been known for a long time that plant cysteine proteases of the papain family are able to cleave immunoglobulins within the hinge region of their heavy chains to yield Fab and Fc fragments (Porter, 1959). Other proteases cleave imm ...
biomolecules
biomolecules

... The other type of macromolecule that one would find in the acid insoluble fraction of any living tissue is the nucleic acid. These are polynucleotides. Together with polysaccharides and polypeptides these comprise the true macromolecular fraction of any living tissue or cell. For nucleic acids, the ...
Document
Document

... Messenger RNA (mRNA) is the blueprint for construction of a protein. Ribosomal RNA (rRNA) is the construction site where the protein is made. Transfer RNA (tRNA) is the truck delivering the proper amino acid to the site at the right time. ...
II. Lipids
II. Lipids

Document
Document

... Sterols • Sterols (steroids) – Are lipids characterized by a carbon skeleton consisting of four fused rings ...
Preview Sample 1
Preview Sample 1

... B) It serves as a structural component of human cells. C) It contains the genetic information found in cells. D) It is an important storage polysaccharide found in animal tissues. E) It forms the regulatory molecules known as enzymes. 10) Which of the following is an example of a pentose sugar? A) f ...
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Proteolysis



Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Low pH or high temperatures can also cause proteolysis non-enzymatically.Proteolysis in organisms serves many purposes; for example, digestive enzymes break down proteins in food to provide amino acids for the organism, while proteolytic processing of a polypeptide chain after its synthesis may be necessary for the production of an active protein. It is also important in the regulation of some physiological and cellular processes, as well as preventing the accumulation of unwanted or abnormal proteins in cells. Consequently, dis-regulation of proteolysis can cause diseases, and is used in some venoms to damage their prey.Proteolysis is important as an analytical tool for studying proteins in the laboratory, as well as industrially, for example in food processing and stain removal.
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