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BIOMOLECULES: INTRODUCTION, STRUCTURE AND FUNCTION
BIOMOLECULES: INTRODUCTION, STRUCTURE AND FUNCTION

... presence of a substance in living tissues as something which was “without doubt the most important of all substances of the living world, and without it life on our planet would probably not exist”. On suggestion of one of his friends, the famous Swedish chemist Berzelius, Mulder named this “most im ...
Fate of glucose:
Fate of glucose:

The Chemistry of Life
The Chemistry of Life

... the amino group of one amino acid and the carboxyl group of the next amino acid in the chain. Proteins are composed of one or more polypeptide chains ,usually at least 100 amino acids in length ...
Amino acid sequence of an immunogenic corneal stromal protein.
Amino acid sequence of an immunogenic corneal stromal protein.

... of the S-100 family. The amino acid identity between CO-Ag and the S-100 proteins ranges from 25% (S100L) to 81% (calgraulin C). The S-100 are a group of low molecular weight (approximately 10 kDa) acidic Ca2+-binding proteins. These proteins are expressed in a cell lineage-specific or tissue-specif ...
Lecture 2
Lecture 2

PPT - FLI - Leibniz Institute for Age Research
PPT - FLI - Leibniz Institute for Age Research

... Human intestinal trefoil factor [NMR structure with 85 models] Human intestinal trefoil factor, hITF, a secretory polypeptide found mainly in the human gastrointestinal tract, is a member of the newly characterized trefoil factor or P-domain peptide family representing putative growth factors. ...
Unit 3
Unit 3

... breakdown of glucose to pyruvate without the use of oxygen. Pyruvate is then converted into lactic acid, which limits the amount of ATP produced (2 ATP molecules). ...
Lecture slides
Lecture slides

... • Prediction remains a challenge – ab-initio (energy minimization) – knowledge-based • Chou-Fasman and GOR methods for SSE prediction • Comparative modeling and protein threading for tertiary structure prediction ...
Biological Molecules Review KEY
Biological Molecules Review KEY

... the smallest unit of matter that cannot normally be broken into smaller particles the process of breaking down large fat droplets into smaller fat droplets the loose association of amino acids in a polypeptide chain with each other, usually through H-bonds. e.g. alpha helix, beta pleated sheet the l ...
Due: 2015. 10. 12. 11:00 am (월)
Due: 2015. 10. 12. 11:00 am (월)

... Let’s assume that there is an allosteric enzyme with one binding site for the substrate, S. And it binds 100 times better on R state (c=KT/KR=100, KT, KR is dissociation constants). If one mole of substrate binds to one mole of the enzyme with one to one ratio, calculate how much L can be changed by ...
Frederick Sanger - Nobel Lecture
Frederick Sanger - Nobel Lecture

... that it was composed of relatively short polypeptide chains since free αamino groups would be found only on those residues (the N-terminal residues) which were present at one end of a chain. Thus the number of chains could be determined from the number of these N-terminal residues. The nature of one ...
Macroevolution
Macroevolution

... guiding questions ...
S1936879815019998_mmc1
S1936879815019998_mmc1

... the semicrystalline phased polymer. Panels II&III: Degradation occurs predominantly through hydrolysis and is bulk degradation from the inside out depending on the concentration of ester bonds, water and carboxylic acid end groups. Polylactides are relatively hydrophilic thus water diffuses into the ...
Enzymeregulation
Enzymeregulation

... Enz 1 is a special type of enzyme called an allosteric enzyme. It causes feedback inhibition. Allosteric enzymes contains two distinct subunits, one with active site (binds substrate A and catalyzes reaction), one with allosteric site (binds E). ...
Structural analysis of GARP
Structural analysis of GARP

... from den Hartigh JC etal,J Cell Biol 1992 ). Domains I and III correspond to L1 and L2, domains II and IV - to CR1 and CR2, respectively. ...
Lecture_09_Metabolic_systems - Home | CISB-ECN
Lecture_09_Metabolic_systems - Home | CISB-ECN

05 - summer quiz 2011.tst
05 - summer quiz 2011.tst

... 39) Water's surface tension and heat storage capacity is accounted for by its A) weight. B) mass. C) hydrogen bonds. D) orbitals. E) size. ...
Display of Artificial Scaffolding Proteins on Yeast Surface
Display of Artificial Scaffolding Proteins on Yeast Surface

... The results described above indicate that S. cerevisiae can express the recombinant scaffolding proteins derived from C. thermocellum CipA on its cell surface. However, FACS analysis of yeast strains displaying the scaffolding proteins with different numbers of cohesins indicated that the expression ...
Common Pattern of Coarse-Grained Charge Distribution of
Common Pattern of Coarse-Grained Charge Distribution of

... In this study, we focused on the net charges of amino acid sequences and found very similar patterns of the coarse-grained charge distribution for protein pairs of analogues and remote homologues. In general, the electrical interaction in water is much weaker than that in a nonpolar environment beca ...
Amino Acids, Peptides, and Proteins
Amino Acids, Peptides, and Proteins

... abbreviation for the amino acids, usually separated by hyphens. The amino terminus is always the Left most amino acid and the carboxyl terminus is always the Right most amino acid. Biological Functions of Proteins Within the cell / organism proteins serve a wide range of important biological functio ...
Outline Overview: The Molecules of Life Macromolecules are
Outline Overview: The Molecules of Life Macromolecules are

... Product = The end result ...
Expression of Semliki Forest Virus Proteins from Cloned
Expression of Semliki Forest Virus Proteins from Cloned

... membrane. These two membrane glycoproteins form a complex with each other in the RER and are then transported via the Golgi apparatus to the PM. At a late stage during their transport the p62 protein is cleaved to E3 and E2. The E2 protein represents most of the p62 polypeptide chain, including the ...
Polar amino acids with negative charge
Polar amino acids with negative charge

... Cysteine is one of two sulfur-containing amino acids; the other is methionine. Cysteine differs from serine in a single atom-- the sulfur of the thiol replaces the oxygen of the alcohol. The amino acids are, however, much more different in their physical and chemical properties than their similarit ...
Protein Structure Prediction
Protein Structure Prediction

... Contribution of -turns in tertiary structure prediction of bioactive peptides • 3D structures of 77 biologically active peptides have been selected from PDB and other databases such as PSST (http://pranag.physics.iisc.ernet.in/psst) and PRF (http://www.genome.ad.jp/) have been selected. • The data ...
Protein structure and function
Protein structure and function

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Proteolysis



Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Low pH or high temperatures can also cause proteolysis non-enzymatically.Proteolysis in organisms serves many purposes; for example, digestive enzymes break down proteins in food to provide amino acids for the organism, while proteolytic processing of a polypeptide chain after its synthesis may be necessary for the production of an active protein. It is also important in the regulation of some physiological and cellular processes, as well as preventing the accumulation of unwanted or abnormal proteins in cells. Consequently, dis-regulation of proteolysis can cause diseases, and is used in some venoms to damage their prey.Proteolysis is important as an analytical tool for studying proteins in the laboratory, as well as industrially, for example in food processing and stain removal.
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