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L. helveticus
L. helveticus

... – highly basic proteins (pI = 9.35-10.4) – mostly non-glycosylated – signal peptide (N- terminal secretion signal ) typical for Sec pathway (25-30 AA) ...
PROTEIN METABOLISM
PROTEIN METABOLISM

... Some regulatory enzymes have half-lives measured in hours or minutes. The majority of the amino acids released during protein degradation are promptly reincorporated into fresh proteins. ...
STRUCTURE AND FUNCTION
STRUCTURE AND FUNCTION

... does not need nitrogen for biosynthesis. Another reason why you would want to keep ammonia out of the cell when ATP levels are low is because once in the cell the ammonia would tend to protonate and dissipate the proton gradient used for ATP synthesis. This effect could be especially harmful to a ce ...
Carbohydrate Fans
Carbohydrate Fans

... How do fats and oils differ? Why do they differ? Where do we find saturated fats? Why are they solid? Where do we find unsaturated fats? Why are they liquid? Explain mono- vs. poly- unsaturated fats. Which are healthier? Why?? What is hydrogenation? Explain margarine. (see above) Why (and how) do we ...
Process Biochemistry
Process Biochemistry

... presence of proteases affects protein gelation. Besides, acid or bitter taste, related to the presence of some peptides and free amino acids in the muscle [6] and intense ammonia odor produced by high concentrations of non-protein nitrogen products were also reported. Such characteristics discourage ...
A Method To Define the Carboxyl Terminal of Proteins
A Method To Define the Carboxyl Terminal of Proteins

... C-terminal sequence is achieved by capillary-HPLC electrospray ionization tandem mass spectrometry of the isolated peptide using a quadrupole ion trap mass spectrometer in the selective reaction monitoring mode. This strategy was successfully applied to the characterization of the C-terminal of prot ...
Evolutionary rate at the protein domain level is
Evolutionary rate at the protein domain level is

... theoretical framework for understanding the molecular clock as well as the apparent differences in the rate of evolution that arise within proteins and across different lineages [13]. Because the mechanism of DNA replication is prone to some small level of error, mutations repeatedly arise in the ge ...
Biol 115 DNA, the Thread of Life
Biol 115 DNA, the Thread of Life

... subunit of the ribosome has three binding sites: an amino acid site (A), a polypeptide site (P), and an exit site (E). The initiator tRNA molecule carrying the amino acid methionine binds to the AUG start codon of the mRNA transcript at the ribosome’s P site where it will become the first amino acid ...
Camp 1 - UCSC Directory of individual web sites
Camp 1 - UCSC Directory of individual web sites

... Features of the Code • For the 15 amino acids coded for by 2, 3, or 4 triplets, it is only the third letter of the codon that varies. Gly, for example, is coded for by GGA, GGG, GGC, and GGU. • The code is almost universal: it the same in viruses, prokaryotes, and eukaryotes; the only exceptions ar ...
BCL-2 Family Proteins: Critical Checkpoints of Apoptotic
BCL-2 Family Proteins: Critical Checkpoints of Apoptotic

... BH3-only proapoptotic proteins : apoptotic sentinels upstream of BAX and BAK 1. Indirect activation model 1) antiapoptotic BCL-2, BCL-XL, MCL-1 : to inhibit BAX and BAK 2) these inhibitory interaction seem to be selective ...
C. The Synthesis of Protein
C. The Synthesis of Protein

... First, at least some introns contain sequences that control gene activity in some way. ...
Ch17WordLectureOutline w pics
Ch17WordLectureOutline w pics

... First, at least some introns contain sequences that control gene activity in some way. ...
Unit 7 Molecular Genetics Chp 17 Protein Synthesis
Unit 7 Molecular Genetics Chp 17 Protein Synthesis

... First, at least some introns contain sequences that control gene activity in some way. ...
Functional analysis of an interspecies chimera of acyl carrier
Functional analysis of an interspecies chimera of acyl carrier

Polyomaviridae
Polyomaviridae

... • Stimulating cell growth pathways by binding cellular DNA, ATPase-helicase, DNA polymerase α association, and binding of transcription preinitiation complex factors. • This abnormal stimulation of the cell cycle is a powerful force for oncogenic transformation. ...
Contents - Garland Science
Contents - Garland Science

... tricarboxylic acid cycle The tricarboxylic acid cycle is regulated at several steps Recent research into a thioredoxin/NADPH redox system for regulating tricarboxylic acid cycle enzymes and other mitochondrial proteins ...
allosteric activator
allosteric activator

... turn over, with the relative rates of enzyme synthesis and degradation ultimately determining the amount of enzymes. In many instances, transcriptional regulation determines the concentrations of specific enzyme, with enzyme proteins degradation playing a minor role. In other instances, protein synt ...
amino acids
amino acids

... • Their R groups are more hydrophilic, due to the presence of hydroxyl groups, sulfur atoms or amide groups which may form hydrogen bonds with water. ...
1 Supplementary data Materials and methods Preparation of the
1 Supplementary data Materials and methods Preparation of the

... monomer) in the cell with 180 seconds between two consecutive injections, while the sample was stirred at 316 rpm. In experiments for studying the effect of the L2 domain on nucleotide binding, the L2 was added into both the cell and the injection syringe to the final concentration of 30 µM. For L2 ...
Document
Document

Unit One
Unit One

... proteins, and nucleic acids. Carbohydrates - made of C, H, O generally in a 1 :2: 1 ratio, polar molecules - can be broken down and used for energy - can form the structural components of cells and nucleic acids - can function as receptors / signal molecules in cell membrane Lipids - "greasy or oily ...
MolecularModeling3
MolecularModeling3

... (5) What are the h­bond pattern differences between alpha helices and beta sheets? Between  antiparallel and parallel beta sheets? Draw diagrams on a piece of paper representing the  h­bond pattern of each secondary structure motif.  An alpha helix is stabilized by h­bonds that form between the N­H  ...
Intro to Biology review - Brookings School District
Intro to Biology review - Brookings School District

... Lipids that are made of many carbon and ...
Chapters 1 and 2 Review
Chapters 1 and 2 Review

... Lipids that are made of many carbon and ...
Supporting text S1
Supporting text S1

... example, both histidine and serine ammonia-lyase are absent. Enzymes necessary for histidine degradation via urocanate or histamine are all absent. Aromatic amino acids cannot be degraded, based on the lack of genes encoding tryptophanase, tryptophan monoxygenase, aromatic-L-amino-acid decarboyxlase ...
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Proteolysis



Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Low pH or high temperatures can also cause proteolysis non-enzymatically.Proteolysis in organisms serves many purposes; for example, digestive enzymes break down proteins in food to provide amino acids for the organism, while proteolytic processing of a polypeptide chain after its synthesis may be necessary for the production of an active protein. It is also important in the regulation of some physiological and cellular processes, as well as preventing the accumulation of unwanted or abnormal proteins in cells. Consequently, dis-regulation of proteolysis can cause diseases, and is used in some venoms to damage their prey.Proteolysis is important as an analytical tool for studying proteins in the laboratory, as well as industrially, for example in food processing and stain removal.
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