Histidine protonation and the activation of viral fusion proteins
... From the X-ray crystal structures of the pre- (1OKE, 1OAN) and post- (1OK8) fusion conformations of the DEN2 sE protein [9,13], it is known that the primary difference between the conformations is a displacement of domain III by 33 Å (1 Å = 0.1 nm) and associated changes of the domain interfaces [ ...
... From the X-ray crystal structures of the pre- (1OKE, 1OAN) and post- (1OK8) fusion conformations of the DEN2 sE protein [9,13], it is known that the primary difference between the conformations is a displacement of domain III by 33 Å (1 Å = 0.1 nm) and associated changes of the domain interfaces [ ...
2.3 Carbon-Based Molecules TEKS 9A
... • Proteins are polymers of amino acid monomers. – Twenty different amino acids are used to build proteins in organisms. – Amino acids differ in side groups, or R groups. – Amino acids are linked by peptide bonds. ...
... • Proteins are polymers of amino acid monomers. – Twenty different amino acids are used to build proteins in organisms. – Amino acids differ in side groups, or R groups. – Amino acids are linked by peptide bonds. ...
Thulashie Sivarajah
... Conclusion: Under normal conditions, Src is only active at certain times. However, mutated Src kinases that are missing tyrosine 527 are active all the time. This leads to several cancers and diseases including Colon, Breast Cancers, Arthrosclerosis, Psoriasis, and Restnoises. Bivalent inhibitors ar ...
... Conclusion: Under normal conditions, Src is only active at certain times. However, mutated Src kinases that are missing tyrosine 527 are active all the time. This leads to several cancers and diseases including Colon, Breast Cancers, Arthrosclerosis, Psoriasis, and Restnoises. Bivalent inhibitors ar ...
Heart Failure
... the LV 72 hours after sTAB (Figure 2A). No significant ubiquitin-like immunoreactivity was detected in regions not subjected to biomechanical stress such as right ventricle or either atria. Of interest, we detected a preponderance of ubiquitin staining in the basal septum, a region previously report ...
... the LV 72 hours after sTAB (Figure 2A). No significant ubiquitin-like immunoreactivity was detected in regions not subjected to biomechanical stress such as right ventricle or either atria. Of interest, we detected a preponderance of ubiquitin staining in the basal septum, a region previously report ...
BCA Assay
... detection and quantitation of total protein. This method combines the well-known reduction of Cu+2 to Cu+1 by protein in an alkaline medium (the biuret reaction) with the highly sensitive and selective colorimetric detection of the cuprous cation (Cu+1) using a unique reagent containing bicinchonini ...
... detection and quantitation of total protein. This method combines the well-known reduction of Cu+2 to Cu+1 by protein in an alkaline medium (the biuret reaction) with the highly sensitive and selective colorimetric detection of the cuprous cation (Cu+1) using a unique reagent containing bicinchonini ...
Chapter 5
... What Determines Protein Structure? • In addition to primary structure, physical and chemical conditions can affect structure • Alterations in pH, salt concentration, temperature, or other environmental factors can cause a protein to unravel • This loss of a protein’s native structure is called dena ...
... What Determines Protein Structure? • In addition to primary structure, physical and chemical conditions can affect structure • Alterations in pH, salt concentration, temperature, or other environmental factors can cause a protein to unravel • This loss of a protein’s native structure is called dena ...
NAD + , NADP +
... anabolic reactions? In most living tissues: [NADP+] + [NADPH] = 10-6 M [NADP+]/[NADPH] is low The above reaction favor the formation of NADP+ , which means NADPH undergoes oxidation and couple with reduction reactions that are mostly anabolic ...
... anabolic reactions? In most living tissues: [NADP+] + [NADPH] = 10-6 M [NADP+]/[NADPH] is low The above reaction favor the formation of NADP+ , which means NADPH undergoes oxidation and couple with reduction reactions that are mostly anabolic ...
AHM1, a Novel Type of Nuclear Matrix–Localized
... The nuclear matrix, operationally defined, is the dynamic fibrogranular structure forming the skeletal framework that surrounds and penetrates the interphase nucleus; it has been implicated in most nuclear functions, including replication, repair, transcription, RNA processing, and RNA transport (Be ...
... The nuclear matrix, operationally defined, is the dynamic fibrogranular structure forming the skeletal framework that surrounds and penetrates the interphase nucleus; it has been implicated in most nuclear functions, including replication, repair, transcription, RNA processing, and RNA transport (Be ...
pdf
... 1. Actively translating proteins were labeled with radioactive amino acids for a brief time (short relative to the time required to complete synthesis). 2. Completed polypeptides were collected, digested with trypsin, and the amount of radioactivity in tryptic fragments was determined. 3. Tryptic fr ...
... 1. Actively translating proteins were labeled with radioactive amino acids for a brief time (short relative to the time required to complete synthesis). 2. Completed polypeptides were collected, digested with trypsin, and the amount of radioactivity in tryptic fragments was determined. 3. Tryptic fr ...
Delivery of a Secreted Soluble Protein to the Vacuole via a
... tonoplast. This is particularly relevant in the case of homologous proteins such as aquaporins, which are found in both membranes. Although amino acid sequence comparisons have revealed differences between the aquaporin homologs (Schaffner, 1998), it is not clear that these domains contain the targe ...
... tonoplast. This is particularly relevant in the case of homologous proteins such as aquaporins, which are found in both membranes. Although amino acid sequence comparisons have revealed differences between the aquaporin homologs (Schaffner, 1998), it is not clear that these domains contain the targe ...
Bio 112 17 sp11
... 14. Describe the structure and function of tRNA. 15. Explain how tRNA is joined to the appropriate amino acid. 16. Describe the structure and functions of ribosomes. 17. Describe the process of translation (including initiation, elongation, and termination) and explain which enzymes, protein factors ...
... 14. Describe the structure and function of tRNA. 15. Explain how tRNA is joined to the appropriate amino acid. 16. Describe the structure and functions of ribosomes. 17. Describe the process of translation (including initiation, elongation, and termination) and explain which enzymes, protein factors ...
Full Text
... also be generated by entering the InterPro block ID (IPB000938) directly into the main 3MATRIX search page. In all visualizations, 3MOTIF and 3MATRIX calculate and display the degree of conservation and the chemical environments of conserved amino acids. In the case of discrete sequence motifs, the ...
... also be generated by entering the InterPro block ID (IPB000938) directly into the main 3MATRIX search page. In all visualizations, 3MOTIF and 3MATRIX calculate and display the degree of conservation and the chemical environments of conserved amino acids. In the case of discrete sequence motifs, the ...
Chapter 7 7 The Behavior of Proteins: Enzymes Mechanisms and
... when different substances are bound to the protein; e.g., inhibition of ATCase by CTP and activation by ...
... when different substances are bound to the protein; e.g., inhibition of ATCase by CTP and activation by ...
Glycine-rich proteins as structural components of plant cell walls
... GRPs are characterized by their high content of glycine residues. GRPs, however, are not necessarily structural proteins, as RNA-binding proteins also have glycine-rich domains [7–9]. Since this article is focused on structural GRPs localized in the cell wall, only proteins are included for which ex ...
... GRPs are characterized by their high content of glycine residues. GRPs, however, are not necessarily structural proteins, as RNA-binding proteins also have glycine-rich domains [7–9]. Since this article is focused on structural GRPs localized in the cell wall, only proteins are included for which ex ...
Peptide fragmentation - University of Szeged, Department of
... While the ions discussed above provide composition information, all the other signals in MS/MS spectra provide information on the sequence. Most frequently the dissociation reaction occurs at the peptide bonds. When the proton (charge) is retained on the N-terminal fragment, b-ions are formed with t ...
... While the ions discussed above provide composition information, all the other signals in MS/MS spectra provide information on the sequence. Most frequently the dissociation reaction occurs at the peptide bonds. When the proton (charge) is retained on the N-terminal fragment, b-ions are formed with t ...
Unknown title - Sigma
... Post-genomic research efforts, high-throughput methodology and advances in areas such as mass spectrometry or electron microscopy have revealed that biological functioning is controlled by biomolecular interaction networks, often in a heterogeneous and dense molecular environment. For example, the c ...
... Post-genomic research efforts, high-throughput methodology and advances in areas such as mass spectrometry or electron microscopy have revealed that biological functioning is controlled by biomolecular interaction networks, often in a heterogeneous and dense molecular environment. For example, the c ...
Preliminary Proposal
... reaction of the compound of interest. pKa more specifically is how the compound will ionize depending on the environmental pH. This is extremely important for functional groups of many important organic and biological molecules because function of that particular molecule is dependent on its charge. ...
... reaction of the compound of interest. pKa more specifically is how the compound will ionize depending on the environmental pH. This is extremely important for functional groups of many important organic and biological molecules because function of that particular molecule is dependent on its charge. ...
Structure and function of the chloroplast signal recognition particle
... therefore posed the question which structural characteristics of the LHCPs determine the transit complex formation with cpSRP. By analogy, with the co-translational targeting system where binding of cytosolic SRP54 to a substrate protein is mediated via its hydrophobic signal sequence, it was shown ...
... therefore posed the question which structural characteristics of the LHCPs determine the transit complex formation with cpSRP. By analogy, with the co-translational targeting system where binding of cytosolic SRP54 to a substrate protein is mediated via its hydrophobic signal sequence, it was shown ...
LS1a Fall 2014 Practice Problem Set 6 1. Name three ways in which
... E. An electron-poor atom or molecule involved in making a new bond F. The bond that is formed between enzyme and substrate G. Region of the enzyme that is involved in carrying out catalysis H. Loss of interactions of a protein or a drug with surrounding solvent (e.g., water) molecules I. The differe ...
... E. An electron-poor atom or molecule involved in making a new bond F. The bond that is formed between enzyme and substrate G. Region of the enzyme that is involved in carrying out catalysis H. Loss of interactions of a protein or a drug with surrounding solvent (e.g., water) molecules I. The differe ...
Plant Cell Wall Biosynthesis
... ‘signal sequence’ that leads this end of the chain through the membrane into the ER lumen. The signal sequence is later removed enzymatically. The new protein is carried through the endomembrane system: ER!cis-Golgi! medial-Golgi!trans-Golgi!plasma membrane. During this journey, the protein may be p ...
... ‘signal sequence’ that leads this end of the chain through the membrane into the ER lumen. The signal sequence is later removed enzymatically. The new protein is carried through the endomembrane system: ER!cis-Golgi! medial-Golgi!trans-Golgi!plasma membrane. During this journey, the protein may be p ...
A Contribution of the Mitochondrial
... same factor that causes a decrease in the thermal stability of the enzyme (Garza-Ramos et al., 1989, 1990). The therm al protection conferred by the mitochondrial ATPase inhibitor protein (Fig. 2, Table I) probably involves a different mechanism, since it binds to a specific region (the ß-subunit) o ...
... same factor that causes a decrease in the thermal stability of the enzyme (Garza-Ramos et al., 1989, 1990). The therm al protection conferred by the mitochondrial ATPase inhibitor protein (Fig. 2, Table I) probably involves a different mechanism, since it binds to a specific region (the ß-subunit) o ...
Macromolecules Exercise Ver8 - STAR
... Proteins are macromolecules that are mainly composed of carbon, hydrogen, oxygen, and nitrogen, but often also contain other elements. Proteins are made up of long chains of amino acids also called polypeptide chains. Some proteins are enzymes that carry out important biochemical processes within th ...
... Proteins are macromolecules that are mainly composed of carbon, hydrogen, oxygen, and nitrogen, but often also contain other elements. Proteins are made up of long chains of amino acids also called polypeptide chains. Some proteins are enzymes that carry out important biochemical processes within th ...
Proteolysis
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Low pH or high temperatures can also cause proteolysis non-enzymatically.Proteolysis in organisms serves many purposes; for example, digestive enzymes break down proteins in food to provide amino acids for the organism, while proteolytic processing of a polypeptide chain after its synthesis may be necessary for the production of an active protein. It is also important in the regulation of some physiological and cellular processes, as well as preventing the accumulation of unwanted or abnormal proteins in cells. Consequently, dis-regulation of proteolysis can cause diseases, and is used in some venoms to damage their prey.Proteolysis is important as an analytical tool for studying proteins in the laboratory, as well as industrially, for example in food processing and stain removal.